CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lidocaine
Accession: CHEBI:6456
browse the term
Definition: The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Synonyms: exact_synonym: N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
related_synonym: 2-(Diethylamino)-2',6'-acetoxylidide; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide; Formula=C14H22N2O; InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17); InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N; Lidoderm; SMILES=CCN(CC)CC(=O)Nc1c(C)cccc1C; alpha-diethylamino-2,6-dimethylacetanilide
xref: CAS:137-58-6; DrugBank:DB00281; Drug_Central:1579; HMDB:HMDB0014426; KEGG:C07073; KEGG:D00358; LINCS:LSM-3165
xref_mesh: MESH:D008012
xref: PMID:11106996; PMID:11120381; PMID:11431418; PMID:11692349; PMID:15056998; PMID:16668583; PMID:17214917; PMID:18940244; Patent:GB706409; Patent:GB758224; Patent:US2441498; Reaxys:2215784; VSDB:1903; Wikipedia:Lidocaine
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ABCA1
ATP binding cassette subfamily A member 1
increases expression
ISO
Lidocaine results in increased expression of ABCA1 mRNA
CTD
PMID:35283115
NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
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ABCA8
ATP binding cassette subfamily A member 8
decreases expression
ISO
Lidocaine results in decreased expression of ABCA8 mRNA
CTD
PMID:35283115
NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,867,289...68,955,392
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ABCB4
ATP binding cassette subfamily B member 4
increases expression
ISO
Lidocaine results in increased expression of ABCB4 mRNA
CTD
PMID:35283115
NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
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ACTN3
actinin alpha 3
increases expression
ISO
Lidocaine results in increased expression of ACTN3 mRNA
CTD
PMID:35283115
NCBI chr11:66,546,395...66,563,334
Ensembl chr11:66,546,395...66,563,334
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ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
increases expression
ISO
Lidocaine results in increased expression of ADAMTS13 mRNA
CTD
PMID:35283115
NCBI chr 9:133,414,337...133,459,386
Ensembl chr 9:133,414,358...133,459,402
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ADAMTS15
ADAM metallopeptidase with thrombospondin type 1 motif 15
decreases expression
ISO
Lidocaine results in decreased expression of ADAMTS15 mRNA
CTD
PMID:35283115
NCBI chr11:130,448,645...130,476,645
Ensembl chr11:130,448,645...130,476,645
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ADGRA2
adhesion G protein-coupled receptor A2
decreases expression
ISO
Lidocaine results in decreased expression of ADGRA2 mRNA
CTD
PMID:35283115
NCBI chr 8:37,796,883...37,844,896
Ensembl chr 8:37,784,191...37,844,896
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AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2
increases expression
ISO
Lidocaine results in increased expression of AGPAT2 mRNA
CTD
PMID:35283115
NCBI chr 9:136,673,143...136,687,457
Ensembl chr 9:136,673,143...136,687,457
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AKAP5
A-kinase anchoring protein 5
decreases expression
ISO
Lidocaine results in decreased expression of AKAP5 mRNA
CTD
PMID:35283115
NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503
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AKT1S1
AKT1 substrate 1
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
CTD
PMID:37914286
NCBI chr19:49,869,033...49,878,356
Ensembl chr19:49,869,033...49,878,459
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ALDH3B1
aldehyde dehydrogenase 3 family member B1
increases expression
ISO
Lidocaine results in increased expression of ALDH3B1 mRNA
CTD
PMID:35283115
NCBI chr11:68,008,547...68,029,276
Ensembl chr11:68,008,578...68,029,282
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ALOX12
arachidonate 12-lipoxygenase, 12S type
increases expression
ISO
Lidocaine results in increased expression of ALOX12 mRNA
CTD
PMID:35283115
NCBI chr17:6,996,049...7,010,754
Ensembl chr17:6,996,049...7,010,754
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ALPK1
alpha kinase 1
increases expression
ISO
Lidocaine results in increased expression of ALPK1 mRNA
CTD
PMID:35283115
NCBI chr 4:112,297,369...112,442,621
Ensembl chr 4:112,285,509...112,442,621
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AMDHD2
amidohydrolase domain containing 2
increases expression
ISO
Lidocaine results in increased expression of AMDHD2 mRNA
CTD
PMID:35283115
NCBI chr16:2,520,371...2,531,417
Ensembl chr16:2,520,357...2,531,422
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AMELX
amelogenin X-linked
increases expression
ISO
Lidocaine results in increased expression of AMELX mRNA
CTD
PMID:35283115
NCBI chr X:11,293,413...11,309,588
Ensembl chr X:11,293,413...11,300,761
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AMPD1
adenosine monophosphate deaminase 1
increases expression
ISO
Lidocaine results in increased expression of AMPD1 mRNA
CTD
PMID:35283115
NCBI chr 1:114,673,098...114,695,546
Ensembl chr 1:114,673,090...114,695,618
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ANGPT2
angiopoietin 2
decreases expression
ISO
Lidocaine results in decreased expression of ANGPT2 mRNA
CTD
PMID:35283115
NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409
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ANGPT4
angiopoietin 4
increases expression
ISO
Lidocaine results in increased expression of ANGPT4 mRNA
CTD
PMID:35283115
NCBI chr20:869,900...916,334
Ensembl chr20:869,900...916,334
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ANGPTL2
angiopoietin like 2
increases expression
ISO
Lidocaine results in increased expression of ANGPTL2 mRNA
CTD
PMID:35283115
NCBI chr 9:127,087,348...127,122,635
Ensembl chr 9:127,087,348...127,122,635
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ANKRD33B
ankyrin repeat domain 33B
increases expression
ISO
Lidocaine results in increased expression of ANKRD33B mRNA
CTD
PMID:35283115
NCBI chr 5:10,564,070...10,657,816
Ensembl chr 5:10,564,070...10,657,816
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ANP32A
acidic nuclear phosphoprotein 32 family member A
increases expression
ISO
Lidocaine results in increased expression of ANP32A mRNA
CTD
PMID:35283115
NCBI chr15:68,778,535...68,820,895
Ensembl chr15:68,778,535...68,820,897
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ANXA6
annexin A6
increases expression
ISO
Lidocaine results in increased expression of ANXA6 mRNA; Lidocaine results in increased expression of ANXA6 protein
CTD
PMID:27018092
NCBI chr 5:151,100,706...151,157,779
Ensembl chr 5:151,100,706...151,157,815
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AOC3
amine oxidase copper containing 3
decreases expression
ISO
Lidocaine results in decreased expression of AOC3 mRNA
CTD
PMID:35283115
NCBI chr17:42,851,199...42,858,124
Ensembl chr17:42,851,184...42,858,130
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APOBEC1
apolipoprotein B mRNA editing enzyme catalytic subunit 1
increases expression
ISO
Lidocaine results in increased expression of APOBEC1 mRNA
CTD
PMID:35283115
NCBI chr12:7,649,400...7,670,599
Ensembl chr12:7,649,400...7,665,908
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APOLD1
apolipoprotein L domain containing 1
increases expression
ISO
Lidocaine results in increased expression of APOLD1 mRNA
CTD
PMID:35283115
NCBI chr12:12,725,917...12,791,466
Ensembl chr12:12,725,917...12,829,975
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AQP4
aquaporin 4
decreases expression
ISO
Lidocaine results in decreased expression of AQP4 mRNA
CTD
PMID:35283115
NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771
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ARHGAP11A
Rho GTPase activating protein 11A
increases expression
ISO
Lidocaine results in increased expression of ARHGAP11A mRNA
CTD
PMID:35283115
NCBI chr15:32,615,144...32,639,941
Ensembl chr15:32,615,144...32,639,941
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ARHGAP30
Rho GTPase activating protein 30
decreases expression
ISO
Lidocaine results in decreased expression of ARHGAP30 mRNA
CTD
PMID:35283115
NCBI chr 1:161,046,946...161,069,891
Ensembl chr 1:161,046,946...161,069,970
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ARHGAP45
Rho GTPase activating protein 45
increases expression
ISO
Lidocaine results in increased expression of ARHGAP45 mRNA
CTD
PMID:35283115
NCBI chr19:1,065,959...1,086,628
Ensembl chr19:1,065,923...1,086,628
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ARHGEF3
Rho guanine nucleotide exchange factor 3
decreases expression
ISO
Lidocaine results in decreased expression of ARHGEF3 mRNA
CTD
PMID:35283115
NCBI chr 3:56,727,420...57,079,268
Ensembl chr 3:56,727,418...57,079,329
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ARL11
ARF like GTPase 11
increases expression
ISO
Lidocaine results in increased expression of ARL11 mRNA
CTD
PMID:35283115
NCBI chr13:49,628,507...49,633,872
Ensembl chr13:49,628,507...49,633,872
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ASPG
asparaginase
increases expression
ISO
Lidocaine results in increased expression of ASPG mRNA
CTD
PMID:35283115
NCBI chr14:104,085,700...104,115,582
Ensembl chr14:104,085,686...104,115,582
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ASPM
assembly factor for spindle microtubules
increases expression
ISO
Lidocaine results in increased expression of ASPM mRNA
CTD
PMID:35283115
NCBI chr 1:197,084,127...197,146,669
Ensembl chr 1:197,084,121...197,146,694
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ASPN
asporin
decreases expression
ISO
Lidocaine results in decreased expression of ASPN mRNA
CTD
PMID:35283115
NCBI chr 9:92,456,205...92,482,506
Ensembl chr 9:92,456,205...92,482,506
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ATAD2
ATPase family AAA domain containing 2
increases expression
ISO
Lidocaine results in increased expression of ATAD2 mRNA
CTD
PMID:35283115
NCBI chr 8:123,319,850...123,416,350
Ensembl chr 8:123,319,850...123,416,350
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ATAD5
ATPase family AAA domain containing 5
increases expression
ISO
Lidocaine results in increased expression of ATAD5 mRNA
CTD
PMID:35283115
NCBI chr17:30,831,966...30,895,869
Ensembl chr17:30,831,966...30,895,869
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ATP2C1
ATPase secretory pathway Ca2+ transporting 1
increases expression
ISO
Lidocaine results in increased expression of ATP2C1 mRNA
CTD
PMID:35283115
NCBI chr 3:130,850,595...131,016,712
Ensembl chr 3:130,850,595...131,016,712
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ATP6V0D2
ATPase H+ transporting V0 subunit d2
increases expression
ISO
Lidocaine results in increased expression of ATP6V0D2 mRNA
CTD
PMID:35283115
NCBI chr 8:86,098,910...86,154,225
Ensembl chr 8:85,987,323...86,154,225
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ATP8B4
ATPase phospholipid transporting 8B4 (putative)
increases expression
ISO
Lidocaine results in increased expression of ATP8B4 mRNA
CTD
PMID:35283115
NCBI chr15:49,858,238...50,181,854
Ensembl chr15:49,858,238...50,182,817
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AUNIP
aurora kinase A and ninein interacting protein
increases expression
ISO
Lidocaine results in increased expression of AUNIP mRNA
CTD
PMID:35283115
NCBI chr 1:25,831,906...25,859,457
Ensembl chr 1:25,831,913...25,859,458
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BAAT
bile acid-CoA:amino acid N-acyltransferase
increases expression
ISO
Lidocaine results in increased expression of BAAT mRNA
CTD
PMID:35283115
NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400
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BCL2L2
BCL2 like 2
decreases expression
ISO
Lidocaine results in decreased expression of BCL2L2 mRNA
CTD
PMID:35283115
NCBI chr14:23,306,833...23,311,751
Ensembl chr14:23,298,790...23,311,751
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BEST2
bestrophin 2
increases expression
ISO
Lidocaine results in increased expression of BEST2 mRNA
CTD
PMID:35283115
NCBI chr19:12,751,791...12,758,458
Ensembl chr19:12,751,702...12,758,458
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BIRC5
baculoviral IAP repeat containing 5
increases expression
ISO
Lidocaine results in increased expression of BIRC5 mRNA
CTD
PMID:35283115
NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
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BLK
BLK proto-oncogene, Src family tyrosine kinase
increases expression
ISO
Lidocaine results in increased expression of BLK mRNA
CTD
PMID:35283115
NCBI chr 8:11,494,387...11,564,599
Ensembl chr 8:11,486,894...11,564,599
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BLNK
B cell linker
increases expression
ISO
Lidocaine results in increased expression of BLNK mRNA
CTD
PMID:35283115
NCBI chr10:96,189,171...96,271,569
Ensembl chr10:96,189,171...96,271,587
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BLVRB
biliverdin reductase B
decreases expression
ISO
Lidocaine results in decreased expression of BLVRB protein
CTD
PMID:27018092
NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764
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BMF
Bcl2 modifying factor
increases expression
ISO
Lidocaine results in increased expression of BMF mRNA
CTD
PMID:35283115
NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
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BPIFA4P
BPI fold containing family A member 4, pseudogene
decreases expression
ISO
Lidocaine results in decreased expression of BPIFA5 mRNA
CTD
PMID:35283115
NCBI chr20:33,193,605...33,210,462
Ensembl chr20:33,193,585...33,210,462 Ensembl chr20:33,193,585...33,210,462
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BPIFB2
BPI fold containing family B member 2
decreases expression
ISO
Lidocaine results in decreased expression of BPIFB2 mRNA
CTD
PMID:35283115
NCBI chr20:33,007,704...33,023,703
Ensembl chr20:33,007,704...33,023,703
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BSN
bassoon presynaptic cytomatrix protein
decreases expression
ISO
Lidocaine results in decreased expression of BSN mRNA
CTD
PMID:35283115
NCBI chr 3:49,554,477...49,673,130
Ensembl chr 3:49,554,477...49,671,549
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BTC
betacellulin
increases expression
ISO
Lidocaine results in increased expression of BTC mRNA
CTD
PMID:35283115
NCBI chr 4:74,744,759...74,794,523
Ensembl chr 4:74,744,759...74,794,523
