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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:C21-steroid hormone
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Accession:CHEBI:64600 term browser browse the term
Definition:A steroid compound with a structure based on a 21-carbon (pregnane) skeleton that acts as a hormone.
Synonyms:related_synonym: C21-steroid hormones


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aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases secretion		 EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone]; Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP Aldosterone results in increased expression of ATP1A1 protein CTD PMID:28438630 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression EXP Aldosterone results in increased expression of GCLC protein CTD PMID:24512358 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Aldosterone results in increased expression of HMOX1 protein CTD PMID:24512358
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; acetovanillone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Aldosterone results in increased expression of and results in increased activity of NFE2L2 protein; diphenyleneiodonium inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Ro 32-0432 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; Thioctic Acid inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]; W 7 inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Aldosterone results in increased expression of SOD1 protein CTD PMID:24512358 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP Aldosterone results in increased expression of TXNRD1 protein CTD PMID:24512358 NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219 		JBrowse link
progesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases secretion EXP AGT protein results in increased secretion of Progesterone CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G CRABP1 cellular retinoic acid binding protein 1 affects expression EXP Progesterone affects the expression of CRABP1 protein CTD PMID:11833939 NCBI chr 7:47,602,316...47,608,865
Ensembl chr 7:47,602,192...47,608,970 		JBrowse link
G CST3 cystatin C affects expression EXP Progesterone affects the expression of CST3 mRNA CTD PMID:20107207 NCBI chr17:30,471,056...30,474,486
Ensembl chr17:30,470,855...30,474,590 		JBrowse link
G CTSB cathepsin B increases expression EXP Progesterone results in increased expression of CTSB mRNA CTD PMID:20107207 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877 		JBrowse link
G CTSL cathepsin L increases expression EXP Progesterone results in increased expression of CTSL mRNA CTD PMID:20107207 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618 		JBrowse link
G EGFR epidermal growth factor receptor affects chemical synthesis EXP EGFR protein affects the chemical synthesis of Progesterone CTD PMID:21520325 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Progesterone inhibits the reaction [estrone benzoate results in decreased expression of FGF2 mRNA] CTD PMID:15120423 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 multiple interactions
decreases expression		 EXP estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form] CTD PMID:15120423 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression
multiple interactions		 EXP Progesterone results in decreased expression of FGFR2 mRNA alternative form
[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of FGFR2 mRNA alternative form		 CTD PMID:15120423 PMID:15976484 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G FSHB follicle stimulating hormone subunit beta increases chemical synthesis
multiple interactions
increases abundance		 EXP FSHB protein results in increased chemical synthesis of Progesterone
4,4'-bisphenol F inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; 4,4'-hexafluorisopropylidene diphenol inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; [FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone; [FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone; bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; bisphenol S inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone; Lapatinib inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; Zearalenone promotes the reaction [FSHB protein results in increased abundance of Progesterone]		 CTD PMID:17656051 PMID:20390873 PMID:20965553 PMID:23375200 PMID:29544186 More... NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions
decreases secretion
increases secretion		 EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone]; GHRL protein results in decreased chemical synthesis of and results in decreased secretion of Progesterone; STAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone]
GHRL protein results in increased secretion of Progesterone		 CTD PMID:17904772 PMID:19528263 PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917 		JBrowse link
G HOXA10 homeobox A10 increases expression
multiple interactions		 EXP Progesterone results in increased expression of HOXA10 mRNA
Estradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA]		 CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases abundance		 EXP [FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; Zearalenone promotes the reaction [IGF1 protein results in increased abundance of Progesterone] CTD PMID:17656051 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G LEP leptin multiple interactions
increases secretion
increases expression		 EXP [TP53 protein co-treated with LEP protein] results in increased secretion of Progesterone
Progesterone results in increased secretion of LEP protein
Progesterone results in increased expression of LEP mRNA		 CTD PMID:22151798 PMID:23153703 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LHB luteinizing hormone subunit beta increases abundance
multiple interactions		 EXP LHB protein results in increased abundance of Progesterone
daidzein inhibits the reaction [LHB protein results in increased abundance of Progesterone]; Lapatinib inhibits the reaction [LHB protein results in increased abundance of Progesterone]		 CTD PMID:19617652 PMID:23375200 NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions EXP Progesterone affects the reaction [OXT protein results in increased abundance of Calcium]; Progesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]; Progesterone inhibits the reaction [OXT protein results in increased transport of Calcium] CTD PMID:16997130 PMID:21370738 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,586...32,606,546 		JBrowse link
G PLAU plasminogen activator, urokinase increases expression EXP Progesterone results in increased expression of PLAU mRNA CTD PMID:23103014 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172 		JBrowse link
G POMC proopiomelanocortin increases secretion EXP POMC protein results in increased secretion of Progesterone CTD PMID:22100847 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
G RBP4 retinol binding protein 4 affects expression EXP Progesterone affects the expression of RBP4 protein CTD PMID:11833939 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP STAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:19528263 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases secretion		 EXP [TP53 protein co-treated with LEP protein] results in increased secretion of Progesterone
TP53 protein results in decreased secretion of Progesterone		 CTD PMID:22151798 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5151
    role 5118
      biological role 5118
        molecular messenger 466
          hormone 415
            steroid hormone 46
              C21-steroid hormone 27
                5alpha-pregnane-3,20-dione 0
                aldosterone + 7
                progesterone + 21
                triamcinolone + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5151
    subatomic particle 5142
      composite particle 5142
        hadron 5142
          baryon 5142
            nucleon 5142
              atomic nucleus 5142
                atom 5142
                  main group element atom 5115
                    p-block element atom 5112
                      carbon group element atom 5030
                        carbon atom 5029
                          organic molecular entity 5029
                            organic molecule 4978
                              organic cyclic compound 4919
                                organic polycyclic compound 194
                                  steroid 110
                                    steroid hormone 46
                                      C21-steroid hormone 27
                                        5alpha-pregnane-3,20-dione 0
                                        aldosterone + 7
                                        progesterone + 21
                                        triamcinolone + 0
paths to the root