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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lincomycin
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Accession:CHEBI:6472 term browser browse the term
Definition:A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
Synonyms:exact_synonym: methyl 6,8-dideoxy-6-({[(2S,4R)-1-methyl-4-propylpyrrolidin-2-yl]carbonyl}amino)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
 related_synonym: Cillimycin;   Formula=C18H34N2O6S;   InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11?,12-,13+,14-,15-,16-,18-/m1/s1;   InChIKey=OJMMVQQUTAEWLP-KIDUDLJLSA-N;   Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside;   SMILES=CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O;   lincomicina;   lincomycine;   lincomycinum
 xref: CAS:154-21-2;   DrugBank:DB01627;   Drug_Central:1582;   HMDB:HMDB0015564;   KEGG:C06812;   KEGG:C14002;   KEGG:D00223;   KEGG:D02346;   LINCS:LSM-5602
 xref_mesh: MESH:D008034
 xref: PMID:24324587;   Reaxys:707677;   Wikipedia:Lincomycin


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lincomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mr1 major histocompatibility complex, class I-related affects expression ISO Lincomycin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Lincomycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
clindamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein
Clindamycin results in increased expression of CYP3A4 mRNA		 CTD PMID:18505790 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Clindamycin results in increased expression of MMP13 mRNA CTD PMID:20338993 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Clindamycin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Clindamycin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
clindamycin phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity ISO clindamycin phosphate results in decreased activity of PON1 protein CTD PMID:16880604 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          lincomycin 6
            clindamycin + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        amino acid 16071
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12971
                                              glutamine family amino acid 10316
                                                L-proline 300
                                                  L-proline derivative 275
                                                    lincomycin 6
                                                      clindamycin + 5
paths to the root