CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | second generation antipsychotic |
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Accession: | CHEBI:65191
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browse the term
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Definition: | Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements. |
Synonyms: | related_synonym: | atypical antipsychotic; atypical antipsychotic agent; atypical antipsychotic agents; atypical antipsychotic drug; atypical antipsychotic drugs; atypical antipsychotics; second generation antipsychotic agent; second generation antipsychotic agents; second generation antipsychotic drug; second generation antipsychotic drugs; second generation antipsychotics |
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Ache |
acetylcholinesterase |
decreases activity |
ISO |
Amisulpride results in decreased activity of ACHE protein |
CTD |
PMID:33844597 |
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NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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Drd2 |
dopamine receptor D2 |
affects binding |
EXP |
Amisulpride binds to DRD2 protein |
CTD |
PMID:12191584 |
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NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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Prl |
prolactin |
increases secretion increases expression multiple interactions |
ISO EXP |
Amisulpride results in increased secretion of PRL protein Amisulpride results in increased expression of PRL protein Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein] |
CTD |
PMID:12106810 PMID:14966260 PMID:14997280 PMID:15665803 PMID:16938372 PMID:18063941 More...
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NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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Vipr2 |
vasoactive intestinal peptide receptor 2 |
decreases expression |
ISO |
Amisulpride results in decreased expression of VIPR2 mRNA |
CTD |
PMID:27900577 |
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NCBI chr 6:143,139,672...143,213,609
Ensembl chr 6:137,001,511...137,070,597
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Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:19583963 |
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NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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Acadl |
acyl-CoA dehydrogenase, long chain |
decreases expression |
EXP |
Aripiprazole results in decreased expression of ACADL mRNA |
CTD |
PMID:17868501 |
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NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:68,333,980...68,372,220
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Adora2a |
adenosine A2a receptor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ADORA2A mRNA |
CTD |
PMID:31476115 |
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NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386
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Arpc1b |
actin related protein 2/3 complex, subunit 1B |
decreases expression |
EXP |
Aripiprazole results in decreased expression of ARPC1B mRNA |
CTD |
PMID:17868501 |
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NCBI chr12:14,595,939...14,609,501
Ensembl chr12:9,480,831...9,495,747
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Bcl10 |
BCL10, immune signaling adaptor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of BCL10 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 2:237,501,181...237,510,821
Ensembl chr 2:234,840,858...234,850,523
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Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of BCL2L1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bcl6 |
BCL6, transcription repressor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of BCL6 mRNA |
CTD |
PMID:31476115 |
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NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
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Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of BID mRNA |
CTD |
PMID:31476115 |
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NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
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C1r |
complement C1r |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in decreased expression of C1R mRNA] |
CTD |
PMID:31476115 |
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NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484
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C2 |
complement C2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of C2 mRNA |
CTD |
PMID:31476115 |
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NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505
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Cbx7 |
chromobox 7 |
decreases expression increases expression |
EXP |
Aripiprazole results in decreased expression of CBX7 mRNA Aripiprazole results in increased expression of CBX7 mRNA |
CTD |
PMID:17868501 |
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NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973
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Ccl19 |
C-C motif chemokine ligand 19 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL19 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308
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Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL2 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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Ccl20 |
C-C motif chemokine ligand 20 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL20 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629
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Ccl22 |
C-C motif chemokine ligand 22 |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in increased expression of CCL22 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr19:10,263,589...10,270,359
Ensembl chr19:10,257,601...10,264,400
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Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL3 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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Ccl4 |
C-C motif chemokine ligand 4 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL4 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231
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Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCL5 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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Ccr3 |
C-C motif chemokine receptor 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CCR3 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 8:132,463,533...132,511,601
Ensembl chr 8:123,616,236...123,634,990
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Cd274 |
CD274 molecule |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CD274 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450
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Cd33 |
CD33 molecule |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CD33 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 1:103,071,985...103,086,687
Ensembl chr 1:93,930,971...93,950,149
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Cd44 |
CD44 molecule |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CD44 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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Cd70 |
Cd70 molecule |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CD70 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 9:2,093,540...2,096,692
Ensembl chr 9:2,006,563...2,009,715
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Cd83 |
CD83 molecule |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CD83 mRNA |
CTD |
PMID:31476115 |
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NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083
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Cdh5 |
cadherin 5 |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in increased expression of CDH5 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr19:821,875...860,931
Ensembl chr19:815,411...854,368
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CDKN1A mRNA |
CTD |
PMID:31476115 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CEBPB mRNA |
CTD |
PMID:31476115 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] |
CTD |
PMID:20097249 |
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NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
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Cfb |
complement factor B |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CFB mRNA |
CTD |
PMID:31476115 |
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NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,951,474...3,976,505
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Cldn5 |
claudin 5 |
decreases expression |
EXP |
Aripiprazole results in decreased expression of CLDN5 mRNA |
CTD |
PMID:17868501 |
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NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992
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Cnr1 |
cannabinoid receptor 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of CNR1 mRNA |
CTD |
PMID:17868501 |
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NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099
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Comt |
catechol-O-methyltransferase |
increases expression |
EXP |
Aripiprazole results in increased expression of COMT mRNA |
CTD |
PMID:17868501 |
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NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
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Creb1 |
cAMP responsive element binding protein 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of CREB1 mRNA |
CTD |
PMID:26894264 |
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NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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Creb5 |
cAMP responsive element binding protein 5 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CREB5 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 4:83,723,587...84,124,786
Ensembl chr 4:82,393,730...82,790,325
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Crebbp |
CREB binding protein |
decreases expression |
EXP |
Aripiprazole results in decreased expression of CREBBP mRNA |
CTD |
PMID:17868501 |
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NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888
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Crmp1 |
collapsin response mediator protein 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of CRMP1 mRNA |
CTD |
PMID:17868501 |
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NCBI chr14:77,734,675...77,780,916
Ensembl chr14:73,509,933...73,556,177
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Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CSF1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704
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Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CSF2 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CSF3 mRNA |
CTD |
PMID:31476115 |
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NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
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Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CX3CL1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833
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Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
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Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CXCL2 mRNA |
CTD |
PMID:31476115 |
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NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
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Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
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Cxcr5 |
C-X-C motif chemokine receptor 5 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CXCR5 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:44,843,413...44,857,893
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Cxcr6 |
C-X-C motif chemokine receptor 6 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CXCR6 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 8:132,311,834...132,317,001
Ensembl chr 8:123,416,325...123,439,526
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Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CYBB mRNA |
CTD |
PMID:31476115 |
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NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586
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Cyld |
CYLD lysine 63 deubiquitinase |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of CYLD mRNA |
CTD |
PMID:31476115 |
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NCBI chr19:34,487,491...34,547,311
Ensembl chr19:18,314,019...18,373,658
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Ddr2 |
discoidin domain receptor tyrosine kinase 2 |
decreases expression |
EXP |
Aripiprazole results in decreased expression of DDR2 mRNA |
CTD |
PMID:17868501 |
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NCBI chr13:84,726,412...84,851,032
Ensembl chr13:82,195,463...82,317,363
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Ddx50 |
DExD-box helicase 50 |
increases expression |
EXP |
Aripiprazole results in increased expression of DDX50 mRNA |
CTD |
PMID:17868501 |
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NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152
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Dnal4 |
dynein, axonemal, light chain 4 |
decreases expression |
EXP |
Aripiprazole results in decreased expression of DNAL4 mRNA |
CTD |
PMID:17868501 |
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NCBI chr 7:113,192,807...113,205,665
Ensembl chr 7:111,312,427...111,325,283 Ensembl chr20:111,312,427...111,325,283
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Dnmt3a |
DNA methyltransferase 3 alpha |
increases expression |
EXP |
Aripiprazole results in increased expression of DNMT3A mRNA |
CTD |
PMID:17868501 |
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NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687
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Drd2 |
dopamine receptor D2 |
multiple interactions |
EXP ISO |
[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine |
CTD |
PMID:17069544 PMID:17327886 |
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NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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Dusp4 |
dual specificity phosphatase 4 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of DUSP4 mRNA |
CTD |
PMID:31476115 |
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NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138
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Dusp6 |
dual specificity phosphatase 6 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of DUSP6 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
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Ebi3 |
Epstein-Barr virus induced 3 |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in increased expression of EBI3 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
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Egr1 |
early growth response 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of EGR1 mRNA; Aripiprazole results in increased expression of EGR1 protein |
CTD |
PMID:17868501 |
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NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
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Egr2 |
early growth response 2 |
increases expression |
EXP |
Aripiprazole results in increased expression of EGR2 mRNA |
CTD |
PMID:17868501 |
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NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562
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Egr4 |
early growth response 4 |
increases expression |
EXP |
Aripiprazole results in increased expression of EGR4 mRNA |
CTD |
PMID:17868501 |
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NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:118,047,869...118,050,328
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Elane |
elastase, neutrophil expressed |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ELANE mRNA |
CTD |
PMID:31476115 |
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NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100
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Elavl2 |
ELAV like RNA binding protein 2 |
increases expression |
EXP |
Aripiprazole results in increased expression of ELAVL2 mRNA |
CTD |
PMID:17868501 |
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NCBI chr 5:105,960,872...106,086,463
Ensembl chr 5:105,960,875...106,109,097
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Ets1 |
ETS proto-oncogene 1, transcription factor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ETS1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:31,045,945...31,168,010
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Exoc2 |
exocyst complex component 2 |
increases expression |
EXP |
Aripiprazole results in increased expression of EXOC2 mRNA |
CTD |
PMID:17868501 |
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NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289
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F2rl1 |
F2R like trypsin receptor 1 |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in increased expression of F2RL1 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226
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Fez1 |
fasciculation and elongation protein zeta 1 |
multiple interactions increases expression |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of FEZ1 mRNA Aripiprazole results in increased expression of FEZ1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:36,544,535...36,589,683
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Fn1 |
fibronectin 1 |
decreases expression |
ISO |
Aripiprazole results in decreased expression of FN1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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Gabrb1 |
gamma-aminobutyric acid type A receptor subunit beta1 |
increases expression |
EXP |
Aripiprazole results in increased expression of GABRB1 mRNA |
CTD |
PMID:26894264 |
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NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948
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G |
Hbegf |
heparin-binding EGF-like growth factor |
decreases expression |
EXP |
Aripiprazole results in decreased expression of HBEGF mRNA |
CTD |
PMID:17868501 |
|
NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
ISO |
Aripiprazole binds to and affects the activity of HTR1A protein; Aripiprazole binds to and results in increased activity of HTR1A protein |
CTD |
PMID:17069544 PMID:21823597 |
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NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions decreases response to substance affects response to substance |
ISO |
Aripiprazole binds to and results in decreased activity of HTR2A protein; Aripiprazole binds to and results in increased activity of HTR2A protein; Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein] HTR2A gene SNP results in decreased susceptibility to Aripiprazole HTR2A protein affects the susceptibility to Aripiprazole |
CTD |
PMID:16314884 PMID:21823597 |
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NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
multiple interactions |
ISO |
Aripiprazole binds to and affects the activity of HTR2C protein |
CTD |
PMID:21823597 |
|
NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ICAM1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G |
Icam4 |
intercellular adhesion molecule 4, Landsteiner-Wiener blood group |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ICAM4 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 8:19,566,075...19,567,171
Ensembl chr 8:19,566,075...19,567,171
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G |
Icoslg |
inducible T-cell co-stimulator ligand |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ICOSLG mRNA |
CTD |
PMID:31476115 |
|
NCBI chr20:10,600,078...10,610,385
Ensembl chr20:10,600,420...10,610,703
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G |
Ifnb1 |
interferon beta 1 |
increases expression multiple interactions |
ISO |
Aripiprazole results in increased expression of IFNB1 mRNA Aripiprazole promotes the reaction [Ozone results in increased expression of IFNB1 mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of IFNG mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr1 |
interferon gamma receptor 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IFNGR1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785
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G |
Ikbke |
inhibitor of nuclear factor kappa B kinase subunit epsilon |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IKBKE mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143
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G |
Il11 |
interleukin 11 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL11 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129
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G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1A mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1B mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r2 |
interleukin 1 receptor type 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1R2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:42,384,433...42,424,725
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G |
Il1rap |
interleukin 1 receptor accessory protein |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1RAP mRNA |
CTD |
PMID:31476115 |
|
NCBI chr11:87,567,813...87,704,346
Ensembl chr11:74,070,304...74,199,530
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G |
Il1rapl2 |
interleukin 1 receptor accessory protein-like 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1RAPL2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr X:100,961,509...102,271,753
Ensembl chr X:100,961,812...102,271,753
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL1RL1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256
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G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL23A mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923
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G |
Il24 |
interleukin 24 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL24 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of IL2RG mRNA |
CTD |
PMID:31476115 |
|
NCBI chr X:70,435,340...70,439,052
Ensembl chr X:66,392,542...66,399,823
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G |
Il4r |
interleukin 4 receptor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL4R mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL5 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL6 mRNA; Aripiprazole promotes the reaction [Ozone results in increased expression of IL6 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Il7r |
interleukin 7 receptor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of IL7R mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:58,454,217...58,477,757
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G |
Inpp5d |
inositol polyphosphate-5-phosphatase D |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of INPP5D mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746
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G |
Irak2 |
interleukin-1 receptor-associated kinase 2 |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in increased expression of IRAK2 mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:146,786,100...146,842,602
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G |
Irf8 |
interferon regulatory factor 8 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of IRF8 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829
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G |
Isg20 |
interferon stimulated exonuclease gene 20 |
increases expression multiple interactions |
ISO |
Aripiprazole results in increased expression of ISG20 mRNA [Aripiprazole co-treated with Ozone] results in increased expression of ISG20 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027
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G |
Itga2 |
integrin subunit alpha 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ITGA2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:46,523,948...46,621,481
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G |
Itga5 |
integrin subunit alpha 5 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of ITGA5 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions decreases activity |
ISO |
Aripiprazole inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Aripiprazole results in decreased activity of KCNH2 protein |
CTD |
PMID:21158687 PMID:28551711 |
|
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
increases expression |
EXP |
Aripiprazole results in increased expression of KCNJ3 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 3:60,353,990...60,518,110
Ensembl chr 3:39,945,351...40,109,124
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G |
Lif |
LIF, interleukin 6 family cytokine |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of LIF mRNA |
CTD |
PMID:31476115 |
|
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
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G |
Lrrn3 |
leucine rich repeat neuronal 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of LRRN3 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 6:64,216,164...64,247,293
Ensembl chr 6:58,489,010...58,520,330
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G |
Lta |
lymphotoxin alpha |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of LTA mRNA |
CTD |
PMID:31476115 |
|
NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859
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G |
Ltb |
lymphotoxin beta |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of LTB mRNA |
CTD |
PMID:31476115 |
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NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,627,537...3,629,381
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of LYN mRNA |
CTD |
PMID:31476115 |
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NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868
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G |
Maob |
monoamine oxidase B |
increases expression |
EXP |
Aripiprazole results in increased expression of MAOB mRNA |
CTD |
PMID:17868501 |
|
NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003
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G |
Mapk6 |
mitogen-activated protein kinase 6 |
increases expression |
EXP |
Aripiprazole results in increased expression of MAPK6 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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G |
Mapkapk2 |
MAPK activated protein kinase 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of MAPKAPK2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of NFKB1 mRNA |
CTD |
PMID:31476115 |
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in increased expression of NFKB2 mRNA] |
CTD |
PMID:31476115 |
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NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of NFKBIA mRNA |
CTD |
PMID:31476115 |
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NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of NLRP3 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G |
Nod2 |
nucleotide-binding oligomerization domain containing 2 |
multiple interactions increases expression |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of NOD2 mRNA Aripiprazole results in increased expression of NOD2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177
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G |
Npdc1 |
neural proliferation, differentiation and control, 1 |
decreases expression |
EXP |
Aripiprazole results in decreased expression of NPDC1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 3:28,618,601...28,624,591
Ensembl chr 3:8,213,663...8,226,866
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G |
Nt5e |
5' nucleotidase, ecto |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of NT5E mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:89,270,696...89,314,881
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G |
Ntm |
neurotrimin |
decreases expression |
EXP |
Aripiprazole results in decreased expression of NTM mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 8:35,634,929...36,625,081
Ensembl chr 8:27,377,773...28,366,595
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G |
Pdcd1lg2 |
programmed cell death 1 ligand 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PDCD1LG2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:236,572,497...236,637,490
Ensembl chr 1:227,158,941...227,223,938
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G |
Pdgfc |
platelet derived growth factor C |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of PDGFC mRNA |
CTD |
PMID:31476115 |
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NCBI chr 2:168,613,409...168,791,575
Ensembl chr 2:166,316,803...166,493,433
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G |
Pdp1 |
pyruvate dehydrogenase phosphatase catalytic subunit 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of PDP1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
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G |
Plau |
plasminogen activator, urokinase |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PLAU mRNA |
CTD |
PMID:31476115 |
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NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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G |
Plaur |
plasminogen activator, urokinase receptor |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PLAUR mRNA |
CTD |
PMID:31476115 |
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NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
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G |
Pou2f2 |
POU class 2 homeobox 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of POU2F2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:89,810,153...89,897,560
Ensembl chr 1:80,685,741...80,724,261
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G |
Prg2 |
proteoglycan 2, pro eosinophil major basic protein |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PRG2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 3:90,469,192...90,472,759
Ensembl chr 3:70,062,535...70,066,101
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
increases expression |
EXP |
Aripiprazole results in increased expression of PRKACA protein |
CTD |
PMID:26894264 |
|
NCBI chr19:41,059,843...41,083,189
Ensembl chr19:24,155,090...24,178,430
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PRKCD mRNA |
CTD |
PMID:31476115 |
|
NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
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G |
Prl |
prolactin |
multiple interactions increases secretion decreases secretion decreases expression |
ISO EXP |
Aripiprazole inhibits the reaction [haloperidol decanoate results in increased expression of PRL protein]; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein] Aripiprazole results in increased secretion of PRL protein Aripiprazole results in decreased secretion of PRL protein Aripiprazole inhibits the reaction [talipexole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein] Aripiprazole results in decreased expression of PRL protein |
CTD |
PMID:8613910 PMID:17873694 PMID:19230981 PMID:19519261 PMID:19653986 PMID:19906340 PMID:20814333 More...