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BUB1
BUB1 mitotic checkpoint serine/threonine kinase
increases expression
ISO
Lidocaine results in increased expression of BUB1 mRNA
CTD
PMID:35283115
NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
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BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
increases expression
ISO
Lidocaine results in increased expression of BUB1B mRNA
CTD
PMID:35283115
NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123
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C1QC
complement C1q C chain
increases expression
ISO
Lidocaine results in increased expression of C1QC mRNA
CTD
PMID:35283115
NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,014...22,648,110
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C6orf132
chromosome 6 open reading frame 132
increases expression
ISO
Lidocaine results in increased expression of C9H6ORF132 mRNA
CTD
PMID:35283115
NCBI chr 6:42,101,119...42,142,620
Ensembl chr 6:42,092,233...42,142,620
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CALCA
calcitonin related polypeptide alpha
increases secretion increases expression multiple interactions
ISO
Lidocaine results in increased secretion of CALCA protein Lidocaine results in increased expression of CALCA mRNA capsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein] Lidocaine inhibits the reaction [Potassium results in increased secretion of CALCA protein]
CTD
PMID:18172555 PMID:18178321 PMID:35283115
NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
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CALHM2
calcium homeostasis modulator family member 2
increases expression
ISO
Lidocaine results in increased expression of CALHM2 mRNA
CTD
PMID:35283115
NCBI chr10:103,446,786...103,452,370
Ensembl chr10:103,446,786...103,452,402
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CAPG
capping actin protein, gelsolin like
increases expression
ISO
Lidocaine results in increased expression of CAPG mRNA
CTD
PMID:35283115
NCBI chr 2:85,391,602...85,419,540
Ensembl chr 2:85,394,753...85,418,432
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CASP3
caspase 3
decreases expression decreases activity increases activity
EXP ISO
Lidocaine results in decreased expression of CASP3 protein Lidocaine results in decreased activity of CASP3 protein Lidocaine results in increased activity of CASP3 protein
CTD
PMID:15099683 PMID:17585225 PMID:20194319 PMID:21047305
NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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CASP9
caspase 9
decreases expression multiple interactions increases expression
EXP ISO
Lidocaine results in decreased expression of CASP9 protein cordycepin inhibits the reaction [Lidocaine results in increased expression of CASP9 mRNA]; cordycepin inhibits the reaction [Lidocaine results in increased expression of CASP9 protein] Lidocaine results in increased expression of CASP9 mRNA; Lidocaine results in increased expression of CASP9 protein
CTD
PMID:20194319 PMID:29382532
NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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CCDC172
coiled-coil domain containing 172
decreases expression
ISO
Lidocaine results in decreased expression of CCDC172 mRNA
CTD
PMID:35283115
NCBI chr10:116,324,448...116,380,029
Ensembl chr10:116,324,448...116,380,029
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CCDC42
coiled-coil domain containing 42
decreases expression
ISO
Lidocaine results in decreased expression of CCDC42 mRNA
CTD
PMID:35283115
NCBI chr17:8,729,935...8,744,836
Ensembl chr17:8,729,935...8,745,219
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CCDC69
coiled-coil domain containing 69
increases expression
ISO
Lidocaine results in increased expression of CCDC69 mRNA
CTD
PMID:35283115
NCBI chr 5:151,181,052...151,224,092
Ensembl chr 5:151,181,052...151,224,093
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CCDC71L
coiled-coil domain containing 71 like
decreases expression
ISO
Lidocaine results in decreased expression of CCDC71L mRNA
CTD
PMID:35283115
NCBI chr 7:106,654,360...106,661,158
Ensembl chr 7:106,654,360...106,661,158
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CCL15
C-C motif chemokine ligand 15
increases expression
ISO
Lidocaine results in increased expression of CCL6 mRNA
CTD
PMID:35283115
NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553
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CCL19
C-C motif chemokine ligand 19
decreases expression
ISO
Lidocaine results in decreased expression of CCL19 mRNA
CTD
PMID:35283115
NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
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CCL2
C-C motif chemokine ligand 2
multiple interactions
EXP
Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
CTD
PMID:14570645
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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CCL20
C-C motif chemokine ligand 20
decreases expression
ISO
Lidocaine results in decreased expression of CCL20 mRNA
CTD
PMID:35283115
NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
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CCL3
C-C motif chemokine ligand 3
increases expression
ISO
Lidocaine results in increased expression of CCL3 mRNA
CTD
PMID:35283115
NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
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CCL4
C-C motif chemokine ligand 4
increases expression
ISO
Lidocaine results in increased expression of CCL4 mRNA
CTD
PMID:35283115
NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
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CCNA1
cyclin A1
affects expression
ISO
Lidocaine affects the expression of CCNA1 mRNA
CTD
PMID:18931217
NCBI chr13:36,431,517...36,442,870
Ensembl chr13:36,431,520...36,442,870
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CCNA2
cyclin A2
affects expression increases expression
ISO
Lidocaine affects the expression of CCNA2 mRNA Lidocaine results in increased expression of CCNA2 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883
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CCNB1
cyclin B1
affects expression increases expression
ISO
Lidocaine affects the expression of CCNB1 mRNA Lidocaine results in increased expression of CCNB1 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
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CCNB2
cyclin B2
affects expression increases expression
ISO
Lidocaine affects the expression of CCNB2 mRNA Lidocaine results in increased expression of CCNB2 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
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CCNC
cyclin C
affects expression
ISO
Lidocaine affects the expression of CCNC mRNA
CTD
PMID:18931217
NCBI chr 6:99,542,387...99,568,814
Ensembl chr 6:99,542,387...99,568,825
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CCND1
cyclin D1
affects expression
ISO
Lidocaine affects the expression of CCND1 mRNA
CTD
PMID:18931217
NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
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CCNE1
cyclin E1
affects expression
ISO
Lidocaine affects the expression of CCNE1 mRNA
CTD
PMID:18931217
NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
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CCNF
cyclin F
affects expression
ISO
Lidocaine affects the expression of CCNF mRNA
CTD
PMID:18931217
NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854
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CCR1
C-C motif chemokine receptor 1
decreases expression
ISO
Lidocaine results in decreased expression of CCR1 mRNA
CTD
PMID:35283115
NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313
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CD200R1
CD200 receptor 1
increases expression
ISO
Lidocaine results in increased expression of CD200R1 mRNA
CTD
PMID:35283115
NCBI chr 3:112,921,205...112,975,103
Ensembl chr 3:112,921,205...112,975,103
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CD276
CD276 molecule
increases expression
ISO
Lidocaine results in increased expression of CD276 mRNA
CTD
PMID:35283115
NCBI chr15:73,683,944...73,714,514
Ensembl chr15:73,683,966...73,714,514
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CD34
CD34 molecule
increases expression
ISO
Lidocaine results in increased expression of CD34 mRNA
CTD
PMID:35283115
NCBI chr 1:207,880,972...207,911,125
Ensembl chr 1:207,880,972...207,911,402
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CD48
CD48 molecule
increases expression
ISO
Lidocaine results in increased expression of CD48 mRNA
CTD
PMID:35283115
NCBI chr 1:160,678,746...160,711,822
Ensembl chr 1:160,678,746...160,711,831
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CD68
CD68 molecule
increases expression
ISO
Lidocaine results in increased expression of CD68 mRNA
CTD
PMID:35283115
NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
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CD72
CD72 molecule
increases expression
ISO
Lidocaine results in increased expression of CD72 mRNA
CTD
PMID:35283115
NCBI chr 9:35,609,982...35,646,857
Ensembl chr 9:35,609,982...35,646,810
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CD84
CD84 molecule
increases expression
ISO
Lidocaine results in increased expression of CD84 mRNA
CTD
PMID:35283115
NCBI chr 1:160,541,098...160,579,496
Ensembl chr 1:160,541,095...160,579,516
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CD86
CD86 molecule
increases expression
ISO
Lidocaine results in increased expression of CD86 mRNA
CTD
PMID:35283115
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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CDC20
cell division cycle 20
increases expression
ISO
Lidocaine results in increased expression of CDC20 mRNA
CTD
PMID:35283115
NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203
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CDC25C
cell division cycle 25C
increases expression
ISO
Lidocaine results in increased expression of CDC25C mRNA
CTD
PMID:35283115
NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
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CDC45
cell division cycle 45
increases expression
ISO
Lidocaine results in increased expression of CDC45 mRNA
CTD
PMID:35283115
NCBI chr22:19,479,466...19,520,612
Ensembl chr22:19,479,457...19,520,612
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CDC6
cell division cycle 6
increases expression
ISO
Lidocaine results in increased expression of CDC6 mRNA
CTD
PMID:35283115
NCBI chr17:40,287,879...40,304,657
Ensembl chr17:40,287,879...40,304,657
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CDCA3
cell division cycle associated 3
increases expression
ISO
Lidocaine results in increased expression of CDCA3 mRNA
CTD
PMID:35283115
NCBI chr12:6,844,798...6,851,286
Ensembl chr12:6,844,793...6,851,292
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CDCA7
cell division cycle associated 7
increases expression
ISO
Lidocaine results in increased expression of CDCA7 mRNA
CTD
PMID:35283115
NCBI chr 2:173,354,872...173,368,997
Ensembl chr 2:173,354,820...173,368,997
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CDCA7L
cell division cycle associated 7 like
increases expression
ISO
Lidocaine results in increased expression of CDCA7L mRNA
CTD
PMID:35283115
NCBI chr 7:21,900,899...21,945,899
Ensembl chr 7:21,900,899...21,945,903
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CDCA8
cell division cycle associated 8
increases expression
ISO
Lidocaine results in increased expression of CDCA8 mRNA
CTD
PMID:35283115
NCBI chr 1:37,692,516...37,709,719
Ensembl chr 1:37,692,481...37,709,719
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CDHR3
cadherin related family member 3
decreases expression
ISO
Lidocaine results in decreased expression of CDHR3 mRNA
CTD
PMID:35283115
NCBI chr 7:105,963,264...106,036,432
Ensembl chr 7:105,876,796...106,036,432
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CDK1
cyclin dependent kinase 1
increases expression
ISO
Lidocaine results in increased expression of CDK1 mRNA
CTD
PMID:35283115
NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
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CDK2
cyclin dependent kinase 2
affects expression increases expression
ISO
Lidocaine affects the expression of CDK2 mRNA Lidocaine results in increased expression of CDK2 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
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CDK4
cyclin dependent kinase 4
affects expression
ISO
Lidocaine affects the expression of CDK4 mRNA
CTD
PMID:18931217
NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
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CDK6
cyclin dependent kinase 6
increases expression
ISO
Lidocaine results in increased expression of CDK6 mRNA
CTD
PMID:35283115
NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573
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CDKL4
cyclin dependent kinase like 4
decreases expression
ISO
Lidocaine results in decreased expression of CDKL4 mRNA
CTD
PMID:35283115
NCBI chr 2:39,168,045...39,247,120
Ensembl chr 2:39,168,045...39,243,983
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CDKN1A
cyclin dependent kinase inhibitor 1A
affects expression increases expression
ISO
Lidocaine affects the expression of CDKN1A mRNA Lidocaine results in increased expression of CDKN1A mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397
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CDKN1B
cyclin dependent kinase inhibitor 1B
affects expression
ISO
Lidocaine affects the expression of CDKN1B mRNA
CTD
PMID:18931217
NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369
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CDKN2A
cyclin dependent kinase inhibitor 2A
affects expression
ISO
Lidocaine affects the expression of CDKN2A mRNA
CTD
PMID:18931217
NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
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CDKN2C
cyclin dependent kinase inhibitor 2C
increases expression
ISO
Lidocaine results in increased expression of CDKN2C mRNA
CTD
PMID:35283115
NCBI chr 1:50,960,745...50,974,634
Ensembl chr 1:50,960,745...50,974,634
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CDT1
chromatin licensing and DNA replication factor 1
increases expression
ISO
Lidocaine results in increased expression of CDT1 mRNA
CTD
PMID:35283115
NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
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CEACAM4
