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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xanthohumol
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Accession:CHEBI:66331 term browser browse the term
Definition:A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.
Synonyms:exact_synonym: (2E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
 related_synonym: 2',4,4'-trihydroxy-6'-methoxy-3'-prenylchalcone;   Formula=C21H22O5;   InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+;   InChIKey=ORXQGKIUCDPEAJ-YRNVUSSQSA-N;   SMILES=COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)\\C=C\\c1ccc(O)cc1
 xref: CAS:6754-58-1;   HMDB:HMDB0037479;   KEGG:C16417;   KNApSAcK:C00007099;   LIPID_MAPS_instance:LMPK12120294
 xref_mesh: MESH:C104536
 xref: MetaCyc:CPD-7119;   PMID:14670594;   PMID:15550272;   PMID:15679315;   PMID:15723722;   PMID:19634869;   PMID:22111577;   Patent:EP2579862;   Patent:WO2009126320;   Reaxys:2226282;   Wikipedia:Xanthohumol
 cyclic_relationship: is_conjugate_acid_of CHEBI:134289


show annotations for term's descendants           Sort by:
xanthohumol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO [xanthohumol binds to and results in decreased activity of ABCC5 protein] which results in decreased export of Hyaluronic Acid; xanthohumol binds to and results in decreased activity of ABCC5 protein; xanthohumol inhibits the reaction [ABCC5 protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO xanthohumol increases expression of Abcg1 protein in liver RGD PMID:23650230 RGD:401842363 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO xanthohumol results in decreased phosphorylation of AKT1 protein
AKT1 protein modified form inhibits the reaction [xanthohumol results in increased expression of BBC3 protein]		 CTD PMID:35229981 PMID:35259468 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions
decreases phosphorylation		 ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]
xanthohumol results in decreased phosphorylation of AKT2 protein		 CTD PMID:23994090 PMID:35229981 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases phosphorylation ISO xanthohumol results in decreased phosphorylation of AKT3 protein CTD PMID:35229981 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
increases expression		 ISO xanthohumol results in increased activity of ALPL protein
xanthohumol results in increased expression of ALPL mRNA		 CTD PMID:16019205 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO xanthohumol results in increased expression of BAK1 protein CTD PMID:35229981 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of BAX protein] CTD PMID:31714664 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of BBC3 mRNA; xanthohumol results in increased expression of BBC3 protein
AKT1 protein modified form inhibits the reaction [xanthohumol results in increased expression of BBC3 protein]; BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP9 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased expression of BBC3 protein]; xanthohumol promotes the reaction [Cisplatin results in increased expression of BBC3 protein]; xanthohumol promotes the reaction [Pemetrexed results in increased expression of BBC3 protein]		 CTD PMID:35259468 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 xanthohumol results in decreased expression of BCL2; xanthohumol results in decreased expression of BCL2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]		 CTD PMID:15995977 PMID:23562496 PMID:26297991 PMID:31714664 PMID:35229981 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO xanthohumol results in increased expression of BCL2L11 alternative form CTD PMID:35229981 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:23994090 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases activity
increases cleavage		 ISO
EXP		 BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; xanthohumol results in increased cleavage of and results in increased activity of CASP3 protein
xanthohumol results in increased activity of CASP3 protein
xanthohumol results in decreased activity of CASP3 protein
xanthohumol inhibits the reaction [Azoxymethane results in decreased expression of CASP3 protein]		 CTD PMID:15995977 PMID:26297991 PMID:27317025 PMID:30240731 PMID:31714664 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO xanthohumol results in increased cleavage of and results in increased activity of CASP7 protein
xanthohumol results in increased activity of CASP7 protein		 CTD PMID:15995977 PMID:30240731 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage		 ISO xanthohumol results in increased cleavage of and results in increased activity of CASP8 protein
xanthohumol results in increased activity of CASP8 protein
xanthohumol results in increased cleavage of CASP8 protein		 CTD PMID:15995977 PMID:26297991 PMID:35229981 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases cleavage		 ISO BBC3 protein affects the reaction [xanthohumol results in increased cleavage of CASP9 protein]; xanthohumol results in increased cleavage of and results in increased activity of CASP9 protein
xanthohumol results in increased activity of CASP9 protein		 CTD PMID:15995977 PMID:26297991 PMID:35229981 PMID:35259468 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cbr1 carbonyl reductase 1 multiple interactions ISO xanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; xanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione] CTD PMID:30849340 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO xanthohumol decreases expression of Ccl2 protein in blood serum RGD PMID:23650230 RGD:401842363 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO xanthohumol results in decreased expression of CCNA2 protein CTD PMID:35229981 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO xanthohumol results in decreased expression of CCNB1 protein CTD PMID:35229981 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 xanthohumol results in decreased expression of CCND1
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]		 CTD PMID:26297991 PMID:27317025 PMID:31714664 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO xanthohumol results in decreased expression of CDK1 protein CTD PMID:35229981 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO xanthohumol results in increased expression of CDKN1A CTD PMID:26297991 PMID:27317025 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO xanthohumol inhibits the reaction [CFTR protein results in increased export of Hyaluronic Acid] CTD PMID:23978416 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA] CTD PMID:23994090 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO xanthohumol increases expression of Cpt1a mRNA in liver RGD PMID:23650230 RGD:401842363 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO xanthohumol results in decreased activity of and results in decreased phosphorylation of CREB1 protein CTD PMID:27317025 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cryz crystallin zeta increases activity ISO xanthohumol results in increased activity of CRYZ protein CTD PMID:17590382 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in decreased phosphorylation of and results in increased activity of CTNNB1 protein] CTD PMID:31714664 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:23994090 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity		 ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]
