Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hepatitis C protease inhibitor
go back to main search page
Accession:CHEBI:64924 term browser browse the term
Definition:An inhibitor of hepatitis C protease, an enzyme required for production of proteins needed for viral assembly.
Synonyms:related_synonym: hepatitis C protease inhibitors



show annotations for term's descendants           Sort by:
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO embelin results in decreased phosphorylation of AKT1 protein CTD PMID:24694877 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atg12 autophagy related 12 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO embelin results in increased cleavage of [ATG12 protein binds to ATG5 protein] CTD PMID:28722333 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO embelin results in increased expression of BAX protein CTD PMID:24694877 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO embelin results in decreased expression of BCL2 protein CTD PMID:24694877 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Becn1 beclin 1 increases expression ISO embelin results in increased expression of BECN1 protein CTD PMID:28722333 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases degradation
ISO embelin results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases degradation
multiple interactions
ISO embelin results in increased degradation of CASP9 protein
3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]
CTD PMID:28722333 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP embelin inhibits the reaction [Paraquat results in decreased expression of CAT protein] CTD PMID:32020686 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO embelin results in decreased expression of CCND1 protein CTD PMID:24694877 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 increases expression ISO embelin results in increased expression of CDH1 protein CTD PMID:24694877 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO embelin results in decreased expression of CDK2 protein CTD PMID:24694877 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO embelin results in decreased expression of CDK6 protein CTD PMID:24694877 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO embelin results in increased cleavage of DFFA protein CTD PMID:28722333 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO embelin results in decreased expression of GLI1 protein CTD PMID:24694877 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Gli2 GLI family zinc finger 2 decreases expression ISO embelin results in decreased expression of GLI2 protein CTD PMID:24694877 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:32020686 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
embelin inhibits the reaction [Paraquat results in increased expression of IL6 protein]
embelin inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]
CTD PMID:32020686 PMID:32735172 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO embelin results in decreased expression of KDR protein CTD PMID:24694877 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO embelin results in decreased expression of MKI67 protein CTD PMID:24694877 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO embelin results in decreased expression of MMP2 protein CTD PMID:24694877 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO embelin results in decreased expression of MMP9 protein CTD PMID:24694877 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO embelin results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]
CTD PMID:24694877 PMID:28722333 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO embelin results in decreased expression of PCNA protein CTD PMID:24694877 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO embelin results in decreased expression of PTGS2 protein CTD PMID:24694877 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP embelin inhibits the reaction [Paraquat results in increased phosphorylation of RELA protein] CTD PMID:32020686 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO embelin results in decreased expression of SNAI1 protein CTD PMID:24694877 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO embelin results in decreased expression of SNAI2 protein CTD PMID:24694877 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO embelin results in increased degradation of SQSTM1 protein CTD PMID:28722333 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO embelin inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein] CTD PMID:32735172 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
embelin inhibits the reaction [Paraquat results in increased expression of TNF protein]
embelin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
CTD PMID:32020686 PMID:32735172 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO embelin results in increased expression of TNFRSF10A protein CTD PMID:24694877 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO embelin results in decreased expression of VEGFA protein CTD PMID:24694877 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases activity
increases degradation
ISO embelin results in decreased activity of XIAP protein
embelin results in increased degradation of XIAP protein
CTD PMID:16339139 PMID:28722333 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 decreases expression ISO embelin results in decreased expression of ZEB1 protein CTD PMID:24694877 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
ledipasvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects binding ISO ledipasvir binds to ABCG2 protein CTD PMID:33954893 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558
JBrowse link
sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:69,614,744...69,622,594
Ensembl chr 1:69,616,601...69,660,558
JBrowse link
telaprevir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] CTD PMID:24927617 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        biochemical role 19579
          enzyme inhibitor 18775
            EC 3.* (hydrolase) inhibitor 18378
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 4480
                protease inhibitor 2288
                  hepatitis C protease inhibitor 39
                    5-O-methyl embelin 0
                    Epclusa 0
                    Harvoni 0
                    Technivie 0
                    Viekira Pak 0
                    arugosin C 0
                    boceprevir 0
                    embelin + 35
                    grazoprevir + 0
                    ledipasvir + 3
                    narlaprevir 0
                    paritaprevir + 0
                    sofosbuvir + 2
                    telaprevir 1
                    vaniprevir 0
paths to the root