pyrrolizidine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pyrrolizidine	go back to main search page
Accession:	CHEBI:64950	browse the term
Definition:	A bicyclic organonitrogen heterocyclic compound comprised of two ortho-fused pyrrolidine rings which share a common nitrogen atom.
Synonyms:	exact_synonym:	hexahydro-1H-pyrrolizine
	related_synonym:	1-azabicyclo[3.3.0]octane; 2,3,5,6,7,8-hexahydro-1H-pyrrolizine; Formula=C7H13N; Hexahydropyrrolizine; InChI=1S/C7H13N/c1-3-7-4-2-6-8(7)5-1/h7H,1-6H2; InChIKey=ADRDEXBBJTUCND-UHFFFAOYSA-N; SMILES=C1CC2CCCN2C1
	xref:	CAS:643-20-9; Reaxys:103088; Wikipedia:Pyrrolizidine

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Genes (753)

monocrotaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abraxas 1, BRCA1 A complex subunit

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA

NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622

G

angiotensin I converting enzyme

increases expression
multiple interactions

Monocrotaline results in increased expression of ACE mRNA; Monocrotaline results in increased expression of ACE protein
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of ACE mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of ACE protein]

PMID:20581171 PMID:30466619

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

angiotensin converting enzyme 2

decreases expression
multiple interactions

Monocrotaline results in decreased expression of ACE2 protein
[Monocrotaline co-treated with angiotensin I (1-7)] results in increased expression of ACE2 mRNA; magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein]

PMID:20581171 PMID:30466619

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

Monocrotaline results in increased expression of ACTA2 protein
18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein]

PMID:31325423 PMID:31734320

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

angiotensinogen

increases expression
multiple interactions

Monocrotaline results in increased expression of AGT protein
magnolol inhibits the reaction [Monocrotaline results in increased expression of AGT protein]

PMID:16936438 PMID:30466619

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

multiple interactions
increases expression

magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein]

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

AKT serine/threonine kinase 1

decreases phosphorylation
increases phosphorylation
multiple interactions

Monocrotaline results in decreased phosphorylation of AKT1 protein
Monocrotaline results in increased phosphorylation of AKT1 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]; Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein; Quercetin affects the reaction [Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]

PMID:18801959 PMID:25460361 PMID:30466619

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
decreases expression

Melatonin inhibits the reaction [Monocrotaline results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

anaphase promoting complex subunit 13

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA

NCBI chr 8:103,205,520...103,213,936
Ensembl chr 8:103,205,520...103,213,936

G

anaphase promoting complex subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

annexin A5

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

AT-rich interaction domain 1A

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA

NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564

G

AT-rich interaction domain 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA

NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512

G

ATM serine/threonine kinase

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA

PMID:21224054 PMID:33884520

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

ATPase, H+ transporting V0 subunit e2

increases expression

Monocrotaline results in increased expression of ATP6V0E2 mRNA

NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777

G

aurora kinase A

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

BRISC and BRCA1 A complex member 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA

NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951

G

BRCA1 associated RING domain 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA

NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA
modafinil inhibits the reaction [monocrotaline increases expression of Bax protein in lung]

CTD
RGD

PMID:21224054 PMID:26959484 PMID:26959484

RGD:329969898, RGD:329969898

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

brain-derived neurotrophic factor

affects expression

Monocrotaline affects the expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

Monocrotaline results in increased expression of BIRC5 mRNA
Quercetin inhibits the reaction [Monocrotaline results in increased expression of BIRC5 mRNA]

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

BLM RecQ like helicase

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA

NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312

G

bone morphogenetic protein 7

increases expression

monocrotaline increases expression of Bmp7 protein in rat lung, pulmonary artery

RGD

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

bone morphogenetic protein receptor type 2

multiple interactions
decreases expression

Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA]
Monocrotaline results in decreased expression of BMPR2 mRNA; Monocrotaline results in decreased expression of BMPR2 protein

PMID:20522807 PMID:21619414 PMID:25460361

NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809

G

BRCA2, DNA repair associated

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA

NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567

G

bromodomain containing 7

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA

NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494

G

BRCA1 interacting DNA helicase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

caspase 3

increases expression
decreases expression
multiple interactions

Monocrotaline results in increased expression of CASP3 mRNA
Monocrotaline results in decreased expression of CASP3 protein
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]

PMID:21619414 PMID:22022327

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions
increases activity

Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

decreases expression
multiple interactions

Monocrotaline results in decreased expression of CAV1 mRNA; Monocrotaline results in decreased expression of CAV1 protein
NCP-2454 inhibits the reaction [Monocrotaline results in decreased expression of CAV1 protein]

PMID:24835767 PMID:25275723

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolin 2

decreases expression

Monocrotaline results in decreased expression of CAV2 mRNA; Monocrotaline results in decreased expression of CAV2 protein

NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244

G

caveolae associated protein 1

decreases expression

Monocrotaline results in decreased expression of CAVIN1 mRNA; Monocrotaline results in decreased expression of CAVIN1 protein

NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120

G

C-C motif chemokine ligand 2

increases expression
multiple interactions

Monocrotaline results in increased expression of CCL2 mRNA; Monocrotaline results in increased expression of CCL2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]

PMID:25051504 PMID:31589899 PMID:36336098

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

affects expression

Monocrotaline affects the expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin B1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cell division cycle 20

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25A

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25B

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cell division cycle 25C

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 7

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cadherin 1

multiple interactions
decreases expression

Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

increases expression
multiple interactions

Monocrotaline results in increased expression of CDH2 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of CDH2 protein]

PMID:31734320 PMID:36942326

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 5

decreases expression

Monocrotaline results in decreased expression of CDH5 protein

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

cyclin-dependent kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA

PMID:21224054 PMID:33884520

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

checkpoint kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

claspin

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

collagen type I alpha 1 chain

multiple interactions

[Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type IV alpha 1 chain

increases expression

Monocrotaline results in increased expression of COL4A1 protein

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cysteine and glycine-rich protein 2

increases expression

Monocrotaline results in increased expression of CSRP2 protein

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

catenin beta 1

multiple interactions
increases expression
decreases expression

Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CTNNB1 protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of CTNNB1 protein]

PMID:21619414 PMID:30466619

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 10

multiple interactions
decreases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA
Monocrotaline results in decreased expression of CXCL10 protein

PMID:21224054 PMID:25051504

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 16

multiple interactions

[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of CXCL16 protein; [Monocrotaline co-treated with Lipopolysaccharides] results in decreased expression of CXCL16 protein

PMID:21279329 PMID:21327618

NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592

G

C-X-C motif chemokine ligand 3

multiple interactions

[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome b-245 beta chain

increases expression

Monocrotaline results in increased expression of CYBB mRNA; Monocrotaline results in increased expression of CYBB protein

PMID:24835767 PMID:24947524

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 3

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

CYP2C19 protein results in increased metabolism of and results in increased activity of Monocrotaline

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing
increases response to substance
increases expression
multiple interactions

CYP3A4 protein results in increased metabolism of Monocrotaline
CYP3A4 protein results in increased susceptibility to Monocrotaline
Monocrotaline results in increased expression of CYP3A4 mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA; [Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]

PMID:19818743 PMID:32682830 PMID:32910235 PMID:33884520

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Monocrotaline results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DnaJ heat shock protein family (Hsp40) member A1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

E2F transcription factor 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA

PMID:21224054 PMID:33884520

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 5

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA

NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990

G

E2F transcription factor 8

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

endothelin 1

multiple interactions
increases expression

4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]
Monocrotaline results in increased expression of EDN1 mRNA; Monocrotaline results in increased expression of EDN1 protein

PMID:16225752 PMID:20967148 PMID:22022327 PMID:30466619

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

endothelin receptor type A

multiple interactions
increases expression

magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]
Monocrotaline results in increased expression of EDNRA mRNA; Monocrotaline results in increased expression of EDNRA protein

PMID:20967148 PMID:22022327 PMID:30466619

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

early growth response 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

extra spindle pole bodies like 1, separase

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

coagulation factor III, tissue factor

multiple interactions

[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of F3 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein]; F3 protein results in increased susceptibility to [Monocrotaline co-treated with Lipopolysaccharides]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

FA complementation group A

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA

NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527

G

FA complementation group B

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

FA complementation group D2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

FA complementation group G

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA

NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029

G

Fas ligand

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

F-box protein 32

increases expression
multiple interactions
decreases expression

Monocrotaline results in increased expression of FBXO32 mRNA
resveratrol inhibits the reaction [Monocrotaline results in decreased expression of FBXO32 mRNA]

PMID:18801959 PMID:22146233

NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436

G

F-box protein 5

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA

NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437

G

Fms related receptor tyrosine kinase 4

decreases expression
multiple interactions

Monocrotaline results in decreased expression of FLT4 mRNA
romiplostim inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]

NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 4

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA

NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874

G

fibronectin 1

increases expression
multiple interactions

Monocrotaline results in increased expression of FN1 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of FN1 protein]
[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]

PMID:24947524 PMID:27870162 PMID:36414118 PMID:36942326

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

forkhead box O3

decreases phosphorylation

Monocrotaline results in decreased phosphorylation of FOXO3 protein

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA

PMID:21224054 PMID:33884520

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

GATA binding protein 3

increases expression
multiple interactions

Monocrotaline results in increased expression of GATA3 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA3 protein]