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NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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G |
Prodh |
proline dehydrogenase |
decreases expression |
EXP |
Aripiprazole results in decreased expression of PRODH mRNA |
CTD |
PMID:17868501 |
|
NCBI chr11:96,414,275...96,431,604
Ensembl chr11:82,910,137...82,927,305
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
increases expression |
EXP |
Aripiprazole results in increased expression of PSMC6 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr15:21,022,314...21,043,785
Ensembl chr15:18,542,563...18,564,055
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of PTGS2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of PYCARD mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
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G |
Rab3a |
RAB3A, member RAS oncogene family |
increases expression |
EXP |
Aripiprazole results in increased expression of RAB3A mRNA |
CTD |
PMID:17868501 |
|
NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
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G |
Rasd1 |
ras related dexamethasone induced 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of RASD1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr10:45,265,975...45,275,279
Ensembl chr10:44,766,455...44,768,186
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G |
Relb |
RELB proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of RELB mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507
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G |
Rig1 |
RNA sensor RIG-1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of RIGI mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
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G |
Sae1 |
SUMO1 activating enzyme subunit 1 |
increases expression |
EXP |
Aripiprazole results in increased expression of SAE1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
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G |
Sbno2 |
strawberry notch homolog 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of SBNO2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 7:10,256,221...10,300,175
Ensembl chr 7:9,605,627...9,649,527
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|
G |
Serpinb2 |
serpin family B member 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of SERPINB2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:24,051,933...24,065,032
Ensembl chr13:23,541,400...23,550,408
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|
G |
Sh2b2 |
SH2B adaptor protein 2 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of SH2B2 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844
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|
G |
Slamf6 |
SLAM family member 6 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of SLAMF6 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:86,916,956...86,937,697
Ensembl chr13:84,383,742...84,405,300
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|
G |
Slc6a4 |
solute carrier family 6 member 4 |
affects binding |
ISO |
Aripiprazole binds to SLC6A4 protein |
CTD |
PMID:21823597 |
|
NCBI chr10:62,322,688...62,357,060
Ensembl chr10:61,826,123...61,858,384
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|
G |
Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases expression |
EXP |
Aripiprazole results in decreased expression of SLCO2B1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:153,959,293...154,007,353
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|
G |
Slit3 |
slit guidance ligand 3 |
increases expression |
EXP |
Aripiprazole results in increased expression of SLIT3 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
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|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
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|
G |
Socs1 |
suppressor of cytokine signaling 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of SOCS1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
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|
G |
Syt17 |
synaptotagmin 17 |
decreases expression multiple interactions |
ISO |
Aripiprazole results in decreased expression of SYT17 mRNA [Aripiprazole co-treated with Ozone] results in decreased expression of SYT17 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:172,695,275...172,761,906
Ensembl chr 1:172,696,120...172,761,960
|
|
G |
Tab1 |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of TAB1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
|
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G |
Tacr3 |
tachykinin receptor 3 |
decreases expression increases expression |
EXP |
Aripiprazole results in decreased expression of TACR3 mRNA Aripiprazole results in increased expression of TACR3 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 2:225,940,497...226,037,756
Ensembl chr 2:223,266,536...223,363,791
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|
G |
Thbd |
thrombomodulin |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of THBD mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
|
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G |
Thbs1 |
thrombospondin 1 |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in increased expression of THBS1 mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:105,056,292...105,071,440
|
|
G |
Ticam1 |
TIR domain containing adaptor molecule 1 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TICAM1 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,102,366...1,123,147
|
|
G |
Tlr3 |
toll-like receptor 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of TLR3 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545
|
|
G |
Tlr5 |
toll-like receptor 5 |
increases expression multiple interactions |
ISO |
Aripiprazole results in increased expression of TLR5 mRNA [Aripiprazole co-treated with Ozone] results in decreased expression of TLR5 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in increased expression of TNF mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Tnfaip3 |
TNF alpha induced protein 3 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFAIP3 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282
|
|
G |
Tnfrsf11b |
TNF receptor superfamily member 11B |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in increased expression of TNFRSF11B mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
|
|
G |
Tnfrsf12a |
TNF receptor superfamily member 12A |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF12A mRNA |
CTD |
PMID:31476115 |
|
NCBI chr10:13,211,670...13,213,666
Ensembl chr10:12,689,890...12,709,045
|
|
G |
Tnfrsf14 |
TNF receptor superfamily member 14 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of TNFRSF14 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:170,768,413...170,776,749
Ensembl chr 5:165,484,262...165,493,703
|
|
G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF1B mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
|
|
G |
Tnfrsf22 |
tumor necrosis factor receptor superfamily, member 22 |
multiple interactions |
ISO |
Aripiprazole inhibits the reaction [Ozone results in decreased expression of TNFRSF10C mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 1:208,269,844...208,285,823
Ensembl chr 1:198,840,453...198,856,309
|
|
G |
Tnfrsf8 |
TNF receptor superfamily member 8 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF8 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:162,406,387...162,451,620
Ensembl chr 5:157,123,185...157,168,421
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|
G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF9 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:161,381,662...161,408,000
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|
G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF10 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
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|
G |
Tnfsf12 |
TNF superfamily member 12 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF12 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr10:54,902,616...54,912,628
Ensembl chr10:54,403,870...54,413,213
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|
G |
Tnfsf15 |
TNF superfamily member 15 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFSF15 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr 5:82,150,376...82,171,743
Ensembl chr 5:77,139,878...77,156,228
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|
G |
Tnfsf18 |
TNF superfamily member 18 |
multiple interactions |
ISO |
[Aripiprazole co-treated with Ozone] results in increased expression of TNFSF18 mRNA |
CTD |
PMID:31476115 |
|
NCBI chr13:76,366,790...76,440,673
Ensembl chr13:73,831,252...73,843,169
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G |
Tubb2a |
tubulin, beta 2A class IIa |
decreases expression |
EXP |
Aripiprazole results in decreased expression of TUBB2A mRNA |
CTD |
PMID:17868501 |
|
NCBI chr17:31,002,186...31,006,057
Ensembl chr17:30,747,503...30,800,714
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
Aripiprazole promotes the reaction [Ozone results in increased expression of VEGFA mRNA] |
CTD |
PMID:31476115 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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|
G |
Wee1 |
WEE1 G2 checkpoint kinase |
increases expression |
EXP |
Aripiprazole results in increased expression of WEE1 mRNA |
CTD |
PMID:17868501 |
|
NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:164,174,779...164,197,688
|
|
G |
Zfp354c |
zinc finger protein 354C |
increases expression |
EXP |
Aripiprazole results in increased expression of ZNF354C mRNA |
CTD |
PMID:17868501 |
|
NCBI chr10:35,630,738...35,647,176
Ensembl chr10:35,132,959...35,145,661
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity decreases expression |
ISO |
Asenapine results in decreased activity of CYP1A2 protein Asenapine results in decreased expression of CYP1A2 mRNA |
CTD |
PMID:32941854 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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|
|
G |
Dhcr7 |
7-dehydrocholesterol reductase |
decreases activity |
ISO |
cariprazine results in decreased activity of DHCR7 protein |
CTD |
PMID:29698737 |
|
NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:199,015,081...199,031,055
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|
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of AARS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
Clozapine results in decreased activity of ABCB11 protein |
CTD |
PMID:22646477 |
|
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases activity |
EXP ISO |
Clozapine inhibits the reaction [Bromocriptine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased expression of ABCB1 protein]; Clozapine inhibits the reaction [Quinpirole results in increased expression of ABCB1 protein] Clozapine results in decreased activity of ABCB1 protein |
CTD |
PMID:9111066 PMID:16810505 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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|
G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
multiple interactions |
EXP |
Clozapine inhibits the reaction [Bromocriptine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [N-n-propylnorapomorphine results in increased activity of ABCB1B promoter]; Clozapine inhibits the reaction [Quinpirole results in increased activity of ABCB1B promoter] |
CTD |
PMID:9111066 |
|
NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
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G |
Abce1 |
ATP binding cassette subfamily E member 1 |
increases expression |
ISO |
Clozapine results in increased expression of ABCE1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:45,109,880...45,134,819
Ensembl chr19:28,205,555...28,230,489
|
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
increases expression |
ISO |
Clozapine results in increased expression of ABCG1 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
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|
G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] |
CTD |
PMID:18834354 |
|
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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|
G |
Ablim2 |
actin binding LIM protein family, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of ABLIM2 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr14:79,090,046...79,214,986
Ensembl chr14:74,866,281...74,990,334
|
|
G |
Acat2 |
acetyl-CoA acetyltransferase 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACAT2 mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
|
|
G |
Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACOT2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:103,611,544...103,619,245
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|
G |
Acot7 |
acyl-CoA thioesterase 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of ACOT7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:167,969,284...168,062,033
Ensembl chr 5:162,684,645...162,779,309
|
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP |
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA |
CTD |
PMID:23226405 |
|
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232
|
|
G |
Actb |
actin, beta |
decreases expression |
ISO |
Clozapine results in decreased expression of ACTB protein |
CTD |
PMID:34122009 |
|
NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
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G |
Actbl2 |
actin, beta-like 2 |
increases expression |
ISO |
Clozapine results in increased expression of ACTBL2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:44,591,391...44,594,138
Ensembl chr 2:42,858,020...42,860,767
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G |
Actr3 |
actin related protein 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of ACTR3 protein |
CTD |
PMID:34122009 |
|
NCBI chr13:39,353,413...39,396,509
Ensembl chr13:36,800,093...36,844,124
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G |
Actr5 |
actin related protein 5 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of ACTR5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:147,282,461...147,295,870
Ensembl chr 3:147,282,624...147,296,110
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G |
Adam1a |
ADAM metallopeptidase domain 1a |
decreases expression |
EXP |
Clozapine results in decreased expression of ADAM1A mRNA |
CTD |
PMID:16715494 |
|
NCBI chr12:35,017,433...35,020,300
Ensembl chr12:35,017,315...35,020,311
|
|
G |
Adamts12 |
ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of ADAMTS12 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
|
|
G |
Adcy5 |
adenylate cyclase 5 |
affects response to substance multiple interactions |
ISO |
ADCY5 protein affects the susceptibility to Clozapine SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine] |
CTD |
PMID:12223546 |
|
NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974
|
|
G |
Adh5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of ADH5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591
|
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression increases expression multiple interactions |
ISO EXP |
Clozapine results in decreased expression of ADIPOQ protein Clozapine results in increased expression of ADIPOQ protein Clozapine results in increased expression of ADIPOQ mRNA Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA] |
CTD |
PMID:17933447 PMID:18162013 PMID:20564506 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
|
|
G |
Adora2a |
adenosine A2a receptor |
decreases expression |
ISO |
Clozapine results in decreased expression of ADORA2A mRNA |
CTD |
PMID:17266109 |
|
NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,853...13,333,386
|
|
G |
Adra1a |
adrenoceptor alpha 1A |
multiple interactions |
EXP |
Clozapine binds to and results in decreased activity of ADRA1A protein |
CTD |
PMID:16545797 |
|
NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
|
|
G |
Agpat1 |
1-acylglycerol-3-phosphate O-acyltransferase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AGPAT1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
|
|
G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]] |
CTD |
PMID:11549694 |
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Aimp1 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of AIMP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:221,151,904...221,175,728
|
|
G |
Ak1 |
adenylate kinase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AK1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:36,310,113...36,320,760
Ensembl chr 3:15,912,485...15,923,041
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
increases expression decreases expression increases phosphorylation |
ISO EXP |
Clozapine results in increased expression of AKT1 mRNA; Clozapine results in increased expression of AKT1 protein Clozapine results in decreased expression of AKT1 mRNA Clozapine results in increased phosphorylation of AKT1 protein |
CTD |
PMID:15860345 PMID:19440698 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Akt2 |
AKT serine/threonine kinase 2 |
increases expression |
EXP |
Clozapine results in increased expression of AKT2 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
|
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G |
Alb |
albumin |
multiple interactions affects binding |
EXP ISO |
Clozapine results in decreased expression of and results in decreased reduction of ALB protein Clozapine binds to ALB protein [[[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine] which affects the activity of ALB protein; [[stearic acid binds to ALB protein] which affects the susceptibility to Clozapine] which affects the reduction of Cysteine; [stearic acid binds to ALB protein] which affects the susceptibility to Clozapine; stearic acid inhibits the reaction [Clozapine binds to ALB protein] |
CTD |
PMID:31400341 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
Clozapine results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
|
|
G |
Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
Clozapine results in increased expression of ALDOA mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182
|
|
G |
Aldob |
aldolase, fructose-bisphosphate B |
increases expression decreases expression |
ISO |
Clozapine results in increased expression of ALDOB protein Clozapine results in decreased expression of ALDOB protein |
CTD |
PMID:34122009 PMID:36482696 |
|
NCBI chr 5:68,684,541...68,697,582
Ensembl chr 5:63,889,046...63,902,116
|
|
G |
Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of ALDOC mRNA Clozapine results in increased expression of ALDOC mRNA |
CTD |
PMID:15860345 PMID:16465460 |
|
NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066
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G |
Alpp |
alkaline phosphatase, placental |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Clozapine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] |
CTD |
PMID:16036225 |
|
NCBI chr 9:95,213,763...95,216,509
Ensembl chr 9:87,765,860...87,768,606
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G |
Alyref |
Aly/REF export factor |
decreases expression |
ISO |
Clozapine results in decreased expression of ALYREF protein |
CTD |
PMID:34122009 |
|
NCBI chr10:106,369,750...106,373,395
Ensembl chr10:105,871,306...105,875,069
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G |
Anxa1 |
annexin A1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa5 |
annexin A5 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369
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G |
Anxa6 |
annexin A6 |
decreases expression |
ISO |
Clozapine results in decreased expression of ANXA6 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,097,109...39,156,433
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G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
|
NCBI chr12:25,261,958...25,272,483
Ensembl chr12:19,625,332...19,756,713
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G |
Ap2b1 |
adaptor related protein complex 2 subunit beta 1 |
increases expression |
EXP |
Clozapine results in increased expression of AP2B1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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|
G |
Ap3b1 |
adaptor related protein complex 3 subunit beta 1 |
increases expression |
ISO |
Clozapine results in increased expression of AP3B1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:27,331,241...27,535,683
Ensembl chr 2:25,600,040...25,800,935
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G |
Apoa5 |
apolipoprotein A5 |
affects response to substance |
EXP |
APOA5 gene polymorphism affects the susceptibility to Clozapine |
CTD |
PMID:17726453 |
|
NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:46,561,229...46,563,816
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G |
Apod |
apolipoprotein D |
increases expression |
ISO |
Clozapine results in increased expression of APOD mRNA; Clozapine results in increased expression of APOD protein |
CTD |
PMID:11158250 PMID:14647396 PMID:17266109 |
|
NCBI chr11:82,936,216...82,957,264
Ensembl chr11:69,431,260...69,452,305
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G |
App |
amyloid beta precursor protein |
increases expression |
ISO |
Clozapine results in increased expression of APP protein |
CTD |
PMID:36482696 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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|
