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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.21.5 (thrombin) inhibitor
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Accession:CHEBI:65232 term browser browse the term
Definition:An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of thrombin (EC 3.4.21.5).
Synonyms:related_synonym: E thrombin inhibitor;   E thrombin inhibitors;   EC 3.4.21.5 inhibitor;   EC 3.4.21.5 inhibitors;   activated blood-coagulation factor II inhibitor;   activated blood-coagulation factor II inhibitors;   beta-thrombin inhibitor;   beta-thrombin inhibitors;   blood-coagulation factor IIa inhibitor;   blood-coagulation factor IIa inhibitors;   factor IIa inhibitor;   factor IIa inhibitors;   fibrinogenase inhibitor;   fibrinogenase inhibitors;   gamma-thrombin inhibitor;   gamma-thrombin inhibitors;   thrombase inhibitor;   thrombase inhibitors;   thrombin (EC 3.4.21.5) inhibitors;   thrombin inhibitor;   thrombin inhibitors;   thrombin-C inhibitor;   thrombin-C inhibitors;   thrombofort inhibitor;   thrombofort inhibitors;   tropostasin inhibitor;   tropostasin inhibitors



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bivalirudin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein decreases expression ISO bivalirudin results in decreased expression of CRP protein CTD PMID:16118546 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
decreases activity
increases cleavage
ISO bivalirudin binds to and results in decreased activity of F2 protein; bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein]
bivalirudin results in decreased activity of F2 protein
F2 protein results in increased cleavage of bivalirudin
CTD PMID:1290488 PMID:8456428 PMID:15080313 PMID:15155122 PMID:16084352 More... NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases activity ISO bivalirudin results in decreased activity of F2R protein CTD PMID:19124943 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F2rl3 F2R like thrombin or trypsin receptor 3 decreases activity ISO bivalirudin results in decreased activity of F2RL3 protein CTD PMID:19124943 NCBI chr16:17,117,441...17,119,434
Ensembl chr16:17,117,441...17,119,472
JBrowse link
G Mpo myeloperoxidase decreases expression ISO bivalirudin results in decreased expression of MPO protein CTD PMID:18701766 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G P2ry12 purinergic receptor P2Y12 affects response to substance ISO P2RY12 affects the susceptibility to bivalirudin CTD PMID:14597584 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression EXP bivalirudin affects the expression of PDGFB protein CTD PMID:10754393 PMID:11316950 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Selp selectin P multiple interactions ISO bivalirudin inhibits the reaction [F2 protein results in increased expression of SELP protein] CTD PMID:16845256 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
dabigatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 decreases expression ISO Dabigatran results in decreased expression of AIF1 protein CTD PMID:27397090 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Dabigatran results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Dabigatran results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO Dabigatran results in decreased activity of F2 protein CTD PMID:17911567 PMID:25138021 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Dabigatran results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Dabigatran results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28585189 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Dabigatran results in decreased expression of GFAP protein CTD PMID:27397090 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Dabigatran results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Dabigatran results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase increases expression ISO Dabigatran results in increased expression of MERTK mRNA CTD PMID:27397090 NCBI chr 3:115,939,351...116,045,141
Ensembl chr 3:115,939,351...116,046,554
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Dabigatran results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA] CTD PMID:28585189 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Dabigatran results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,081,259...14,083,336
Ensembl chr 1:14,081,328...14,082,149
JBrowse link
G Pax3 paired box 3 decreases expression ISO Dabigatran results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:79,567,455...79,664,042
Ensembl chr 9:79,568,634...79,664,042
JBrowse link
G Pax6 paired box 6 increases expression ISO Dabigatran results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Dabigatran results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032
JBrowse link
G Rcor2 REST corepressor 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA] CTD PMID:28585189 NCBI chr 1:204,453,403...204,461,403
Ensembl chr 1:204,454,360...204,460,838
JBrowse link
G Ret ret proto-oncogene multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein] CTD PMID:28585189 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28585189 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Snca synuclein alpha multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA] CTD PMID:28585189 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Dabigatran results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:140,638,984...140,644,766
Ensembl chr 3:140,638,984...140,644,766
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:28585189 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Uncx UNC homeobox decreases expression ISO Dabigatran results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:15,092,779...15,097,300
Ensembl chr12:15,092,784...15,097,300
JBrowse link
glycyrrhizinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Glycyrrhizic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Glycyrrhizic Acid results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA] CTD PMID:28549656 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 multiple interactions ISO Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA] CTD PMID:28549656 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein] CTD PMID:31150628 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO
EXP
Glycyrrhizic Acid results in decreased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]
CTD PMID:33030083 PMID:33522686 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein] CTD PMID:32525084 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of Glycyrrhizic Acid CTD PMID:8831264 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Gentamicins results in decreased expression of AQP2 protein] CTD PMID:12969435 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein] CTD PMID:29452068 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO Glycyrrhizic Acid binds to and results in increased activity of AR protein
Glycyrrhizic Acid affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Glycyrrhizic Acid results in increased expression of BAD mRNA CTD PMID:35844403 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Glycyrrhizic Acid results in increased expression of BAX mRNA CTD PMID:35844403 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Glycyrrhizic Acid results in decreased expression of BCL2 mRNA
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of BCL2 mRNA
CTD PMID:35844403 PMID:37659683 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp2 caspase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP2 protein] CTD PMID:22051199 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP3 protein]; Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP3 mRNA
Glycyrrhizic Acid results in increased activity of CASP3 protein
CTD PMID:22051199 PMID:31150628 PMID:35844403 PMID:37659683 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP6 protein] CTD PMID:22051199 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
EXP
ISO
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP8 mRNA
Glycyrrhizic Acid results in increased activity of CASP8 protein
CTD PMID:22051199 PMID:35844403 PMID:37659683 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP9 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP9 mRNA
Glycyrrhizic Acid results in increased activity of CASP9 protein
CTD PMID:22051199 PMID:35844403 PMID:37659683 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA] CTD PMID:27585667 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CCND1 mRNA CTD PMID:35844403 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein] CTD PMID:33030083 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Glycyrrhizic Acid results in increased expression of CDH1 protein CTD PMID:33522686 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of CDK4 mRNA CTD PMID:35844403 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Glycyrrhizic Acid results in increased expression of CDKN1A mRNA CTD PMID:35844403 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA] CTD PMID:34302803 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA] CTD PMID:34302803 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA] CTD PMID:34302803 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein] CTD PMID:29452068 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]
Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A4 protein
CTD PMID:22982774 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
ISO Glycyrrhizic Acid results in decreased expression of CYP7A1 mRNA
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]
CTD PMID:22982774 PMID:28549656 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein] CTD PMID:22051199 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:34302803 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Glycyrrhizic Acid inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with BCG Vaccine] results in increased activity of GPT protein]
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein]
CTD PMID:19196740 PMID:28549656 PMID:37794747 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of HES1 mRNA CTD PMID:35844403 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions
decreases activity
ISO
EXP
Glycyrrhizic Acid results in decreased secretion of HMGB1 protein
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein]
Glycyrrhizic Acid results in decreased activity of HMGB1 protein
CTD PMID:27585667 PMID:27689324 PMID:27783111 PMID:32525084 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein] CTD PMID:17917259 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNA CTD PMID:10474021 PMID:11798659 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Ifng interferon gamma affects expression ISO Glycyrrhizic Acid affects the expression of IFNG mRNA CTD PMID:16945185 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA CTD PMID:11412311 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNA; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B protein CTD PMID:11412311 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein] CTD PMID:33030083 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein]
CTD PMID:21644799 PMID:26524701 PMID:29452068 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins1 insulin 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of JAG1 mRNA CTD PMID:35844403 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA] CTD PMID:34302803 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein] CTD PMID:32525084 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein] CTD PMID:34302803 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein] CTD PMID:34302803 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Picryl Chloride results in increased secretion of MMP2 protein]
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP2 mRNA