CEA cell adhesion molecule 4
increases expression
ISO
Lidocaine results in increased expression of CEACAM4 mRNA
CTD
PMID:35283115
NCBI chr19:41,613,436...41,627,074
Ensembl chr19:41,619,015...41,627,074
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CENPA
centromere protein A
increases expression
ISO
Lidocaine results in increased expression of CENPA mRNA
CTD
PMID:35283115
NCBI chr 2:26,786,056...26,794,589
Ensembl chr 2:26,764,289...26,801,067
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CENPE
centromere protein E
increases expression
ISO
Lidocaine results in increased expression of CENPE mRNA
CTD
PMID:35283115
NCBI chr 4:103,105,811...103,198,343
Ensembl chr 4:103,105,349...103,198,445
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CENPH
centromere protein H
increases expression
ISO
Lidocaine results in increased expression of CENPH mRNA
CTD
PMID:35283115
NCBI chr 5:69,189,583...69,210,357
Ensembl chr 5:69,189,574...69,210,357
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CENPM
centromere protein M
increases expression
ISO
Lidocaine results in increased expression of CENPM mRNA
CTD
PMID:35283115
NCBI chr22:41,927,196...41,947,152
Ensembl chr22:41,927,514...41,947,152
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CENPO
centromere protein O
increases expression
ISO
Lidocaine results in increased expression of CENPO mRNA
CTD
PMID:35283115
NCBI chr 2:24,793,425...24,822,376
Ensembl chr 2:24,793,136...24,822,376
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CENPT
centromere protein T
increases expression
ISO
Lidocaine results in increased expression of CENPT mRNA
CTD
PMID:35283115
NCBI chr16:67,828,157...67,847,693
Ensembl chr16:67,828,157...67,847,811
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CENPU
centromere protein U
increases expression
ISO
Lidocaine results in increased expression of CENPU mRNA
CTD
PMID:35283115
NCBI chr 4:184,694,085...184,734,096
Ensembl chr 4:184,694,085...184,734,130
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CENPW
centromere protein W
increases expression
ISO
Lidocaine results in increased expression of CENPW mRNA
CTD
PMID:35283115
NCBI chr 6:126,340,115...126,483,320
Ensembl chr 6:126,340,115...126,348,875
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CEP55
centrosomal protein 55
increases expression
ISO
Lidocaine results in increased expression of CEP55 mRNA
CTD
PMID:35283115
NCBI chr10:93,496,612...93,529,092
Ensembl chr10:93,496,612...93,529,092
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CEP72
centrosomal protein 72
increases expression
ISO
Lidocaine results in increased expression of CEP72 mRNA
CTD
PMID:35283115
NCBI chr 5:612,340...676,616
Ensembl chr 5:612,340...667,168
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CES1
carboxylesterase 1
increases hydrolysis
ISO
CES1D protein results in increased hydrolysis of Lidocaine
CTD
PMID:12019189
NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
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CFD
complement factor D
increases expression
ISO
Lidocaine results in increased expression of CFD mRNA
CTD
PMID:35283115
NCBI chr19:859,664...863,641
Ensembl chr19:859,453...867,884
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CGAS
cyclic GMP-AMP synthase
increases expression
ISO
Lidocaine results in increased expression of CGAS mRNA
CTD
PMID:35283115
NCBI chr 6:73,423,711...73,452,297
Ensembl chr 6:73,413,515...73,452,297
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CHAF1B
chromatin assembly factor 1 subunit B
increases expression
ISO
Lidocaine results in increased expression of CHAF1B mRNA
CTD
PMID:35283115
NCBI chr21:36,385,392...36,419,015
Ensembl chr21:36,385,392...36,419,015
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CHODL
chondrolectin
decreases expression
ISO
Lidocaine results in decreased expression of CHODL mRNA
CTD
PMID:35283115
NCBI chr21:17,917,340...18,267,370
Ensembl chr21:17,901,263...18,267,373
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CHTF18
chromosome transmission fidelity factor 18
increases expression
ISO
Lidocaine results in increased expression of CHTF18 mRNA
CTD
PMID:35283115
NCBI chr16:788,620...798,074
Ensembl chr16:788,046...800,737
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CIP2A
cellular inhibitor of PP2A
increases expression
ISO
Lidocaine results in increased expression of CIP2A mRNA
CTD
PMID:35283115
NCBI chr 3:108,549,864...108,589,438
Ensembl chr 3:108,549,864...108,589,644
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CKAP2
cytoskeleton associated protein 2
increases expression
ISO
Lidocaine results in increased expression of CKAP2 mRNA
CTD
PMID:35283115
NCBI chr13:52,455,478...52,476,627
Ensembl chr13:52,455,429...52,476,628
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CKS2
CDC28 protein kinase regulatory subunit 2
increases expression
ISO
Lidocaine results in increased expression of CKS2 mRNA
CTD
PMID:35283115
NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703
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CLCF1
cardiotrophin like cytokine factor 1
increases expression
ISO
Lidocaine results in increased expression of CLCF1 mRNA
CTD
PMID:35283115
NCBI chr11:67,364,168...67,374,177
Ensembl chr11:67,364,168...67,374,177
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CLDN14
claudin 14
increases expression
ISO
Lidocaine results in increased expression of CLDN14 mRNA
CTD
PMID:35283115
NCBI chr21:36,460,621...36,576,569
Ensembl chr21:36,460,621...36,576,569
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CLDN23
claudin 23
increases expression
ISO
Lidocaine results in increased expression of CLDN23 mRNA
CTD
PMID:35283115
NCBI chr 8:8,701,937...8,704,096
Ensembl chr 8:8,701,937...8,704,096
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CLEC12A
C-type lectin domain family 12 member A
increases expression
ISO
Lidocaine results in increased expression of CLEC12A mRNA
CTD
PMID:35283115
NCBI chr12:9,951,268...10,006,150
Ensembl chr12:9,951,316...9,995,694
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CLEC2D
C-type lectin domain family 2 member D
increases expression
ISO
Lidocaine results in increased expression of CLEC2D mRNA
CTD
PMID:35283115
NCBI chr12:9,669,713...9,699,553
Ensembl chr12:9,664,969...9,699,553
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CLEC4E
C-type lectin domain family 4 member E
decreases expression
ISO
Lidocaine results in decreased expression of CLEC4E mRNA
CTD
PMID:35283115
NCBI chr12:8,533,275...8,540,905
Ensembl chr12:8,533,305...8,540,905
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CLEC7A
C-type lectin domain containing 7A
increases expression
ISO
Lidocaine results in increased expression of CLEC7A mRNA
CTD
PMID:35283115
NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258
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CMTM3
CKLF like MARVEL transmembrane domain containing 3
increases expression
ISO
Lidocaine results in increased expression of CMTM3 mRNA
CTD
PMID:35283115
NCBI chr16:66,603,996...66,613,892
Ensembl chr16:66,603,874...66,613,892
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CNDP1
carnosine dipeptidase 1
increases expression
ISO
Lidocaine results in increased expression of CNDP1 mRNA
CTD
PMID:35283115
NCBI chr18:74,534,500...74,587,212
Ensembl chr18:74,534,500...74,587,212
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CNGA2
cyclic nucleotide gated channel subunit alpha 2
increases expression
ISO
Lidocaine results in increased expression of CNGA2 mRNA
CTD
PMID:35283115
NCBI chr X:151,734,746...151,745,564
Ensembl chr X:151,734,746...151,745,564
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CNR2
cannabinoid receptor 2
increases expression
ISO
Lidocaine results in increased expression of CNR2 mRNA
CTD
PMID:35283115
NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362
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CNTN5
contactin 5
decreases expression
ISO
Lidocaine results in decreased expression of CNTN5 mRNA
CTD
PMID:35283115
NCBI chr11:99,020,949...100,358,885
Ensembl chr11:99,020,949...100,358,885
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CNTNAP1
contactin associated protein 1
decreases expression
ISO
Lidocaine results in decreased expression of CNTNAP1 mRNA
CTD
PMID:35283115
NCBI chr17:42,682,531...42,699,993
Ensembl chr17:42,682,531...42,699,993
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CNTNAP3
contactin associated protein family member 3
increases expression
ISO
Lidocaine results in increased expression of CNTNAP3 mRNA
CTD
PMID:35283115
NCBI chr 9:39,064,710...39,288,167
Ensembl chr 9:39,064,710...39,288,315
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CP
ceruloplasmin
decreases expression
ISO
Lidocaine results in decreased expression of CP mRNA
CTD
PMID:35283115
NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829
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CRH
corticotropin releasing hormone
increases expression
ISO
Lidocaine results in increased expression of CRH mRNA
CTD
PMID:35283115
NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
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CRISPLD1
cysteine rich secretory protein LCCL domain containing 1
decreases expression
ISO
Lidocaine results in decreased expression of CRISPLD1 mRNA
CTD
PMID:35283115
NCBI chr 8:74,984,505...75,034,558
Ensembl chr 8:74,984,505...75,034,558
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CRTAP
cartilage associated protein
increases expression
ISO
Lidocaine results in increased expression of CRTAP mRNA
CTD
PMID:35283115
NCBI chr 3:33,114,014...33,147,773
Ensembl chr 3:33,114,014...33,147,773
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CSF2RA
colony stimulating factor 2 receptor subunit alpha
increases expression
ISO
Lidocaine results in increased expression of CSF2RA mRNA
CTD
PMID:35283115
NCBI chr X:1,268,814...1,325,218 NCBI chr Y:1,268,814...1,325,218
Ensembl chr Y:1,268,793...1,325,373 Ensembl chr X:1,268,793...1,325,373
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CSRP3
cysteine and glycine rich protein 3
increases expression
ISO
Lidocaine results in increased expression of CSRP3 mRNA
CTD
PMID:35283115
NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
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CTSC
cathepsin C
increases expression
ISO
Lidocaine results in increased expression of CTSC mRNA
CTD
PMID:35283115
NCBI chr11:88,293,592...88,337,736
Ensembl chr11:88,265,069...88,359,684
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CTSZ
cathepsin Z
increases expression
ISO
Lidocaine results in increased expression of CTSZ mRNA
CTD
PMID:35283115
NCBI chr20:58,995,185...59,007,254
Ensembl chr20:58,985,686...59,008,238
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CUX1
cut like homeobox 1
increases expression
ISO
Lidocaine results in increased expression of CUX1 mRNA
CTD
PMID:35283115
NCBI chr 7:101,816,007...102,283,958
Ensembl chr 7:101,815,904...102,283,958
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CXCL1
C-X-C motif chemokine ligand 1
decreases expression
ISO
Lidocaine results in decreased expression of CXCL1 mRNA
CTD
PMID:35283115
NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
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CXCL12
C-X-C motif chemokine ligand 12
decreases expression
ISO
Lidocaine results in decreased expression of CXCL12 mRNA
CTD
PMID:35283115
NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493
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CXCL13
C-X-C motif chemokine ligand 13
decreases expression
ISO
Lidocaine results in decreased expression of CXCL13 mRNA
CTD
PMID:35283115
NCBI chr 4:77,511,753...77,611,834
Ensembl chr 4:77,511,753...77,611,834
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CXCL16
C-X-C motif chemokine ligand 16
increases expression
ISO
Lidocaine results in increased expression of CXCL16 mRNA
CTD
PMID:35283115
NCBI chr17:4,733,533...4,739,928
Ensembl chr17:4,733,533...4,739,928
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CXCL8
C-X-C motif chemokine ligand 8
multiple interactions
EXP
[Methylprednisolone co-treated with Lidocaine] results in decreased expression of CXCL8 protein
CTD
PMID:11280320
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CYBB
cytochrome b-245 beta chain
increases expression
ISO
Lidocaine results in increased expression of CYBB mRNA
CTD
PMID:35283115
NCBI chr X:37,780,059...37,813,461
Ensembl chr X:37,780,018...37,813,461
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CYP1A2
cytochrome P450 family 1 subfamily A member 2
affects metabolic processing
EXP
CYP1A2 protein affects the metabolism of Lidocaine
CTD
PMID:15447735
NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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CYP2D7
cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
increases expression
ISO
Lidocaine results in increased expression of CYP2D1 mRNA
CTD
PMID:35283115
NCBI chr22:42,139,576...42,144,483
Ensembl chr22:42,140,203...42,149,455
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CYP3A4
cytochrome P450 family 3 subfamily A member 4
affects metabolic processing increases metabolic processing decreases ethylation decreases methylation multiple interactions
EXP
CYP3A4 protein affects the metabolism of Lidocaine CYP3A4 protein results in increased metabolism of Lidocaine CYP3A4 protein results in decreased ethylation of Lidocaine CYP3A4 protein results in decreased methylation of Lidocaine Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine]
CTD
PMID:9298257 PMID:15383492 PMID:15447735 PMID:15887009 PMID:18846481
NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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CYP3A5
cytochrome P450 family 3 subfamily A member 5
decreases methylation
EXP
CYP3A5 protein results in decreased methylation of Lidocaine
CTD
PMID:15383492
NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
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CYTIP
cytohesin 1 interacting protein
increases expression
ISO
Lidocaine results in increased expression of CYTIP mRNA
CTD
PMID:35283115
NCBI chr 2:157,414,619...157,444,089
Ensembl chr 2:157,409,360...157,491,093
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DAPL1
death associated protein like 1
increases expression
ISO
Lidocaine results in increased expression of DAPL1 mRNA
CTD
PMID:35283115
NCBI chr 2:158,795,317...158,815,990
Ensembl chr 2:158,795,317...158,862,781
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DBF4
DBF4-CDC7 kinase regulatory subunit
increases expression
ISO