xanthohumol results in increased expression of CYP1A1 mRNA
xanthohumol results in decreased activity of CYP1A1 protein		 CTD PMID:22138251 PMID:23503627 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of CYP1A2 mRNA
xanthohumol inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]		 CTD PMID:22138251 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [xanthohumol results in decreased activity of DIO1 protein] which affects the metabolism of Triiodothyronine, Reverse CTD PMID:25962824 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity
multiple interactions		 ISO xanthohumol results in decreased activity of DIO2 protein
[xanthohumol results in decreased activity of DIO2 protein] which affects the metabolism of Thyroxine		 CTD PMID:25962824 PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity
multiple interactions		 ISO xanthohumol results in decreased activity of DIO3 protein
[xanthohumol results in decreased activity of DIO3 protein] which affects the metabolism of Triiodothyronine		 CTD PMID:25962824 PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [xanthohumol results in decreased expression of ESR1 protein]; xanthohumol promotes the reaction [Estradiol results in decreased expression of ESR1 protein] CTD PMID:32986415 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:23994090 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
decreases phosphorylation		 ISO FOXO3 protein affects the reaction [xanthohumol results in increased cleavage of CASP3 protein]; FOXO3 protein affects the reaction [xanthohumol results in increased expression of BBC3 protein]
xanthohumol results in decreased phosphorylation of FOXO3 protein		 CTD PMID:35259468 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gab2 GRB2-associated binding protein 2 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA] CTD PMID:23994090 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression
multiple interactions		 ISO xanthohumol results in decreased expression of GSTA1 mRNA
[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA		 CTD PMID:22138251 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of GSTP1 mRNA; xanthohumol results in increased expression of GSTP1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of GSTP1 protein; [Resveratrol co-treated with xanthohumol] results in increased expression of GSTP1 mRNA		 CTD PMID:23085367 PMID:32070777 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression ISO xanthohumol results in increased expression of GSTT1 mRNA; xanthohumol results in increased expression of GSTT1 protein CTD PMID:23085367 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO xanthohumol results in increased expression of HMOX1 mRNA; xanthohumol results in increased expression of HMOX1 protein CTD PMID:23085367 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO xanthohumol results in decreased expression of ICAM1 protein CTD PMID:23503627 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [xanthohumol results in increased expression of IL1B protein] CTD PMID:31629901 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO xanthohumol results in decreased expression of IL6 mRNA CTD PMID:16019205 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
decreases activity
increases phosphorylation		 ISO xanthohumol results in decreased phosphorylation of MAPK1 protein
xanthohumol results in decreased activity of MAPK1 protein
xanthohumol results in increased phosphorylation of MAPK1 protein		 CTD PMID:26297991 PMID:27317025 PMID:35229981 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases phosphorylation ISO xanthohumol results in decreased phosphorylation of MAPK11 protein CTD PMID:35229981 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 decreases phosphorylation ISO xanthohumol results in decreased phosphorylation of MAPK12 protein CTD PMID:35229981 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases phosphorylation ISO xanthohumol results in decreased phosphorylation of MAPK14 protein CTD PMID:35229981 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
decreases activity
increases phosphorylation		 ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]
xanthohumol results in decreased phosphorylation of MAPK3 protein
xanthohumol results in decreased activity of MAPK3 protein
xanthohumol results in increased phosphorylation of MAPK3 protein		 CTD PMID:23994090 PMID:26297991 PMID:27317025 PMID:35229981 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO xanthohumol results in increased phosphorylation of MAPK8 protein CTD PMID:35229981 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO xanthohumol results in increased phosphorylation of MAPK9 protein CTD PMID:35229981 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO xanthohumol results in decreased expression of MKI67 protein CTD PMID:35259468 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO xanthohumol results in decreased expression of and results in decreased activity of MMP9 protein
xanthohumol results in decreased expression of MMP9 mRNA
xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]		 CTD PMID:23562496 PMID:23994090 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of MYC protein] CTD PMID:31714664 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl2 myosin light chain 2 multiple interactions ISO xanthohumol results in decreased phosphorylation of and results in decreased activity of MYL2 protein CTD PMID:23503627 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Nat2 N-acetyltransferase 2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of NAT2 mRNA CTD PMID:22138251 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:23994090 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
increases activity
increases expression
multiple interactions		 ISO xanthohumol affects the localization of NFE2L2 protein
xanthohumol results in increased activity of NFE2L2 protein
xanthohumol results in increased expression of NFE2L2 mRNA; xanthohumol results in increased expression of NFE2L2 protein