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

GATA binding protein 4

multiple interactions
increases expression

Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA4 protein]

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

G

GATA binding protein 6

increases expression
multiple interactions

Monocrotaline results in increased expression of GATA6 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA6 protein]

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions
decreases expression

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glial fibrillary acidic protein

affects expression

Monocrotaline affects the expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutamic--pyruvic transaminase

increases activity
increases expression
multiple interactions

Monocrotaline results in increased activity of GPT protein
Monocrotaline results in increased expression of GPT protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]; Melatonin inhibits the reaction [Monocrotaline results in increased expression of GPT protein]
[TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein

PMID:24418708 PMID:28818515 PMID:31470032 PMID:31589899 PMID:37350538

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

Monocrotaline results in increased phosphorylation of GSK3B protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions
increases activity
decreases expression

Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]
Monocrotaline results in decreased expression of GSR mRNA; Monocrotaline results in decreased expression of GSR protein

PMID:29908794 PMID:31407471

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase, mu 5

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

H19 imprinted maternally expressed transcript

increases expression
multiple interactions
decreases expression

monocrotaline increases expression of H19 protein in lung
melatonin inhibits the reaction [monocrotaline decreases expression of H19 RNA in pulmonary artery smooth muscle cells]

RGD

PMID:30547791 PMID:30240970 PMID:30240970 PMID:30547791

RGD:155882573, RGD:156430315, RGD:156430315, RGD:155882573

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

H2A.X variant histone

increases expression

Monocrotaline results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heparin binding growth factor

affects expression

Monocrotaline affects the expression of HDGF mRNA

NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747

G

high mobility group box 1

increases secretion

Monocrotaline results in increased secretion of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions
increases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA
Monocrotaline results in increased expression of HMOX1 mRNA
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]

PMID:21224054 PMID:29908794

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
affects expression
increases secretion

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA
liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]; liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]
Monocrotaline results in increased secretion of HSPD1 protein

PMID:21224054 PMID:31504964 PMID:31589899

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family E (Hsp10) member 1

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

5-hydroxytryptamine receptor 2A

multiple interactions
increases expression

Quercetin inhibits the reaction [Monocrotaline results in increased expression of HTR2A mRNA]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

intercellular adhesion molecule 1

multiple interactions

[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

decreases expression
multiple interactions

Monocrotaline results in decreased expression of ID1 mRNA
treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

insulin-like growth factor 1 receptor

increases expression
multiple interactions

monocrotaline increases expression of Igf1r RNA in pulmonary artery smooth muscle cells
melatonin inhibits the reaction [monocrotaline increases expression of Igf1r RNA in pulmonary artery smooth muscle cells]

RGD

PMID:30240970 PMID:30240970

RGD:156430315, RGD:156430315

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 10

multiple interactions
decreases expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein
Monocrotaline results in decreased expression of IL10 protein

PMID:21327618 PMID:25051504

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

decreases expression

Monocrotaline results in decreased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases secretion
increases expression
affects expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA
Monocrotaline results in increased secretion of IL1B protein
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL1B mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein]
Monocrotaline results in increased expression of IL1B mRNA; Monocrotaline results in increased expression of IL1B protein
Monocrotaline affects the expression of IL1B mRNA

PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:31407471 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
treatment
increases expression
increases secretion
decreases expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]
modafinil inhibits the reaction [monocrotaline increases expression of Il6 protein in lung]
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of IL6 protein]
Monocrotaline results in increased expression of IL6 mRNA; Monocrotaline results in increased expression of IL6 protein
Monocrotaline results in increased secretion of IL6 protein
Monocrotaline results in decreased expression of IL6 protein

CTD
RGD

PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:25275723 More...

RGD:329969898, RGD:329969898

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 1

increases expression

Monocrotaline results in increased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

jagged canonical Notch ligand 1

increases expression
multiple interactions

Monocrotaline results in increased expression of JAG1 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of JAG1 protein]

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

jagged canonical Notch ligand 2

increases expression
multiple interactions

Monocrotaline results in increased expression of JAG2 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of JAG2 protein]

NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818

G

potassium voltage-gated channel subfamily A member 5

decreases expression

Monocrotaline results in decreased expression of KCNA5 mRNA

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

G

potassium voltage-gated channel subfamily B member 1

decreases expression

Monocrotaline results in decreased expression of KCNB1 mRNA

NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194

G

potassium calcium-activated channel subfamily N member 4

increases expression
multiple interactions

monocrotaline increases expression of Kcnn4 protein in lung and smooth muscle cell of the pulmonary artery
modafinil inhibits the reaction [monocrotaline increases expression of Kcnn4 protein in lung and smooth muscle cell of the pulmonary artery]

RGD

PMID:26959484 PMID:26959484

RGD:329969898, RGD:329969898

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

kinase insert domain receptor

multiple interactions
decreases expression

romiplostim inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

kinesin family member 11

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 23

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

leptin

multiple interactions
affects expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]
Monocrotaline affects the expression of LEP protein

PMID:21327618 PMID:25051504

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

galectin 3

multiple interactions

[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein]

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

LIM domain containing 2

increases expression

Monocrotaline results in increased expression of LIMD2 mRNA

NCBI chr10:91,090,279...91,092,772
Ensembl chr10:91,090,280...91,092,775

G

latent transforming growth factor beta binding protein 2

increases expression

Monocrotaline increases expression of Ltbp2 mRNA in the heart right ventricle

RGD

NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208

G

lymphatic vessel endothelial hyaluronan receptor 1

decreases expression

Monocrotaline results in decreased expression of LYVE1 protein

NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309

G

mitogen activated protein kinase kinase kinase 7

increases phosphorylation
multiple interactions

Monocrotaline increases phosphorylation of Map3k7 protein in the lung
Paeoniflorin inhibits the reaction [monocrotaline increases phosphorylation of Map3k7 protein in the lung]

RGD

PMID:22388934 PMID:35582418 PMID:35582418

RGD:155791648, RGD:155804297, RGD:155804297

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Monocrotaline results in increased phosphorylation of MAPK1 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Monocrotaline results in increased phosphorylation of MAPK3 protein
magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mediator of DNA damage checkpoint 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA

NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240

G

MDM2 proto-oncogene

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

increases expression

Monocrotaline results in increased expression of MGAT5B mRNA

NCBI chr10:102,120,757...102,190,235
Ensembl chr10:102,120,445...102,190,233

G

microRNA 122

increases expression

Monocrotaline results in increased expression of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

microRNA 132

decreases expression

Monocrotaline results in decreased expression of MIR132 mRNA

NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796

G

microRNA 138-1

decreases expression

Monocrotaline results in decreased expression of MIR138-1 mRNA

NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064

G

microRNA 200a

increases expression
multiple interactions

monocrotaline increases expression of Mir200a RNA in pulmonary artery smooth muscle cells
melatonin inhibits the reaction [monocrotaline increases expression of Mir200a RNA in pulmonary artery smooth muscle cells]

RGD

PMID:30240970 PMID:30240970

RGD:156430315, RGD:156430315

NCBI chr 5:166,648,494...166,648,582

G

microRNA 200b

multiple interactions
decreases expression

Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of MIR200B]

NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366

G

microRNA 200c

decreases expression
multiple interactions

Monocrotaline results in decreased expression of MIR200C
Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of MIR200C]

NCBI chr 4:157,523,679...157,523,747

G

microRNA 2964

decreases expression

Monocrotaline results in decreased expression of MIR219B mRNA

NCBI chr 3:13,118,623...13,118,722
Ensembl chr 3:13,118,623...13,118,722

G

microRNA 301b

decreases expression

Monocrotaline results in decreased expression of MIR301B mRNA

NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893

G

microRNA 370

decreases expression

Monocrotaline results in decreased expression of MIR370 mRNA

NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335

G

microRNA 382

decreases expression

Monocrotaline results in decreased expression of MIR382 mRNA

NCBI chr 6:128,748,539...128,748,618

G

microRNA 410

decreases expression

Monocrotaline results in decreased expression of MIR410 mRNA

NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434

G

microRNA 489

decreases expression

Monocrotaline results in decreased expression of MIR489 mRNA

NCBI chr 4:31,693,355...31,693,460
Ensembl chr 4:31,693,355...31,693,460

G

microRNA 500

decreases expression

Monocrotaline results in decreased expression of MIR500 mRNA

NCBI chr X:15,258,778...15,258,857
Ensembl chr X:15,258,768...15,258,859

G

microRNA 551b

decreases expression

Monocrotaline results in decreased expression of MIR551B mRNA

NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300

G

microRNA 675

decreases expression
multiple interactions

monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle cells
melatonin inhibits the reaction [monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle cells]

RGD

PMID:30240970 PMID:30240970

RGD:156430315, RGD:156430315

NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358

G

microRNA 93

decreases expression

Monocrotaline results in decreased expression of MIR93 mRNA

NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221

G

microRNA 98

decreases expression

Monocrotaline results in decreased expression of MIR98 mRNA

NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342

G

microRNA let-7b

decreases expression

Monocrotaline results in decreased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

G

marker of proliferation Ki-67

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

mutL homolog 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA

NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617

G

matrix metallopeptidase 2

increases expression
multiple interactions

Monocrotaline results in increased expression of MMP2 mRNA
[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]

PMID:22022327 PMID:31470032

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
increases expression

[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; SIRT3 protein affects the reaction [Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]]
Monocrotaline results in increased expression of MMP9 mRNA; Monocrotaline results in increased expression of MMP9 protein
[TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; romiplostim inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]

PMID:27870162 PMID:29908794 PMID:31470032 PMID:31504964 PMID:31589899 More...