G |
Arc |
activity-regulated cytoskeleton-associated protein |
decreases expression |
EXP |
Clozapine results in decreased expression of ARC mRNA |
CTD |
PMID:18208916 |
|
NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:106,555,785...106,559,378
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G |
Arhgef9 |
Cdc42 guanine nucleotide exchange factor 9 |
decreases expression |
ISO |
Clozapine results in decreased expression of ARHGEF9 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr X:59,919,560...60,077,538
Ensembl chr X:59,920,870...60,077,513
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G |
Arl8a |
ARF like GTPase 8A |
decreases expression |
ISO |
Clozapine results in decreased expression of ARL8A protein |
CTD |
PMID:34122009 |
|
NCBI chr13:49,137,632...49,146,633
Ensembl chr13:46,585,845...46,594,851
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G |
Armt1 |
acidic residue methyltransferase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ARMT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
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G |
Arpc4 |
actin related protein 2/3 complex, subunit 4 |
affects expression |
ISO |
Clozapine affects the expression of ARPC4 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:146,522,176...146,532,785
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|
G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ASAH1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr16:57,669,927...57,701,349
Ensembl chr16:50,966,229...51,008,233
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Clozapine results in increased expression of ASNS mRNA; Clozapine results in increased expression of ASNS protein |
CTD |
PMID:15342952 PMID:17175557 PMID:36482696 |
|
NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
increases expression |
ISO |
Clozapine results in increased expression of ASPH protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:27,398,933...27,611,519
Ensembl chr 5:22,603,486...22,813,876
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G |
Ass1 |
argininosuccinate synthase 1 |
increases expression |
ISO |
Clozapine results in increased expression of ASS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903
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|
G |
Atad3a |
ATPase family, AAA domain containing 3A |
decreases expression |
ISO |
Clozapine results in decreased expression of ATAD3A protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:171,632,545...171,652,725
Ensembl chr 5:166,350,304...166,370,482
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|
G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
increases expression |
ISO |
Clozapine results in increased expression of ATP2A3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:58,079,710...58,111,279
Ensembl chr10:57,582,128...57,612,748
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|
G |
Atp5f1b |
ATP synthase F1 subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of ATP5F1B protein |
CTD |
PMID:19441803 |
|
NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273
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|
G |
Atp5pb |
ATP synthase peripheral stalk-membrane subunit b |
increases expression |
ISO |
Clozapine results in increased expression of ATP5PB protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:196,112,459...196,123,737
Ensembl chr 2:193,424,047...193,435,418
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G |
Atp6v1a |
ATPase H+ transporting V1 subunit A |
decreases expression |
ISO |
Clozapine results in decreased expression of ATP6V1A protein |
CTD |
PMID:34122009 |
|
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
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G |
Atp6v1b1 |
ATPase H+ transporting V1 subunit B1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ATP6V1B1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
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G |
Atp6v1b2 |
ATPase H+ transporting V1 subunit B2 |
decreases expression |
EXP ISO |
Clozapine results in decreased expression of ATP6V1B2 protein |
CTD |
PMID:19441803 PMID:34122009 |
|
NCBI chr16:25,384,254...25,408,388
Ensembl chr16:20,617,518...20,641,745
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|
G |
Atxn10 |
ataxin 10 |
increases expression |
ISO |
Clozapine results in increased expression of ATXN10 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:118,321,516...118,444,967
Ensembl chr 7:116,441,613...116,565,087
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G |
Axin2 |
axin 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of AXIN2 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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G |
Bace2 |
beta-secretase 2 |
increases expression |
ISO |
Clozapine results in increased expression of BACE2 protein |
CTD |
PMID:36482696 |
|
NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO EXP |
Clozapine results in increased expression of BAX mRNA; Clozapine results in increased expression of BAX protein CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA] Clozapine results in decreased expression of BAX protein |
CTD |
PMID:16160616 PMID:17069804 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of BAZ1B protein |
CTD |
PMID:34122009 |
|
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bcar1 |
BCAR1 scaffold protein, Cas family member |
decreases expression |
ISO |
Clozapine results in decreased expression of BCAR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Clozapine results in increased expression of BCL2 mRNA; Clozapine results in increased expression of BCL2 protein |
CTD |
PMID:15126120 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l14 |
Bcl2-like 14 |
decreases expression |
ISO |
Clozapine results in decreased expression of BCL2L14 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086
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|
G |
Bdnf |
brain-derived neurotrophic factor |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of BDNF mRNA Clozapine results in increased expression of BDNF mRNA; Clozapine results in increased expression of BDNF protein |
CTD |
PMID:11488957 PMID:12478621 PMID:17442489 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Bet1l |
Bet1 golgi vesicular membrane trafficking protein-like |
decreases expression |
EXP |
Clozapine results in decreased expression of BET1L mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:205,361,041...205,365,036
Ensembl chr 1:195,931,411...195,935,040
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G |
Bik |
BCL2-interacting killer |
multiple interactions increases expression |
ISO |
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA] |
CTD |
PMID:16160616 |
|
NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:114,672,277...114,691,296
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|
G |
Bptf |
bromodomain PHD finger transcription factor |
decreases expression |
ISO |
Clozapine results in decreased expression of BPTF mRNA |
CTD |
PMID:14647396 |
|
NCBI chr10:92,480,007...92,582,485
Ensembl chr10:91,982,758...92,082,769
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G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
Clozapine results in increased expression of BZW1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
decreases expression |
ISO EXP |
Clozapine results in decreased expression of CACNA1A mRNA |
CTD |
PMID:14647396 PMID:16715494 |
|
NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225
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G |
Calcoco1 |
calcium binding and coiled coil domain 1 |
increases expression |
ISO |
Clozapine results in increased expression of CALCOCO1 protein |
CTD |
PMID:36482696 |
|
NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:133,834,707...133,849,422
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G |
Calm2 |
calmodulin 2 |
increases expression |
EXP |
Clozapine results in increased expression of CALM2 mRNA |
CTD |
PMID:19289156 |
|
NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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G |
Calr |
calreticulin |
decreases expression |
ISO |
Clozapine results in decreased expression of CALR protein |
CTD |
PMID:34122009 |
|
NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
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G |
Calu |
calumenin |
decreases expression |
ISO |
Clozapine results in decreased expression of CALU protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:58,914,456...58,941,957
Ensembl chr 4:57,948,997...57,976,593
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G |
Camk2a |
calcium/calmodulin-dependent protein kinase II alpha |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of CAMK2A mRNA Clozapine results in increased expression of CAMK2A mRNA Clozapine results in decreased expression of CAMK2A protein |
CTD |
PMID:15860345 PMID:17266109 PMID:19289156 |
|
NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMK2B mRNA |
CTD |
PMID:15860345 |
|
NCBI chr14:85,059,166...85,148,121
Ensembl chr14:80,845,238...80,933,994
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G |
Camk2d |
calcium/calmodulin-dependent protein kinase II delta |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMK2D mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:217,698,324...217,961,898
Ensembl chr 2:215,024,004...215,286,178
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
increases expression decreases expression |
EXP |
Clozapine results in increased expression of CAMK4 mRNA Clozapine results in decreased expression of CAMK4 protein |
CTD |
PMID:15860345 PMID:19289156 |
|
NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487
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G |
Camkk1 |
calcium/calmodulin-dependent protein kinase kinase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMKK1 protein |
CTD |
PMID:19289156 |
|
NCBI chr10:58,135,872...58,159,023
Ensembl chr10:57,637,391...57,660,498
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of CAMKK2 protein |
CTD |
PMID:19289156 |
|
NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279
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G |
Canx |
calnexin |
decreases expression |
ISO |
Clozapine results in decreased expression of CANX protein |
CTD |
PMID:34122009 |
|
NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821
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G |
Cars1 |
cysteinyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of CARS1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:198,753,691...198,795,941
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G |
Cartpt |
CART prepropeptide |
decreases expression |
EXP |
Clozapine results in decreased expression of CARTPT mRNA |
CTD |
PMID:14696011 |
|
NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:31,255,098...31,290,713
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G |
Casp1 |
caspase 1 |
increases activity |
ISO |
Clozapine results in increased activity of CASP1 protein |
CTD |
PMID:34935985 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
Clozapine results in increased activity of CASP3 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein] |
CTD |
PMID:22700542 PMID:24709159 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases activity multiple interactions |
ISO |
Clozapine results in increased activity of CASP7 protein Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G |
Cat |
catalase |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Corticosterone results in increased activity of CAT protein]; Clozapine inhibits the reaction [Lipopolysaccharides inhibits the reaction [Corticosterone results in increased activity of CAT protein]] |
CTD |
PMID:14730115 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of CCAR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:31,228,624...31,271,233
Ensembl chr20:30,685,916...30,728,526
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G |
Ccdc47 |
coiled-coil domain containing 47 |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of CCDC47 protein [Cuprizone co-treated with Clozapine] results in increased expression of CCDC47 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
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G |
Cck |
cholecystokinin |
multiple interactions increases expression |
EXP |
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein] Clozapine results in increased expression of CCK mRNA |
CTD |
PMID:10974607 PMID:16567023 |
|
NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084
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|
G |
Cckbr |
cholecystokinin B receptor |
increases expression |
ISO |
Clozapine results in increased expression of CCKBR mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 1:169,183,578...169,193,583
Ensembl chr 1:159,771,733...159,814,881
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G |
Ccl1 |
C-C motif chemokine ligand 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CCL1 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr10:67,625,962...67,628,740
Ensembl chr10:67,128,331...67,131,159
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|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CCND1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Ccnd3 |
cyclin D3 |
increases expression |
EXP |
Clozapine results in increased expression of CCND3 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
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|
G |
Ccnl1 |
cyclin L1 |
increases expression |
EXP |
Clozapine results in increased expression of CCNL1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
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|
G |
Cct7 |
chaperonin containing TCP1 subunit 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of CCT7 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:119,546,730...119,563,973
Ensembl chr 4:117,989,232...118,006,580
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|
G |
Cd276 |
Cd276 molecule |
decreases expression |
ISO |
Clozapine results in decreased expression of CD276 protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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|
G |
Cd63 |
Cd63 molecule |
increases expression |
ISO |
Clozapine results in increased expression of CD63 protein |
CTD |
PMID:36482696 |
|
NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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|
G |
Cdipt |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
increases expression |
ISO |
Clozapine results in increased expression of CDIPT protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:181,583,141...181,587,408
|
|
G |
Cdk4 |
cyclin-dependent kinase 4 |
increases expression |
EXP |
Clozapine results in increased expression of CDK4 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
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|
G |
Cdk5 |
cyclin-dependent kinase 5 |
increases expression |
EXP |
Clozapine results in increased expression of CDK5 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112
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G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
increases expression |
ISO |
Clozapine results in increased expression of CDK5R1 mRNA |
CTD |
PMID:17266109 |
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NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions increases expression |
ISO |
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein] Clozapine results in increased expression of CEBPA mRNA; Clozapine results in increased expression of CEBPA protein |
CTD |
PMID:20564506 |
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NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
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G |
Cenpv |
centromere protein V |
increases expression |
ISO |
Clozapine results in increased expression of CENPV protein |
CTD |
PMID:34122009 |
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NCBI chr10:47,713,778...47,746,800
Ensembl chr10:47,214,490...47,228,761
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G |
Cfap210 |
cilia and flagella associated protein 210 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of CFAP210 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:54,520,455...54,554,677
Ensembl chr 3:54,520,458...54,554,607
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G |
Chchd2 |
coiled-coil-helix-coiled-coil-helix domain containing 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of CHCHD2 protein |
CTD |
PMID:34122009 |
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NCBI chr12:32,464,847...32,470,871
Ensembl chr12:26,828,736...26,834,755
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G |
Chd4 |
chromodomain helicase DNA binding protein 4 |
decreases expression |
ISO |
Clozapine results in decreased expression of CHD4 protein |
CTD |
PMID:34122009 |
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NCBI chr 4:159,584,623...159,617,867
Ensembl chr 4:157,899,391...157,931,541
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G |
Chga |
chromogranin A |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of CHGA mRNA Clozapine results in increased expression of CHGA mRNA |
CTD |
PMID:12437575 |
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NCBI chr 6:127,460,895...127,472,238
Ensembl chr 6:121,696,051...121,707,398
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G |
Chl1 |
cell adhesion molecule L1-like |
decreases expression |
ISO |
Clozapine results in decreased expression of CHL1 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 4:137,847,648...138,062,077
Ensembl chr 4:136,291,463...136,503,265
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G |
Chn1 |
chimerin 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CHN1 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 3:78,917,329...79,084,040
Ensembl chr 3:58,510,536...58,676,490
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G |
Chordc1 |
cysteine and histidine rich domain containing 1 |
increases expression |
ISO |
Clozapine results in increased expression of CHORDC1 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
affects binding increases expression multiple interactions |
ISO EXP |
Clozapine analog binds to CHRM1 protein; Clozapine binds to CHRM1 protein Clozapine results in increased expression of CHRM1 protein Clozapine inhibits the reaction [Dextroamphetamine results in decreased expression of CHRM1 protein] |
CTD |
PMID:11997696 PMID:16983399 PMID:18806925 |
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NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356
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G |
Ckap4 |
cytoskeleton-associated protein 4 |
increases expression |
ISO |
Clozapine results in increased expression of CKAP4 protein |
CTD |
PMID:34122009 |
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NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
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G |
Clic1 |
chloride intracellular channel 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of CLIC1 protein |
CTD |
PMID:34122009 |
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NCBI chr20:3,769,522...3,778,367
Ensembl chr20:3,761,461...3,773,712
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G |
Clic4 |
chloride intracellular channel 4 |
increases expression |
ISO |
Clozapine results in increased expression of CLIC4 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:152,737,371...152,797,118
Ensembl chr 5:147,453,712...147,513,452
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G |
Clock |
clock circadian regulator |
affects response to substance |
ISO |
CLOCK gene SNP affects the susceptibility to Clozapine |
CTD |
PMID:15331141 |
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NCBI chr14:32,262,747...32,346,872
Ensembl chr14:31,908,566...31,990,400
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G |
Clta |
clathrin, light chain A |
decreases expression |
EXP |
Clozapine results in decreased expression of CLTA mRNA |
CTD |
PMID:15860345 |
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NCBI chr 5:63,022,046...63,059,223
Ensembl chr 5:58,245,442...58,263,472
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G |
Cltb |
clathrin, light chain B |
decreases expression |
EXP |
Clozapine results in decreased expression of CLTB mRNA |
CTD |
PMID:15860345 |
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NCBI chr17:10,006,416...10,024,278
Ensembl chr17:10,001,513...10,019,169
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G |
Cnp |
2',3'-cyclic nucleotide 3' phosphodiesterase |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of CNP mRNA Clozapine results in decreased expression of CNP protein Clozapine results in increased expression of CNP mRNA |
CTD |
PMID:17266109 PMID:34122009 |
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NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720
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G |
Coil |
coilin |
increases expression |
EXP |
Clozapine results in increased expression of COIL mRNA |
CTD |
PMID:16715494 |
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NCBI chr10:74,286,279...74,307,597
Ensembl chr10:73,789,488...73,810,393
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G |
Col5a2 |
collagen type V alpha 2 chain |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of COL5A2 protein |
CTD |
PMID:34122009 |