Lidocaine results in increased expression of DBF4 mRNA
CTD
PMID:35283115
NCBI chr 7:87,876,493...87,909,553
Ensembl chr 7:87,876,216...87,909,553
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DCN
decorin
decreases expression
ISO
Lidocaine results in decreased expression of DCN mRNA
CTD
PMID:35283115
NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
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DDAH2
DDAH family member 2, ADMA-independent
decreases expression increases expression
ISO
Lidocaine results in decreased expression of DDAH2 protein Lidocaine results in increased expression of DDAH2 mRNA
CTD
PMID:27018092
NCBI chr 6:31,727,040...31,730,263
Ensembl chr 6:31,727,038...31,730,617
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DDIAS
DNA damage induced apoptosis suppressor
increases expression
ISO
Lidocaine results in increased expression of DDIAS mRNA
CTD
PMID:35283115
NCBI chr11:82,901,736...82,934,659
Ensembl chr11:82,899,975...82,958,277
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DDX60
DExD/H-box helicase 60
increases expression
ISO
Lidocaine results in increased expression of DDX60 mRNA
CTD
PMID:35283115
NCBI chr 4:168,216,294...168,325,979
Ensembl chr 4:168,216,291...168,318,883
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DENND2D
DENN domain containing 2D
increases expression
ISO
Lidocaine results in increased expression of DENND2D mRNA
CTD
PMID:35283115
NCBI chr 1:111,185,969...111,204,578
Ensembl chr 1:111,185,969...111,204,535
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DEPTOR
DEP domain containing MTOR interacting protein
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
CTD
PMID:37914286
NCBI chr 8:119,873,722...120,050,918
Ensembl chr 8:119,873,717...120,050,918
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DIAPH3
diaphanous related formin 3
increases expression
ISO
Lidocaine results in increased expression of DIAPH3 mRNA
CTD
PMID:35283115
NCBI chr13:59,665,583...60,163,928
Ensembl chr13:59,665,583...60,163,928
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DIO3
iodothyronine deiodinase 3
decreases expression
ISO
Lidocaine results in decreased expression of DIO3 mRNA
CTD
PMID:35283115
NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452
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DLGAP5
DLG associated protein 5
increases expression
ISO
Lidocaine results in increased expression of DLGAP5 mRNA
CTD
PMID:35283115
NCBI chr14:55,148,135...55,191,585
Ensembl chr14:55,148,112...55,191,608
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DNAJB7
DnaJ heat shock protein family (Hsp40) member B7
decreases expression
ISO
Lidocaine results in decreased expression of DNAJB7 mRNA
CTD
PMID:35283115
NCBI chr22:40,859,549...40,862,113
Ensembl chr22:40,859,549...40,862,113
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DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
increases expression
ISO
Lidocaine results in increased expression of DNAJC22 mRNA
CTD
PMID:35283115
NCBI chr12:49,346,888...49,353,690
Ensembl chr12:49,346,888...49,357,546
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DNASE2
deoxyribonuclease 2, lysosomal
increases expression
ISO
Lidocaine results in increased expression of DNASE2 mRNA
CTD
PMID:35283115
NCBI chr19:12,875,209...12,881,449
Ensembl chr19:12,875,209...12,881,595
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DOCK8
dedicator of cytokinesis 8
increases expression
ISO
Lidocaine results in increased expression of DOCK8 mRNA
CTD
PMID:35283115
NCBI chr 9:211,257...465,255
Ensembl chr 9:214,854...465,259
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DPEP2
dipeptidase 2
increases expression
ISO
Lidocaine results in increased expression of DPEP2 mRNA
CTD
PMID:35283115
NCBI chr16:67,987,390...68,000,619
Ensembl chr16:67,987,394...68,000,586
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DPH6
diphthamine biosynthesis 6
decreases expression
ISO
Lidocaine results in decreased expression of DPH6 mRNA
CTD
PMID:35283115
NCBI chr15:35,144,977...35,546,165
Ensembl chr15:35,217,345...35,546,193
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DSCC1
DNA replication and sister chromatid cohesion 1
increases expression
ISO
Lidocaine results in increased expression of DSCC1 mRNA
CTD
PMID:35283115
NCBI chr 8:119,833,976...119,855,894
Ensembl chr 8:119,833,976...119,855,894
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DTL
denticleless E3 ubiquitin protein ligase homolog
decreases expression
ISO
Lidocaine results in decreased expression of DTL mRNA
CTD
PMID:35283115
NCBI chr 1:212,035,748...212,105,013
Ensembl chr 1:212,035,553...212,107,400
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DTX4
deltex E3 ubiquitin ligase 4
increases expression
ISO
Lidocaine results in increased expression of DTX4 mRNA
CTD
PMID:35283115
NCBI chr11:59,171,430...59,208,588
Ensembl chr11:59,171,430...59,208,588
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E2F1
E2F transcription factor 1
affects expression
ISO
Lidocaine affects the expression of E2F1 mRNA
CTD
PMID:18931217
NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
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E2F2
E2F transcription factor 2
affects expression
ISO
Lidocaine affects the expression of E2F2 mRNA
CTD
PMID:18931217
NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233
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E2F3
E2F transcription factor 3
affects expression increases expression
ISO
Lidocaine affects the expression of E2F3 mRNA Lidocaine results in increased expression of E2F3 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714
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E2F4
E2F transcription factor 4
affects expression
ISO
Lidocaine affects the expression of E2F4 mRNA
CTD
PMID:18931217
NCBI chr16:67,192,155...67,198,918
Ensembl chr16:67,192,155...67,198,918
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ECT2
epithelial cell transforming 2
increases expression
ISO
Lidocaine results in increased expression of ECT2 mRNA
CTD
PMID:35283115
NCBI chr 3:172,750,726...172,829,265
Ensembl chr 3:172,750,682...172,821,474
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EFCAB11
EF-hand calcium binding domain 11
increases expression
ISO
Lidocaine results in increased expression of EFCAB11 mRNA
CTD
PMID:35283115
NCBI chr14:89,794,669...89,954,777
Ensembl chr14:89,794,669...89,954,777
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EGR1
early growth response 1
increases expression
ISO
Lidocaine results in increased expression of EGR1 mRNA
CTD
PMID:35283115
NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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EGR2
early growth response 2
increases expression
ISO
Lidocaine results in increased expression of EGR2 mRNA
CTD
PMID:35283115
NCBI chr10:62,811,996...62,819,167
Ensembl chr10:62,811,996...62,819,167
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EME1
essential meiotic structure-specific endonuclease 1
increases expression
ISO
Lidocaine results in increased expression of EME1 mRNA
CTD
PMID:35283115
NCBI chr17:50,373,229...50,381,483
Ensembl chr17:50,373,220...50,381,483
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EMP1
epithelial membrane protein 1
increases expression
ISO
Lidocaine results in increased expression of EMP1 mRNA
CTD
PMID:35283115
NCBI chr12:13,196,726...13,219,941
Ensembl chr12:13,196,723...13,219,941
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EMP3
epithelial membrane protein 3 (MAM blood group)
increases expression
ISO
Lidocaine results in increased expression of EMP3 mRNA
CTD
PMID:35283115
NCBI chr19:48,325,552...48,330,553
Ensembl chr19:48,321,310...48,330,559
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ENGASE
endo-beta-N-acetylglucosaminidase
increases expression
ISO
Lidocaine results in increased expression of ENGASE mRNA
CTD
PMID:35283115
NCBI chr17:79,074,824...79,088,599
Ensembl chr17:79,074,824...79,088,599
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EPCAM
epithelial cell adhesion molecule
increases expression
ISO
Lidocaine results in increased expression of EPCAM mRNA
CTD
PMID:35283115
NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601
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EPOR
erythropoietin receptor
increases expression
ISO
Lidocaine results in increased expression of EPOR mRNA
CTD
PMID:35283115
NCBI chr19:11,377,207...11,384,314
Ensembl chr19:11,377,207...11,384,342
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EPSTI1
epithelial stromal interaction 1
increases expression
ISO
Lidocaine results in increased expression of EPSTI1 mRNA
CTD
PMID:35283115
NCBI chr13:42,886,388...42,992,241
Ensembl chr13:42,886,388...42,992,271
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ERCC6L
ERCC excision repair 6 like, spindle assembly checkpoint helicase
increases expression
ISO
Lidocaine results in increased expression of ERCC6L mRNA
CTD
PMID:35283115
NCBI chr X:72,204,665...72,239,027
Ensembl chr X:72,204,657...72,239,027
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ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
increases expression
ISO
Lidocaine results in increased expression of ESCO2 mRNA
CTD
PMID:35283115
NCBI chr 8:27,771,974...27,819,660
Ensembl chr 8:27,771,949...27,812,640
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ESM1
endothelial cell specific molecule 1
decreases expression
ISO
Lidocaine results in decreased expression of ESM1 mRNA
CTD
PMID:35283115
NCBI chr 5:54,977,867...54,985,593
Ensembl chr 5:54,977,867...55,022,671
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ESPL1
extra spindle pole bodies like 1, separase
increases expression
ISO
Lidocaine results in increased expression of ESPL1 mRNA
CTD
PMID:35283115
NCBI chr12:53,268,299...53,293,638
Ensembl chr12:53,268,299...53,293,638
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ESR1
estrogen receptor 1
increases expression
EXP
Lidocaine results in increased expression of ESR1 mRNA
CTD
PMID:22083529
NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619
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F10
coagulation factor X
increases expression
ISO
Lidocaine results in increased expression of F10 mRNA
CTD
PMID:35283115
NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529
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F2RL3
F2R like thrombin or trypsin receptor 3
increases expression
ISO
Lidocaine results in increased expression of F2RL3 mRNA
CTD
PMID:35283115
NCBI chr19:16,888,999...16,892,606
Ensembl chr19:16,888,999...16,892,606
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FAM72A
family with sequence similarity 72 member A
increases expression
ISO
Lidocaine results in increased expression of FAM72A mRNA
CTD
PMID:35283115
NCBI chr 1:206,186,179...206,205,773
Ensembl chr 1:206,186,179...206,204,414
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FANCD2
FA complementation group D2
increases expression
ISO
Lidocaine results in increased expression of FANCD2 mRNA
CTD
PMID:35283115
NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,370...10,101,932
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FBLN2
fibulin 2
increases expression
ISO
Lidocaine results in increased expression of FBLN2 mRNA
CTD
PMID:35283115
NCBI chr 3:13,549,125...13,638,404
Ensembl chr 3:13,549,125...13,638,422
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FBXL21P
F-box and leucine rich repeat protein 21, pseudogene
increases expression
ISO
Lidocaine results in increased expression of FBXL21 mRNA
CTD
PMID:35283115
NCBI chr 5:135,930,297...135,941,996
Ensembl chr 5:135,934,368...135,941,671
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FBXO5
F-box protein 5
increases expression
ISO
Lidocaine results in increased expression of FBXO5 mRNA
CTD
PMID:35283115
NCBI chr 6:152,970,535...152,983,579
Ensembl chr 6:152,970,519...152,983,579
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FCRL2
Fc receptor like 2
increases expression
ISO
Lidocaine results in increased expression of FCRL2 mRNA
CTD
PMID:35283115
NCBI chr 1:157,745,733...157,777,132
Ensembl chr 1:157,745,733...157,777,132
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FGD2
FYVE, RhoGEF and PH domain containing 2
increases expression
ISO
Lidocaine results in increased expression of FGD2 mRNA
CTD
PMID:35283115
NCBI chr 6:37,005,655...37,029,069
Ensembl chr 6:37,005,646...37,029,299
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FGF20
fibroblast growth factor 20
decreases expression
ISO
Lidocaine results in decreased expression of FGF20 mRNA
CTD
PMID:35283115
NCBI chr 8:16,992,181...17,002,345
Ensembl chr 8:16,992,181...17,002,345
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FGFBP1
fibroblast growth factor binding protein 1
decreases expression
ISO
Lidocaine results in decreased expression of FGFBP1 mRNA
CTD
PMID:35283115
NCBI chr 4:15,935,577...15,938,740
Ensembl chr 4:15,935,577...15,938,740
G
FIGNL1
fidgetin like 1
increases expression
ISO
Lidocaine results in increased expression of FIGNL1 mRNA
CTD
PMID:35283115
NCBI chr 7:50,444,133...50,450,350
Ensembl chr 7:50,444,128...50,450,390
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FITM1
fat storage inducing transmembrane protein 1
increases expression
ISO
Lidocaine results in increased expression of FITM1 mRNA
CTD
PMID:35283115
NCBI chr14:24,130,659...24,132,847
Ensembl chr14:24,130,659...24,132,849
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FLNC
filamin C
increases expression
ISO
Lidocaine results in increased expression of FLNC mRNA
CTD
PMID:35283115
NCBI chr 7:128,830,406...128,859,272
Ensembl chr 7:128,830,406...128,859,274
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FLT3
fms related receptor tyrosine kinase 3
decreases expression
ISO
Lidocaine results in decreased expression of FLT3 mRNA
CTD
PMID:35283115
NCBI chr13:28,003,274...28,100,576
Ensembl chr13:28,003,274...28,100,592
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FOLR2
folate receptor beta
increases expression
ISO
Lidocaine results in increased expression of FOLR2 mRNA
CTD
PMID:35283115
NCBI chr11:72,216,794...72,221,950
Ensembl chr11:72,216,601...72,221,950
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions affects expression
ISO
Lidocaine inhibits the reaction [Bee Venoms promotes the reaction [Methamphetamine results in increased expression of FOS protein]] Lidocaine inhibits the reaction [Propofol results in increased expression of FOS protein] Lidocaine affects the expression of FOS protein
CTD
PMID:7887109 PMID:17136530 PMID:20950675
NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190
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FSCN3
fascin actin-bundling protein 3
increases expression
ISO
Lidocaine results in increased expression of FSCN3 mRNA
CTD
PMID:35283115
NCBI chr 7:127,593,736...127,602,144
Ensembl chr 7:127,591,409...127,602,144
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GALC
galactosylceramidase
increases expression
ISO
Lidocaine results in increased expression of GALC mRNA
CTD
PMID:35283115
NCBI chr14:87,933,014...87,993,667
Ensembl chr14:87,837,820...87,993,665
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GALNT3
polypeptide N-acetylgalactosaminyltransferase 3
increases expression
ISO
Lidocaine results in increased expression of GALNT3 mRNA
CTD
PMID:35283115
NCBI chr 2:165,747,588...165,794,692
Ensembl chr 2:165,747,588...165,846,201
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GASK1B
golgi associated kinase 1B
increases expression
ISO
Lidocaine results in increased expression of FAM198B mRNA
CTD
PMID:35283115
NCBI chr 4:158,124,474...158,173,025
Ensembl chr 4:158,124,474...158,173,318
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GDF15
growth differentiation factor 15
increases expression
ISO
Lidocaine results in increased expression of GDF15 mRNA
CTD
PMID:35283115
NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176
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GDF3
growth differentiation factor 3
increases expression
ISO
Lidocaine results in increased expression of GDF3 mRNA
CTD
PMID:35283115
NCBI chr12:7,689,784...7,695,775
Ensembl chr12:7,689,784...7,695,775
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GDF7
growth differentiation factor 7
decreases expression
ISO
Lidocaine results in decreased expression of GDF7 mRNA
CTD
PMID:35283115
NCBI chr 2:20,667,144...20,679,243
Ensembl chr 2:20,667,144...20,679,243
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GDNF
glial cell derived neurotrophic factor
increases expression
ISO
Lidocaine results in increased expression of GDNF mRNA
CTD
PMID:35283115
NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041
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GEN1
GEN1 Holliday junction 5' flap endonuclease
increases expression
ISO
Lidocaine results in increased expression of GEN1 mRNA
CTD
PMID:35283115
NCBI chr 2:17,753,278...17,788,946
Ensembl chr 2:17,753,858...17,788,946
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GINS1
GINS complex subunit 1
increases expression
ISO
Lidocaine results in increased expression of GINS1 mRNA
CTD
PMID:35283115
NCBI chr20:25,407,673...25,448,563
Ensembl chr20:25,391,008...25,452,700
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GLDN
gliomedin
increases expression
ISO
Lidocaine results in increased expression of GLDN mRNA
CTD
PMID:35283115
NCBI chr15:51,341,655...51,413,365
Ensembl chr15:51,341,655...51,408,005
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GLIPR1
GLI pathogenesis related 1
increases expression
ISO
Lidocaine results in increased expression of GLIPR1 mRNA
CTD
PMID:35283115
NCBI chr12:75,480,755...75,503,863
Ensembl chr12:75,480,753...75,503,863
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GNB2
G protein subunit beta 2
increases expression
ISO
Lidocaine results in increased expression of GNB2 mRNA; Lidocaine results in increased expression of GNB2 protein
CTD
PMID:27018092
NCBI chr 7:100,673,740...100,679,169
Ensembl chr 7:100,673,567...100,679,174
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GPNMB
glycoprotein nmb
increases expression
ISO
Lidocaine results in increased expression of GPNMB mRNA
CTD
PMID:35283115
NCBI chr 7:23,246,775...23,275,108
Ensembl chr 7:23,235,967...23,275,108
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GPR182
G protein-coupled receptor 182
decreases expression
ISO
Lidocaine results in decreased expression of GPR182 mRNA
CTD
PMID:35283115
NCBI chr12:56,994,492...56,998,877
Ensembl chr12:56,994,492...56,998,447
G
GPR31
G protein-coupled receptor 31
increases expression
ISO
Lidocaine results in increased expression of GPR31 mRNA
CTD
PMID:35283115
NCBI chr 6:167,155,247...167,157,980
Ensembl chr 6:167,155,247...167,157,980
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GPR34
G protein-coupled receptor 34
increases expression
ISO
Lidocaine results in increased expression of GPR34 mRNA
CTD
PMID:35283115
NCBI chr X:41,688,973...41,697,275
Ensembl chr X:41,688,973...41,697,275
G
GPR65
G protein-coupled receptor 65
increases expression
ISO
Lidocaine results in increased expression of GPR65 mRNA
CTD
PMID:35283115
NCBI chr14:88,005,135...88,014,811
Ensembl chr14:88,005,135...88,014,811
G
GRN
granulin precursor
increases expression
ISO
Lidocaine results in increased expression of GRN mRNA
CTD
PMID:35283115
NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106
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GSG1
germ cell associated 1
increases expression
ISO
Lidocaine results in increased expression of GSG1 mRNA
CTD
PMID:35283115
NCBI chr12:13,083,532...13,103,667
Ensembl chr12:13,083,532...13,103,683
G
H1-9P
H1.9 linker histone, pseudogene
increases expression
ISO
Lidocaine results in increased expression of HILS1 mRNA
CTD
PMID:35283115
NCBI chr17:50,171,428...50,172,476
Ensembl chr17:50,171,514...50,171,936
G
H19
H19 imprinted maternally expressed transcript
increases expression
ISO
Lidocaine results in increased expression of H19 mRNA
CTD
PMID:35283115
NCBI chr11:1,995,176...2,001,266
Ensembl chr11:1,995,165...2,004,552
G
H2AC11
H2A clustered histone 11
increases expression
ISO
Lidocaine results in increased expression of HIST1H2AH mRNA
CTD
PMID:35283115
NCBI chr 6:27,133,043...27,133,535
Ensembl chr 6:27,133,043...27,135,292
G
H2AC25
H2A clustered histone 25
decreases expression
ISO
Lidocaine results in decreased expression of H2AC25 mRNA
CTD
PMID:35283115
NCBI chr 1:228,457,364...228,457,873
Ensembl chr 1:228,434,777...228,457,873
G
H2AC8
H2A clustered histone 8
increases expression
ISO
Lidocaine results in increased expression of HIST1H2AF mRNA
CTD
PMID:35283115
NCBI chr 6:26,216,921...26,217,437
Ensembl chr 6:26,216,921...26,218,515
G
HASPIN
histone H3 associated protein kinase
increases expression
ISO
Lidocaine results in increased expression of GSG2 mRNA
CTD
PMID:35283115
NCBI chr17:3,723,903...3,726,699
Ensembl chr17:3,723,903...3,726,699
G
HAVCR1
hepatitis A virus cellular receptor 1
increases expression
ISO
Lidocaine results in increased expression of HAVCR1 mRNA
CTD
PMID:35283115
NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
G
HAVCR2
hepatitis A virus cellular receptor 2
increases expression
ISO
Lidocaine results in increased expression of HAVCR2 mRNA
CTD
PMID:35283115
NCBI chr 5:157,085,832...157,109,044
Ensembl chr 5:157,085,422...157,142,869
G
HBEGF
heparin binding EGF like growth factor
increases expression
ISO
Lidocaine results in increased expression of HBEGF mRNA
CTD
PMID:35283115
NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603
G
HCLS1
hematopoietic cell-specific Lyn substrate 1
increases expression
ISO
Lidocaine results in increased expression of HCLS1 mRNA
CTD
PMID:35283115
NCBI chr 3:121,631,399...121,660,903
Ensembl chr 3:121,631,399...121,660,927
G
HCST
hematopoietic cell signal transducer
increases expression
ISO
Lidocaine results in increased expression of HCST mRNA
CTD
PMID:35283115
NCBI chr19:35,902,529...35,904,377
Ensembl chr19:35,902,529...35,904,377
G
HEBP2
heme binding protein 2
decreases expression
ISO
Lidocaine results in decreased expression of HEBP2 mRNA
CTD
PMID:35283115
NCBI chr 6:138,403,531...138,422,197
Ensembl chr 6:138,403,531...138,422,197
G
HGD
homogentisate 1,2-dioxygenase
increases expression
ISO
Lidocaine results in increased expression of HGD mRNA
CTD
PMID:35283115
NCBI chr 3:120,628,172...120,682,239
Ensembl chr 3:120,628,172...120,682,269
G
HK3
hexokinase 3
increases expression
ISO
Lidocaine results in increased expression of HK3 mRNA
CTD
PMID:35283115
NCBI chr 5:176,880,869...176,899,346
Ensembl chr 5:176,880,869...176,899,346
G
HLA-DMB
major histocompatibility complex, class II, DM beta
increases expression
ISO
Lidocaine results in increased expression of RT1-DMB mRNA
CTD
PMID:35283115
NCBI chr 6:32,934,636...32,941,028
Ensembl chr 6:32,934,629...32,941,028
G
HLA-F
major histocompatibility complex, class I, F
decreases expression
ISO
Lidocaine results in decreased expression of RT1-CE5 mRNA
CTD
PMID:35283115
NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528
G
HMGB1
high mobility group box 1
multiple interactions
ISO
Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein]; Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA]
CTD
PMID:21288974
NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
G
HMGB2
high mobility group box 2
increases expression
ISO
Lidocaine results in increased expression of HMGB2 mRNA
CTD
PMID:35283115
NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
G
HMMR
hyaluronan mediated motility receptor
increases expression
ISO
Lidocaine results in increased expression of HMMR mRNA
CTD
PMID:35283115
NCBI chr 5:163,460,632...163,491,941
Ensembl chr 5:163,460,203...163,491,941
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HMOX1
heme oxygenase 1
increases expression
ISO
Lidocaine results in increased expression of HMOX1 mRNA
CTD
PMID:35283115
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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HORMAD2
HORMA domain containing 2
increases expression
ISO
Lidocaine results in increased expression of HORMAD2 mRNA
CTD
PMID:35283115
NCBI chr22:30,077,732...30,207,456
Ensembl chr22:30,080,464...30,177,075
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HPGD
15-hydroxyprostaglandin dehydrogenase
increases expression
ISO
Lidocaine results in increased expression of HPGD mRNA
CTD
PMID:35283115
NCBI chr 4:174,490,175...174,522,893
Ensembl chr 4:174,490,175...174,523,154
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HPGDS
hematopoietic prostaglandin D synthase
increases expression
ISO
Lidocaine results in increased expression of HPGDS mRNA
CTD
PMID:35283115
NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876
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HRH1
histamine receptor H1
affects binding multiple interactions
EXP
HRH1 protein binds to Lidocaine [HRH1 protein binds to Lidocaine] which results in increased import of Calcium
CTD
PMID:32061592
NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
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HSPA1B
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
Lidocaine results in increased expression of HSPA1B mRNA
CTD
PMID:35283115
NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
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HVCN1
hydrogen voltage gated channel 1
increases expression
ISO
Lidocaine results in increased expression of HVCN1 mRNA
CTD
PMID:35283115
NCBI chr12:110,648,686...110,704,952
Ensembl chr12:110,627,841...110,704,950
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IFI30
IFI30 lysosomal thiol reductase
increases expression
ISO
Lidocaine results in increased expression of IFI30 mRNA
CTD
PMID:35283115
NCBI chr19:18,173,813...18,178,117
Ensembl chr19:18,173,162...18,178,117
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IFI44L
interferon induced protein 44 like
increases expression
ISO
Lidocaine results in increased expression of IFI44L mRNA
CTD
PMID:35283115
NCBI chr 1:78,620,448...78,646,145
Ensembl chr 1:78,619,902...78,646,145
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IGF1
insulin like growth factor 1
increases expression
ISO
Lidocaine results in increased expression of IGF1 mRNA
CTD
PMID:35283115
NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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IGFBP2
insulin like growth factor binding protein 2
increases expression
ISO
Lidocaine results in increased expression of IGFBP2 mRNA
CTD
PMID:35283115
NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
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IL10RA
interleukin 10 receptor subunit alpha
increases expression
ISO
Lidocaine results in increased expression of IL10RA mRNA
CTD
PMID:35283115
NCBI chr11:117,986,394...118,003,037
Ensembl chr11:117,986,370...118,003,037
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IL13
interleukin 13
decreases expression
ISO
Lidocaine results in decreased expression of IL13 protein
CTD
PMID:18382663
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL16
interleukin 16
increases expression
ISO
Lidocaine results in increased expression of IL16 mRNA
CTD
PMID:35283115
NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058
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IL1RAP
interleukin 1 receptor accessory protein
increases expression
ISO
Lidocaine results in increased expression of IL1RAP mRNA
CTD
PMID:35283115
NCBI chr 3:190,514,085...190,659,750
Ensembl chr 3:190,514,051...190,659,750
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IL33
interleukin 33
increases expression
ISO
Lidocaine results in increased expression of IL33 mRNA
CTD
PMID:35283115
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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IL4
interleukin 4
decreases expression
ISO
Lidocaine results in decreased expression of IL4 protein
CTD
PMID:18382663
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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IL6
interleukin 6
decreases expression
EXP
Lidocaine results in decreased expression of IL6 protein
CTD
PMID:16378115
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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INAVA
innate immunity activator
increases expression
ISO
Lidocaine results in increased expression of INAVA mRNA
CTD
PMID:35283115
NCBI chr 1:200,891,531...200,915,742
Ensembl chr 1:200,891,048...200,915,742
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INSYN2B
inhibitory synaptic factor family member 2B
decreases expression
ISO
Lidocaine results in decreased expression of INSYN2B mRNA
CTD
PMID:35283115
NCBI chr 5:169,861,303...169,980,495
Ensembl chr 5:169,861,303...169,980,495
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IQGAP3
IQ motif containing GTPase activating protein 3
increases expression
ISO
Lidocaine results in increased expression of IQGAP3 mRNA
CTD
PMID:35283115
NCBI chr 1:156,525,405...156,572,565
Ensembl chr 1:156,525,405...156,572,604
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IRAK2
interleukin 1 receptor associated kinase 2
increases expression
ISO
Lidocaine results in increased expression of IRAK2 mRNA
CTD