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

increases activity
multiple interactions

Monocrotaline results in increased activity of MPO protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]

PMID:31504964 PMID:31589899

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MRE11 homolog, double strand break repair nuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA

NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279

G

mutS homolog 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

G

mutS homolog 6

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA

NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956

G

MYD88, innate immune signal transduction adaptor

decreases response to substance

MYD88 gene mutant form results in decreased susceptibility to Monocrotaline

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

myosin heavy chain 6

decreases expression

Monocrotaline results in decreased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

increases expression

Monocrotaline results in increased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects response to substance
decreases expression

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]
NFE2L2 gene mutant form affects the susceptibility to Monocrotaline

PMID:29908794 PMID:31504964

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions
increases expression

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA
4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
Monocrotaline results in increased expression of NOS2 mRNA; Monocrotaline results in increased expression of NOS2 protein

PMID:16225752 PMID:21224054 PMID:22022327 PMID:25460361 PMID:30466619 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases activity
multiple interactions
decreases expression
increases expression

Monocrotaline results in decreased activity of NOS3 protein
4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]
Monocrotaline results in decreased expression of NOS3 mRNA; Monocrotaline results in decreased expression of NOS3 protein

PMID:16225752 PMID:22022327 PMID:25460361 PMID:30466619

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

increases expression
multiple interactions

Monocrotaline results in increased expression of NOTCH1 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH1 protein]

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

notch receptor 2

increases expression
multiple interactions

Monocrotaline results in increased expression of NOTCH2 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH2 protein]

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

NADPH oxidase 1

increases expression

Monocrotaline results in increased expression of NOX1 mRNA

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

increases expression

Monocrotaline results in increased expression of NOX4 mRNA; Monocrotaline results in increased expression of NOX4 protein

PMID:24835767 PMID:24947524

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

natriuretic peptide A

increases expression

Monocrotaline results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

increases expression
multiple interactions

Monocrotaline results in increased expression of NPPB mRNA; Monocrotaline results in increased expression of NPPB protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NPPB protein]

PMID:16936438 PMID:36942326

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

decreases expression
increases expression
multiple interactions

Monocrotaline results in decreased expression of NQO1 mRNA
Monocrotaline results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

increases activity
multiple interactions

Monocrotaline results in increased activity of NR1I2 protein
[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]]

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

proliferating cell nuclear antigen

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 4

decreases expression
multiple interactions

monocrotaline decreases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells
melatonin inhibits the reaction [monocrotaline decreases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells]

RGD

PMID:30240970 PMID:30240970

RGD:156430315, RGD:156430315

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

platelet and endothelial cell adhesion molecule 1

decreases expression
multiple interactions

Monocrotaline results in decreased expression of PECAM1 mRNA; Monocrotaline results in decreased expression of PECAM1 protein
romiplostim inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]

PMID:31470032 PMID:33122006

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

PHD finger protein 10

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA

NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038

G

phosphatidylinositol glycan anchor biosynthesis, class L

decreases expression

Monocrotaline results in decreased expression of PIGL mRNA

NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145

G

protein kinase, membrane associated tyrosine/threonine 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA

NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995

G

PBX/knotted 1 homeobox 1

decreases expression

Monocrotaline results in decreased expression of PKNOX1 mRNA

NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727

G

polo-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA

NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400

G

polo-like kinase 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA

NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947

G

polo-like kinase 3

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

polo-like kinase 4

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

plasmalemma vesicle associated protein

decreases expression

Monocrotaline results in decreased expression of PLVAP mRNA

NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301

G

cytochrome p450 oxidoreductase

affects metabolic processing

POR protein affects the metabolism of Monocrotaline

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

periostin

increases expression

Monocrotaline results in increased expression of POSTN protein

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

POU class 2 homeobox 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

protein phosphatase, Mg2+/Mn2+ dependent, 1J

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA

NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882

G

protein phosphatase, Mg2+/Mn2+ dependent, 1L

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA

NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2, regulatory subunit B'', beta

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA

NCBI chr14:88,507...95,750
Ensembl chr14:89,176...95,750

G

protein phosphatase 2 regulatory subunit B', epsilon

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA

NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872

G

protein regulator of cytokinesis 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

protein kinase cAMP-dependent type II regulatory subunit alpha

increases expression

Monocrotaline results in increased expression of PRKAR2A mRNA

NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline]

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

protein kinase cGMP-dependent 1

decreases expression
multiple interactions

Monocrotaline results in decreased expression of PRKG1 protein
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein]

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

proteasome 20S subunit alpha 1

increases expression
multiple interactions

Monocrotaline results in increased expression of PSMA1 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA]

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit alpha 3

increases expression
multiple interactions

Monocrotaline results in increased expression of PSMA3 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA]

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 26S subunit, ATPase 2

increases expression

Monocrotaline results in increased expression of PSMC2 mRNA

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, ATPase 6

increases expression
multiple interactions

Monocrotaline results in increased expression of PSMC6 mRNA
Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA]

NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055

G

prostaglandin I2 synthase

increases expression

Monocrotaline increases expression of Ptgis mRNA in lung

RGD

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

RAD1 checkpoint DNA exonuclease

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA

NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689

G

RAD21 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA

NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817

G

RAD50 double strand break repair protein

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

RB transcriptional corepressor like 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RELA proto-oncogene, NF-kB subunit

increases localization
multiple interactions
increases expression

Monocrotaline results in increased localization of RELA protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]

PMID:31504964 PMID:31589899

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

replication factor C subunit 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA

NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370

G

replication factor C subunit 2

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA

NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557

G

replication factor C subunit 3

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 4

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

replication factor C subunit 5

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA

NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312

G

ribosomal protein S6

increases phosphorylation
multiple interactions

Monocrotaline results in increased phosphorylation of RPS6 protein
Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of RPS6 protein]

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

serpin family E member 1

multiple interactions

[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA

PMID:21224054 PMID:31470032

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sirtuin 3

decreases expression
multiple interactions

Monocrotaline results in decreased expression of SIRT3 mRNA; Monocrotaline results in decreased expression of SIRT3 protein
Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 mRNA]; Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 protein]; SIRT3 protein affects the reaction [Melatonin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]]

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

G

solute carrier family 19 member 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 22 member 1

multiple interactions
increases uptake

Monocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 6 member 4

multiple interactions
increases expression

Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]
Monocrotaline results in increased expression of SLC6A4 protein
Atorvastatin inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 protein]

PMID:17042913 PMID:17575010

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

SMAD family member 1

multiple interactions
decreases phosphorylation
decreases expression

Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]; Fluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein]

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

SMAD family member 3

increases phosphorylation
multiple interactions

Monocrotaline results in increased phosphorylation of SMAD3 protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SWI/SNF related BAF chromatin remodeling complex subunit B1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA

NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620

G

SWI/SNF related BAF chromatin remodeling complex subunit C1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA

NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720

G

structural maintenance of chromosomes 1A

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA

NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056

G

structural maintenance of chromosomes 3

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA

NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522

G

snail family transcriptional repressor 1

multiple interactions
increases expression

Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

SRY-box transcription factor 17

decreases expression

Monocrotaline decreases expression of Sox17 protein in the lung

RGD

NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228

G

sequestosome 1

increases expression
multiple interactions

Monocrotaline results in increased expression of SQSTM1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

STAG2 cohesin complex component

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA

NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677

G

signal transducer and activator of transcription 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

[Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; NCP-2454 inhibits the reaction [Monocrotaline results in increased phosphorylation of STAT3 protein]

PMID:25275723 PMID:27870162

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

thromboxane A2 receptor

multiple interactions
affects response to substance
increases expression

[TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; TBXA2R protein affects the reaction [Monocrotaline results in increased expression of TBXA2R mRNA]

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

thromboxane A synthase 1

increases expression

Monocrotaline results in increased expression of TBXAS1 mRNA

NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096

G

transferrin

multiple interactions

[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of TF protein; [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TF protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]

PMID:21279329 PMID:21327618

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

increases expression

Monocrotaline results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

multiple interactions
increases expression

[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; [Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of TGFB1 protein]

PMID:25275723 PMID:27870162 PMID:31734320

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thrombopoietin

decreases response to substance
multiple interactions

THPO protein results in decreased susceptibility to Monocrotaline
THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]

Ensembl chr11:80,182,820...80,188,167

G

Thy-1 cell surface antigen

increases expression

Monocrotaline results in increased expression of THY1 protein

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

TIR domain containing adaptor molecule 1

decreases response to substance

TICAM1 gene mutant form results in decreased susceptibility to Monocrotaline

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

Monocrotaline results in increased expression of TIMP1 mRNA
Simvastatin inhibits the reaction [Monocrotaline results in increased expression of TIMP1 mRNA]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tousled-like kinase 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

toll-like receptor 4

increases expression
multiple interactions
decreases response to substance

Monocrotaline results in increased expression of TLR4 protein
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]
TLR4 gene mutant form results in decreased susceptibility to Monocrotaline
TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]

PMID:31504964 PMID:31589899

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

transmembrane p24 trafficking protein 2

increases expression

Monocrotaline results in increased expression of TMED2 mRNA

NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903

G

tumor necrosis factor

multiple interactions
increases expression
affects expression
increases secretion
decreases expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TNF protein
modafinil inhibits the reaction [monocrotaline increases expression of Tnf protein in lung]
Monocrotaline affects the expression of TNF mRNA
angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein]
Monocrotaline results in increased expression of TNF mRNA; Monocrotaline results in increased expression of TNF protein
Monocrotaline results in increased secretion of TNF protein
Monocrotaline results in decreased expression of TNF protein

CTD
RGD

PMID:20581171 PMID:21327618 PMID:25051504 PMID:31407471 PMID:31504964 More...