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NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:47,448,736...47,598,154
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions affects response to substance increases response to substance |
EXP ISO |
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine] COMT protein affects the susceptibility to Clozapine COMT gene polymorphism results in increased susceptibility to Clozapine |
CTD |
PMID:15190105 PMID:17123785 |
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NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
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G |
Cops3 |
COP9 signalosome subunit 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of COPS3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:45,117,664...45,151,868
Ensembl chr10:44,618,115...44,641,597
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G |
Coro1b |
coronin 1B |
decreases expression |
ISO |
Clozapine results in decreased expression of CORO1B protein |
CTD |
PMID:34122009 |
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NCBI chr 1:210,872,437...210,877,876
Ensembl chr 1:201,443,014...201,448,416
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G |
Cplx2 |
complexin 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of CPLX2 mRNA |
CTD |
PMID:17266109 |
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NCBI chr17:10,224,673...10,297,974
Ensembl chr17:10,222,347...10,293,855
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G |
Cpn1 |
carboxypeptidase N subunit 1 |
increases expression |
EXP |
Clozapine results in increased expression of CPN1 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
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G |
Cpne1 |
copine 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CPNE1 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:165,047,615...165,089,994
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpt2 |
carnitine palmitoyltransferase 2 |
multiple interactions |
EXP |
[Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [Clozapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA |
CTD |
PMID:23226405 |
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NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions decreases phosphorylation |
ISO |
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of CREB1 protein] Clozapine results in decreased phosphorylation of CREB1 protein |
CTD |
PMID:12871586 |
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NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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G |
Crh |
corticotropin releasing hormone |
decreases expression |
ISO |
Clozapine results in decreased expression of CRH mRNA |
CTD |
PMID:16205782 |
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NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
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G |
Crhbp |
corticotropin releasing hormone binding protein |
decreases expression |
EXP |
Clozapine results in decreased expression of CRHBP mRNA |
CTD |
PMID:16715494 |
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NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:26,692,403...26,704,710
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G |
Crp |
C-reactive protein |
increases expression |
ISO |
Clozapine results in increased expression of CRP protein |
CTD |
PMID:17685758 |
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NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G |
Csf3 |
colony stimulating factor 3 |
multiple interactions |
ISO |
CSF3 protein inhibits the reaction [Clozapine results in increased expression of BAX mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of BIK mRNA]; CSF3 protein inhibits the reaction [Clozapine results in increased expression of TP53 mRNA] |
CTD |
PMID:16160616 |
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NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of CSNK2A1 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:140,709,991...140,756,696
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G |
Cst3 |
cystatin C |
increases expression |
ISO |
Clozapine results in increased expression of CST3 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 3:156,790,061...156,794,116
Ensembl chr 3:136,336,920...136,340,822
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G |
Cstf1 |
cleavage stimulation factor subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of CSTF1 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:161,144,522...161,156,294
Ensembl chr 3:161,144,548...161,156,300
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of CSTF2 protein |
CTD |
PMID:34122009 |
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NCBI chr X:101,546,809...101,572,760
Ensembl chr X:97,253,586...97,279,476
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G |
Ctbp1 |
C-terminal binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of CTBP1 protein |
CTD |
PMID:34122009 |
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NCBI chr14:81,679,956...81,707,331
Ensembl chr14:77,455,696...77,482,821
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G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of CTNNB1 protein DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein] |
CTD |
PMID:16144542 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctrl |
chymotrypsin-like |
increases expression |
EXP |
Clozapine results in increased expression of CTRL mRNA |
CTD |
PMID:16715494 |
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NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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G |
Ctsk |
cathepsin K |
increases expression |
EXP |
Clozapine results in increased expression of CTSK mRNA |
CTD |
PMID:16715494 |
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NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
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G |
Cttn |
cortactin |
increases expression |
ISO |
Clozapine results in increased expression of CTTN protein |
CTD |
PMID:34122009 |
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NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164
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G |
Cul2 |
cullin 2 |
increases expression |
ISO |
Clozapine results in increased expression of CUL2 protein |
CTD |
PMID:34122009 |
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NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
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G |
Cul3 |
cullin 3 |
increases expression |
ISO |
Clozapine results in increased expression of CUL3 protein |
CTD |
PMID:34122009 |
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NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression decreases secretion multiple interactions increases secretion |
ISO EXP |
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in decreased secretion of CXCL1 protein belnacasan inhibits the reaction [Clozapine results in increased secretion of CXCL1 protein] |
CTD |
PMID:17346280 PMID:34935985 PMID:36482696 |
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NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
decreases secretion |
ISO |
Clozapine results in decreased secretion of CXCL10 protein |
CTD |
PMID:36482696 |
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NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
decreases expression decreases secretion |
ISO |
Clozapine results in decreased expression of CXCL1 mRNA Clozapine results in decreased secretion of CXCL1 protein |
CTD |
PMID:17346280 PMID:36482696 |
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NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
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G |
Cxhxorf49 |
similar to human chromosome X open reading frame 49 |
increases expression |
ISO |
Clozapine results in increased expression of CXORF49 protein |
CTD |
PMID:34122009 |
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NCBI chr X:66,911,430...66,915,407
Ensembl chr X:66,911,431...66,915,293
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G |
Cyb5b |
cytochrome b5 type B |
increases expression |
EXP |
Clozapine results in increased expression of CYB5B mRNA |
CTD |
PMID:19441803 |
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NCBI chr19:51,972,611...52,006,477
Ensembl chr19:35,062,813...35,098,249
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G |
Cyb5r1 |
cytochrome b5 reductase 1 |
increases expression |
ISO |
Clozapine results in increased expression of CYB5R1 protein |
CTD |
PMID:34122009 |
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NCBI chr13:48,401,061...48,407,466
Ensembl chr13:45,849,091...45,855,458
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity increases metabolic processing |
EXP ISO |
Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] Clozapine results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of Clozapine |
CTD |
PMID:18493746 PMID:18809730 PMID:33814510 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases response to substance multiple interactions increases metabolic processing increases expression affects metabolic processing affects response to substance decreases metabolic processing |
ISO EXP |
CYP1A2 gene SNP results in decreased susceptibility to Clozapine Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CYP1A2 protein results in increased metabolism of Clozapine Clozapine results in increased expression of CYP1A2 mRNA CYP1A2 gene polymorphism affects the metabolism of Clozapine; CYP1A2 protein affects the metabolism of Clozapine; CYP1A2 protein polymorphism affects the metabolism of Clozapine [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Smoke affects the reaction [CYP1A2 gene polymorphism affects the metabolism of Clozapine]; Smoke promotes the reaction [CYP1A2 protein results in increased metabolism of Clozapine] CYP1A2 gene SNP affects the susceptibility to Clozapine; CYP1A2 protein affects the susceptibility to Clozapine CYP1A2 gene SNP results in increased metabolism of Clozapine; CYP1A2 protein results in increased metabolism of Clozapine CYP1A2 gene SNP results in decreased metabolism of Clozapine |
CTD |
PMID:11151749 PMID:11763009 PMID:12919186 PMID:12969762 PMID:15206669 PMID:15286053 PMID:15883149 PMID:15949157 PMID:16044115 PMID:18493746 PMID:18809730 PMID:23397584 PMID:27320963 More...
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing decreases activity |
ISO |
CYP1B1 protein results in increased metabolism of Clozapine Clozapine results in decreased activity of CYP1B1 protein |
CTD |
PMID:18809730 PMID:33814510 |
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
multiple interactions increases metabolic processing |
ISO |
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CYP2C19 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:23397584 PMID:27320963 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
increases metabolic processing |
ISO |
CYP2C8 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:27320963 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects metabolic processing increases metabolic processing multiple interactions |
ISO |
CYP2D6 protein affects the metabolism of Clozapine CYP2D6 protein results in increased metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine |
CTD |
PMID:15286053 PMID:18809730 PMID:23397584 PMID:27320963 |
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NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp2j4 |
cytochrome P450, family 2, subfamily j, polypeptide 4 |
increases metabolic processing |
ISO |
CYP2J2 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases metabolic processing affects metabolic processing multiple interactions |
ISO |
CYP3A4 protein results in increased metabolism of Clozapine CYP3A4 protein affects the metabolism of Clozapine [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine; Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] |
CTD |
PMID:15286053 PMID:18809730 PMID:21402137 PMID:23397584 PMID:27320963 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases metabolic processing |
ISO |
CYP3A5 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
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G |
Dab1 |
DAB adaptor protein 1 |
increases expression |
EXP |
Clozapine results in increased expression of DAB1 mRNA |
CTD |
PMID:19359144 |
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NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:119,140,533...119,510,552
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G |
Dab2 |
DAB adaptor protein 2 |
increases expression |
ISO |
Clozapine results in increased expression of DAB2 protein |
CTD |
PMID:36482696 |
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NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476
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G |
Daglb |
diacylglycerol lipase, beta |
increases expression |
ISO |
Clozapine results in increased expression of DAGLB protein |
CTD |
PMID:36482696 |
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NCBI chr12:16,173,345...16,215,777
Ensembl chr12:11,059,732...11,102,154
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G |
Dcaf6 |
DDB1 and CUL4 associated factor 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of DCAF6 mRNA |
CTD |
PMID:14647396 |
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NCBI chr13:80,159,282...80,260,510
Ensembl chr13:77,626,307...77,727,512
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G |
Dclk1 |
doublecortin-like kinase 1 |
increases expression |
ISO EXP |
Clozapine results in increased expression of DCLK1 mRNA |
CTD |
PMID:15860345 PMID:18797397 |
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NCBI chr 2:141,567,215...141,861,088
Ensembl chr 2:139,417,163...139,710,956
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G |
Ddc |
dopa decarboxylase |
multiple interactions increases expression |
ISO |
Clozapine results in increased expression of and results in increased activity of DDC protein Clozapine results in increased expression of DDC mRNA |
CTD |
PMID:16415089 |
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NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208
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G |
Ddx46 |
DEAD-box helicase 46 |
increases expression |
ISO |
Clozapine results in increased expression of DDX46 protein |
CTD |
PMID:34122009 |
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NCBI chr17:8,947,237...8,993,705
Ensembl chr17:8,944,454...8,988,439
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G |
Dennd10 |
DENN domain containing 10 |
increases expression |
EXP |
Clozapine results in increased expression of DENND10 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 1:259,950,955...259,974,459
Ensembl chr 1:259,950,866...259,974,455
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G |
Depp1 |
DEPP autophagy regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:149,910,779...149,914,542
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G |
Dgcr6 |
DiGeorge syndrome critical region gene 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of DGCR6 protein |
CTD |
PMID:34122009 |
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NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823
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G |
Dgka |
diacylglycerol kinase, alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of DGKA mRNA |
CTD |
PMID:15860345 |
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NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,148,735...1,175,110
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
increases expression |
ISO |
Clozapine results in increased expression of DHCR24 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137
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Dhcr7 |
7-dehydrocholesterol reductase |
increases expression |
ISO |
Clozapine results in increased expression of DHCR7 mRNA |
CTD |
PMID:17052361 |
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NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:199,015,081...199,031,055
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Dhx30 |
DExH-box helicase 30 |
increases expression |
ISO |
Clozapine results in increased expression of DHX30 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:118,943,186...118,975,319
Ensembl chr 8:110,064,752...110,097,381
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G |
Dhx38 |
DEAH-box helicase 38 |
decreases expression |
ISO |
Clozapine results in decreased expression of DHX38 protein |
CTD |
PMID:34122009 |
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NCBI chr19:37,512,893...37,530,135
Ensembl chr19:37,512,891...37,530,140
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G |
Disc1 |
DISC1 scaffold protein |
decreases response to substance affects response to substance |
ISO |
DISC1 gene mutant form results in decreased susceptibility to Clozapine DISC1 protein affects the susceptibility to Clozapine |
CTD |
PMID:20531374 |
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NCBI chr19:69,911,548...70,120,970
Ensembl chr19:53,014,616...53,219,778
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
decreases expression increases expression |
EXP ISO |
Clozapine results in decreased expression of DLAT mRNA Clozapine results in increased expression of DLAT protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479 Ensembl chr 1:50,978,051...51,004,479
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G |
Dlg2 |
discs large MAGUK scaffold protein 2 |
increases expression |
ISO |
Clozapine results in increased expression of DLG2 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:153,864,545...155,916,238
Ensembl chr 1:144,451,472...146,499,475
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
decreases expression |
ISO |
Clozapine results in decreased expression of DLST protein |
CTD |
PMID:34122009 |
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NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296
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G |
Dnah11 |
dynein, axonemal, heavy chain 11 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of DNAH11 protein |
CTD |
PMID:34122009 |
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NCBI chr 6:144,982,130...145,298,523
Ensembl chr 6:138,839,177...139,155,536
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of DNAJA3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:11,361,168...11,386,599
Ensembl chr10:10,854,732...10,880,161
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G |
Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
increases expression |
ISO |
Clozapine results in increased expression of DNAJB11 protein |
CTD |
PMID:34122009 |
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NCBI chr11:91,656,334...91,672,800
Ensembl chr11:78,150,429...78,180,407
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G |
Dpf1 |
double PHD fingers 1 |
affects expression |
ISO |
Clozapine affects the expression of DPF1 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 1:93,729,683...93,743,425
Ensembl chr 1:84,602,336...84,615,950
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G |
Dpp3 |
dipeptidylpeptidase 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of DPP3 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:202,204,693...202,228,541
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of DPYSL3 protein |
CTD |
PMID:34122009 |
|
NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,377,181...35,480,157
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G |
Dpysl4 |
dihydropyrimidinase-like 4 |
decreases expression |
ISO |
Clozapine results in decreased expression of DPYSL4 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:203,312,646...203,328,523
Ensembl chr 1:193,883,106...193,898,914
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G |
Dr1 |
down-regulator of transcription 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of DR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:1,603,203...1,614,556
Ensembl chr14:1,458,223...1,469,638
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G |
Drd1 |
dopamine receptor D1 |
affects binding decreases expression affects response to substance |
ISO EXP |
Clozapine binds to DRD1 protein Clozapine results in decreased expression of DRD1 mRNA Clozapine analog binds to DRD1 protein DRD1 gene polymorphism affects the susceptibility to Clozapine; DRD1 protein affects the susceptibility to Clozapine |
CTD |
PMID:1352677 PMID:9723970 PMID:11997696 PMID:17092969 PMID:17266109 |
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NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions affects binding affects response to substance decreases expression increases response to substance |
ISO EXP |
[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein Clozapine binds to DRD2 protein DRD2 protein affects the susceptibility to Clozapine Clozapine results in decreased expression of DRD2 mRNA Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA Clozapine binds to DRD2 protein alternative form DRD2 gene SNP results in increased susceptibility to Clozapine DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine |
CTD |
PMID:1352677 PMID:9723970 PMID:11997696 PMID:12476322 PMID:15286066 PMID:15716360 PMID:15781964 PMID:15830237 PMID:16033416 PMID:16144542 PMID:16278074 PMID:17266109 PMID:20375926 More...
