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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lupulone
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Accession:CHEBI:6574 term browser browse the term
Definition:A beta-bitter acid in which the acyl group is specified as 3-methylbutanoyl.
Synonyms:exact_synonym: 3,5-dihydroxy-2-(3-methylbutanoyl)-4,6,6-tris(3-methylbut-2-en-1-yl)cyclohexa-2,4-dien-1-one
 related_synonym: Formula=C26H38O4;   InChI=1S/C26H38O4/c1-16(2)9-10-20-23(28)22(21(27)15-19(7)8)25(30)26(24(20)29,13-11-17(3)4)14-12-18(5)6/h9,11-12,19,28-29H,10,13-15H2,1-8H3;   InChIKey=LSDULPZJLTZEFD-UHFFFAOYSA-N;   Lupulon;   SMILES=C=1(C(C(C(C(CC(C)C)=O)=C(C1CC=C(C)C)O)=O)(CC=C(C)C)CC=C(C)C)O;   beta-Lupulic acid;   hop beta-acid
 xref: CAS:468-28-0;   HMDB:HMDB0030041;   KEGG:C10706;   KNApSAcK:C00002701
 xref_mesh: MESH:C008299
 xref: MetaCyc:CPD-7110;   PMID:14827882;   PMID:14920156;   PMID:17434926;   PMID:18276602;   PMID:18383859;   PMID:18726190;   PMID:20885891;   PMID:21517917;   PMID:21519792;   PMID:24168111;   PMID:24948953;   PMID:24954859;   Reaxys:6983327
 cyclic_relationship: is_conjugate_acid_of CHEBI:134343


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lupulone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects expression ISO lupulon affects the expression of BAX protein CTD PMID:17434926 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO lupulon affects the expression of BCL2 protein CTD PMID:17434926 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO lupulon results in increased expression of FAS protein CTD PMID:17434926 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO lupulon results in increased expression of FASLG protein CTD PMID:17434926 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO lupulon results in increased expression of TNFRSF10A protein CTD PMID:17434926 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          lupulone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  phenols 18674
                                    phenolic donor 601
                                      phloroglucinol 65
                                        2-acylphloroglucinol 5
                                          beta-bitter acid 5
                                            lupulone 5
paths to the root