RGD:329969898, RGD:329969898

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 10

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

tenascin N

increases expression

Monocrotaline results in increased expression of TNN protein

NCBI chr13:72,319,160...72,386,362
Ensembl chr13:72,319,155...72,408,156

G

DNA topoisomerase II binding protein 1

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA

NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674

G

tumor protein p53

multiple interactions

[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

tubulin, beta 3 class III

decreases expression

Monocrotaline results in decreased expression of TUBB3 protein

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

thioredoxin 2

decreases expression
multiple interactions

Monocrotaline results in decreased expression of TXN2 mRNA; Monocrotaline results in decreased expression of TXN2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

thioredoxin reductase 1

decreases expression

Monocrotaline results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

decreases expression
multiple interactions

Monocrotaline results in decreased expression of TXNRD2 mRNA; Monocrotaline results in decreased expression of TXNRD2 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

ubiquitin-conjugating enzyme E2B

increases expression

Monocrotaline results in increased expression of UBE2B mRNA

NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665

G

ubiquitin-conjugating enzyme E2G 1

increases expression

Monocrotaline results in increased expression of UBE2G1 mRNA

NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568

G

uracil-DNA glycosylase

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

vascular cell adhesion molecule 1

increases expression

Monocrotaline results in increased expression of VCAM1 protein

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions
increases expression

[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of VEGFA protein
monocrotaline increases expression of Vegfa protein in lung
Monocrotaline results in increased expression of VEGFA protein

CTD
RGD

PMID:21327618 PMID:25051504 PMID:26959484

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

increases expression
multiple interactions

Monocrotaline results in increased expression of VIM protein
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of VIM protein]

PMID:24947524 PMID:36942326

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-ray repair cross complementing 4

multiple interactions

[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA

NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808

G

zinc finger E-box binding homeobox 1

multiple interactions
increases expression

Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of ZEB1 protein]

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

senecionine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 3

decreases expression

senecionine results in decreased expression of ABCA3 protein

NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745

G

ATP binding cassette subfamily B member 11

decreases expression

senecionine results in decreased expression of ABCB11 mRNA

PMID:26100227 PMID:31606820

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

decreases expression

senecionine results in decreased expression of ABCB1 mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

senecionine results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

decreases expression

senecionine results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

increases expression

senecionine results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

decreases expression

senecionine results in decreased expression of ABCC2 mRNA

PMID:26100227 PMID:31606820

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

increases expression
decreases expression

senecionine results in increased expression of ABCC3 mRNA
senecionine results in decreased expression of ABCC3 mRNA

PMID:24641316 PMID:26100227 PMID:31606820

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

decreases expression

senecionine results in decreased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 6

decreases expression

senecionine results in decreased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

abhydrolase domain containing 11

increases expression

senecionine results in increased expression of ABHD11 protein

NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398

G

ankyrin repeat and BTB domain containing 2

increases expression

senecionine results in increased expression of ABTB2 protein

NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548

G

acetyl-CoA acyltransferase 1A

increases expression

senecionine results in increased expression of ACAA1A protein

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

senecionine results in increased expression of ACAA1B protein

NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825

G

acyl-CoA thioesterase 13

increases expression

senecionine results in increased expression of ACOT13 protein

NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851

G

acyl-CoA thioesterase 2

increases expression

senecionine results in increased expression of ACOT2 protein

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acyl-CoA thioesterase 3

increases expression

senecionine results in increased expression of ACOT3 protein

NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427

G

acyl-CoA thioesterase 4

increases expression

senecionine results in increased expression of ACOT4 protein

NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917

G

acyl-CoA synthetase long-chain family member 3

decreases expression

senecionine results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase long-chain family member 4

decreases expression

senecionine results in decreased expression of ACSL4 protein

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

acyl-CoA synthetase medium-chain family member 3

decreases expression

senecionine results in decreased expression of ACSM3 mRNA

NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184

G

acyl-CoA synthetase short-chain family member 3

increases expression

senecionine results in increased expression of ACSS3 protein

NCBI chr 7:42,241,261...42,450,209
Ensembl chr 7:42,242,652...42,450,230

G

actin gamma 2, smooth muscle

decreases expression

senecionine results in decreased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

ADAM metallopeptidase domain 8

increases expression

senecionine results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases expression

senecionine results in increased expression of ADH1 protein

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

ALF transcription elongation factor 3

decreases expression

senecionine results in decreased expression of AFF3 mRNA

NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247

G

alanine--glyoxylate aminotransferase

decreases expression

senecionine results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

allograft inflammatory factor 1

decreases expression

senecionine results in decreased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

A-kinase anchoring protein 12

increases expression

senecionine results in increased expression of AKAP12 protein

NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886

G

aldehyde dehydrogenase 1 family, member A1

increases expression

senecionine results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

increases expression

senecionine results in increased expression of ALDH1B1 protein

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 6 family, member A1

increases expression

senecionine results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

senecionine results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

anaphase promoting complex subunit 2

increases expression

senecionine results in increased expression of ANAPC2 protein

NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178

G

ankyrin repeat domain 1

decreases expression

senecionine results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

annexin A1

increases expression

senecionine results in increased expression of ANXA1 protein

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

amyloid P component, serum

decreases expression

senecionine results in decreased expression of APCS protein

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein B

decreases expression

senecionine results in decreased expression of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein C1

decreases expression

senecionine results in decreased expression of APOC1 protein

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein H

decreases expression

senecionine results in decreased expression of APOH protein

NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329

G

apolipoprotein M

decreases expression

senecionine results in decreased expression of APOM protein

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

G

aquaporin 4

decreases expression

senecionine results in decreased expression of AQP4 protein

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

aquaporin 8

increases expression

senecionine results in increased expression of AQP8 protein

NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158

G

amphiregulin

increases expression

senecionine results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho GTPase activating protein 11A

increases expression

senecionine results in increased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

ARL6 interacting reticulophagy regulator 1

decreases expression

senecionine results in decreased expression of ARL6IP1 protein

NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994

G

ARF like GTPase 6 interacting protein 4

decreases expression

senecionine results in decreased expression of ARL6IP4 protein

NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799

G

ATPase family, AAA domain containing 2

increases expression

senecionine results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

activating transcription factor 3

increases expression

senecionine results in increased expression of ATF3 protein

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase cation transporting 13A2

decreases expression

senecionine results in decreased expression of ATP13A2 protein

NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

senecionine results in increased expression of ATP2A3 protein

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase inhibitory factor subunit 1

decreases expression

senecionine results in decreased expression of ATP5IF1 protein

NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668

G

ATPase H+ transporting V1 subunit H

increases expression

senecionine results in increased expression of ATP6V1H protein

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

ATP synthase mitochondrial F1 complex assembly factor 2

increases expression

senecionine results in increased expression of ATPAF2 protein

NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026

G

axin 2

decreases expression

senecionine results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

Beta-1,3-galactosyltransferase 1

decreases expression

senecionine results in decreased expression of B3GALT1 protein

NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313

G

bile acid CoA:amino acid N-acyltransferase

decreases expression

senecionine results in decreased expression of BAAT mRNA

PMID:24641316 PMID:26100227

NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685

G

Bcl2-like 1

decreases expression

senecionine results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BCL3, transcription coactivator

increases expression

senecionine results in increased expression of BCL3 protein

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL2 interacting protein 3

decreases expression

senecionine results in decreased expression of BNIP3 protein

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

biorientation of chromosomes in cell division 1-like 1

decreases expression

senecionine results in decreased expression of BOD1L protein

NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490

G

bisphosphoglycerate mutase

increases expression

senecionine results in increased expression of BPGM protein

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

betacellulin

increases expression

senecionine results in increased expression of BTC protein

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

complement C3

decreases expression

senecionine results in decreased expression of C3 protein

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C3a receptor 1

increases expression

senecionine results in increased expression of C3AR1 mRNA

NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701

G

complement C4B

decreases expression

senecionine results in decreased expression of C4B protein

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

complement C5

decreases expression

senecionine results in decreased expression of C5 protein

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

cathelicidin antimicrobial peptide

increases expression

senecionine results in increased expression of CAMP protein

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

carbonic anhydrase 1

increases expression

senecionine results in increased expression of CA1 protein

NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208

G

carbonic anhydrase 2

increases expression

senecionine results in increased expression of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 5A

increases expression

senecionine results in increased expression of CA5A protein

NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906

G

carbonic anhydrase 5B

increases expression

senecionine results in increased expression of CA5B protein

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837

G

caspase 12

increases expression

senecionine results in increased expression of CASP12 mRNA

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions

senecionine results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

senecionine results in increased activity of and results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

senecionine results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

caveolin 1

decreases expression

senecionine results in decreased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

caveolae associated protein 3

decreases expression

senecionine results in decreased expression of CAVIN3 protein

NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161

G

coiled-coil domain containing 137

decreases expression

senecionine results in decreased expression of CCDC137 protein

NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158

G

cyclin A2

increases expression

senecionine results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin E2

increases expression

senecionine results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G1

increases expression

senecionine results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cell cycle progression 1

decreases expression

senecionine results in decreased expression of CCPG1 protein

NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430

G

CD163 molecule

decreases expression

senecionine results in decreased expression of CD163 protein

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

CD177 molecule

increases expression

senecionine results in increased expression of CD177 protein

NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621

G

Cd300 molecule-like family member G

decreases expression

senecionine results in decreased expression of CD300LG protein

NCBI chr10:86,991,886...87,009,248
Ensembl chr10:86,991,921...87,008,733

G

Cd47 molecule

increases expression

senecionine results in increased expression of CD47 mRNA; senecionine results in increased expression of CD47 protein