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NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
affects response to substance multiple interactions decreases response to substance |
ISO |
DRD3 protein affects the susceptibility to Clozapine DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form] DRD3 gene polymorphism results in decreased susceptibility to Clozapine |
CTD |
PMID:15579174 PMID:20029384 |
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NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596
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G |
Drd4 |
dopamine receptor D4 |
affects binding multiple interactions affects response to substance |
ISO EXP |
Clozapine binds to DRD4 protein Clozapine binds to Drd4 protein Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein] Clozapine analog binds to DRD4 protein DRD4 gene polymorphism affects the susceptibility to Clozapine |
CTD RGD |
PMID:11997696 PMID:16223700 PMID:31323226 PMID:8078498 |
RGD:7248459 |
NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553
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G |
Drp2 |
dystrophin related protein 2 |
increases expression |
EXP |
Clozapine results in increased expression of DRP2 mRNA alternative form |
CTD |
PMID:16715494 |
|
NCBI chr X:101,900,743...101,951,403
Ensembl chr X:97,607,719...97,655,684
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G |
Dtnbp1 |
dystrobrevin binding protein 1 |
increases response to substance affects response to substance |
ISO |
DTNBP1 gene polymorphism results in increased susceptibility to Clozapine DTNBP1 protein affects the susceptibility to Clozapine |
CTD |
PMID:19369910 |
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NCBI chr17:19,685,218...19,776,668
Ensembl chr17:19,685,215...19,776,661
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G |
Dusp1 |
dual specificity phosphatase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of DUSP1 mRNA |
CTD |
PMID:15860345 |
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NCBI chr10:17,184,853...17,187,646
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G |
Dusp6 |
dual specificity phosphatase 6 |
decreases expression |
EXP |
Clozapine results in decreased expression of DUSP6 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
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G |
Dvl3 |
dishevelled segment polarity protein 3 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of DVL3 protein DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein] |
CTD |
PMID:16144542 |
|
NCBI chr11:93,869,834...93,887,013
Ensembl chr11:80,366,117...80,382,462
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G |
Dync1li1 |
dynein cytoplasmic 1 light intermediate chain 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of DYNC1LI1 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:114,376,662...114,410,934
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G |
Dync1li2 |
dynein, cytoplasmic 1 light intermediate chain 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of DYNC1LI2 protein |
CTD |
PMID:34122009 |
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NCBI chr19:538,207...561,110
Ensembl chr19:531,812...554,670
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G |
Edc4 |
enhancer of mRNA decapping 4 |
increases expression |
ISO |
Clozapine results in increased expression of EDC4 protein |
CTD |
PMID:34122009 |
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NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
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G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
increases expression |
ISO |
Clozapine results in increased expression of EEF1A2 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G |
Eef1d |
eukaryotic translation elongation factor 1 delta |
decreases expression |
ISO |
Clozapine results in decreased expression of EEF1D protein |
CTD |
PMID:34122009 |
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NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:107,581,930...107,608,799
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G |
Egr1 |
early growth response 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of EGR1 mRNA; Clozapine results in decreased expression of EGR1 protein |
CTD |
PMID:17028028 PMID:18208916 |
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NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
affects expression decreases expression |
ISO EXP |
Clozapine affects the expression of EGR2 mRNA Clozapine results in decreased expression of EGR2 protein |
CTD |
PMID:17028028 PMID:19401217 |
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NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562
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G |
Egr3 |
early growth response 3 |
affects response to substance |
ISO |
EGR3 protein affects the susceptibility to Clozapine |
CTD |
PMID:17637609 |
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NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627
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G |
Eif2s3 |
eukaryotic translation initiation factor 2 subunit gamma |
increases expression |
ISO |
Clozapine results in increased expression of EIF2S3 protein |
CTD |
PMID:34122009 |
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NCBI chr X:62,910,292...62,933,936
Ensembl chr X:58,917,490...58,940,686
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G |
Eif3c |
eukaryotic translation initiation factor 3, subunit C |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF3C protein |
CTD |
PMID:34122009 |
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NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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G |
Eif3j |
eukaryotic translation initiation factor 3, subunit J |
increases expression |
ISO |
Clozapine results in increased expression of EIF3J protein |
CTD |
PMID:34122009 |
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NCBI chr 3:108,985,103...109,007,341
Ensembl chr 3:108,985,118...109,007,953
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G |
Eif3m |
eukaryotic translation initiation factor 3, subunit M |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of EIF3M protein |
CTD |
PMID:34122009 |
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NCBI chr 3:91,424,754...91,442,358
Ensembl chr 3:91,416,325...91,442,392
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G |
Eif4a3 |
eukaryotic translation initiation factor 4A3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EIF4A3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:105,047,567...105,057,561
Ensembl chr10:104,549,038...104,559,057
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of EIF4E protein |
CTD |
PMID:34122009 |
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NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif5b |
eukaryotic translation initiation factor 5B |
increases expression |
ISO |
Clozapine results in increased expression of EIF5B protein |
CTD |
PMID:34122009 |
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NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:40,222,898...40,277,482
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G |
Eif6 |
eukaryotic translation initiation factor 6 |
decreases expression |
ISO |
Clozapine results in decreased expression of EIF6 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:164,785,162...164,791,410
Ensembl chr 3:144,325,036...144,331,401
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G |
Elk1 |
ETS transcription factor ELK1 |
decreases phosphorylation |
ISO |
Clozapine results in decreased phosphorylation of ELK1 protein |
CTD |
PMID:12871586 |
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NCBI chr X:3,692,367...3,709,252
Ensembl chr X:1,139,756...1,155,713
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G |
Eno1 |
enolase 1 |
increases expression |
EXP |
Clozapine results in increased expression of ENO1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Eno3 |
enolase 3 |
increases expression |
ISO |
Clozapine results in increased expression of ENO3 protein |
CTD |
PMID:34122009 |
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NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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G |
Epha7 |
Eph receptor A7 |
increases expression |
ISO |
Clozapine results in increased expression of EPHA7 mRNA |
CTD |
PMID:17266109 |
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NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
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G |
Ephb3 |
Eph receptor B3 |
increases expression |
ISO |
Clozapine results in increased expression of EPHB3 protein |
CTD |
PMID:34122009 |
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NCBI chr11:93,345,098...93,363,775
Ensembl chr11:79,840,668...79,859,370
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G |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of ERAP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:5,666,337...5,705,256
Ensembl chr 2:3,931,904...3,972,447
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
affects phosphorylation |
EXP |
Clozapine affects the phosphorylation of ERBB2 protein |
CTD |
PMID:26961615 |
|
NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
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G |
Erbb4 |
erb-b2 receptor tyrosine kinase 4 |
multiple interactions |
EXP |
Clozapine results in increased expression of and results in increased phosphorylation of ERBB4 protein |
CTD |
PMID:26961615 |
|
NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595
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G |
Erh |
ERH, mRNA splicing and mitosis factor |
increases expression |
ISO |
Clozapine results in increased expression of ERH protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:106,012,255...106,022,521
Ensembl chr 6:100,280,930...100,291,210
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G |
Erp44 |
endoplasmic reticulum protein 44 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of ERP44 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:67,313,245...67,406,207
Ensembl chr 5:62,516,551...62,610,761
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G |
Ewsr1 |
EWS RNA-binding protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of EWSR1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544
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G |
Exosc4 |
exosome component 4 |
increases expression |
ISO |
Clozapine results in increased expression of EXOSC4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:109,928,491...109,931,233
Ensembl chr 7:108,047,831...108,050,573
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G |
Ezr |
ezrin |
decreases expression |
ISO |
Clozapine results in decreased expression of EZR protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:46,967,658...47,011,505
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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G |
Fan1 |
FANCD2 and FANCI associated nuclease 1 |
increases expression |
ISO |
Clozapine results in increased expression of FAN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:117,917,099...117,944,977
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G |
Farsa |
phenylalanyl-tRNA synthetase subunit alpha |
increases expression |
ISO |
Clozapine results in increased expression of FARSA protein |
CTD |
PMID:34122009 |
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NCBI chr19:40,196,255...40,205,830
Ensembl chr19:23,268,869...23,300,980
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G |
Farsb |
phenylalanyl-tRNA synthetase subunit beta |
increases expression |
ISO |
Clozapine results in increased expression of FARSB protein |
CTD |
PMID:34122009 |
|
NCBI chr 9:87,336,321...87,395,546
Ensembl chr 9:79,887,842...79,947,045
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA |
CTD |
PMID:20564506 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
multiple interactions |
ISO |
[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA |
CTD |
PMID:16510162 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G |
Fasn |
fatty acid synthase |
increases expression |
ISO |
Clozapine results in increased expression of FASN mRNA |
CTD |
PMID:16027736 PMID:17052361 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression |
ISO |
Clozapine results in increased expression of FDPS mRNA |
CTD |
PMID:17052361 |
|
NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:174,486,665...174,507,776
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G |
Fen1 |
flap structure-specific endonuclease 1 |
increases expression |
ISO |
Clozapine results in increased expression of FEN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:216,270,016...216,274,873
Ensembl chr 1:206,844,884...206,850,003
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G |
Fgf2 |
fibroblast growth factor 2 |
increases expression |
EXP |
Clozapine results in increased expression of FGF2 mRNA |
CTD |
PMID:11264663 |
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NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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G |
Fgl1 |
fibrinogen-like 1 |
increases expression |
ISO |
Clozapine results in increased expression of FGL1 protein |
CTD |
PMID:36482696 |
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NCBI chr16:57,824,127...57,854,413
Ensembl chr16:51,120,694...51,151,093
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G |
Fhod1 |
formin homology 2 domain containing 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of FHOD1 protein |
CTD |
PMID:34122009 |
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NCBI chr19:33,206,492...33,225,448
Ensembl chr19:33,206,492...33,225,356
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G |
Fkbp8 |
FKBP prolyl isomerase 8 |
decreases expression |
ISO |
Clozapine results in decreased expression of FKBP8 protein |
CTD |
PMID:34122009 |
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NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612
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G |
Flot2 |
flotillin 2 |
increases expression |
ISO |
Clozapine results in increased expression of FLOT2 protein |
CTD |
PMID:34122009 |
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NCBI chr10:63,424,084...63,445,811
Ensembl chr10:62,920,665...62,947,756
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G |
Fmo1 |
flavin containing dimethylaniline monoxygenase 1 |
increases metabolic processing |
ISO |
FMO1 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 |
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NCBI chr13:77,715,405...77,747,666
Ensembl chr13:75,182,176...75,214,647
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G |
Fmo3 |
flavin containing dimethylaniline monoxygenase 3 |
increases metabolic processing |
ISO |
FMO3 protein results in increased metabolism of Clozapine |
CTD |
PMID:18809730 PMID:27320963 |
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NCBI chr13:77,838,899...77,868,869
Ensembl chr13:75,309,374...75,328,028
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G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Clozapine results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:25,077,349...25,080,675
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression decreases expression |
EXP ISO |
Clozapine affects the reaction [Haloperidol results in increased expression of FOS protein]; Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] Clozapine results in increased expression of FOS protein Clozapine analog results in increased expression of FOS protein; Clozapine results in increased expression of FOS mRNA; Clozapine results in increased expression of FOS protein Clozapine results in decreased expression of FOS protein |
CTD |
PMID:10435392 PMID:11166331 PMID:11440804 PMID:11997696 PMID:12093589 PMID:12243769 PMID:12464447 PMID:17028028 PMID:18208916 PMID:18521575 PMID:19695244 PMID:28272498 More...
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NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions decreases expression |
ISO EXP |
Clozapine results in increased expression of FOSB protein alternative form Clozapine results in increased expression of FOSB mRNA; Clozapine results in increased expression of FOSB protein DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form] Clozapine results in decreased expression of FOSB mRNA |
CTD |
PMID:11259127 PMID:12093589 PMID:12243769 PMID:15579174 PMID:19695244 |
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NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:78,954,115...78,961,465
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of FOSL1 mRNA |
CTD |
PMID:18208916 |
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NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
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G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of FOSL2 mRNA |
CTD |
PMID:12093589 PMID:12243769 |
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NCBI chr 6:30,017,952...30,039,269
Ensembl chr 6:24,300,956...24,320,034
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G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
Clozapine results in increased expression of FOXP2 mRNA |
CTD |
PMID:17266109 |
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NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:43,133,912...43,711,683
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G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of FSTL1 protein |
CTD |
PMID:34122009 |
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NCBI chr11:76,400,870...76,454,053
Ensembl chr11:62,779,783...62,948,677
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G |
Fubp1 |
far upstream element binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of FUBP1 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases expression |
ISO |
Clozapine results in decreased expression of G6PD protein |
CTD |
PMID:34122009 |
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NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
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G |
Gabarapl2 |
GABA type A receptor associated protein like 2 |
increases expression |
ISO |
Clozapine results in increased expression of GABARAPL2 protein |
CTD |
PMID:36482696 |
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NCBI chr19:56,819,826...56,830,662
Ensembl chr19:39,910,534...39,924,628
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G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of GABBR1 mRNA |
CTD |
PMID:17266109 |
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NCBI chr20:1,469,779...1,499,352
Ensembl chr20:1,464,534...1,493,994
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
increases expression |
ISO |
Clozapine results in increased expression of GABRA1 mRNA |
CTD |
PMID:17266109 |
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NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
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G |
Gabrb3 |
gamma-aminobutyric acid type A receptor subunit beta 3 |
increases expression |
EXP |
Clozapine results in increased expression of GABRB3 mRNA |
CTD |
PMID:18923069 |
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NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961
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G |
Gad1 |
glutamate decarboxylase 1 |
increases expression decreases methylation multiple interactions |
ISO EXP |
Clozapine results in increased expression of GAD1 mRNA Clozapine results in decreased methylation of GAD1 promoter Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter]; Valproic Acid promotes the reaction [Clozapine results in decreased methylation of GAD1 promoter] |
CTD |
PMID:12887421 PMID:15061247 PMID:17942719 PMID:18757738 PMID:18923069 |
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NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333
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G |
Gad2 |
glutamate decarboxylase 2 |
increases expression |
ISO EXP |
Clozapine results in increased expression of GAD2 mRNA |
CTD |
PMID:17266109 PMID:18923069 |
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NCBI chr17:89,671,718...89,734,246
Ensembl chr17:84,763,628...84,826,155
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP ISO |
Clozapine results in increased expression of GAPDH mRNA Clozapine results in increased expression of GAPDH protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
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G |
Gart |
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
increases expression |
ISO |
Clozapine results in increased expression of GART protein |
CTD |
PMID:34122009 |
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NCBI chr11:44,351,841...44,377,086
Ensembl chr11:30,865,889...30,891,125
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G |
Gatm |
glycine amidinotransferase |
increases expression |
ISO |
Clozapine results in increased expression of GATM protein |
CTD |
PMID:34122009 |
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NCBI chr 3:130,112,508...130,137,664
Ensembl chr 3:109,658,951...109,684,129
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G |
Gcc2 |
GRIP and coiled-coil domain containing 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of GCC2 protein |
CTD |
PMID:34122009 |
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NCBI chr20:26,788,472...26,836,728
Ensembl chr20:26,247,404...26,293,613
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Clozapine results in increased expression of GDF15 protein |
CTD |
PMID:36482696 |
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NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
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G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Clozapine results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:181,366,626...181,383,063
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of GFAP protein Clozapine results in increased expression of GFAP mRNA |
CTD |
PMID:18585900 PMID:19441803 |
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NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
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G |
Ghitm |
growth hormone inducible transmembrane protein |
increases expression |
ISO |
Clozapine results in increased expression of GHITM protein |
CTD |
PMID:34122009 |
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NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
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G |
Gimap5 |
GTPase, IMAP family member 5 |
decreases expression |
EXP |
Clozapine results in decreased expression of GIMAP5 mRNA |
CTD |
PMID:16715494 |
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NCBI chr 4:79,025,151...79,031,917
Ensembl chr 4:77,687,564...77,703,086
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G |
Gip |
gastric inhibitory polypeptide |
increases expression |
EXP |
Clozapine results in increased expression of GIP mRNA; Clozapine results in increased expression of GIP protein |
CTD |
PMID:16402076 |
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NCBI chr10:81,465,070...81,473,216
Ensembl chr10:80,968,352...80,976,503
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G |
Gja1 |
gap junction protein, alpha 1 |
increases expression |
EXP |
Clozapine results in increased expression of GJA1 protein |
CTD |