PMID:35283115
NCBI chr 3:10,164,919...10,243,745
Ensembl chr 3:10,164,919...10,243,745
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IRF5
interferon regulatory factor 5
increases expression
ISO
Lidocaine results in increased expression of IRF5 mRNA
CTD
PMID:35283115
NCBI chr 7:128,937,032...128,950,038
Ensembl chr 7:128,937,457...128,950,038
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IRF8
interferon regulatory factor 8
increases expression
ISO
Lidocaine results in increased expression of IRF8 mRNA
CTD
PMID:35283115
NCBI chr16:85,899,162...85,922,609
Ensembl chr16:85,899,116...85,922,606
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ISG20
interferon stimulated exonuclease gene 20
increases expression
ISO
Lidocaine results in increased expression of ISG20 mRNA
CTD
PMID:35283115
NCBI chr15:88,635,632...88,656,483
Ensembl chr15:88,635,670...88,656,483
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ITGA4
integrin subunit alpha 4
increases expression
ISO
Lidocaine results in increased expression of ITGA4 mRNA
CTD
PMID:35283115
NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940
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ITGA5
integrin subunit alpha 5
increases expression
ISO
Lidocaine results in increased expression of ITGA5 mRNA
CTD
PMID:35283115
NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266
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ITGAM
integrin subunit alpha M
multiple interactions increases expression
EXP ISO
Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] Lidocaine results in increased expression of ITGAM mRNA
CTD
PMID:9336308 PMID:35283115
NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
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ITGAX
integrin subunit alpha X
increases expression
ISO
Lidocaine results in increased expression of ITGAX mRNA
CTD
PMID:35283115
NCBI chr16:31,355,176...31,382,999
Ensembl chr16:31,355,134...31,382,999
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ITGB2
integrin subunit beta 2
multiple interactions
EXP
Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]]
CTD
PMID:9336308
NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989
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ITSN1
intersectin 1
increases expression
ISO
Lidocaine results in increased expression of ITSN1 mRNA
CTD
PMID:35283115
NCBI chr21:33,642,501...33,899,861
Ensembl chr21:33,642,400...33,899,861
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IZUMO2
IZUMO family member 2
decreases expression
ISO
Lidocaine results in decreased expression of IZUMO2 mRNA
CTD
PMID:35283115
NCBI chr19:50,152,548...50,163,281
Ensembl chr19:50,152,548...50,163,281
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JAG1
jagged canonical Notch ligand 1
decreases expression
ISO
Lidocaine results in decreased expression of JAG1 mRNA
CTD
PMID:35283115
NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999
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KCNB2
potassium voltage-gated channel subfamily B member 2
decreases expression
ISO
Lidocaine results in decreased expression of KCNB2 mRNA
CTD
PMID:35283115
NCBI chr 8:72,537,225...72,938,349
Ensembl chr 8:72,537,225...72,938,349
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KCNH2
potassium voltage-gated channel subfamily H member 2
decreases activity
EXP
Lidocaine results in decreased activity of KCNH2 protein
CTD
PMID:24052561
NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
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KCNK18
potassium two pore domain channel subfamily K member 18
multiple interactions
EXP
Lidocaine inhibits the reaction [KCNK18 protein results in increased transport of Potassium]
CTD
PMID:12754259
NCBI chr10:117,197,489...117,210,299
Ensembl chr10:117,197,489...117,210,299
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KCNK9
potassium two pore domain channel subfamily K member 9
multiple interactions
ISO
Lidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]
CTD
PMID:10734076
NCBI chr 8:139,600,838...139,703,123
Ensembl chr 8:139,600,838...139,704,109
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KCNN4
potassium calcium-activated channel subfamily N member 4
increases expression
ISO
Lidocaine results in increased expression of KCNN4 mRNA
CTD
PMID:35283115
NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976
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KCTD19
potassium channel tetramerization domain containing 19
decreases expression
ISO
Lidocaine results in decreased expression of KCTD19 mRNA
CTD
PMID:35283115
NCBI chr16:67,289,432...67,326,741
Ensembl chr16:67,289,428...67,326,760
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KIF11
kinesin family member 11
increases expression
ISO
Lidocaine results in increased expression of KIF11 mRNA
CTD
PMID:35283115
NCBI chr10:92,593,130...92,655,395
Ensembl chr10:92,574,105...92,655,395
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KIF14
kinesin family member 14
increases expression
ISO
Lidocaine results in increased expression of KIF14 mRNA
CTD
PMID:35283115
NCBI chr 1:200,551,497...200,620,751
Ensembl chr 1:200,551,497...200,620,751
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KIF18A
kinesin family member 18A
increases expression
ISO
Lidocaine results in increased expression of KIF18A mRNA
CTD
PMID:35283115
NCBI chr11:28,020,619...28,108,156
Ensembl chr11:28,020,619...28,108,156
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KIF18B
kinesin family member 18B
increases expression
ISO
Lidocaine results in increased expression of KIF18B mRNA
CTD
PMID:35283115
NCBI chr17:44,924,711...44,947,773
Ensembl chr17:44,924,709...44,947,773
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KIF20A
kinesin family member 20A
increases expression
ISO
Lidocaine results in increased expression of KIF20A mRNA
CTD
PMID:35283115
NCBI chr 5:138,179,112...138,187,723
Ensembl chr 5:138,178,719...138,187,723
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KIF22
kinesin family member 22
increases expression
ISO
Lidocaine results in increased expression of KIF22 mRNA
CTD
PMID:35283115
NCBI chr16:29,790,751...29,805,385
Ensembl chr16:29,790,727...29,805,385
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KIF28P
kinesin family member 28, pseudogene
decreases expression
ISO
Lidocaine results in decreased expression of KIF28P mRNA
CTD
PMID:35283115
NCBI chr 1:246,771,878...246,784,760
Ensembl chr 1:246,771,837...246,839,611
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KIFC1
kinesin family member C1
increases expression
ISO
Lidocaine results in increased expression of KIFC1 mRNA
CTD
PMID:35283115
NCBI chr 6:33,391,461...33,409,896
Ensembl chr 6:33,391,823...33,409,896
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KLC1
kinesin light chain 1
decreases expression
ISO
Lidocaine results in decreased expression of KLC1 mRNA
CTD
PMID:35283115
NCBI chr14:103,629,211...103,701,544
Ensembl chr14:103,561,896...103,714,249
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KLHL38
kelch like family member 38
increases expression
ISO
Lidocaine results in increased expression of KLHL38 mRNA
CTD
PMID:35283115
NCBI chr 8:123,644,442...123,653,801
Ensembl chr 8:123,644,442...123,653,801
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KLHL6
kelch like family member 6
increases expression
ISO
Lidocaine results in increased expression of KLHL6 mRNA
CTD
PMID:35283115
NCBI chr 3:183,487,551...183,555,706
Ensembl chr 3:183,487,551...183,555,706
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KMO
kynurenine 3-monooxygenase
increases expression
ISO
Lidocaine results in increased expression of KMO mRNA
CTD
PMID:35283115
NCBI chr 1:241,532,378...241,595,642
Ensembl chr 1:241,532,134...241,595,642
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KNG1
kininogen 1
multiple interactions decreases activity
EXP
Lidocaine inhibits the reaction [[Propofol co-treated with Pharmaceutical Vehicles] results in increased expression of KNG1 protein modified form] Lidocaine results in decreased activity of KNG1 protein
CTD
PMID:1371395 PMID:10655909
NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410
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KNSTRN
kinetochore localized astrin (SPAG5) binding protein
increases expression
ISO
Lidocaine results in increased expression of KNSTRN mRNA
CTD
PMID:35283115
NCBI chr15:40,382,721...40,394,288
Ensembl chr15:40,382,721...40,394,288
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KNTC1
kinetochore associated 1
increases expression
ISO
Lidocaine results in increased expression of KNTC1 mRNA
CTD
PMID:35283115
NCBI chr12:122,527,249...122,626,396
Ensembl chr12:122,527,246...122,626,396
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KPNA2
karyopherin subunit alpha 2
increases expression
ISO
Lidocaine results in increased expression of KPNA2 mRNA
CTD
PMID:35283115
NCBI chr17:68,035,735...68,046,854
Ensembl chr17:68,035,636...68,047,364
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KPNA7
karyopherin subunit alpha 7
decreases expression
ISO
Lidocaine results in decreased expression of KPNA7 mRNA
CTD
PMID:35283115
NCBI chr 7:99,145,804...99,219,419
Ensembl chr 7:99,173,572...99,250,075
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KRT34
keratin 34
decreases expression
ISO
Lidocaine results in decreased expression of KRT34 mRNA
CTD
PMID:35283115
NCBI chr17:41,377,669...41,383,816
Ensembl chr17:41,377,669...41,382,306
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KRT8
keratin 8
increases expression
ISO
Lidocaine results in increased expression of KRT8 mRNA
CTD
PMID:35283115
NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954
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LALBA
lactalbumin alpha
decreases expression
ISO
Lidocaine results in decreased expression of LALBA mRNA
CTD
PMID:35283115
NCBI chr12:48,567,684...48,571,845
Ensembl chr12:48,567,684...48,570,066
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LAPTM5
lysosomal protein transmembrane 5
increases expression
ISO
Lidocaine results in increased expression of LAPTM5 mRNA
CTD
PMID:35283115
NCBI chr 1:30,732,469...30,757,774
Ensembl chr 1:30,732,469...30,757,774
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LCP1
lymphocyte cytosolic protein 1
increases expression
ISO
Lidocaine results in increased expression of LCP1 mRNA
CTD
PMID:35283115
NCBI chr13:46,125,923...46,182,177
Ensembl chr13:46,125,920...46,211,871
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LCP2
lymphocyte cytosolic protein 2
increases expression
ISO
Lidocaine results in increased expression of LCP2 mRNA
CTD
PMID:35283115
NCBI chr 5:170,246,233...170,297,777
Ensembl chr 5:170,246,233...170,297,815
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LGALS1
galectin 1
decreases expression
ISO
Lidocaine results in decreased expression of LGALS1 protein
CTD
PMID:18382663
NCBI chr22:37,675,636...37,679,802
Ensembl chr22:37,675,636...37,679,802
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LGALS12
galectin 12
decreases expression
ISO
Lidocaine results in decreased expression of LGALS12 mRNA
CTD
PMID:35283115
NCBI chr11:63,506,084...63,516,772
Ensembl chr11:63,506,052...63,516,774
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LGALS3BP
galectin 3 binding protein
increases expression
ISO
Lidocaine results in increased expression of LGALS3BP mRNA
CTD
PMID:35283115
NCBI chr17:78,971,255...78,979,923
Ensembl chr17:78,971,238...78,979,947
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LIMK2
LIM domain kinase 2
increases expression
ISO
Lidocaine results in increased expression of LIMK2 mRNA
CTD
PMID:35283115
NCBI chr22:31,212,298...31,280,080
Ensembl chr22:31,212,239...31,280,080
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LPL
lipoprotein lipase
increases expression
ISO
Lidocaine results in increased expression of LPL mRNA
CTD
PMID:35283115
NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
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LPXN
leupaxin
increases expression
ISO
Lidocaine results in increased expression of LPXN mRNA
CTD
PMID:35283115
NCBI chr11:58,526,871...58,578,891
Ensembl chr11:58,526,871...58,578,220
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LRR1
leucine rich repeat protein 1
increases expression
ISO
Lidocaine results in increased expression of LRR1 mRNA
CTD
PMID:35283115
NCBI chr14:49,598,940...49,614,672
Ensembl chr14:49,598,761...49,614,672
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LRRC8E
leucine rich repeat containing 8 VRAC subunit E
increases expression
ISO
Lidocaine results in increased expression of LRRC8E mRNA
CTD
PMID:35283115
NCBI chr19:7,888,510...7,902,016
Ensembl chr19:7,888,505...7,902,021
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LSM2
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
increases expression
ISO
Lidocaine results in increased expression of LSM2 mRNA
CTD
PMID:35283115
NCBI chr 6:31,797,396...31,806,966
Ensembl chr 6:31,797,396...31,806,966
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LST1
leukocyte specific transcript 1
increases expression
ISO
Lidocaine results in increased expression of LST1 mRNA
CTD
PMID:35283115
NCBI chr 6:31,586,277...31,588,909
Ensembl chr 6:31,586,124...31,588,909
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LYL1
LYL1 basic helix-loop-helix family member
increases expression
ISO
Lidocaine results in increased expression of LYL1 mRNA
CTD
PMID:35283115
NCBI chr19:13,099,033...13,102,858
Ensembl chr19:13,099,033...13,103,161
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MAD2L1
mitotic arrest deficient 2 like 1
increases expression
ISO
Lidocaine results in increased expression of MAD2L1 mRNA
CTD
PMID:35283115
NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858
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MALRD1
MAM and LDL receptor class A domain containing 1
increases expression
ISO
Lidocaine results in increased expression of MALRD1 mRNA
CTD
PMID:35283115
NCBI chr10:19,046,927...19,734,478
Ensembl chr10:19,048,801...19,790,401
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MAN2B1
mannosidase alpha class 2B member 1
increases expression
ISO
Lidocaine results in increased expression of MAN2B1 mRNA
CTD
PMID:35283115
NCBI chr19:12,646,512...12,666,742
Ensembl chr19:12,643,831...12,666,742
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MAN2B2
mannosidase alpha class 2B member 2
increases expression
ISO
Lidocaine results in increased expression of MAN2B2 mRNA
CTD
PMID:35283115
NCBI chr 4:6,575,189...6,623,362
Ensembl chr 4:6,575,189...6,623,362