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

cytidine and dCMP deaminase domain containing 1

decreases expression

senecionine results in decreased expression of CDADC1 protein

NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576

G

CDK5 regulatory subunit associated protein 1-like 1

decreases expression

senecionine results in decreased expression of CDKAL1 protein

NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524

G

cyclin-dependent kinase inhibitor 1A

increases expression

senecionine results in increased expression of CDKN1A mRNA
senecionine results in increased expression of CDKN1A protein

PMID:32419051 PMID:35357534

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxyl ester lipase

decreases expression

senecionine results in decreased expression of CEL protein

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

centromere protein Q

increases expression

senecionine results in increased expression of CENPQ mRNA

NCBI chr 9:19,957,122...19,972,807
Ensembl chr 9:19,957,048...19,972,789

G

centromere protein W

increases expression

senecionine results in increased expression of CENPW mRNA

NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464

G

centrosomal protein 97

increases expression

senecionine results in increased expression of CEP97 protein

NCBI chr11:44,683,503...44,711,471
Ensembl chr11:44,683,506...44,711,471

G

complement factor H

decreases expression

senecionine results in decreased expression of CFH protein

NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838

G

cingulin-like 1

decreases expression

senecionine results in decreased expression of CGNL1 protein

NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917

G

chromosome alignment maintaining phosphoprotein 1

increases expression

senecionine results in increased expression of CHAMP1 protein

NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984

G

chromatin target of PRMT1

decreases expression

senecionine results in decreased expression of CHTOP protein

NCBI chr 2:175,981,266...175,992,820
Ensembl chr 2:175,981,271...175,992,748

G

calcium and integrin binding 1

increases expression

senecionine results in increased expression of CIB1 protein

NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423

G

corepressor interacting with RBPJ, 1

decreases expression

senecionine results in decreased expression of CIR1 protein

NCBI chr 3:58,158,923...58,188,799
Ensembl chr 3:58,158,951...58,188,789

G

cytoskeleton associated protein 2

increases expression

senecionine results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

creatine kinase, mitochondrial 1

decreases expression

senecionine results in decreased expression of CKMT1 protein

NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758

G

creatine kinase, mitochondrial 2

decreases expression

senecionine results in decreased expression of CKMT2 mRNA

NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430

G

C-type lectin domain family 3, member B

decreases expression

senecionine results in decreased expression of CLEC3B protein

NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835

G

C-type lectin domain family 4, member A1

increases expression

senecionine results in increased expression of CLEC4A1 mRNA

NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008

G

C-type lectin domain family 4, member F

decreases expression

senecionine results in decreased expression of CLEC4F mRNA
senecionine results in decreased expression of CLEC4F protein

PMID:32419051 PMID:35357534

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

senecionine results in decreased expression of CNBP protein

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

centriolin

decreases expression

senecionine results in decreased expression of CNTRL protein

NCBI chr 3:18,428,147...18,500,362
Ensembl chr 3:18,428,103...18,500,380

G

collagen type XVIII alpha 1 chain

decreases expression

senecionine results in decreased expression of COL18A1 protein

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

COP9 signalosome subunit 3

increases expression

senecionine results in increased expression of COPS3 protein

NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597

G

coronin 1A

increases expression

senecionine results in increased expression of CORO1A protein

NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534

G

carboxypeptidase A1

decreases expression

senecionine results in decreased expression of CPA1 protein

NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544

G

carboxypeptidase B2

decreases expression

senecionine results in decreased expression of CPB2 protein

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

G

cysteine-rich with EGF-like domains 1

decreases expression

senecionine results in decreased expression of CRELD1 protein

NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499

G

cysteine-rich with EGF-like domains 2

decreases expression

senecionine results in decreased expression of CRELD2 protein

NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543

G

cysteine rich protein 1

decreases expression

senecionine results in decreased expression of CRIP1 protein

NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620

G

colony stimulating factor 1 receptor

decreases expression

senecionine results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

CTD nuclear envelope phosphatase 1

increases expression

senecionine results in increased expression of CTDNEP1 protein

NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781

G

chymotrypsin-like

decreases expression

senecionine results in decreased expression of CTRB1 protein

NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626

G

cathepsin G

increases expression

senecionine results in increased expression of CTSG protein

NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353

G

C-X-C motif chemokine ligand 12

decreases expression

senecionine results in decreased expression of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 4

increases expression

senecionine results in increased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 11, subfamily a, polypeptide 1

increases expression

senecionine results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

senecionine results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression
decreases expression

senecionine results in increased expression of CYP1A2 mRNA
senecionine results in decreased expression of CYP1A2 mRNA

PMID:26100227 PMID:31606820

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

senecionine results in increased expression of CYP1B1 mRNA

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

senecionine results in increased expression of CYP2A13 mRNA

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 3

increases expression

senecionine results in increased expression of CYP2A4 protein

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
affects expression

senecionine results in increased expression of CYP2B6 mRNA
senecionine affects the expression of CYP2B10 mRNA

PMID:26100227 PMID:31606820

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression

senecionine results in decreased expression of CYP2C18 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
decreases expression

senecionine results in increased expression of CYP2E1 mRNA
senecionine results in decreased expression of CYP2E1 mRNA

PMID:26100227 PMID:31606820

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 18

increases expression

senecionine results in increased expression of CYP3A43 mRNA

NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
increases response to substance

senecionine results in increased expression of CYP3A4 mRNA
CYP3A4 protein results in increased susceptibility to senecionine

PMID:26100227 PMID:32910235

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

decreases expression

senecionine results in decreased expression of CYP3A5 mRNA

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily f, polypeptide 1

decreases expression

senecionine results in decreased expression of CYP4F12 mRNA

NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

senecionine results in decreased expression of CYP7A1 mRNA

PMID:24641316 PMID:26100227 PMID:31606820

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 8 subfamily B member 1

decreases expression

senecionine results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

CYFIP related Rac1 interactor A

increases expression

senecionine results in increased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

debranching RNA lariats 1

increases expression

senecionine results in increased expression of DBR1 protein

NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030

G

DNA damage-induced apoptosis suppressor

increases expression

senecionine results in increased expression of DDIAS mRNA

NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462

G

death effector domain-containing

decreases expression

senecionine results in decreased expression of DEDD protein

NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332

G

deoxyguanosine kinase

increases expression

senecionine results in increased expression of DGUOK protein

NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733

G

dehydrogenase/reductase 2

increases expression

senecionine results in increased expression of DHRS2 mRNA

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

dehydrogenase/reductase 9

increases expression

senecionine results in increased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

diaphanous-related formin 3

increases expression

senecionine results in increased expression of DIAPH3 mRNA

NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975

G

disco-interacting protein 2 homolog A

decreases expression

senecionine results in decreased expression of DIP2A protein

NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217

G

DLG associated protein 5

increases expression

senecionine results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

deleted in malignant brain tumors 1

decreases expression

senecionine results in decreased expression of DMBT1 protein

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

senecionine results in increased expression of DNAJB9 protein

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C12

decreases expression

senecionine results in decreased expression of DNAJC12 protein

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

DnaJ heat shock protein family (Hsp40) member C15

decreases expression

senecionine results in decreased expression of DNAJC15 protein

NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675

G

diphthamide biosynthesis 5

increases expression

senecionine results in increased expression of DPH5 protein

NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433

G

dihydropyrimidine dehydrogenase

decreases expression

senecionine results in decreased expression of DPYD mRNA

NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982

G

denticleless E3 ubiquitin protein ligase homolog

increases expression

senecionine results in increased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dual specificity phosphatase 1

increases expression

senecionine results in increased expression of DUSP1 protein

NCBI chr10:16,680,478...16,683,275

G

dynein light chain LC8-type 2

decreases expression

senecionine results in decreased expression of DYNLL2 protein

NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805

G

ectodysplasin A2 receptor

increases expression

senecionine results in increased expression of EDA2R mRNA

NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268

G

epidermal growth factor receptor

decreases expression

senecionine results in decreased expression of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 3, subunit G

decreases expression

senecionine results in decreased expression of EIF3G protein

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808

G

eukaryotic translation initiation factor 4B

decreases expression

senecionine results in decreased expression of EIF4B protein

NCBI chr 7:133,206,637...133,228,436

G

E74 like ETS transcription factor 1

decreases expression

senecionine results in decreased expression of ELF1 protein

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

ELOVL fatty acid elongase 1

decreases expression

senecionine results in decreased expression of ELOVL1 protein

NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958

G

elastin microfibril interfacer 2

increases expression

senecionine results in increased expression of EMILIN2 mRNA

NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352

G

endoglin

decreases expression

senecionine results in decreased expression of ENG protein

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 3

increases expression

senecionine results in increased expression of ENO3 protein

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

ectonucleoside triphosphate diphosphohydrolase 5

increases expression

senecionine results in increased expression of ENTPD5 protein

NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530

G

Eph receptor A2

increases expression

senecionine results in increased expression of EPHA2 protein

NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117

G

epoxide hydrolase 2

decreases expression

senecionine results in decreased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

