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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lipoprotein
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Accession:CHEBI:6495 term browser browse the term
Definition:A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
Synonyms:exact_synonym: lipoproteins
 related_synonym: lipoprotein particle
 xref: KEGG:C01834


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high-density lipoprotein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M multiple interactions ISO High-density lipoprotein inhibits the reaction [cholesterol increases expression of ITGAM protein on monocytes and granulocytes]
High-density lipoprotein inhibits the reaction [PMA increases expression of ITGAM protein on monocytes] 		RGD PMID:26026058 PMID:18617650 RGD:329853768, RGD:329901662 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
low-density lipoprotein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M increases expression ISO Low-density lipoprotein increases expression of ITGAM protein on monocytes RGD PMID:22901456 RGD:329853769 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
oxidised LDL term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions
increases phosphorylation 		ISO Albiflorin inhibits the reaction [oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells]
Oxidized LDL increases phosphorylation of MAP3K7 protein in umbilical vein endothelial cells 		RGD PMID:35601145 PMID:35601145 RGD:155804296, RGD:155804296 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression
increases expression 		ISO Oxidized LDL decreases expression of Nr1h3 mRNA and protein in vascular smooth muscle cells
Oxidized LDL increases expression of NR1H3 protein in macrophages 		RGD PMID:27807703 PMID:32780606 RGD:401850553, RGD:401850600 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 increases expression
decreases expression 		ISO Oxidized low-density lipoprotein increases expression of PHACTR1 mRNA in umbilical vein endothelial cells
Oxidized low density lipoprotein decreases expression of intermediate length PHACTR1 mRNA in macrophages
Oxidized low density lipoprotein increases expression of short length PHACTR1 mRNA in macrophages 		RGD PMID:36091033 PMID:27187934 PMID:27187934 RGD:401900131, RGD:401900169, RGD:401900169 NCBI chr17:21,769,006...22,246,227
Ensembl chr17:21,768,662...22,244,586 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO Oxidized LDL decreases expression of PTGIS mRNA in aortic endothelial cells and aortic smooth muscle cells RGD PMID:22112851 RGD:401959395 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression ISO Oxidized-LDL increases expression of PTPN1 mRNA and protein in endothelial cell of umbilical vein RGD PMID:35747159 RGD:401976383 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    chemical entity 20869
      molecular entity 20868
        polyatomic entity 20813
          non-covalently-bound molecular entity 6
            inclusion compound 6
              clathrate compound 6
                lipoprotein 6
                  high-density lipoprotein 1
                  intermediate-density lipoprotein 0
                  low-density lipoprotein + 6
                  very-low-density lipoprotein 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      carboacyl group 18080
                                        univalent carboacyl group 18080
                                          carbamoyl group 17916
                                            carboxamide 17916
                                              peptide 11667
                                                polypeptide 333
                                                  protein polypeptide chain 26
                                                    protein 26
                                                      simple protein 6
                                                        apoprotein 6
                                                          apolipoprotein 6
                                                            lipoprotein 6
                                                              high-density lipoprotein 1
                                                              intermediate-density lipoprotein 0
                                                              low-density lipoprotein + 6
                                                              very-low-density lipoprotein 0
paths to the root