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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sappanchalcone
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Accession:CHEBI:66172 term browser browse the term
Definition:A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy groups at positions 3, 4 and 4' and a methoxy group at position 2'. Isolated from Caesalpinia sappan, it exhibits neuroprotective and cytoprotective activity.
Synonyms:exact_synonym: (2E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
 related_synonym: 3,4,4'-trihydroxy-2'-methoxychalcone;   Formula=C16H14O5;   InChI=1S/C16H14O5/c1-21-16-9-11(17)4-5-12(16)13(18)6-2-10-3-7-14(19)15(20)8-10/h2-9,17,19-20H,1H3/b6-2+;   InChIKey=JVGNTXGHBHMJDO-QHHAFSJGSA-N;   SMILES=COc1cc(O)ccc1C(=O)\\C=C\\c1ccc(O)c(O)c1
 xref: CAS:94344-54-4;   LIPID_MAPS_instance:LMPK12120114
 xref_mesh: MESH:C044363
 xref: PMID:19173220;   PMID:19420770;   PMID:20621084;   PMID:21963806;   Patent:KR20070060715;   Patent:KR20120007809;   Patent:WO2007066928;   Reaxys:5968372


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sappanchalcone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO sappanchalcone affects the localization of AIFM1 protein CTD PMID:32590072 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO sappanchalcone results in increased expression of BAX protein CTD PMID:21963806 PMID:32590072 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sappanchalcone results in decreased expression of BCL2 protein CTD PMID:21963806 PMID:32590072 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO sappanchalcone results in increased activity of CASP3 protein
sappanchalcone results in increased cleavage of CASP3 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO sappanchalcone results in increased cleavage of CASP7 protein CTD PMID:32590072 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO sappanchalcone results in increased cleavage of CASP8 protein CTD PMID:32590072 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage		 ISO sappanchalcone results in increased activity of CASP9 protein
sappanchalcone results in increased cleavage of CASP9 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO sappanchalcone results in increased phosphorylation of MAPK8 protein CTD PMID:21963806 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sappanchalcone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:21963806 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO sappanchalcone results in increased cleavage of PARP1 protein CTD PMID:32590072 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sappanchalcone affects the localization of RELA protein CTD PMID:21963806 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO sappanchalcone results in increased expression of TP53 protein
sappanchalcone results in increased expression of and results in increased phosphorylation of TP53 protein		 CTD PMID:21963806 PMID:32590072 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      chemical role 19473
        antioxidant 16145
          sappanchalcone 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    ketone 17258
                                      alpha,beta-unsaturated ketone 9978
                                        enone 9978
                                          chalcones 945
                                            chalcone 132
                                              trans-chalcone 132
                                                sappanchalcone 12
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