EPM2A glucan phosphatase, laforin

increases expression

senecionine results in increased expression of EPM2A protein

NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555

G

endoplasmic reticulum protein 29

increases expression

senecionine results in increased expression of ERP29 protein

NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

senecionine results in increased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

estrogen related receptor, alpha

decreases expression

senecionine results in decreased expression of ESRRA protein

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ETHE1, persulfide dioxygenase

decreases expression

senecionine results in decreased expression of ETHE1 mRNA

NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052

G

ethanolamine-phosphate phospho-lyase

increases expression

senecionine results in increased expression of ETNPPL protein

NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212

G

ETS proto-oncogene 2, transcription factor

increases expression

senecionine results in increased expression of ETS2 protein

NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319

G

ETS variant transcription factor 6

decreases expression

senecionine results in decreased expression of ETV6 protein

NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992

G

exostosin glycosyltransferase 1

decreases expression

senecionine results in decreased expression of EXT1 protein

NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357

G

coagulation factor XIII A1 chain

increases expression

senecionine results in increased expression of F13A1 protein

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

fumarylacetoacetate hydrolase domain containing 2A

increases expression

senecionine results in increased expression of FAHD2A protein

NCBI chr 3:114,657,176...114,665,349
Ensembl chr 3:114,655,865...114,665,356

G

FA complementation group D2

increases expression

senecionine results in increased expression of FANCD2 mRNA

NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412

G

Fas cell surface death receptor

increases expression

senecionine metabolite results in increased expression of FAS mRNA
senecionine results in increased expression of FAS mRNA

PMID:30465738 PMID:32419051

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

F-box protein 21

increases expression

senecionine results in increased expression of FBXO21 protein

NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133

G

Fc gamma receptor 3A

increases expression

senecionine results in increased expression of FCGR3A mRNA

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

farnesyl diphosphate farnesyl transferase 1

decreases expression

senecionine results in decreased expression of FDFT1 protein

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

fibrinogen-like 1

decreases expression

senecionine results in decreased expression of FGL1 protein

NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093

G

fission, mitochondrial 1

decreases expression

senecionine results in decreased expression of FIS1 protein

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

flavin containing dimethylaniline monoxygenase 3

increases expression

senecionine results in increased expression of FMO3 protein

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

flavin containing dimethylaniline monoxygenase 4

decreases expression

senecionine results in decreased expression of FMO4 mRNA

NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874

G

flavin containing dimethylaniline monoxygenase 5

decreases expression

senecionine results in decreased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

fragile X messenger ribonucleoprotein 1

decreases expression

senecionine results in decreased expression of FMR1 protein

NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050

G

fibronectin type III domain containing 3B

decreases expression

senecionine results in decreased expression of FNDC3B protein

NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830

G

folate receptor beta

decreases expression

senecionine results in decreased expression of FOLR2 protein

NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724

G

FERM domain containing 4B

decreases expression

senecionine results in decreased expression of FRMD4B protein

NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197

G

FtsJ RNA 2'-O-methyltransferase 3

decreases expression

senecionine results in decreased expression of FTSJ3 protein

NCBI chr10:91,180,945...91,187,389
Ensembl chr10:91,180,696...91,187,397

G

FYN binding protein 2

decreases expression

senecionine results in decreased expression of FYB2 protein

NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910

G

forty-two-three domain containing 1

decreases expression

senecionine results in decreased expression of FYTTD1 protein

NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511

G

G0/G1switch 2

increases expression

senecionine results in increased expression of G0S2 protein

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphate dehydrogenase

increases expression

senecionine results in increased expression of G6PDX protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GC, vitamin D binding protein

decreases expression

senecionine results in decreased expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glucokinase regulator

increases expression

senecionine results in increased expression of GCKR protein

NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654

G

glycine cleavage system protein H

increases expression

senecionine results in increased expression of GCSH protein

NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792

G

GTP binding protein overexpressed in skeletal muscle

increases expression

senecionine results in increased expression of GEM mRNA

NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222

G

growth hormone receptor

decreases expression

senecionine results in decreased expression of GHR protein

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

glutaminase

increases expression

senecionine results in increased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

glycine-N-acyltransferase

decreases expression

senecionine results in decreased expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

glycine N-methyltransferase

increases expression

senecionine results in increased expression of GNMT mRNA

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

G patch domain containing 4

increases expression

senecionine results in increased expression of GPATCH4 protein

NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684

G

glypican 1

decreases expression

senecionine results in decreased expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

glycerophosphocholine phosphodiesterase 1

increases expression

senecionine results in increased expression of GPCPD1 protein

NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517

G

gephyrin

decreases expression

senecionine results in decreased expression of GPHN mRNA

NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612

G

G protein-coupled receptor, class C, group 5, member A

increases expression

senecionine results in increased expression of GPRC5A mRNA

NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260

G

G-protein signaling modulator 3

increases expression

senecionine results in increased expression of GPSM3 protein

NCBI chr20:4,157,123...4,158,984
Ensembl chr20:4,157,123...4,159,035

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

senecionine results in increased activity of GPT protein
POR protein affects the reaction [senecionine results in increased expression of GPT protein]

PMID:24641316 PMID:31606820

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor AMPA type subunit 3

increases expression

senecionine results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

granulin precursor

decreases expression

senecionine results in decreased expression of GRN protein

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

GrpE-like 1, mitochondrial

increases expression

senecionine results in increased expression of GRPEL1 protein

NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200

G

glutathione S-transferase alpha 4

decreases expression

senecionine results in decreased expression of GSTA4 mRNA

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase theta 1

decreases expression

senecionine results in decreased expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

granzyme A

decreases expression

senecionine results in decreased expression of GZMA mRNA

NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493

G

H1.4 linker histone, cluster member

decreases expression

senecionine results in decreased expression of H1-4 protein

NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403

G

H2A.X variant histone

increases expression

senecionine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

HAUS augmin like complex subunit 2

decreases expression

senecionine results in decreased expression of HAUS2 protein

NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157

G

hemoglobin alpha, adult chain 1

increases expression

senecionine results in increased expression of HBA protein

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

increases expression

senecionine results in increased expression of HBB-B1 protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

high density lipoprotein binding protein

decreases expression

senecionine results in decreased expression of HDLBP protein

NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

increases expression

senecionine results in increased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

HIC ZBTB transcriptional repressor 2

decreases expression

senecionine results in decreased expression of HIC2 protein

NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

senecionine results in decreased expression of HMGCR protein

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

hyaluronan-mediated motility receptor

increases expression

senecionine results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

HNF1 homeobox A

decreases expression

senecionine results in decreased expression of HNF1A protein

NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104

G

histamine N-methyltransferase

decreases expression

senecionine results in decreased expression of HNMT mRNA

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

G

4-hydroxy-2-oxoglutarate aldolase 1

increases expression

senecionine results in increased expression of HOGA1 protein

NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568

G

haptoglobin

decreases expression

senecionine results in decreased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases expression

senecionine results in increased expression of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock transcription factor 1

increases activity

senecionine results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

Huntingtin interacting protein K

decreases expression

senecionine results in decreased expression of HYPK protein

NCBI chr 3:108,434,997...108,436,370
Ensembl chr 3:108,432,539...108,436,370

G

intercellular adhesion molecule 1

increases expression

senecionine results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

senecionine results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

intraflagellar transport 25

increases expression

senecionine results in increased expression of IFT25 protein

NCBI chr 5:122,035,588...122,062,421
Ensembl chr 5:122,035,581...122,062,421

G

insulin-like growth factor binding protein 4

decreases expression

senecionine results in decreased expression of IGFBP4 protein

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

immunoglobulin heavy constant gamma 1

increases expression

senecionine results in increased expression of IGHG1 protein

Ensembl chr 6:132,389,370...132,393,397

G

interleukin 11

increases expression

senecionine metabolite results in increased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 13 receptor subunit alpha 1

decreases expression

senecionine results in decreased expression of IL13RA1 protein

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 17 receptor D

increases expression

senecionine results in increased expression of IL17RD mRNA

NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556

G

interleukin 1 beta

increases expression

senecionine metabolite results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6 cytokine family signal transducer

decreases expression

senecionine results in decreased expression of IL6ST protein

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

inosine monophosphate dehydrogenase 2

increases expression

senecionine results in increased expression of IMPDH2 protein

NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359

G

INTS3 and NABP interacting protein

decreases expression

senecionine results in decreased expression of INIP protein

NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628

G

indolethylamine N-methyltransferase

decreases expression

senecionine results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

iron-sulfur cluster assembly 1

increases expression

senecionine results in increased expression of ISCA1 protein

NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955

G

ISG15 ubiquitin-like modifier

increases expression

senecionine results in increased expression of ISG15 protein

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

increases expression

senecionine results in increased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