[xanthohumol co-treated with phenethyl isothiocyanate] results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of and results in increased activity of NFE2L2 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 mRNA; [xanthohumol co-treated with Resveratrol] results in increased expression of NFE2L2 protein		 CTD PMID:23085367 PMID:32070777 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression
decreases activity		 ISO [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of and results in decreased activity of NFKB1 protein; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of NFKB1 mRNA; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased expression of NFKB1 mRNA
xanthohumol results in decreased activity of NFKB1 protein		 CTD PMID:32070777 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP xanthohumol inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA] CTD PMID:31714664 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO xanthohumol results in increased expression of NQO1 protein
xanthohumol results in increased expression of NQO1 mRNA; xanthohumol results in increased expression of NQO1 protein
[indole-3-carbinol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [Resveratrol co-treated with xanthohumol] results in increased expression of NQO1 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in increased expression of NQO1 protein		 CTD PMID:23085367 PMID:26473469 PMID:32070777 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA] CTD PMID:23994090 NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO xanthohumol results in increased cleavage of PARP1 protein CTD PMID:15995977 PMID:35229981 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA] CTD PMID:23994090 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity
multiple interactions
decreases expression		 ISO
EXP		 xanthohumol results in decreased activity of PTGS2 protein
xanthohumol inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]
xanthohumol results in decreased expression of PTGS2 mRNA
[xanthohumol co-treated with indole-3-carbinol] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 mRNA; [xanthohumol co-treated with phenethyl isothiocyanate] results in decreased expression of PTGS2 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of PTGS2 mRNA		 CTD PMID:17590382 PMID:31714664 PMID:32070777 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pxn paxillin decreases expression ISO xanthohumol results in decreased expression of PXN protein CTD PMID:23503627 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
decreases activity		 ISO [indole-3-carbinol co-treated with xanthohumol] results in decreased activity of RELA protein; [indole-3-carbinol co-treated with xanthohumol] results in decreased expression of RELA mRNA; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of and results in decreased activity of RELA protein; [phenethyl isothiocyanate co-treated with xanthohumol] results in decreased expression of RELA mRNA; [Resveratrol co-treated with xanthohumol] results in decreased activity of RELA protein; [Resveratrol co-treated with xanthohumol] results in decreased expression of RELA mRNA
xanthohumol results in decreased expression of RELA mRNA
xanthohumol results in decreased activity of RELA protein		 CTD PMID:32070777 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases cleavage ISO xanthohumol results in increased cleavage of RIPK1 protein CTD PMID:35229981 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G S100a4 S100 calcium-binding protein A4 decreases expression ISO xanthohumol results in decreased expression of S100A4 protein CTD PMID:23503627 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO xanthohumol decreases expression of Scd1 mRNA in liver RGD PMID:23650230 RGD:401842363 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA] CTD PMID:23994090 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO xanthohumol decreases expression of Srebf1 mRNA in liver RGD PMID:23650230 RGD:401842363 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO xanthohumol decreases expression of Srebp2 protein in liver RGD PMID:23650230 RGD:401842363 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases expression
decreases expression		 ISO xanthohumol results in increased expression of SULT1A1 mRNA
xanthohumol results in decreased expression of SULT1A1 mRNA		 CTD PMID:22138251 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA] CTD PMID:23994090 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO xanthohumol results in increased expression of TFF1 mRNA CTD PMID:16019205 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO xanthohumol inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:23503627 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
decreases response to substance		 ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of AKT2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CLCN7 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of GAB2 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MAPK3 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of PIK3CG mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of SRC mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]; xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA]
xanthohumol results in decreased susceptibility to TNFSF11 protein		 CTD PMID:23994090 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO xanthohumol results in increased expression of TP53; xanthohumol results in increased expression of TP53 mRNA; xanthohumol results in increased expression of TP53 protein CTD PMID:23085367 PMID:26297991 PMID:27317025 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TRAF6 mRNA] CTD PMID:23994090 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases expression		 ISO xanthohumol promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of UGT1A1 mRNA]
xanthohumol results in increased expression of UGT1A1 mRNA		 CTD PMID:22138251 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [xanthohumol co-treated with 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline] results in increased expression of UGT1A2 mRNA CTD PMID:22138251 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vwf von Willebrand factor increases expression ISO xanthohumol results in increased expression of VWF mRNA CTD PMID:16019205 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        antimicrobial agent 18250
          antiviral agent 11343
            xanthohumol 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    ketone 17263
                                      alpha,beta-unsaturated ketone 9980
                                        enone 9980
                                          chalcones 946
                                            xanthohumol 86
paths to the root