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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PX-866
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Accession:CHEBI:65345 term browser browse the term
Definition:An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.
Synonyms:exact_synonym: (1E,4S,4aR,5R,6aS,9aR)-1-{[di(prop-2-en-1-yl)amino]methylidene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,7,10-trioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
 related_synonym: Formula=C29H35NO8;   InChI=1S/C29H35NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20(32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8,14,18-19,21,34H,1-2,9-13,15H2,3-6H3/b17-14+/t18-,19+,21+,28-,29-/m0/s1;   InChIKey=QIUASFSNWYMDFS-NILGECQDSA-N;   SMILES=[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)C(O)=C2\\C(=C/N(CC=C)CC=C)C(=O)O[C@H](COC)[C@]12C
 xref_mesh: MESH:C496788
 xref: Reaxys:12534000


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PX-866 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of AKT1 protein
PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]		 CTD PMID:25805502 PMID:28634229 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Axin2 axin 2 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA CTD PMID:27017931 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of BAD protein
[PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein		 CTD PMID:20473884 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA CTD PMID:27017931 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 affects response to substance ISO CAMKK2 protein affects the susceptibility to PX-866 CTD PMID:28634229 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA CTD PMID:27017931 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions		 ISO PX-866 results in decreased expression of CCNE2 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA		 CTD PMID:26660119 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA CTD PMID:25805502 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdc6 cell division cycle 6 multiple interactions
decreases expression		 ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA
PX-866 results in decreased expression of CDC6 mRNA		 CTD PMID:26660119 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA CTD PMID:27017931 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA CTD PMID:25805502 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA CTD PMID:26660119 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA] CTD PMID:25805502 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA CTD PMID:27017931 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA CTD PMID:26660119 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA CTD PMID:27017931 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases phosphorylation
multiple interactions		 ISO PX-866 results in decreased phosphorylation of MDM2 protein
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein		 CTD PMID:27017931 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA] CTD PMID:25805502 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein CTD PMID:26660119 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA] CTD PMID:25805502 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sort1 sortilin 1 multiple interactions
decreases expression		 ISO [PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]
PX-866 results in decreased expression of SORT1 protein		 CTD PMID:25805502 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354 		JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA CTD PMID:27017931 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        inhibitor 18947
          autophagy inhibitor 868
            wortmannin 296
              PX-866 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      monocarboxylic acid 18027
                                        acetic acid 11097
                                          acetate ester 4059
                                            wortmannin 296
                                              PX-866 22
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