integrin subunit alpha M

increases expression

senecionine results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

inter-alpha-trypsin inhibitor heavy chain 2

decreases expression

senecionine results in decreased expression of ITIH2 protein

NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841

G

inter-alpha trypsin inhibitor, heavy chain 3

decreases expression

senecionine results in decreased expression of ITIH3 protein

NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924

G

integral membrane protein 2B

decreases expression

senecionine results in decreased expression of ITM2B protein

NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917

G

junctional adhesion molecule 3

increases expression

senecionine results in increased expression of JAM3 mRNA

NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355

G

joining chain of multimeric IgA and IgM

decreases expression

senecionine results in decreased expression of JCHAIN protein

NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298

G

jumonji domain containing 6, arginine demethylase and lysine hydroxylase

increases expression

senecionine results in increased expression of JMJD6 protein

NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

senecionine results in increased expression of JUNB protein

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

kinesin family member 11

increases expression

senecionine results in increased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 18A

increases expression

senecionine results in increased expression of KIF18A mRNA

NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582

G

kinetochore scaffold 1

increases expression

senecionine results in increased expression of KNL1 mRNA

NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915

G

kinetochore associated 1

increases expression

senecionine results in increased expression of KNTC1 mRNA

NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561

G

keratin 19

decreases expression

senecionine results in decreased expression of KRT19 protein

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

kinectin 1

decreases expression

senecionine results in decreased expression of KTN1 protein

NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578

G

kynurenine aminotransferase 1

decreases expression

senecionine results in decreased expression of KYAT1 mRNA

NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355

G

La ribonucleoprotein 4

decreases expression

senecionine results in decreased expression of LARP4 protein

NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811

G

lipopolysaccharide binding protein

increases expression

senecionine results in increased expression of LBP mRNA

NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586

G

lipocalin 2

increases expression

senecionine results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

galectin 2

decreases expression

senecionine results in decreased expression of LGALS2 protein

NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802

G

leucine rich repeat containing G protein coupled receptor 5

decreases expression

senecionine results in decreased expression of LGR5 mRNA

NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446

G

lin-37 DREAM MuvB core complex component

decreases expression

senecionine results in decreased expression of LIN37 protein

NCBI chr 1:85,809,065...85,813,235
Ensembl chr 1:85,809,074...85,812,991

G

lon peptidase 1, mitochondrial

increases expression

senecionine results in increased expression of LONP1 protein

NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771

G

LDL receptor related protein 1

decreases expression

senecionine results in decreased expression of LRP1 protein

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

leucine rich repeat containing 59

decreases expression

senecionine results in decreased expression of LRRC59 protein

NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533

G

lactotransferrin

increases expression

senecionine results in increased expression of LTF protein

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

lysozyme 2

increases expression

senecionine results in increased expression of LYZ2 protein

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

macoilin 1

decreases expression

senecionine results in decreased expression of MACO1 protein

NCBI chr 5:147,012,416...147,075,265
Ensembl chr 5:147,012,867...147,075,001

G

mitotic arrest deficient 2 like 1

increases expression

senecionine results in increased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAF bZIP transcription factor F

increases expression

senecionine results in increased expression of MAFF mRNA
senecionine results in increased expression of MAFF protein

PMID:26100227 PMID:35357534

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAF bZIP transcription factor K

increases expression

senecionine results in increased expression of MAFK protein

NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048

G

mal, T-cell differentiation protein

increases expression

senecionine results in increased expression of MAL mRNA

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

monoamine oxidase A

decreases expression

senecionine results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase kinase 3

increases expression

senecionine results in increased expression of MAP2K3 protein

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

microtubule-associated protein 7

decreases expression

senecionine results in decreased expression of MAP7 protein

NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574

G

microtubule-associated protein, RP/EB family, member 2

decreases expression

senecionine results in decreased expression of MAPRE2 protein

NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044

G

microtubule associated serine/threonine kinase-like

increases expression

senecionine results in increased expression of MASTL mRNA

NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353

G

mannose binding lectin 2

increases expression

senecionine results in increased expression of MBL2 protein

NCBI chr 1:228,016,439...228,024,736

G

minichromosome maintenance complex component 3

increases expression

senecionine results in increased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 5

increases expression

senecionine results in increased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

methyltransferase 21A, HSPA lysine

increases expression

senecionine results in increased expression of METTL21A protein

NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550

G

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase

decreases expression

senecionine results in decreased expression of MGAT5 protein

NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513

G

mitochondrial genome maintenance exonuclease 1

increases expression

senecionine results in increased expression of MGME1 protein

NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932

G

O-6-methylguanine-DNA methyltransferase

increases expression

senecionine results in increased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

MIB E3 ubiquitin protein ligase 2

decreases expression

senecionine results in decreased expression of MIB2 protein

NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650

G

mitochondrial contact site and cristae organizing system subunit 10

decreases expression

senecionine results in decreased expression of MICOS10 protein

NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485

G

marker of proliferation Ki-67

increases expression

senecionine results in increased expression of MKI67 mRNA

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

increases expression

senecionine results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 9

increases expression
multiple interactions

senecionine results in increased expression of MMP9 mRNA
senecionine results in increased expression of MMP9 mRNA; senecionine results in increased expression of MMP9 protein
Leu-Ser-Lys-Leu peptide inhibits the reaction [senecionine results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

multimerin 1

increases expression

senecionine results in increased expression of MMRN1 protein

NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474

G

mannose-P-dolichol utilization defect 1

decreases expression

senecionine results in decreased expression of MPDU1 protein

NCBI chr10:54,374,719...54,380,301
Ensembl chr10:54,374,725...54,380,447

G

myeloperoxidase

increases expression

senecionine results in increased expression of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mercaptopyruvate sulfurtransferase

increases expression

senecionine results in increased expression of MPST protein

NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141

G

mitochondrial ribosomal protein L42

increases expression

senecionine results in increased expression of MRPL42 protein

NCBI chr 7:30,117,977...30,141,757
Ensembl chr 7:30,117,977...30,141,639

G

methylsterol monooxygenase 1

decreases expression

senecionine results in decreased expression of MSMO1 protein

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mitochondrially encoded cytochrome c oxidase III

increases expression

senecionine results in increased expression of COX3 protein

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

decreases expression

senecionine results in decreased expression of ND3 protein

NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798

G

metallothionein 2A

increases expression

senecionine results in increased expression of MT2 mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

senecionine results in increased expression of MTHFD1L protein

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

MTSS I-BAR domain containing 1

decreases expression

senecionine results in decreased expression of MTSS1 protein

NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968

G

microtubule associated scaffold protein 1

decreases expression

senecionine results in decreased expression of MTUS1 protein

NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793

G

MYB proto-oncogene like 1

increases expression

senecionine results in increased expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYB proto-oncogene like 2

increases expression

senecionine results in increased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

myosin binding protein C3

decreases expression

senecionine results in decreased expression of MYBPC3 mRNA

NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405

G

myozenin 2

decreases expression

senecionine results in decreased expression of MYOZ2 mRNA

NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221

G

NEDD4 binding protein 2-like 1

decreases expression

senecionine results in decreased expression of N4BP2L1 protein

NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257

G

napsin A aspartic peptidase

increases expression

senecionine results in increased expression of NAPSA protein

NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094

G

non-SMC condensin I complex, subunit H

increases expression

senecionine results in increased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

neutrophil cytosolic factor 4

increases expression

senecionine results in increased expression of NCF4 protein

NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389

G

NDC80 kinetochore complex component

increases expression

senecionine results in increased expression of NDC80 mRNA

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

nebulin

decreases expression

senecionine results in decreased expression of NEB mRNA

NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574

G

nuclear factor I/A

decreases expression

senecionine results in decreased expression of NFIA protein

NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885

G

nucleolar protein interacting with the FHA domain of MKI67

decreases expression

senecionine results in decreased expression of NIFK protein

NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896

G

nicotinamide N-methyltransferase

decreases expression

senecionine results in decreased expression of NNMT mRNA

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

NOP16 nucleolar protein

decreases expression

senecionine results in decreased expression of NOP16 protein

NCBI chr17:10,022,950...10,027,867
Ensembl chr17:10,022,932...10,027,867

G

nitric oxide synthase 2

increases expression

senecionine results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

N-acetylneuraminate pyruvate lyase

increases expression

senecionine results in increased expression of NPL protein

NCBI chr13:65,655,099...65,697,464
Ensembl chr13:65,655,118...65,697,372

G

NAD(P)H quinone dehydrogenase 1

increases expression

senecionine results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

senecionine results in decreased expression of NR0B2 mRNA

PMID:24641316 PMID:31606820

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group D, member 1

increases expression

senecionine results in increased expression of NR1D1 protein

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

senecionine results in decreased expression of NR1H4 mRNA
senecionine results in decreased expression of NR1H4 protein

PMID:24641316 PMID:35357534

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 1, group I, member 3

decreases expression

senecionine results in decreased expression of NR1I3 mRNA

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

senecionine results in decreased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neuronal cell adhesion molecule

increases expression

senecionine results in increased expression of NRCAM mRNA

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neuregulin 1

increases expression

senecionine results in increased expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neuropilin 1

decreases expression

senecionine results in decreased expression of NRP1 protein

NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633

G

neurotrimin

decreases expression

senecionine results in decreased expression of NTM protein

NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

decreases expression

senecionine results in decreased expression of NUCKS1 protein

NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229

G

nudix hydrolase 7

increases expression

senecionine results in increased expression of NUDT7 protein

NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081

G

nucleolar and spindle associated protein 1

increases expression

senecionine results in increased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

orosomucoid 1

decreases expression

senecionine results in decreased expression of ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