PMID:18585900 |
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NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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G |
Glp1r |
glucagon-like peptide 1 receptor |
multiple interactions decreases expression |
EXP |
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein] |
CTD |
PMID:37087062 |
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NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241
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G |
Glrx3 |
glutaredoxin 3 |
increases expression |
ISO |
Clozapine results in increased expression of GLRX3 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:201,671,410...201,701,722
Ensembl chr 1:192,241,701...192,272,010
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G |
Glul |
glutamate-ammonia ligase |
decreases expression |
ISO |
Clozapine results in decreased expression of GLUL protein |
CTD |
PMID:36482696 |
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NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108
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G |
Gna12 |
G protein subunit alpha 12 |
decreases expression increases expression |
EXP ISO |
Clozapine results in decreased expression of GNA12 mRNA Clozapine results in increased expression of GNA12 protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr12:18,919,629...19,000,185
Ensembl chr12:13,805,698...13,886,255
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G |
Gnai1 |
G protein subunit alpha i1 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI1 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:16,814,001...16,896,417
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI2 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:108,288,401...108,308,979
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G |
Gnai3 |
G protein subunit alpha i3 |
decreases expression |
EXP |
Clozapine results in decreased expression of GNAI3 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 2:198,430,920...198,468,874
Ensembl chr 2:195,742,642...195,780,742
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G |
Gnas |
GNAS complex locus |
decreases expression multiple interactions increases expression |
EXP ISO |
Clozapine results in decreased expression of GNAS mRNA [Cuprizone co-treated with Clozapine] results in decreased expression of GNAS protein Clozapine results in increased expression of GNAS protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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G |
Gnb3 |
G protein subunit beta 3 |
decreases response to substance increases expression affects response to substance increases response to substance |
ISO EXP |
GNB3 gene polymorphism results in decreased susceptibility to Clozapine Clozapine results in increased expression of GNB3 protein GNB3 protein affects the susceptibility to Clozapine GNB3 gene polymorphism results in increased susceptibility to Clozapine |
CTD |
PMID:16139171 PMID:16141801 PMID:18855531 |
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NCBI chr 4:159,325,741...159,331,443
Ensembl chr 4:157,639,469...157,645,173
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G |
Golga3 |
golgin A3 |
increases expression |
ISO |
Clozapine results in increased expression of GOLGA3 protein |
CTD |
PMID:34122009 |
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NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509 Ensembl chr 4:46,454,870...46,500,509
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G |
Golgb1 |
golgin B1 |
increases expression |
ISO |
Clozapine results in increased expression of GOLGB1 protein |
CTD |
PMID:34122009 |
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NCBI chr11:77,348,573...77,406,165
Ensembl chr11:63,843,986...63,900,770
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
increases expression multiple interactions |
EXP ISO |
Clozapine results in increased expression of GOT2 mRNA [Cuprizone co-treated with Clozapine] results in increased expression of GOT2 protein |
CTD |
PMID:15860345 PMID:34122009 |
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NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpd2 |
glycerol-3-phosphate dehydrogenase 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of GPD2 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:62,209,432...62,346,590
Ensembl chr 3:41,801,930...41,936,901
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G |
Gpi |
glucose-6-phosphate isomerase |
increases expression |
ISO |
Clozapine results in increased expression of GPI protein |
CTD |
PMID:34122009 |
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NCBI chr 1:95,965,389...95,996,932
Ensembl chr 1:86,828,216...86,856,086
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
[Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein |
CTD |
PMID:36482696 |
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NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression |
ISO |
Clozapine results in increased expression of GPX1 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
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G |
Grik2 |
glutamate ionotropic receptor kainate type subunit 2 |
increases expression |
EXP |
Clozapine results in increased expression of GRIK2 mRNA |
CTD |
PMID:18923069 |
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NCBI chr20:53,717,564...54,415,283
Ensembl chr20:52,133,851...52,838,375
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G |
Grik5 |
glutamate ionotropic receptor kainate type subunit 5 |
affects expression decreases expression |
ISO EXP |
Clozapine affects the expression of GRIK5 mRNA Clozapine results in decreased expression of GRIK5 mRNA |
CTD |
PMID:14647396 PMID:18923069 |
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NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
decreases expression increases expression |
ISO EXP |
Clozapine results in decreased expression of GRIN1 mRNA Clozapine results in increased expression of GRIN1 mRNA |
CTD |
PMID:12020038 PMID:12608697 PMID:17266109 PMID:18923069 |
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NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2A mRNA |
CTD |
PMID:12608697 PMID:18923069 |
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NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2B mRNA |
CTD |
PMID:18923069 |
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NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279
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G |
Grin2c |
glutamate ionotropic receptor NMDA type subunit 2C |
decreases expression |
EXP |
Clozapine results in decreased expression of GRIN2C mRNA |
CTD |
PMID:18923069 |
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NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,488,431...100,506,427
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G |
Grk6 |
G protein-coupled receptor kinase 6 |
decreases expression |
EXP |
Clozapine results in decreased expression of GRK6 mRNA |
CTD |
PMID:16715494 |
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NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,177,019...9,192,644
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of GSK3A protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein] |
CTD |
PMID:16144542 |
|
NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation increases expression multiple interactions |
ISO EXP |
Clozapine results in increased phosphorylation of GSK3B protein Clozapine results in increased expression of GSK3B protein DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] |
CTD |
PMID:16144542 PMID:19359144 PMID:19440698 |
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
decreases activity increases glutathionylation |
ISO |
GSTA1 protein results in decreased activity of Clozapine GSTA1 protein results in increased glutathionylation of Clozapine |
CTD |
PMID:20849150 |
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NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstm1 |
glutathione S-transferase mu 1 |
decreases activity increases expression increases glutathionylation |
ISO EXP |
GSTM1 protein results in decreased activity of Clozapine Clozapine results in increased expression of GSTM1 mRNA GSTM1 protein results in increased glutathionylation of Clozapine |
CTD |
PMID:15860345 PMID:20849150 |
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NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of GSTM2 mRNA |
CTD |
PMID:15860345 |
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NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
decreases activity affects metabolic processing increases glutathionylation affects binding |
ISO |
Clozapine metabolite results in decreased activity of GSTP1 protein; GSTP1 protein results in decreased activity of Clozapine GSTP1 protein affects the metabolism of Clozapine metabolite GSTP1 protein results in increased glutathionylation of Clozapine Clozapine metabolite binds to GSTP1 protein |
CTD |
PMID:20849150 PMID:21639118 PMID:24185126 |
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NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G |
H1f2 |
H1.2 linker histone, cluster member |
increases expression |
ISO |
Clozapine results in increased expression of H1-2 protein |
CTD |
PMID:34122009 |
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NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,388,477...41,392,635
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G |
H2ac18 |
H2A clustered histone 18 |
increases expression |
ISO |
Clozapine results in increased expression of H2AC18 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 2:186,497,271...186,497,865
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G |
H2ac20 |
H2A clustered histone 20 |
increases expression |
ISO |
Clozapine results in increased expression of H2AC20 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:186,468,748...186,469,226
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G |
H2aj |
H2A.J histone |
increases expression |
ISO |
Clozapine results in increased expression of H2AJ protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:169,675,752...169,677,006
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G |
Haao |
3-hydroxyanthranilate 3,4-dioxygenase |
decreases expression |
ISO |
Clozapine results in decreased expression of HAAO protein |
CTD |
PMID:36482696 |
|
NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877
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G |
Hacd3 |
3-hydroxyacyl-CoA dehydratase 3 |
increases expression |
ISO |
Clozapine results in increased expression of HACD3 protein |
CTD |
PMID:34122009 |
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NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:65,501,240...65,538,507
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G |
Hadhb |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
increases expression |
ISO |
Clozapine results in increased expression of HADHB protein |
CTD |
PMID:34122009 |
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NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869
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G |
Hars1 |
histidyl-tRNA synthetase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HARS1 protein |
CTD |
PMID:34122009 |
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NCBI chr18:28,655,669...28,672,712
Ensembl chr18:28,381,655...28,398,740
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G |
Hat1 |
histone acetyltransferase 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of HAT1 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
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G |
Hcls1 |
hematopoietic cell specific Lyn substrate 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of HCLS1 protein |
CTD |
PMID:34122009 |
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NCBI chr11:77,322,873...77,346,333
Ensembl chr11:63,817,476...63,841,014
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G |
Hdgfl2 |
HDGF like 2 |
increases expression |
ISO |
Clozapine results in increased expression of HDGFRP2 protein |
CTD |
PMID:34122009 |
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NCBI chr 9:996,687...1,016,352
Ensembl chr 9:909,614...929,186
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G |
Higd1a |
HIG1 hypoxia inducible domain family, member 1A |
increases expression |
ISO |
Clozapine results in increased expression of HIGD1A mRNA |
CTD |
PMID:14647396 |
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NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:121,514,156...121,523,443
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G |
Hmgb2 |
high mobility group box 2 |
increases expression |
ISO |
Clozapine results in increased expression of HMGB2 protein |
CTD |
PMID:34122009 |
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NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140 Ensembl chr 1:32,710,658...32,713,140
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases expression increases activity |
ISO |
[Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Triglycerides Clozapine results in increased expression of HMGCR mRNA |
CTD |
PMID:16027736 PMID:17052361 |
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NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HMGCS1 mRNA |
CTD |
PMID:16027736 PMID:17052361 |
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NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO |
Clozapine results in increased expression of HMOX1 mRNA |
CTD |
PMID:18227147 |
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G |
Hnrnpd |
heterogeneous nuclear ribonucleoprotein D |
decreases expression |
ISO |
Clozapine results in decreased expression of HNRNPD protein |
CTD |
PMID:34122009 |
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NCBI chr14:9,918,630...9,938,072
Ensembl chr14:9,615,479...9,633,786
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G |
Hnrnph2 |
heterogeneous nuclear ribonucleoprotein H2 |
decreases expression |
ISO |
Clozapine results in decreased expression of HNRNPH2 protein |
CTD |
PMID:36482696 |
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NCBI chr X:102,074,175...102,080,115
Ensembl chr X:97,780,785...97,787,041
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G |
Homer1 |
homer scaffold protein 1 |
increases expression multiple interactions |
EXP |
Clozapine results in increased expression of HOMER1 mRNA Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA] |
CTD |
PMID:12464447 PMID:15860345 |
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NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:24,543,093...24,644,785
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G |
Hpcal1 |
hippocalcin-like 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of HPCAL1 mRNA |
CTD |
PMID:12437575 |
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NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:40,478,208...40,584,687
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G |
Hpcal4 |
hippocalcin-like 4 |
affects expression |
EXP |
Clozapine affects the expression of HPCAL4 mRNA |
CTD |
PMID:12437575 |
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NCBI chr 5:140,739,577...140,751,529
Ensembl chr 5:135,454,540...135,466,416
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G |
Hpn |
hepsin |
increases expression |
ISO |
Clozapine results in increased expression of HPN mRNA |
CTD |
PMID:15342952 |
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NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:86,337,087...86,352,811
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G |
Hrh1 |
histamine receptor H 1 |
affects binding |
ISO |
Clozapine binds to HRH1 protein |
CTD |
PMID:16983399 |
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NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455
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G |
Hrh3 |
histamine receptor H3 |
multiple interactions |
EXP |
Clozapine binds to Hrh3 protein; Clozapine inhibits the reaction [N-methylhistamine binds to Hrh3 protein] |
RGD |
PMID:10869375 |
RGD:632981 |
NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:167,191,558...167,196,642
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G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of HSD17B10 protein |
CTD |
PMID:34122009 |
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NCBI chr X:24,568,551...24,571,012
Ensembl chr X:21,089,122...21,109,488
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G |
Hsd17b12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
increases expression |
ISO |
Clozapine results in increased expression of HSD17B12 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:79,990,056...80,113,617
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
decreases expression |
ISO |
Clozapine results in decreased expression of HSPA9 protein |
CTD |
PMID:34122009 |
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NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions affects binding |
ISO EXP |
Clozapine binds to and affects the activity of HTR1A protein Clozapine binds to HTR1A protein |
CTD |
PMID:9723970 PMID:15482641 |
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NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1d |
5-hydroxytryptamine receptor 1D |
decreases expression |
EXP |
Clozapine results in decreased expression of HTR1D mRNA |
CTD |
PMID:16715494 |
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NCBI chr 5:148,656,252...148,676,532
Ensembl chr 5:148,674,495...148,675,619
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
increases response to substance affects binding multiple interactions decreases expression decreases activity affects response to substance increases expression |
ISO EXP |
HTR2A gene SNP results in increased susceptibility to Clozapine Clozapine analog binds to HTR2A protein; Clozapine binds to HTR2A protein Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein] Clozapine results in decreased expression of HTR2A mRNA; Clozapine results in decreased expression of HTR2A protein Clozapine results in decreased activity of HTR2A protein [[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]; Clozapine binds to and results in decreased activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] HTR2A protein affects the susceptibility to Clozapine Clozapine results in increased expression of HTR2A mRNA |
CTD |
PMID:7520908 PMID:9723970 PMID:11997696 PMID:14751426 PMID:15380371 PMID:15542763 PMID:16314884 PMID:16983399 PMID:17868938 PMID:18976543 PMID:20521326 More...
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NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
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G |
Htr2c |
5-hydroxytryptamine receptor 2C |
affects binding decreases expression affects response to substance |
ISO EXP |
Clozapine binds to HTR2C protein Clozapine results in decreased expression of HTR2C mRNA HTR2C gene polymorphism affects the susceptibility to Clozapine; HTR2C gene SNP affects the susceptibility to Clozapine; HTR2C promoter SNP affects the susceptibility to Clozapine; HTR2C protein affects the susceptibility to Clozapine |
CTD |
PMID:9723970 PMID:12668355 PMID:15635667 PMID:16983399 PMID:17868938 PMID:19142101 PMID:19142110 More...
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NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
multiple interactions affects response to substance |
ISO |
Clozapine binds to and results in decreased activity of HTR3A protein HTR3A protein affects the susceptibility to Clozapine |
CTD |
PMID:19696922 PMID:20168265 |
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NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:49,242,020...49,254,389
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G |
Htr6 |
5-hydroxytryptamine receptor 6 |
multiple interactions affects binding |
ISO |
Clozapine binds to and results in decreased activity of HTR6 protein [Cuprizone co-treated with Clozapine] results in increased expression of HTR6 protein Clozapine binds to HTR6 protein |
CTD |
PMID:11406289 PMID:16983399 PMID:34122009 |
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NCBI chr 5:156,579,901...156,595,147
Ensembl chr 5:151,296,662...151,311,912
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G |
Htr7 |
5-hydroxytryptamine receptor 7 |
affects binding multiple interactions |
ISO |
Clozapine binds to HTR7 protein [Clozapine binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] |
CTD |
PMID:14578406 PMID:20827463 |
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NCBI chr 1:243,049,064...243,173,636
Ensembl chr 1:233,636,452...233,760,626
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
EXP |
Clozapine results in increased expression of ID2 mRNA |
CTD |
PMID:12437575 |
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NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
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G |
Idh2 |
isocitrate dehydrogenase (NADP(+)) 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of IDH2 protein |
CTD |
PMID:34122009 |
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NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of IDI1 protein |
CTD |
PMID:34122009 |
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NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
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G |
Ifng |
interferon gamma |
affects expression decreases expression |
ISO |
Clozapine affects the expression of IFNG protein Clozapine results in decreased expression of IFNG mRNA |
CTD |
PMID:17346280 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr1 |
interferon gamma receptor 1 |
increases expression |
ISO |
Clozapine results in increased expression of IFNGR1 protein |
CTD |
PMID:36482696 |
|
NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785
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G |
Igf1 |
insulin-like growth factor 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of IGF1 protein |
CTD |
PMID:11769361 |
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NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of IGFBP1 protein |
CTD |
PMID:36482696 |
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NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
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G |
Il10 |
interleukin 10 |
decreases expression |
EXP |
Clozapine results in decreased expression of IL10 protein |
CTD |
PMID:24709159 |
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NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
increases secretion multiple interactions |
EXP |
Clozapine results in increased secretion of IL1B protein belnacasan inhibits the reaction [Clozapine results in increased secretion of IL1B protein] |
CTD |
PMID:34935985 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
increases secretion |
ISO |
Clozapine results in increased secretion of IL2RA protein |
CTD |
PMID:8067274 |
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NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
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G |
Il5 |
interleukin 5 |
affects expression |
ISO |
Clozapine affects the expression of IL5 protein |
CTD |
PMID:17346280 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
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G |
Ilkap |
ILK associated serine/threonine phosphatase |
decreases expression |
EXP |
Clozapine results in decreased expression of ILKAP mRNA |