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MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
multiple interactions increases expression
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of MAP1LC3A protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased expression of MAP1LC3A protein]; MK-8722 promotes the reaction [Lidocaine results in increased expression of MAP1LC3A protein]
CTD
PMID:37914286
NCBI chr20:34,546,844...34,560,345
Ensembl chr20:34,546,854...34,560,345
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MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
increases expression
ISO
Lidocaine results in increased expression of MAP4K1 mRNA
CTD
PMID:35283115
NCBI chr19:38,587,641...38,617,953
Ensembl chr19:38,587,641...38,618,882
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MAPK1
mitogen-activated protein kinase 1
multiple interactions
ISO
Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD
PMID:12196597
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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MAPK3
mitogen-activated protein kinase 3
multiple interactions
ISO
Lidocaine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD
PMID:12196597
NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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MASTL
microtubule associated serine/threonine kinase like
increases expression
ISO
Lidocaine results in increased expression of MASTL mRNA
CTD
PMID:35283115
NCBI chr10:27,154,479...27,187,953
Ensembl chr10:27,154,824...27,187,953
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MBP
myelin basic protein
multiple interactions decreases expression
ISO
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein] Lidocaine results in decreased expression of MBP mRNA; Lidocaine results in decreased expression of MBP protein
CTD
PMID:33166664
NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683
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MCL1
MCL1 apoptosis regulator, BCL2 family member
increases expression
ISO
Lidocaine results in increased expression of MCL1 mRNA
CTD
PMID:35283115
NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
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MCM10
minichromosome maintenance 10 replication initiation factor
increases expression
ISO
Lidocaine results in increased expression of MCM10 mRNA
CTD
PMID:35283115
NCBI chr10:13,161,558...13,211,110
Ensembl chr10:13,161,558...13,211,110
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MCM2
minichromosome maintenance complex component 2
increases expression
ISO
Lidocaine results in increased expression of MCM2 mRNA
CTD
PMID:35283115
NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,223...127,622,436
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MCM3
minichromosome maintenance complex component 3
increases expression
ISO
Lidocaine results in increased expression of MCM3 mRNA
CTD
PMID:35283115
NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
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MCM4
minichromosome maintenance complex component 4
increases expression
ISO
Lidocaine results in increased expression of MCM4 mRNA
CTD
PMID:35283115
NCBI chr 8:47,960,941...47,978,160
Ensembl chr 8:47,960,185...47,978,160
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MCM5
minichromosome maintenance complex component 5
increases expression
ISO
Lidocaine results in increased expression of MCM5 mRNA
CTD
PMID:35283115
NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431
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MCM6
minichromosome maintenance complex component 6
increases expression
ISO
Lidocaine results in increased expression of MCM6 mRNA
CTD
PMID:35283115
NCBI chr 2:135,839,626...135,876,443
Ensembl chr 2:135,839,626...135,876,443
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MEOX1
mesenchyme homeobox 1
decreases expression
ISO
Lidocaine results in decreased expression of MEOX1 mRNA
CTD
PMID:35283115
NCBI chr17:43,640,389...43,661,922
Ensembl chr17:43,640,389...43,661,922
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MERTK
MER proto-oncogene, tyrosine kinase
increases expression
ISO
Lidocaine results in increased expression of MERTK mRNA
CTD
PMID:35283115
NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561
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MILR1
mast cell immunoglobulin like receptor 1
increases expression
ISO
Lidocaine results in increased expression of MILR1 mRNA
CTD
PMID:35283115
NCBI chr17:64,449,115...64,497,356
Ensembl chr17:64,449,037...64,492,770
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MIR199A2
microRNA 199a-2
multiple interactions increases expression
ISO
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MBP protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA] Lidocaine results in increased expression of MIR199A2 mRNA
CTD
PMID:33166664
NCBI chr 1:172,144,535...172,144,644
Ensembl chr 1:172,144,535...172,144,644
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MIS18A
MIS18 kinetochore protein A
increases expression
ISO
Lidocaine results in increased expression of MIS18A mRNA
CTD
PMID:35283115
NCBI chr21:32,154,682...32,279,049
Ensembl chr21:32,268,228...32,279,049
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MIS18BP1
MIS18 binding protein 1
increases expression
ISO
Lidocaine results in increased expression of MIS18BP1 mRNA
CTD
PMID:35283115
NCBI chr14:45,203,190...45,253,202
Ensembl chr14:45,203,190...45,253,540
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MLST8
MTOR associated protein, LST8 homolog
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
CTD
PMID:37914286
NCBI chr16:2,205,454...2,209,453
Ensembl chr16:2,204,248...2,209,453
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MMP12
matrix metallopeptidase 12
increases expression
ISO
Lidocaine results in increased expression of MMP12 mRNA
CTD
PMID:35283115
NCBI chr11:102,862,736...102,874,982
Ensembl chr11:102,862,736...102,874,982
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MMP3
matrix metallopeptidase 3
multiple interactions increases expression
ISO
cordycepin inhibits the reaction [Lidocaine results in increased expression of MMP3 mRNA]; cordycepin inhibits the reaction [Lidocaine results in increased expression of MMP3 protein] Lidocaine results in increased expression of MMP3 mRNA; Lidocaine results in increased expression of MMP3 protein
CTD
PMID:29382532
NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609
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MMP7
matrix metallopeptidase 7
increases expression
ISO
Lidocaine results in increased expression of MMP7 mRNA
CTD
PMID:35283115
NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
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MMS22L
MMS22 like, DNA repair protein
increases expression
ISO
Lidocaine results in increased expression of MMS22L mRNA
CTD
PMID:35283115
NCBI chr 6:97,142,161...97,284,035
Ensembl chr 6:97,142,161...97,283,217
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MOBP
myelin associated oligodendrocyte basic protein
decreases expression
ISO
Lidocaine results in decreased expression of MOBP mRNA
CTD
PMID:35283115
NCBI chr 3:39,467,680...39,529,497
Ensembl chr 3:39,467,198...39,529,479
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MOG
myelin oligodendrocyte glycoprotein
multiple interactions decreases expression
ISO
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MOG mRNA]
CTD
PMID:33166664
NCBI chr 6:29,657,092...29,672,365
Ensembl chr 6:29,657,002...29,672,372
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MS4A1
membrane spanning 4-domains A1
decreases expression
ISO
Lidocaine results in decreased expression of MS4A1 mRNA
CTD
PMID:35283115
NCBI chr11:60,455,847...60,470,752
Ensembl chr11:60,455,846...60,470,752
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MS4A4A
membrane spanning 4-domains A4A
increases expression
ISO
Lidocaine results in increased expression of MS4A4A mRNA
CTD
PMID:35283115
NCBI chr11:60,280,666...60,308,970
Ensembl chr11:60,185,657...60,318,080
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MSR1
macrophage scavenger receptor 1
increases expression
ISO
Lidocaine results in increased expression of MSR1 mRNA
CTD
PMID:35283115
NCBI chr 8:16,107,881...16,192,651
Ensembl chr 8:16,107,878...16,567,490
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MTBP
MDM2 binding protein
increases expression
ISO
Lidocaine results in increased expression of MTBP mRNA
CTD
PMID:35283115
NCBI chr 8:120,445,419...120,523,636
Ensembl chr 8:120,445,400...120,542,133
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MTOR
mechanistic target of rapamycin kinase
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
CTD
PMID:37914286
NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
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MXD3
MAX dimerization protein 3
increases expression
ISO
Lidocaine results in increased expression of MXD3 mRNA
CTD
PMID:35283115
NCBI chr 5:177,305,499...177,312,752
Ensembl chr 5:177,301,461...177,312,757
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MYBL2
MYB proto-oncogene like 2
increases expression
ISO
Lidocaine results in increased expression of MYBL2 mRNA
CTD
PMID:35283115
NCBI chr20:43,667,114...43,716,482
Ensembl chr20:43,667,019...43,716,495
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MYBPC2
myosin binding protein C2
increases expression
ISO
Lidocaine results in increased expression of MYBPC2 mRNA
CTD
PMID:35283115
NCBI chr19:50,432,892...50,466,321
Ensembl chr19:50,432,892...50,466,321
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MYLK3
myosin light chain kinase 3
increases expression
ISO
Lidocaine results in increased expression of MYLK3 mRNA
CTD
PMID:35283115
NCBI chr16:46,702,282...46,763,246
Ensembl chr16:46,702,282...46,790,407
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MYO18B
myosin XVIIIB
increases expression
ISO
Lidocaine results in increased expression of MYO18B mRNA
CTD
PMID:35283115
NCBI chr22:25,742,188...26,063,847
Ensembl chr22:25,742,144...26,031,045
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MYO1F
myosin IF
increases expression
ISO
Lidocaine results in increased expression of MYO1F mRNA
CTD
PMID:35283115
NCBI chr19:8,520,778...8,577,442
Ensembl chr19:8,517,463...8,577,442
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MYO7A
myosin VIIA
increases expression
ISO
Lidocaine results in increased expression of MYO7A mRNA
CTD
PMID:35283115
NCBI chr11:77,128,246...77,215,241
Ensembl chr11:77,128,246...77,215,241
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MYRF
myelin regulatory factor
decreases expression multiple interactions
ISO
Lidocaine results in decreased expression of MYRF mRNA; Lidocaine results in decreased expression of MYRF protein [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF mRNA]; [Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of MYRF protein]
CTD
PMID:33166664
NCBI chr11:61,752,636...61,788,518
Ensembl chr11:61,752,636...61,788,518
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NAGLU
N-acetyl-alpha-glucosaminidase
increases expression
ISO
Lidocaine results in increased expression of NAGLU mRNA
CTD
PMID:35283115
NCBI chr17:42,536,241...42,544,449
Ensembl chr17:42,536,241...42,544,449
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NAV1
neuron navigator 1
decreases expression
ISO
Lidocaine results in decreased expression of NAV1 mRNA
CTD
PMID:35283115
NCBI chr 1:201,539,127...201,826,969
Ensembl chr 1:201,539,127...201,826,969
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NCAN
neurocan
increases expression
ISO
Lidocaine results in increased expression of NCAN mRNA
CTD
PMID:35283115
NCBI chr19:19,211,958...19,252,233
Ensembl chr19:19,211,958...19,252,233
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NCAPG
non-SMC condensin I complex subunit G
increases expression
ISO
Lidocaine results in increased expression of NCAPG mRNA
CTD
PMID:35283115
NCBI chr 4:17,810,979...17,844,865
Ensembl chr 4:17,810,979...17,844,865
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NCAPG2
non-SMC condensin II complex subunit G2
increases expression
ISO
Lidocaine results in increased expression of NCAPG2 mRNA
CTD
PMID:35283115
NCBI chr 7:158,631,169...158,704,804
Ensembl chr 7:158,631,169...158,704,804
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NCAPH
non-SMC condensin I complex subunit H
increases expression
ISO
Lidocaine results in increased expression of NCAPH mRNA
CTD
PMID:35283115
NCBI chr 2:96,335,766...96,377,091
Ensembl chr 2:96,335,766...96,377,091
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NCF1
neutrophil cytosolic factor 1
increases expression
ISO
Lidocaine results in increased expression of NCF1 mRNA
CTD
PMID:35283115
NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
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NCKAP1L
NCK associated protein 1 like
increases expression
ISO
Lidocaine results in increased expression of NCKAP1L mRNA
CTD
PMID:35283115
NCBI chr12:54,497,752...54,548,243
Ensembl chr12:54,497,752...54,548,243
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NDC80
NDC80 kinetochore complex component
increases expression
ISO
Lidocaine results in increased expression of NDC80 mRNA
CTD
PMID:35283115
NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
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NEFM
neurofilament medium chain
multiple interactions decreases expression
EXP ISO
NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]
CTD
PMID:34193770
NCBI chr 8:24,913,761...24,919,093
Ensembl chr 8:24,913,758...24,919,098
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NEIL3
nei like DNA glycosylase 3
increases expression
ISO
Lidocaine results in increased expression of NEIL3 mRNA
CTD
PMID:35283115
NCBI chr 4:177,309,874...177,371,268
Ensembl chr 4:177,309,874...177,362,936
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NEK2
NIMA related kinase 2
increases expression
ISO
Lidocaine results in increased expression of NEK2 mRNA
CTD
PMID:35283115
NCBI chr 1:211,658,256...211,675,621
Ensembl chr 1:211,658,657...211,675,630
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NES
nestin
increases expression
ISO
Lidocaine results in increased expression of NES mRNA
CTD
PMID:35283115
NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
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NFASC
neurofascin
decreases expression
ISO
Lidocaine results in decreased expression of NFASC mRNA
CTD
PMID:35283115
NCBI chr 1:204,828,652...205,022,822
Ensembl chr 1:204,828,651...205,022,822
