EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor	go back to main search page
Accession:	CHEBI:65065	browse the term
Definition:	An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of site-specific DNA-methyltransferase (adenine-specific), EC 2.1.1.72.
Synonyms:	related_synonym:	DNA adenine methyltransferase inhibitor; DNA adenine methyltransferase inhibitors; Dam inhibitor; Dam inhibitors; EC 2.1.1.72 inhibitor; EC 2.1.1.72 inhibitors; modification methylase inhibitor; modification methylase inhibitors; restriction-modification system inhibitor; restriction-modification system inhibitors; site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) inhibitors; site-specific DNA-methyltransferase (adenine-specific) inhibitor; site-specific DNA-methyltransferase (adenine-specific) inhibitors

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Genes (28)

S-adenosyl-L-homocysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosylhomocysteinase

increases hydrolysis

AHCY results in increased hydrolysis of S-Adenosylhomocysteine

NCBI chr 3:164,029,338...164,044,562
Ensembl chr 3:143,569,094...143,584,393

G

aryl hydrocarbon receptor

increases abundance
multiple interactions

AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

5'-aminolevulinate synthase 2

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA]

NCBI chr X:22,890,650...22,914,046
Ensembl chr X:19,463,171...19,486,519

G

amyloid beta precursor protein

increases expression
multiple interactions
decreases methylation

S-Adenosylhomocysteine results in increased expression of APP protein
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein

PMID:19635394 PMID:22064374

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

ATPase copper transporting beta

increases abundance

ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636

G

beta-secretase 1

increases expression

S-Adenosylhomocysteine results in increased expression of BACE1 protein

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876

G

coactivator-associated arginine methyltransferase 1

decreases activity

S-Adenosylhomocysteine results in decreased activity of CARM1 protein

NCBI chr 8:28,373,370...28,418,056
Ensembl chr 8:20,097,254...20,147,689

G

collagen type I alpha 1 chain

decreases expression

S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

decreases expression

S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

catechol-O-methyltransferase

decreases activity

S-Adenosylhomocysteine results in decreased activity of COMT protein

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

DNA methyltransferase 1

decreases activity
multiple interactions

S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]

PMID:16037419 PMID:22064374

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659

G

fibroblast growth factor 19

decreases abundance

FGF19 protein results in decreased abundance of S-Adenosylhomocysteine

NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:200,056,644...200,060,287

G

hemoglobin subunit beta

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA]

NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012

G

hydroxymethylbilane synthase

multiple interactions

[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA]

NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957

G

matrix metallopeptidase 2

increases expression
multiple interactions

S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

NFKB inhibitor alpha

decreases expression

S-Adenosylhomocysteine results in decreased expression of NFKBIA protein

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

nuclear receptor subfamily 0, group B, member 2

decreases abundance

NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609

G

8-oxoguanine DNA glycosylase

multiple interactions
decreases expression
decreases methylation

Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766

G

phosphatidylethanolamine N-methyltransferase

multiple interactions

PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]

NCBI chr10:45,275,434...45,349,651
Ensembl chr10:44,775,911...44,850,013

G

PPARG coactivator 1 alpha

increases expression

S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656

G

protein arginine methyltransferase 1

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT1 protein

NCBI chr 1:104,595,339...104,605,552
Ensembl chr 1:95,458,850...95,468,345

G

protein arginine methyltransferase 5

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT5 protein

NCBI chr15:31,938,927...31,948,318
Ensembl chr15:27,968,910...27,978,296

G

protein arginine methyltransferase 6

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT6 protein

NCBI chr 2:200,615,780...200,620,790
Ensembl chr 2:197,927,220...197,933,648

G

protein arginine methyltransferase 7

decreases activity

S-Adenosylhomocysteine results in decreased activity of PRMT7 protein

NCBI chr19:51,020,596...51,071,401
Ensembl chr19:34,110,747...34,162,577

G

presenilin 1

multiple interactions
increases expression
decreases methylation

Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650

G

solute carrier family 19 member 1

affects abundance

SLC19A1 protein affects the abundance of S-Adenosylhomocysteine

NCBI chr20:11,583,928...11,601,959
Ensembl chr20:11,584,411...11,601,972

G

Sp1 transcription factor

multiple interactions

S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

TIMP metallopeptidase inhibitor 2

decreases expression

S-Adenosylhomocysteine results in decreased expression of TIMP2 protein

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
biological role	19878
biochemical role	19586
enzyme inhibitor	18783
EC 2.* (transferase) inhibitor	14985
EC 2.1.* (C1-transferase) inhibitor	3782
EC 2.1.1.* (methyltransferases) inhibitor	691
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor	28
S-adenosyl-L-homocysteine	28

paths to the root