CTD |
PMID:15860345 |
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NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892
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G |
Inha |
inhibin subunit alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of INHA mRNA |
CTD |
PMID:16715494 |
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NCBI chr 9:84,443,109...84,446,010
Ensembl chr 9:76,993,589...76,997,248
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Clozapine results in increased expression of INHBE mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:63,176,219...63,179,172
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G |
Ins2 |
insulin 2 |
affects secretion increases expression |
ISO |
Clozapine affects the secretion of INS protein Clozapine results in increased expression of INS protein |
CTD |
PMID:11769361 PMID:16601995 |
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G |
Itga6 |
integrin subunit alpha 6 |
increases expression |
ISO |
Clozapine results in increased expression of ITGA6 protein |
CTD |
PMID:34122009 |
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NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:56,617,268...56,689,428
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G |
Jak1 |
Janus kinase 1 |
increases expression |
ISO |
Clozapine results in increased expression of JAK1 protein |
CTD |
PMID:36482696 |
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NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein] |
CTD |
PMID:18976543 |
|
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of JUN mRNA Clozapine results in increased expression of JUN mRNA |
CTD |
PMID:12093589 PMID:15860345 PMID:18208916 |
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Clozapine results in increased expression of JUNB mRNA |
CTD |
PMID:12093589 PMID:19695244 |
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NCBI chr19:40,081,126...40,082,910
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Clozapine results in decreased expression of JUND mRNA |
CTD |
PMID:12093589 |
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NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799
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G |
Kcna1 |
potassium voltage-gated channel subfamily A member 1 |
increases expression |
ISO |
Clozapine results in increased expression of KCNA1 mRNA |
CTD |
PMID:18797397 |
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NCBI chr 4:161,150,378...161,160,051
Ensembl chr 4:159,464,188...159,472,682
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium] |
CTD |
PMID:21158687 |
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NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
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G |
Kcnip3 |
potassium voltage-gated channel interacting protein 3 |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of KCNIP3 mRNA Clozapine results in increased expression of KCNIP3 mRNA |
CTD |
PMID:17266109 PMID:18797397 |
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NCBI chr 3:135,130,331...135,196,031
Ensembl chr 3:114,677,030...114,743,556
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G |
Kcnk2 |
potassium two pore domain channel subfamily K member 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of KCNK2 mRNA |
CTD |
PMID:15542763 |
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NCBI chr13:103,297,387...103,494,686
Ensembl chr13:100,766,113...100,963,435
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G |
Kctd12 |
potassium channel tetramerization domain containing 12 |
decreases expression |
ISO |
Clozapine results in decreased expression of KCTD12 protein |
CTD |
PMID:34122009 |
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NCBI chr15:86,214,786...86,220,725
Ensembl chr15:79,801,191...79,806,282
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G |
Kdr |
kinase insert domain receptor |
increases expression |
ISO |
Clozapine results in increased expression of KDR protein |
CTD |
PMID:34122009 |
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NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
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G |
Khdrbs1 |
KH RNA binding domain containing, signal transduction associated 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of KHDRBS1 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:147,337,048...147,374,604
Ensembl chr 5:142,063,570...142,089,180
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G |
Kif13b |
kinesin family member 13B |
increases expression |
ISO |
Clozapine results in increased expression of KIF13B protein |
CTD |
PMID:34122009 |
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NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879
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G |
Kif5c |
kinesin family member 5C |
decreases expression |
ISO |
Clozapine results in decreased expression of KIF5C protein |
CTD |
PMID:34122009 |
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NCBI chr 3:54,441,266...54,591,630
Ensembl chr 3:34,032,105...34,182,413
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G |
Kiz |
kizuna centrosomal protein |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of KIZ protein |
CTD |
PMID:34122009 |
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NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190
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G |
Klhdc2 |
kelch domain containing 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of KLHDC2 protein |
CTD |
PMID:34122009 |
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NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
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G |
Kmt2a |
lysine methyltransferase 2A |
increases expression decreases expression multiple interactions |
ISO |
Clozapine results in increased expression of KMT2A mRNA Clozapine results in decreased expression of KMT2A mRNA Clozapine promotes the reaction [KMT2A protein binds to GAD1 promoter] |
CTD |
PMID:14647396 PMID:17942719 |
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NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:45,118,814...45,193,181
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G |
Kpna4 |
karyopherin subunit alpha 4 |
multiple interactions increases expression |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of KPNA4 protein Clozapine results in increased expression of KPNA4 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
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G |
Kremen1 |
kringle containing transmembrane protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of KREMEN1 protein |
CTD |
PMID:34122009 |
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NCBI chr14:84,295,931...84,361,534
Ensembl chr14:80,084,403...80,147,516
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G |
Lactb2 |
lactamase, beta 2 |
increases expression |
ISO |
Clozapine results in increased expression of LACTB2 protein |
CTD |
PMID:34122009 |
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NCBI chr 5:10,352,165...10,374,928
Ensembl chr 5:5,569,067...5,596,429
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of LAMP1 protein |
CTD |
PMID:34122009 |
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NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883
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G |
Lamtor3 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
increases expression |
ISO |
Clozapine results in increased expression of LAMTOR3 mRNA |
CTD |
PMID:14647396 |
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NCBI chr 2:229,084,795...229,097,028
Ensembl chr 2:226,411,400...226,423,607
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G |
Larp7 |
La ribonucleoprotein 7, transcriptional regulator |
increases expression |
ISO |
Clozapine results in increased expression of LARP7 protein |
CTD |
PMID:34122009 |
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NCBI chr 2:215,997,641...216,012,833
Ensembl chr 2:215,997,649...216,012,865
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G |
Lcn1 |
lipocalin 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of LCN1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:29,930,943...29,935,418
Ensembl chr 3:9,532,915...9,536,577
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G |
Ldhb |
lactate dehydrogenase B |
increases expression |
EXP |
Clozapine results in increased expression of LDHB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403
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G |
Ldlr |
low density lipoprotein receptor |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of LDLR mRNA Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA] |
CTD |
PMID:17052361 PMID:20564506 |
|
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
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G |
Leap2 |
liver enriched antimicrobial peptide 2 |
increases expression |
ISO |
Clozapine results in increased expression of LEAP2 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr10:38,081,001...38,082,073
Ensembl chr10:37,577,855...37,581,244
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G |
Lemd2 |
LEM domain nuclear envelope protein 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of LEMD2 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:5,284,275...5,298,281
Ensembl chr20:5,282,397...5,296,626
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G |
Lep |
leptin |
affects response to substance increases expression |
ISO EXP |
LEP protein affects the susceptibility to Clozapine Clozapine results in increased expression of LEP protein |
CTD |
PMID:16402076 PMID:17502770 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Lgals8 |
galectin 8 |
increases expression |
ISO |
Clozapine results in increased expression of LGALS8 protein |
CTD |
PMID:36482696 |
|
NCBI chr17:62,716,368...62,744,272
Ensembl chr17:58,028,105...58,052,764
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G |
Lipa |
lipase A, lysosomal acid type |
increases expression |
ISO |
Clozapine results in increased expression of LIPA protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633
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G |
Lmod2 |
leiomodin 2 |
increases expression |
ISO |
Clozapine results in increased expression of LMOD2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
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G |
Lpl |
lipoprotein lipase |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of LPL mRNA; Clozapine results in decreased expression of LPL protein Clozapine results in increased expression of LPL mRNA |
CTD |
PMID:17266109 PMID:19682446 |
|
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
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G |
Lrp10 |
LDL receptor related protein 10 |
increases expression |
ISO |
Clozapine results in increased expression of LRP10 protein |
CTD |
PMID:36482696 |
|
NCBI chr15:31,891,358...31,897,530
Ensembl chr15:27,920,259...27,927,505
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G |
Lrpprc |
leucine-rich pentatricopeptide repeat containing |
increases expression |
ISO |
Clozapine results in increased expression of LRPPRC protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:9,859,867...9,942,293
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G |
Lrrk2 |
leucine-rich repeat kinase 2 |
increases expression |
ISO |
Clozapine results in increased expression of LRRK2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703
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G |
Lss |
lanosterol synthase |
increases expression multiple interactions |
ISO |
Clozapine results in increased expression of LSS mRNA [Cuprizone co-treated with Clozapine] results in decreased expression of LSS protein |
CTD |
PMID:15342952 PMID:17175557 PMID:34122009 |
|
NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,092,774...12,118,762
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G |
Lta4h |
leukotriene A4 hydrolase |
decreases expression |
ISO |
Clozapine results in decreased expression of LTA4H protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
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G |
Magt1 |
magnesium transporter 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MAGT1 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:75,104,040...75,145,247
Ensembl chr X:71,038,489...71,079,699
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G |
Mal |
mal, T-cell differentiation protein |
decreases expression |
ISO |
Clozapine results in decreased expression of MAL mRNA |
CTD |
PMID:17266109 PMID:18797397 |
|
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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G |
Maob |
monoamine oxidase B |
increases expression |
ISO |
Clozapine results in increased expression of MAOB mRNA |
CTD |
PMID:17266109 |
|
NCBI chr X:8,490,405...8,594,065
Ensembl chr X:5,907,266...6,011,003
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G |
Map1a |
microtubule-associated protein 1A |
increases expression decreases expression |
EXP ISO |
Clozapine results in increased expression of MAP1A mRNA Clozapine results in decreased expression of MAP1A protein |
CTD |
PMID:15860345 PMID:34122009 |
|
NCBI chr 3:128,716,907...128,736,638
Ensembl chr 3:108,263,151...108,282,899
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G |
Map1b |
microtubule-associated protein 1B |
decreases expression |
ISO |
Clozapine results in decreased expression of MAP1B protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases lipidation multiple interactions |
ISO |
Clozapine results in increased lipidation of MAP1LC3B protein [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein |
CTD |
PMID:36482696 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G |
Map1s |
microtubule-associated protein 1S |
increases expression |
ISO |
Clozapine results in increased expression of MAP1S protein |
CTD |
PMID:34122009 |
|
NCBI chr16:18,551,573...18,561,760
Ensembl chr16:18,517,574...18,527,988
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of MAP2K1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases expression decreases expression |
ISO EXP |
Clozapine results in increased expression of MAP2K2 mRNA Clozapine results in decreased expression of MAP2K2 mRNA |
CTD |
PMID:14647396 PMID:15860345 |
|
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases expression |
EXP |
Clozapine results in decreased expression of MAP2K5 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Map3k1 |
mitogen-activated protein kinase kinase kinase 1 |
increases expression |
EXP |
Clozapine results in increased expression of MAP3K1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463
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G |
Map3k12 |
mitogen activated protein kinase kinase kinase 12 |
increases expression |
EXP |
Clozapine results in increased expression of MAP3K12 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 7:135,507,082...135,527,396
Ensembl chr 7:133,630,835...133,640,789
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO EXP |
Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK1 protein] Clozapine results in decreased expression of MAPK1 mRNA Clozapine results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:12871586 PMID:15860345 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
affects expression |
EXP |
Clozapine affects the expression of MAPK14 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
Clozapine results in decreased phosphorylation of MAPK3 protein Clozapine inhibits the reaction [Haloperidol results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:12871586 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk6 |
mitogen-activated protein kinase 6 |
affects expression |
EXP |
Clozapine affects the expression of MAPK6 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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G |
Mapk8ip1 |
mitogen-activated protein kinase 8 interacting protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of MAPK8IP1 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
affects expression |
EXP |
Clozapine affects the expression of MAPK9 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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G |
Mapre1 |
microtubule-associated protein, RP/EB family, member 1 |
decreases expression multiple interactions |
ISO |
Clozapine results in decreased expression of MAPRE1 protein [Cuprizone co-treated with Clozapine] results in decreased expression of MAPRE1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:162,679,020...162,707,167
Ensembl chr 3:142,212,955...142,246,983
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression |
EXP |
Clozapine results in decreased expression of MAS1 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:47,880,309...47,911,709
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G |
Mat2a |
methionine adenosyltransferase 2A |
decreases expression |
ISO |
Clozapine results in decreased expression of MAT2A protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:104,488,466...104,495,493
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G |
Mat2b |
methionine adenosyltransferase 2 non-catalytic beta subunit |
decreases expression |
ISO |
Clozapine results in decreased expression of MAT2B protein |
CTD |
PMID:34122009 |
|
NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
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G |
Mbp |
myelin basic protein |
increases expression |
ISO |
Clozapine results in increased expression of MBP mRNA |
CTD |
PMID:17266109 PMID:17346280 |
|
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
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G |
Mc1r |
melanocortin 1 receptor |
increases expression |
ISO |
Clozapine results in increased expression of MC1R mRNA |
CTD |
PMID:17346280 |
|
NCBI chr19:68,360,950...68,363,877
Ensembl chr19:51,453,239...51,454,192
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G |
Mdc1 |
mediator of DNA damage checkpoint 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MDC1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240
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G |
Mdh1 |
malate dehydrogenase 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of MDH1 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925
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G |
Mfn2 |
mitofusin 2 |
decreases expression multiple interactions |
EXP |
Clozapine results in decreased expression of MFN2 protein PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] |
CTD |
PMID:37087062 |
|
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342
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G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
increases expression |
ISO |
Clozapine results in increased expression of MLKL protein |
CTD |
PMID:31220554 |
|
NCBI chr19:56,186,860...56,213,886
Ensembl chr19:39,276,785...39,304,502
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G |
Mmp10 |
matrix metallopeptidase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of MMP10 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:4,689,840...4,697,748
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G |
Mmp14 |
matrix metallopeptidase 14 |
increases expression |
ISO |
Clozapine results in increased expression of MMP14 protein |
CTD |
PMID:36482696 |
|
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
Clozapine results in decreased expression of MMP7 mRNA |
CTD |
PMID:17346280 |
|
NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
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G |
Mobp |
myelin-associated oligodendrocyte basic protein |
increases expression |
ISO |
Clozapine results in increased expression of MOBP mRNA |
CTD |
PMID:15542763 PMID:17266109 |
|
NCBI chr 8:128,747,117...128,777,238
Ensembl chr 8:119,869,626...119,899,563
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G |
Mpo |
myeloperoxidase |
affects response to substance increases activity multiple interactions increases oxidation |
ISO |
MPO protein affects the susceptibility to Clozapine Clozapine results in increased activity of MPO protein Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid] MPO protein results in increased oxidation of Clozapine |
CTD |
PMID:24588327 PMID:35575633 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G |
Mpp3 |
MAGUK p55 scaffold protein 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of MPP3 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr10:87,445,905...87,475,461
Ensembl chr10:86,945,714...86,974,737
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G |
Mr1 |
major histocompatibility complex, class I-related |
affects expression |
ISO |
Clozapine affects the expression of MR1 mRNA |
CTD |
PMID:25811541 |
|
NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970
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G |
Mta2 |
metastasis associated 1 family, member 2 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MTA2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:205,837,964...205,846,946
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G |
Mtdh |
metadherin |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MTDH protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:67,192,592...67,250,819
Ensembl chr 7:65,306,400...65,364,413
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G |
Mthfr |
methylenetetrahydrofolate reductase |
affects response to substance |
ISO |
MTHFR gene polymorphism affects the susceptibility to Clozapine; MTHFR protein affects the susceptibility to Clozapine |
CTD |
PMID:20547447 |
|
NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797
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G |
Myadm |
myeloid-associated differentiation marker |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MYADM protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:65,864,173...65,874,035
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G |
Mybbp1a |
MYB binding protein 1a |
increases expression |
ISO |
Clozapine results in increased expression of MYBBP1A protein |
CTD |
PMID:34122009 |
|
NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,056,874...57,067,255
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G |
Myh10 |
myosin heavy chain 10 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of MYH10 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,394,389...53,525,165
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G |
Myh3 |
myosin heavy chain 3 |
increases expression |
ISO |
Clozapine results in increased expression of MYH3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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G |
Myl1 |
myosin, light chain 1 |
increases expression |
ISO |
Clozapine results in increased expression of MYL1 protein |
CTD |
PMID:34122009 |
|
Ensembl chr 9:68,437,517...68,458,261
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|
G |
Naa10 |
N(alpha)-acetyltransferase 10, NatA catalytic subunit |
decreases expression |
ISO |
Clozapine results in decreased expression of NAA10 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:156,807,378...156,812,632
Ensembl chr X:151,656,056...151,661,252
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G |
Nap1l4 |
nucleosome assembly protein 1-like 4 |
increases expression |
ISO |
Clozapine results in increased expression of NAP1L4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:198,709,697...198,746,093