CTD PMID:16945185 PMID:37659683 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP9 mRNA CTD PMID:37659683 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein] CTD PMID:37794747 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein] CTD PMID:32525084 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA] CTD PMID:28549656 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein] CTD PMID:29452068 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:11412311 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein] CTD PMID:29452068 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein] CTD PMID:17917259 PMID:21644799 PMID:23373965 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of NOTCH1 mRNA CTD PMID:35844403 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA] CTD PMID:28549656 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Glycyrrhizic Acid results in increased expression of NR0B2 mRNA CTD PMID:22982774 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Glycyrrhizic Acid results in increased activity of NR1I2 protein
NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]
CTD PMID:22982774 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CD protein CTD PMID:21644799 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases activity ISO Glycyrrhizic Acid results in decreased activity of PIK3CG protein CTD PMID:21644799 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:34302803 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:17917259 PMID:21644799 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rad21 RAD21 cohesin complex component decreases binding ISO Glycyrrhizinic acid decreases binding of RAD21 protein to SMC3 protein in lymphoma cells RGD PMID:21880767 RGD:243065267 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein]
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein]
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene affects the localization of RELA protein]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased phosphorylation of RELA protein]
CTD PMID:11412311 PMID:22051199 PMID:26524701 PMID:29452068 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin decreases activity ISO Glycyrrhizic Acid results in decreased activity of REN protein CTD PMID:20460744 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA] CTD PMID:34302803 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein] CTD PMID:25162824 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA] CTD PMID:34302803 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA] CTD PMID:28549656 NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA] CTD PMID:28549656 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Glycyrrhizic Acid results in decreased expression of SMAD4 protein CTD PMID:33522686 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO Glycyrrhizic Acid results in increased expression of SMAD7 protein CTD PMID:33522686 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Sod1 superoxide dismutase 1 increases activity ISO Glycyrrhizic Acid results in increased activity of SOD1 protein CTD PMID:37659683 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SOD2 protein] CTD PMID:25162824 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Glycyrrhizic Acid affects the reaction [Doxorubicin results in increased expression of SQSTM1 protein] CTD PMID:32525084 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Glycyrrhizic Acid inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] CTD PMID:25162824 PMID:33030083 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR1 protein CTD PMID:33522686 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO Glycyrrhizic Acid results in decreased expression of TGFBR2 protein CTD PMID:33522686 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein] CTD PMID:27689324 PMID:27783111 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tjp2 tight junction protein 2 multiple interactions ISO Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP2 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP2 protein] CTD PMID:27689324 PMID:27783111 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
CTD PMID:17917259 PMID:21644799 PMID:26524701 PMID:33030083 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Glycyrrhizic Acid results in increased expression of TP53 mRNA CTD PMID:35844403 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
lepirudin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions ISO lepirudin binds to and results in decreased activity of F2 protein CTD PMID:15080313 PMID:18449412 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
melagatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions ISO melagatran binds to and results in decreased activity of F2 protein CTD PMID:16084352 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
procyanidin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO procyanidin B1 results in increased expression of ACOX1 mRNA CTD PMID:22227333 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of AKT protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of AKT protein CTD PMID:34342938 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO [[procyanidin B1 co-treated with procyanidin B3] co-treated with Catechin] results in increased expression of AQP3 mRNA CTD PMID:33294640 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Casp3 caspase 3 decreases expression ISO procyanidin B1 results in decreased expression of CASP3 mRNA CTD PMID:34684730 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression ISO procyanidin B1 results in increased expression of CAT protein CTD PMID:34684730 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO procyanidin B1 results in increased expression of CPT1A mRNA CTD PMID:22227333 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in decreased expression of and results in decreased phosphorylation of GSK3B protein; procyanidin B1 results in decreased expression of and results in decreased phosphorylation of GSK3B protein CTD PMID:34342938 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gys2 glycogen synthase 2 multiple interactions