3-oxoacyl-ACP synthase, mitochondrial

increases expression

senecionine results in increased expression of OXSM protein

NCBI chr15:9,210,443...9,215,852
Ensembl chr15:9,210,547...9,214,558

G

poly(A) binding protein, cytoplasmic 1

decreases expression

senecionine results in decreased expression of PABPC1 protein

NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744

G

poly (ADP-ribose) polymerase 1

decreases expression

senecionine results in decreased expression of PARP1 protein

PMID:29458164 PMID:35357534

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PCNA clamp associated factor

increases expression

senecionine results in increased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proprotein convertase subtilisin/kexin type 9

decreases expression

senecionine results in decreased expression of PCSK9 protein

NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688

G

phosducin like

increases expression

senecionine results in increased expression of PDCL protein

NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
Ensembl chr 3:21,110,167...21,119,715

G

phosphodiesterase 12

increases expression

senecionine results in increased expression of PDE12 protein

NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887

G

phosphodiesterase 7B

decreases expression

senecionine results in decreased expression of PDE7B protein

NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900

G

protein disulfide isomerase family A, member 2

decreases expression

senecionine results in decreased expression of PDIA2 protein

NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931

G

PDZ domain containing RING finger 3

decreases expression

senecionine results in decreased expression of PDZRN3 protein

NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959

G

period circadian regulator 3

decreases expression

senecionine results in decreased expression of PER3 protein

NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607

G

PHD finger protein 14

decreases expression

senecionine results in decreased expression of PHF14 protein

NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885

G

phosphotyrosine interaction domain containing 1

decreases expression

senecionine results in decreased expression of PID1 protein

NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044

G

piezo-type mechanosensitive ion channel component 1

increases expression

senecionine results in increased expression of PIEZO1 protein

NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501

G

polymeric immunoglobulin receptor

decreases expression

senecionine results in decreased expression of PIGR protein

NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875

G

polycystin 2, transient receptor potential cation channel

decreases expression

senecionine results in decreased expression of PKD2 protein

NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825

G

phospholipase C, gamma 2

increases expression

senecionine results in increased expression of PLCG2 protein

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

phospholipase D1

decreases expression

senecionine results in decreased expression of PLD1 protein

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

phospholipase D family, member 4

increases expression

senecionine results in increased expression of PLD4 mRNA

NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376

G

plasminogen

decreases expression

senecionine results in decreased expression of PLG protein

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

perilipin 2

increases expression

senecionine results in increased expression of PLIN2 protein

NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319

G

polo-like kinase 4

increases expression

senecionine results in increased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

phospholamban

decreases expression

senecionine results in decreased expression of PLN mRNA

NCBI chr20:32,629,537...32,639,559

G

PML nuclear body scaffold

decreases expression

senecionine results in decreased expression of PML protein

NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971

G

patatin-like phospholipase domain containing 2

increases expression

senecionine results in increased expression of PNPLA2 protein

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

RNA polymerase I subunit G

increases expression

senecionine results in increased expression of POLR1G protein

NCBI chr 1:79,007,490...79,010,766
Ensembl chr 1:79,007,490...79,010,766

G

cytochrome p450 oxidoreductase

multiple interactions
affects response to substance

POR protein affects the reaction [senecionine results in increased expression of GPT protein]
POR protein affects the susceptibility to senecionine

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peptidylprolyl isomerase F

increases expression

senecionine results in increased expression of PPIF protein

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

senecionine results in decreased expression of PPP1R3B protein

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein regulator of cytokinesis 1

increases expression

senecionine results in increased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

peroxiredoxin 3

increases expression

senecionine results in increased expression of PRDX3 protein

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

proteoglycan 4

decreases expression

senecionine results in decreased expression of PRG4 protein

NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119

G

prolactin receptor

decreases expression

senecionine results in decreased expression of PRLR protein

NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718

G

prospero homeobox 1

decreases expression

senecionine results in decreased expression of PROX1 protein

NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183

G

proline rich 12

decreases expression

senecionine results in decreased expression of PRR12 protein

NCBI chr 1:95,510,015...95,534,002
Ensembl chr 1:95,509,931...95,533,652

G

prosaposin

decreases expression

senecionine results in decreased expression of PSAP protein

NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498

G

PC4 and SRSF1 interacting protein 1

decreases expression

senecionine results in decreased expression of PSIP1 protein

NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257

G

proteasome 26S subunit, non-ATPase 10

increases expression

senecionine results in increased expression of PSMD10 protein

NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097

G

prostaglandin I2 synthase

decreases expression

senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 2

increases expression

senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, D

decreases expression

senecionine results in decreased expression of PTPRD mRNA
senecionine results in decreased expression of PTPRD protein

PMID:26100227 PMID:35357534

NCBI chr 5:90,046,993...90,698,977
NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396

G

RAB11a, member RAS oncogene family

decreases expression

senecionine results in decreased expression of RAB11A protein

NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525

G

Rap guanine nucleotide exchange factor 4

decreases expression

senecionine results in decreased expression of RAPGEF4 mRNA

NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316

G

Ras association domain family member 1

increases expression

senecionine results in increased expression of RASSF1 protein

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

ribosomal biogenesis factor

decreases expression

senecionine results in decreased expression of RBIS protein

NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339

G

RNA binding motif protein 3

decreases expression

senecionine results in decreased expression of RBM3 protein

NCBI chr X:14,348,909...14,352,387
Ensembl chr X:14,348,910...14,353,580

G

ring finger and CCCH-type domains 1

increases expression

senecionine results in increased expression of RC3H1 protein

NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839

G

RNA terminal phosphate cyclase-like 1

decreases expression

senecionine results in decreased expression of RCL1 protein

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

REX4 homolog, 3'-5' exonuclease

decreases expression

senecionine results in decreased expression of REXO4 protein

NCBI chr 3:10,280,654...10,291,003
Ensembl chr 3:10,280,654...10,290,996

G

ring finger protein 1

decreases expression

senecionine results in decreased expression of RING1 protein

NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620

G

ribosomal protein L34

decreases expression

senecionine results in decreased expression of RPL34 protein

NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111
Ensembl chr17:219,284,382...219,288,111

G

ribosomal protein L36

decreases expression

senecionine results in decreased expression of RPL36 protein

NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897

G

ribosomal protein lateral stalk subunit P1

increases expression

senecionine results in increased expression of RPLP1 protein

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S27

decreases expression

senecionine results in decreased expression of RPS27 protein

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

increases expression

senecionine results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

Ras-related GTP binding B

increases expression

senecionine results in increased expression of RRAGB protein

NCBI chr X:18,184,619...18,234,639
Ensembl chr X:18,184,992...18,234,639

G

ribosome binding protein 1

decreases expression

senecionine results in decreased expression of RRBP1 protein

NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981

G

ribonucleotide reductase catalytic subunit M1

increases expression

senecionine results in increased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

RRN3 homolog, RNA polymerase I transcription factor

increases expression

senecionine results in increased expression of RRN3 protein

NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663

G

radical S-adenosyl methionine domain containing 2

increases expression

senecionine results in increased expression of RSAD2 protein

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

ribosomal L24 domain containing 1

decreases expression

senecionine results in decreased expression of RSL24D1 protein

NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001

G

retinoid X receptor alpha

decreases expression

senecionine results in decreased expression of RXRA protein

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

S100 calcium-binding protein A4

increases expression

senecionine results in increased expression of S100A4 protein

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

S100 calcium binding protein A6

increases expression

senecionine results in increased expression of S100A6 protein

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

S100 calcium binding protein A9

increases expression

senecionine results in increased expression of S100A9 protein

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

serum amyloid A4

decreases expression

senecionine results in decreased expression of SAA4 protein

NCBI chr 1:97,247,580...97,251,882

G

SAP domain containing ribonucleoprotein

decreases expression

senecionine results in decreased expression of SARNP protein

NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332

G

spermidine/spermine N1-acetyl transferase 1

increases expression

senecionine results in increased expression of SAT1 mRNA

NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813

G

stearoyl-CoA desaturase

decreases expression

senecionine results in decreased expression of SCD1 protein

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

syndecan 2

decreases expression

senecionine results in decreased expression of SDC2 protein

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

syndecan 4

decreases expression

senecionine results in decreased expression of SDC4 protein

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

short chain dehydrogenase/reductase family 42E, member 1

increases expression

senecionine results in increased expression of SDR42E1 protein

NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901

G

SECIS binding protein 2-like

decreases expression

senecionine results in decreased expression of SECISBP2L protein

NCBI chr 3:112,989,613...113,036,060
Ensembl chr 3:112,991,908...113,035,884

G

semaphorin 3E

decreases expression

senecionine results in decreased expression of SEMA3E protein

NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229

G

semaphorin 4B

decreases expression

senecionine results in decreased expression of SEMA4B protein

NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775

G

serpin family A member 10

decreases expression

senecionine results in decreased expression of SERPINA10 protein

NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544

G

serpin family A member 3N

decreases expression

senecionine results in decreased expression of SERPINA3N protein

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433