Ensembl chr 1:198,709,701...198,746,020
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G |
Nat10 |
N-acetyltransferase 10 |
decreases expression |
ISO |
Clozapine results in decreased expression of NAT10 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927
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G |
Ncan |
neurocan |
decreases expression |
ISO |
Clozapine results in decreased expression of NCAN mRNA |
CTD |
PMID:18797397 |
|
NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436
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|
G |
Ncapg |
non-SMC condensin I complex, subunit G |
increases expression |
ISO |
Clozapine results in increased expression of NCAPG protein |
CTD |
PMID:34122009 |
|
NCBI chr14:69,616,473...69,645,445
Ensembl chr14:65,404,163...65,432,902
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|
G |
Ncaph |
non-SMC condensin I complex, subunit H |
decreases expression |
ISO |
Clozapine results in decreased expression of NCAPH protein |
CTD |
PMID:34122009 PMID:36482696 |
|
NCBI chr 3:134,825,271...134,852,502
Ensembl chr 3:114,371,941...114,399,180
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G |
Ncbp1 |
nuclear cap binding protein subunit 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of NCBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:65,211,632...65,244,532
Ensembl chr 5:60,415,982...60,449,089
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|
G |
Ncl |
nucleolin |
increases expression |
ISO |
Clozapine results in increased expression of NCL mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:86,998,019...87,008,136
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|
G |
Ncoa4 |
nuclear receptor coactivator 4 |
increases expression |
ISO |
Clozapine results in increased expression of NCOA4 protein |
CTD |
PMID:36482696 |
|
NCBI chr16:7,395,502...7,415,846
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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|
G |
Ndufv2 |
NADH:ubiquinone oxidoreductase core subunit V2 |
increases expression |
EXP |
Clozapine results in increased expression of NDUFV2 mRNA |
CTD |
PMID:19441803 |
|
NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:105,690,455...105,710,713
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|
G |
Nectin2 |
nectin cell adhesion molecule 2 |
decreases expression |
ISO |
Clozapine results in decreased expression of NECTIN2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:88,500,086...88,535,474
Ensembl chr 1:79,372,119...79,407,360
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|
G |
Nedd4 |
NEDD4 E3 ubiquitin protein ligase |
decreases expression |
ISO |
Clozapine results in decreased expression of NEDD4 mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:73,383,695...73,468,951
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|
G |
Nes |
nestin |
decreases expression |
ISO |
Clozapine results in decreased expression of NES protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects response to substance |
ISO |
NFE2L2 protein affects the susceptibility to Clozapine |
CTD |
PMID:21540358 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases expression |
EXP |
Clozapine results in decreased expression of NFKB1 protein |
CTD |
PMID:16500086 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G |
Ngfr |
nerve growth factor receptor |
decreases expression |
ISO EXP |
Clozapine results in decreased expression of NGFR protein; Clozapine results in decreased expression of NGFR protein alternative form Clozapine results in decreased expression of NGFR mRNA |
CTD |
PMID:12111809 PMID:14598305 PMID:16513140 |
|
NCBI chr10:81,012,077...81,030,305
Ensembl chr10:80,515,299...80,533,518
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G |
Nifk |
nucleolar protein interacting with the FHA domain of MKI67 |
decreases expression |
ISO |
Clozapine results in decreased expression of NIFK protein |
CTD |
PMID:34122009 |
|
NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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G |
Nnmt |
nicotinamide N-methyltransferase |
increases expression |
ISO |
Clozapine results in increased expression of NNMT protein |
CTD |
PMID:34122009 |
|
NCBI chr 8:57,820,156...57,851,301
Ensembl chr 8:48,933,598...48,946,655
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G |
Nnt |
nicotinamide nucleotide transhydrogenase |
decreases expression |
ISO |
Clozapine results in decreased expression of NNT protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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G |
Noc2l |
NOC2-like nucleolar associated transcriptional repressor |
increases expression |
ISO |
Clozapine results in increased expression of NOC2L protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:172,102,369...172,114,168
Ensembl chr 5:166,820,161...166,831,949
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G |
Nomo1 |
Nodal modulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of NOMO3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:105,641,867...105,692,708
Ensembl chr 1:96,505,484...96,556,279
|
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G |
Nop53 |
NOP53 ribosome biogenesis factor |
affects expression |
ISO |
Clozapine affects the expression of NOP53 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 1:85,757,271...85,765,089
Ensembl chr 1:76,629,069...76,636,902
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G |
Notch2 |
notch receptor 2 |
increases expression |
ISO |
Clozapine results in increased expression of NOTCH2 protein |
CTD |
PMID:36482696 |
|
NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
|
|
G |
Nploc4 |
NPL4 homolog, ubiquitin recognition factor |
decreases expression |
ISO |
Clozapine results in decreased expression of NPLOC4 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913
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G |
Nptn |
neuroplastin |
increases expression |
ISO |
Clozapine results in increased expression of NPTN mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 8:67,892,678...67,959,231
Ensembl chr 8:58,996,887...59,063,401
|
|
G |
Nptx2 |
neuronal pentraxin 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of NPTX2 mRNA |
CTD |
PMID:18208916 |
|
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
|
|
G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Clozapine results in decreased expression of NPY mRNA |
CTD |
PMID:16516965 |
|
NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
|
|
G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
affects response to substance increases reduction multiple interactions |
ISO |
NQO2 gene SNP affects the susceptibility to Clozapine NQO2 protein results in increased reduction of Clozapine metabolite Clozapine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] |
CTD |
PMID:14617031 PMID:29281794 |
|
NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320
|
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Clozapine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]] |
CTD |
PMID:21402137 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
|
|
G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
multiple interactions |
ISO |
Clozapine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] |
CTD |
PMID:16581232 |
|
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
|
|
G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
increases expression decreases expression |
EXP |
Clozapine results in increased expression of NR4A1 mRNA Clozapine results in decreased expression of NR4A1 mRNA |
CTD |
PMID:10987852 PMID:11564422 PMID:19695244 |
|
NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297
|
|
G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
increases expression |
ISO |
Clozapine results in increased expression of NR4A2 mRNA |
CTD |
PMID:17266109 |
|
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877
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|
G |
Nrg1 |
neuregulin 1 |
increases expression affects expression affects response to substance |
ISO EXP |
Clozapine results in increased expression of NRG1 mRNA Clozapine affects the expression of NRG1 protein NRG1 protein affects the susceptibility to Clozapine |
CTD |
PMID:15706234 PMID:18184445 PMID:19502011 |
|
NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
|
|
G |
Nsf |
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
decreases expression |
ISO |
Clozapine results in decreased expression of NSF protein |
CTD |
PMID:34122009 |
|
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
|
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G |
Ntng2 |
netrin G2 |
increases expression |
EXP |
Clozapine results in increased expression of NTNG2 mRNA |
CTD |
PMID:17507910 |
|
NCBI chr 3:32,889,856...32,949,032
Ensembl chr 3:12,492,639...12,545,890
|
|
G |
Nts |
neurotensin |
increases expression |
EXP |
Clozapine results in increased expression of NTS mRNA |
CTD |
PMID:12887421 |
|
NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423
|
|
G |
Numa1 |
nuclear mitotic apparatus protein 1 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of NUMA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855
|
|
G |
Numbl |
NUMB-like, endocytic adaptor protein |
decreases expression |
ISO |
Clozapine results in decreased expression of NUMBL mRNA |
CTD |
PMID:18797397 |
|
NCBI chr 1:91,677,437...91,701,415
Ensembl chr 1:82,550,054...82,573,776
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|
G |
Nup160 |
nucleoporin 160 |
increases expression |
ISO |
Clozapine results in increased expression of NUP160 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565
|
|
G |
Nup50 |
nucleoporin 50 |
increases expression |
ISO |
Clozapine results in increased expression of NUP50 protein |
CTD |
PMID:34122009 |
|
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
|
|
G |
Nup54 |
nucleoporin 54 |
decreases expression |
ISO |
Clozapine results in decreased expression of NUP54 protein |
CTD |
PMID:34122009 |
|
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
|
|
G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Clozapine results in increased expression of NUPR1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
|
NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:181,213,368...181,215,281
|
|
G |
Osbpl8 |
oxysterol binding protein-like 8 |
increases expression |
ISO |
Clozapine results in increased expression of OSBPL8 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:48,483,259...48,636,151
Ensembl chr 7:46,596,983...46,749,888
|
|
G |
Oxt |
oxytocin/neurophysin I prepropeptide |
affects response to substance |
ISO |
OXT protein affects the susceptibility to Clozapine |
CTD |
PMID:20196918 |
|
NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:117,782,650...117,783,490
|
|
G |
Pakap |
paralemmin A kinase anchor protein |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PALM2AKAP2 protein |
CTD |
PMID:34122009 |
|
NCBI chr 5:76,976,906...77,443,656
Ensembl chr 5:72,181,718...72,648,524
|
|
G |
Pank3 |
pantothenate kinase 3 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in increased expression of PANK3 protein |
CTD |
PMID:34122009 |
|
NCBI chr10:20,733,191...20,757,017
Ensembl chr10:20,229,129...20,252,955
|
|
G |
Park7 |
Parkinsonism associated deglycase |
increases expression |
ISO |
Clozapine results in increased expression of PARK7 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
|
|
G |
Pcbp1 |
poly(rC) binding protein 1 |
increases expression |
ISO |
Clozapine results in increased expression of PCBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:118,972,661...118,976,500
|
|
G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
decreases expression |
ISO |
Clozapine results in decreased expression of PCK2 protein |
CTD |
PMID:34122009 |
|
NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283
|
|
G |
Pclo |
piccolo (presynaptic cytomatrix protein) |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PCLO protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:20,646,604...21,005,171
Ensembl chr 4:19,695,315...20,049,885
|
|
G |
Pcm1 |
pericentriolar material 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of PCM1 mRNA |
CTD |
PMID:19048012 |
|
NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091
|
|
G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
increases expression |
ISO |
Clozapine results in increased expression of PCNP protein |
CTD |
PMID:34122009 |
|
NCBI chr11:58,061,885...58,076,436
Ensembl chr11:44,592,742...44,607,348
|
|
G |
Pcsk1n |
proprotein convertase subtilisin/kexin type 1 inhibitor |
affects expression |
ISO |
Clozapine affects the expression of PCSK1N mRNA |
CTD |
PMID:14647396 |
|
NCBI chr X:17,251,963...17,255,405
Ensembl chr X:14,580,038...14,583,566
|
|
G |
Pdcd11 |
programmed cell death 11 |
increases expression |
ISO |
Clozapine results in increased expression of PDCD11 protein |
CTD |
PMID:34122009 |
|
NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:245,980,880...246,021,999
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|
G |
Pde10a |
phosphodiesterase 10A |
increases expression |
ISO EXP |
Clozapine results in increased expression of PDE10A mRNA Clozapine results in increased expression of PDE10A mRNA; Clozapine results in increased expression of PDE10A protein |
CTD |
PMID:17266109 PMID:18222493 |
|
NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:51,770,132...52,216,563
|
|
G |
Pde1b |
phosphodiesterase 1B |
increases expression |
ISO |
Clozapine results in increased expression of PDE1B mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:134,627,322...134,654,580
|
|
G |
Pde4a |
phosphodiesterase 4A |
decreases expression |
EXP |
Clozapine results in decreased expression of PDE4A protein |
CTD |
PMID:20222156 |
|
NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:19,703,290...19,751,961
|
|
G |
Pde4b |
phosphodiesterase 4B |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of PDE4B protein Clozapine results in increased expression of PDE4B mRNA; Clozapine results in increased expression of PDE4B protein |
CTD |
PMID:18222493 PMID:20222156 |
|
NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696
|
|
G |
Pdia3 |
protein disulfide isomerase family A, member 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of PDIA3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236
|
|
G |
Pdia4 |
protein disulfide isomerase family A, member 4 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PDIA4 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
|
|
G |
Pdlim5 |
PDZ and LIM domain 5 |
decreases expression |
ISO |
Clozapine results in decreased expression of PDLIM5 protein |
CTD |
PMID:34122009 |
|
NCBI chr 2:233,625,478...233,793,582
Ensembl chr 2:230,952,248...231,120,275
|
|
G |
Pebp1 |
phosphatidylethanolamine binding protein 1 |
decreases expression |
ISO |
Clozapine results in decreased expression of PEBP1 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862
|
|
G |
Penk |
proenkephalin |
decreases expression increases expression |
EXP |
Clozapine results in decreased expression of PENK mRNA Clozapine results in increased expression of PENK mRNA |
CTD |
PMID:1635659 PMID:12887421 |
|
NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129
|
|
G |
Pfdn5 |
prefoldin subunit 5 |
increases expression |
ISO |
Clozapine results in increased expression of PFDN5 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr 7:135,330,364...135,335,102
Ensembl chr 7:133,451,453...133,456,516
|
|
G |
Pfkp |
phosphofructokinase, platelet |
increases expression |
EXP |
Clozapine results in increased expression of PFKP mRNA |
CTD |
PMID:15860345 |
|
NCBI chr17:68,639,749...68,704,055
Ensembl chr17:63,729,780...63,794,018
|
|
G |
Pgam5 |
PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
decreases expression |
ISO |
Clozapine results in decreased expression of PGAM5 protein |
CTD |
PMID:34122009 |
|
NCBI chr12:52,069,023...52,076,131
Ensembl chr12:46,409,369...46,416,420
|
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G |
Pgk1 |
phosphoglycerate kinase 1 |
increases expression |
EXP |
Clozapine results in increased expression of PGK1 mRNA |
CTD |
PMID:15860345 |
|
NCBI chr X:75,336,988...75,352,962
Ensembl chr X:71,271,440...71,287,418
|
|
G |
Pgrmc1 |
progesterone receptor membrane component 1 |
multiple interactions |
EXP |
PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of GLP1R protein]; PGRMC1 protein inhibits the reaction [Clozapine results in decreased expression of MFN2 protein] |
CTD |
PMID:37087062 |
|
NCBI chr X:120,698,610...120,706,805
Ensembl chr X:115,832,884...115,888,682
|
|
G |
Phactr1 |
phosphatase and actin regulator 1 |
increases expression |
ISO |
Clozapine results in increased expression of PHACTR1 mRNA |
CTD |
PMID:14647396 |
|
NCBI chr17:21,769,006...22,246,227
Ensembl chr17:21,562,721...22,039,831
|
|
G |
Phf14 |
PHD finger protein 14 |
multiple interactions |
ISO |
[Cuprizone co-treated with Clozapine] results in decreased expression of PHF14 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,009,264...40,195,885
|
|
G |
Pik3r3 |
phosphoinositide-3-kinase regulatory subunit 3 |
decreases expression |
EXP |
Clozapine results in decreased expression of PIK3R3 mRNA |
CTD |
PMID:16715494 |
|
NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583
|
|
G |
Pitpnb |
phosphatidylinositol transfer protein, beta |
increases expression |
ISO |
Clozapine results in increased expression of PITPNB protein |
CTD |
PMID:34122009 |
|
NCBI chr12:50,909,140...50,958,193
Ensembl chr12:45,249,333...45,298,314
|
|
G |
Pkib |
cAMP-dependent protein kinase inhibitor beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PKIB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr20:37,511,564...37,608,607
Ensembl chr20:36,905,340...37,062,187
|
|
G |
Pkm |
pyruvate kinase M1/2 |
increases expression |
EXP |
Clozapine results in increased expression of PKM mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
|
|
G |
Plcb1 |
phospholipase C beta 1 |
increases expression |
ISO |
Clozapine results in increased expression of PLCB1 mRNA |
CTD |
PMID:16465460 |
|
NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:122,060,031...122,772,869
|
|
G |
Plp1 |
proteolipid protein 1 |
decreases expression increases expression |
ISO |
Clozapine results in decreased expression of PLP1 mRNA Clozapine results in increased expression of PLP1 mRNA |
CTD |
PMID:17266109 PMID:18797397 |
|
NCBI chr X:104,933,921...104,993,317
Ensembl chr X:100,185,767...100,201,032
|
|
G |
Pls3 |
plastin 3 |
decreases expression |
ISO |
Clozapine results in decreased expression of PLS3 protein |
CTD |
PMID:34122009 |
|
NCBI chr X:116,401,247...116,495,898
Ensembl chr X:111,589,254...111,683,891
|
|
G |
Pnma1 |
PNMA family member 1 |
increases expression |
ISO |
Clozapine results in increased expression of PNMA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
|
|
G |
Pon3 |
paraoxonase 3 |
increases expression |
ISO |
Clozapine results in increased expression of PON3 protein |
CTD |
PMID:34122009 |
|
NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:33,349,168...33,383,855
|
|
G |
Ppa1 |
inorganic pyrophosphatase 1 |
increases expression |
ISO |
Clozapine results in increased expression of PPA1 protein |
CTD |
PMID:34122009 |
|
NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
|
|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression |
ISO |
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein] Clozapine results in increased expression of PPARG mRNA; Clozapine results in increased expression of PPARG protein |
CTD |
PMID:20564506 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G |
Ppm1a |
protein phosphatase, Mg2+/Mn2+ dependent, 1A |
decreases expression |
EXP |
Clozapine results in decreased expression of PPM1A mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:97,174,955...97,216,585
Ensembl chr 6:91,438,834...91,480,697
|
|
G |
Ppm1b |
protein phosphatase, Mg2+/Mn2+ dependent, 1B |
decreases expression |
EXP |
Clozapine results in decreased expression of PPM1B mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:15,399,559...15,460,301
Ensembl chr 6:9,655,765...9,707,974
|
|
G |
Ppp1cb |
protein phosphatase 1 catalytic subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1CB mRNA |
CTD |
PMID:15860345 |
|
NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:23,960,998...23,992,824
|
|
G |
Ppp1cc |
protein phosphatase 1 catalytic subunit gamma |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1CC mRNA |
CTD |
PMID:15860345 |
|
NCBI chr12:40,043,822...40,061,301
Ensembl chr12:34,383,072...34,400,553
|
|
G |
Ppp1r14b |
protein phosphatase 1, regulatory (inhibitor) subunit 14B |
decreases expression |
ISO |
Clozapine results in decreased expression of PPP1R14B protein |
CTD |
PMID:34122009 |
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NCBI chr 1:213,594,416...213,596,527
Ensembl chr 1:204,163,299...204,167,319 Ensembl chr12:204,163,299...204,167,319
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G |
Ppp1r1a |
protein phosphatase 1, regulatory (inhibitor) subunit 1A |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1R1A mRNA |
CTD |
PMID:15860345 |
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NCBI chr 7:136,533,031...136,540,687
Ensembl chr 7:134,654,579...134,662,230
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G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
multiple interactions increases phosphorylation |
ISO |
Clozapine inhibits the reaction [Serotonin results in decreased phosphorylation of PPP1R1B protein]; Clozapine inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] Clozapine results in increased phosphorylation of PPP1R1B protein |
CTD |
PMID:11880652 PMID:12871586 |
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NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
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G |
Ppp1r2 |
protein phosphatase 1, regulatory (inhibitor) subunit 2 |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP1R2 mRNA |
CTD |
PMID:15860345 |
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NCBI chr11:82,977,634...82,999,426
Ensembl chr11:69,472,555...69,494,463
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G |
Ppp1r9b |
protein phosphatase 1, regulatory subunit 9B |
increases expression |
EXP |
Clozapine results in increased expression of PPP1R9B protein |
CTD |
PMID:16844384 |
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NCBI chr10:80,434,888...80,450,919
Ensembl chr10:79,938,066...79,954,083
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2CA mRNA |
CTD |
PMID:15860345 |
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NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
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G |
Ppp2cb |
protein phosphatase 2 catalytic subunit beta |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2CB mRNA |
CTD |
PMID:15860345 |
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NCBI chr16:65,261,178...65,282,658
Ensembl chr16:58,558,122...58,579,576
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G |
Ppp2r1a |
protein phosphatase 2 scaffold subunit A alpha |
increases expression |
EXP |
Clozapine results in increased expression of PPP2R1A mRNA |
CTD |
PMID:15860345 |
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NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129
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G |
Ppp2r2a |
protein phosphatase 2, regulatory subunit B, alpha |
decreases expression |
EXP |
Clozapine results in decreased expression of PPP2R2A mRNA |
CTD |
PMID:15860345 |
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