increases activity
ISO [procyanidin B1 co-treated with p-coumaric acid] results in increased activity of GYS2 protein
procyanidin B1 results in increased activity of GYS2 protein
CTD PMID:34342938 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO procyanidin B1 results in increased expression of HMOX1 mRNA; procyanidin B1 results in increased expression of HMOX1 protein CTD PMID:30544155 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Insr insulin receptor multiple interactions
increases expression
ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of INSR protein
procyanidin B1 results in increased expression of INSR protein
CTD PMID:34342938 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein
[procyanidin B1 co-treated with p-coumaric acid] results in increased expression of and results in increased phosphorylation of IRS1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of IRS1 protein
CTD PMID:34342938 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 multiple interactions ISO procyanidin B1 binds to and results in decreased activity of KCNH1 protein CTD PMID:32533968 NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
JBrowse link
G Ly96 lymphocyte antigen 96 affects binding
multiple interactions
ISO procyanidin B1 binds to [TLR4 protein binds to LY96 protein]
procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of LY96 mRNA]
CTD PMID:26037075 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:26037075 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases ubiquitination
multiple interactions
increases expression
ISO procyanidin B1 results in decreased ubiquitination of NFE2L2 protein
procyanidin B1 affects the localization of and results in increased activity of and results in increased stability of NFE2L2 protein
procyanidin B1 results in increased expression of NFE2L2 protein
CTD PMID:30544155 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 mRNA]; procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB1 protein] CTD PMID:26037075 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase increases expression ISO procyanidin B1 results in increased expression of OGG1 mRNA; procyanidin B1 results in increased expression of OGG1 protein CTD PMID:34684730 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases activity
ISO [procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PCK1 protein
procyanidin B1 results in decreased activity of PCK1 protein
CTD PMID:34342938 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO [p-coumaric acid co-treated with procyanidin B1] results in increased expression of and results in increased phosphorylation of PIK3R1 protein; procyanidin B1 results in increased expression of and results in increased phosphorylation of PIK3R1 protein CTD PMID:34342938 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 affects binding
decreases expression
decreases activity
ISO procyanidin B1 binds to PTPN1 protein
procyanidin B1 results in decreased expression of PTPN1 mRNA; procyanidin B1 results in decreased expression of PTPN1 protein
procyanidin B1 results in decreased activity of PTPN1 protein
CTD PMID:33992895 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
decreases activity
ISO [procyanidin B1 co-treated with p-coumaric acid] results in decreased activity of PYGL protein
procyanidin B1 results in decreased activity of PYGL protein
CTD PMID:34342938 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases expression
ISO [procyanidin B1 co-treated with p-coumaric acid] results in increased expression of SLC2A4 protein
procyanidin B1 results in increased expression of SLC2A4 protein
CTD PMID:34342938 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions EXP procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC3A2 mRNA] CTD PMID:25551766 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP procyanidin B1 promotes the reaction [Glutamic Acid results in increased expression of SLC7A11 mRNA] CTD PMID:25551766 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Tlr4 toll-like receptor 4 affects binding ISO procyanidin B1 binds to [TLR4 protein binds to LY96 protein] CTD PMID:26037075 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; procyanidin B1 inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:26037075 PMID:27473819 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO procyanidin B1 results in decreased expression of TRP53 mRNA; procyanidin B1 results in decreased expression of TRP53 protein CTD PMID:34684730 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO procyanidin B1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 mRNA] CTD PMID:26037075 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO procyanidin B1 inhibits the reaction [Oxygen deficiency results in decreased expression of TXNRD1 protein] CTD PMID:35883890 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
ximelagatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin decreases cleavage
multiple interactions
ISO ximelagatran results in decreased cleavage of F2 protein
ximelagatran binds to and results in decreased activity of F2 protein
CTD PMID:15155122 PMID:16084352 PMID:16194202 PMID:17314111 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          enzyme inhibitor 18775
            EC 3.* (hydrolase) inhibitor 18379
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4454
                EC 3.4.21.* (serine endopeptidase) inhibitor 1987
                  EC 3.4.21.5 (thrombin) inhibitor 143
                    Ac-(D)Phe-Pro-boroArg-OH 0
                    DuP-714 0
                    bivalirudin 8
                    dabigatran + 28
                    dabigatran etexilate 0
                    dabigatran etexilate methanesulfonate 0
                    desirudin 0
                    glycyrrhizinic acid 88
                    lepirudin 1
                    melagatran + 1
                    procyanidin B1 + 29
                    ximelagatran 1
paths to the root