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NFE2
nuclear factor, erythroid 2
decreases expression
ISO
Lidocaine results in decreased expression of NFE2 mRNA
CTD
PMID:35283115
NCBI chr12:54,292,111...54,301,015
Ensembl chr12:54,292,111...54,301,015
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NFKBID
NFKB inhibitor delta
increases expression
ISO
Lidocaine results in increased expression of NFKBID mRNA
CTD
PMID:35283115
NCBI chr19:35,887,952...35,902,303
Ensembl chr19:35,887,630...35,902,303
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NGF
nerve growth factor
decreases expression multiple interactions
EXP ISO
Lidocaine results in decreased expression of NGF protein NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein] NGF protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]
CTD
PMID:34193770
NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
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NGFR
nerve growth factor receptor
increases expression
ISO
Lidocaine results in increased expression of NGFR mRNA
CTD
PMID:35283115
NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
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NKAIN1
sodium/potassium transporting ATPase interacting 1
increases expression
ISO
Lidocaine results in increased expression of NKAIN1 mRNA
CTD
PMID:35283115
NCBI chr 1:31,179,745...31,239,887
Ensembl chr 1:31,179,745...31,239,887
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NNAT
neuronatin
decreases expression multiple interactions
EXP ISO
Lidocaine results in decreased expression of NNAT protein NGF protein inhibits the reaction [Lidocaine results in decreased expression of NNAT protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NEFM protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of NGF protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]
CTD
PMID:34193770
NCBI chr20:37,521,250...37,523,690
Ensembl chr20:37,521,206...37,523,690
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NR1I2
nuclear receptor subfamily 1 group I member 2
increases activity
EXP
Lidocaine results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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NSL1
NSL1 component of MIS12 kinetochore complex
increases expression
ISO
Lidocaine results in increased expression of NSL1 mRNA
CTD
PMID:35283115
NCBI chr 1:212,726,153...212,791,777
Ensembl chr 1:212,726,153...212,791,782
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NT5DC2
5'-nucleotidase domain containing 2
increases expression
ISO
Lidocaine results in increased expression of NT5DC2 mRNA
CTD
PMID:35283115
NCBI chr 3:52,524,387...52,535,027
Ensembl chr 3:52,524,385...52,535,054
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NUF2
NUF2 component of NDC80 kinetochore complex
increases expression
ISO
Lidocaine results in increased expression of NUF2 mRNA
CTD
PMID:35283115
NCBI chr 1:163,321,954...163,355,759
Ensembl chr 1:163,266,576...163,355,764
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NUSAP1
nucleolar and spindle associated protein 1
increases expression
ISO
Lidocaine results in increased expression of NUSAP1 mRNA
CTD
PMID:35283115
NCBI chr15:41,332,881...41,381,046
Ensembl chr15:41,320,794...41,381,050
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OASL
2'-5'-oligoadenylate synthetase like
increases expression
ISO
Lidocaine results in increased expression of OASL mRNA
CTD
PMID:35283115
NCBI chr12:121,017,761...121,039,246
Ensembl chr12:121,017,763...121,039,246
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OIP5
Opa interacting protein 5
increases expression
ISO
Lidocaine results in increased expression of OIP5 mRNA
CTD
PMID:35283115
NCBI chr15:41,309,273...41,332,591
Ensembl chr15:41,309,273...41,332,591
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OLR1
oxidized low density lipoprotein receptor 1
increases expression
ISO
Lidocaine results in increased expression of OLR1 mRNA
CTD
PMID:35283115
NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138
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OPLAH
5-oxoprolinase, ATP-hydrolysing
increases expression
ISO
Lidocaine results in increased expression of OPLAH mRNA
CTD
PMID:35283115
NCBI chr 8:144,050,322...144,063,961
Ensembl chr 8:144,051,266...144,063,965
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OR10A6
olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)
decreases expression
ISO
Lidocaine results in decreased expression of OR10A48 mRNA
CTD
PMID:35283115
NCBI chr11:7,924,592...7,931,268
Ensembl chr11:7,924,592...7,931,268
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OR6K2
olfactory receptor family 6 subfamily K member 2
increases expression
ISO
Lidocaine results in increased expression of OR6K2 mRNA
CTD
PMID:35283115
NCBI chr 1:158,699,678...158,700,652
Ensembl chr 1:158,699,678...158,700,652
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ORC1
origin recognition complex subunit 1
increases expression
ISO
Lidocaine results in increased expression of ORC1 mRNA
CTD
PMID:35283115
NCBI chr 1:52,372,829...52,409,503
Ensembl chr 1:52,372,829...52,404,423
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ORM1
orosomucoid 1
affects binding multiple interactions
EXP
Lidocaine binds to ORM1 protein alternative form Lidocaine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
CTD
PMID:8946472
NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479
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ORM2
orosomucoid 2
affects binding multiple interactions
EXP
Lidocaine binds to ORM2 protein alternative form Lidocaine inhibits the reaction [Imipramine binds to ORM2 protein alternative form]
CTD
PMID:8946472
NCBI chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251
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OTULINL
OTU deubiquitinase with linear linkage specificity like
increases expression
ISO
Lidocaine results in increased expression of FAM105A mRNA
CTD
PMID:35283115
NCBI chr 5:14,581,792...14,616,180
Ensembl chr 5:14,581,792...14,616,180
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OVCH2
ovochymase 2
decreases expression
ISO
Lidocaine results in decreased expression of OVCH2 mRNA
CTD
PMID:35283115
NCBI chr11:7,678,693...7,706,477
Ensembl chr11:7,689,437...7,706,477
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PARP10
poly(ADP-ribose) polymerase family member 10
increases expression
ISO
Lidocaine results in increased expression of PARP10 mRNA
CTD
PMID:35283115
NCBI chr 8:143,977,158...144,012,764
Ensembl chr 8:143,977,153...144,012,772
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PARP14
poly(ADP-ribose) polymerase family member 14
increases expression
ISO
Lidocaine results in increased expression of PARP14 mRNA
CTD
PMID:35283115
NCBI chr 3:122,680,839...122,730,840
Ensembl chr 3:122,680,839...122,730,840
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PCDH15
protocadherin related 15
decreases expression
ISO
Lidocaine results in decreased expression of PCDH15 mRNA
CTD
PMID:35283115
NCBI chr10:53,802,771...55,627,942
Ensembl chr10:53,802,771...55,627,942
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PCDHA12
protocadherin alpha 12
increases expression
ISO
Lidocaine results in increased expression of PCDHA12 mRNA
CTD
PMID:35283115
NCBI chr 5:140,875,308...141,012,347
Ensembl chr 5:140,875,302...141,012,347
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PCLAF
PCNA clamp associated factor
increases expression
ISO
Lidocaine results in increased expression of PCLAF mRNA
CTD
PMID:35283115
NCBI chr15:64,364,304...64,387,687
Ensembl chr15:64,364,304...64,387,687
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PDCD1
programmed cell death 1
increases expression
ISO
Lidocaine results in increased expression of PDCD1 mRNA
CTD
PMID:35283115
NCBI chr 2:241,849,884...241,858,894
Ensembl chr 2:241,849,884...241,858,894
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PDE6B
phosphodiesterase 6B
increases expression
ISO
Lidocaine results in increased expression of PDE6B mRNA
CTD
PMID:35283115
NCBI chr 4:625,573...670,782
Ensembl chr 4:625,573...670,782
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PF4
platelet factor 4
increases expression
ISO
Lidocaine results in increased expression of PF4 mRNA
CTD
PMID:35283115
NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
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PGAP1
post-GPI attachment to proteins inositol deacylase 1
increases expression
ISO
Lidocaine results in increased expression of PGAP1 mRNA
CTD
PMID:35283115
NCBI chr 2:196,833,004...196,926,707
Ensembl chr 2:196,833,004...196,927,796
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PHLDB3
pleckstrin homology like domain family B member 3
increases expression
ISO
Lidocaine results in increased expression of PHLDB3 mRNA
CTD
PMID:35283115
NCBI chr19:43,475,103...43,504,746
Ensembl chr19:43,474,341...43,504,935
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PI15
peptidase inhibitor 15
decreases expression
ISO
Lidocaine results in decreased expression of PI15 mRNA
CTD
PMID:35283115
NCBI chr 8:74,824,534...74,855,029
Ensembl chr 8:74,824,534...74,855,029
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
increases expression
ISO
Lidocaine results in increased expression of PIK3CG mRNA
CTD
PMID:35283115
NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
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PIMREG
PICALM interacting mitotic regulator
increases expression
ISO
Lidocaine results in increased expression of FAM64A mRNA
CTD
PMID:35283115
NCBI chr17:6,444,455...6,451,469
Ensembl chr17:6,444,441...6,451,469
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PINK1
PTEN induced kinase 1
increases expression multiple interactions
ISO
Lidocaine results in increased expression of PINK1 protein bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of PINK1 protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased expression of PINK1 protein]; MK-8722 promotes the reaction [Lidocaine results in increased expression of PINK1 protein]
CTD
PMID:37914286
NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511
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PIP
prolactin induced protein
increases expression
ISO
Lidocaine results in increased expression of PIP mRNA
CTD
PMID:35283115
NCBI chr 7:143,132,077...143,139,739
Ensembl chr 7:143,132,077...143,139,739
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PLA2G2A
phospholipase A2 group IIA
decreases expression
ISO
Lidocaine results in decreased expression of PLA2G2A mRNA
CTD
PMID:35283115
NCBI chr 1:19,975,431...19,980,434
Ensembl chr 1:19,975,431...19,980,416
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PLAC8
placenta associated 8
decreases expression
ISO
Lidocaine results in decreased expression of PLAC8 mRNA
CTD
PMID:35283115
NCBI chr 4:83,090,048...83,114,729
Ensembl chr 4:83,059,493...83,137,075
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PLAU
plasminogen activator, urokinase
increases expression
ISO
Lidocaine results in increased expression of PLAU mRNA
CTD
PMID:35283115
NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
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PLAUR
plasminogen activator, urokinase receptor
increases expression
ISO
Lidocaine results in increased expression of PLAUR mRNA
CTD
PMID:35283115
NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547
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PLBD1
phospholipase B domain containing 1
increases expression
ISO
Lidocaine results in increased expression of PLBD1 mRNA
CTD
PMID:35283115
NCBI chr12:14,503,661...14,567,883
Ensembl chr12:14,503,661...14,567,883
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PLCB2
phospholipase C beta 2
increases expression
ISO
Lidocaine results in increased expression of PLCB2 mRNA
CTD
PMID:35283115
NCBI chr15:40,284,256...40,307,935
Ensembl chr15:40,278,176...40,307,935
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PLD4
phospholipase D family member 4
increases expression
ISO
Lidocaine results in increased expression of PLD4 mRNA
CTD
PMID:35283115
NCBI chr14:104,924,879...104,937,785
Ensembl chr14:104,924,713...104,937,761
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PLEK2
pleckstrin 2
decreases expression
ISO
Lidocaine results in decreased expression of PLEK2 mRNA
CTD
PMID:35283115
NCBI chr14:67,386,984...67,412,165
Ensembl chr14:67,386,984...67,412,167
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PLEKHA2
pleckstrin homology domain containing A2
increases expression
ISO
Lidocaine results in increased expression of PLEKHA2 mRNA
CTD
PMID:35283115
NCBI chr 8:38,901,346...38,973,912
Ensembl chr 8:38,901,235...38,973,912
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PLIN2
perilipin 2
increases expression
ISO
Lidocaine results in increased expression of PLIN2 mRNA
CTD
PMID:35283115
NCBI chr 9:19,108,388...19,127,492
Ensembl chr 9:19,108,375...19,149,290
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PLN
phospholamban
decreases expression
ISO
Lidocaine results in decreased expression of PLN mRNA
CTD
PMID:35283115
NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716
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PLP1
proteolipid protein 1
multiple interactions decreases expression
ISO
[Antagomirs results in decreased expression of MIR199A2 mRNA] inhibits the reaction [Lidocaine results in decreased expression of PLP1 mRNA]
CTD
PMID:33166664
NCBI chr X:103,776,506...103,792,619
Ensembl chr X:103,773,718...103,792,619
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PM20D2
peptidase M20 domain containing 2
increases expression
ISO
Lidocaine results in increased expression of PM20D2 mRNA
CTD
PMID:35283115
NCBI chr 6:89,093,940...89,165,565
Ensembl chr 6:89,146,055...89,165,565
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PMF1
polyamine modulated factor 1
increases expression
ISO
Lidocaine results in increased expression of PMF1 mRNA
CTD
PMID:35283115
NCBI chr 1:156,213,007...156,240,042
Ensembl chr 1:156,212,993...156,240,042
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POF1B
POF1B actin binding protein
decreases expression
ISO
Lidocaine results in decreased expression of POF1B mRNA
CTD
PMID:35283115
NCBI chr X:85,277,396...85,379,665
Ensembl chr X:85,277,396...85,379,717
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POLA1
DNA polymerase alpha 1, catalytic subunit
increases expression
ISO
Lidocaine results in increased expression of POLA1 mRNA
CTD
PMID:35283115
NCBI chr X:24,693,918...24,996,986
Ensembl chr X:24,693,873...24,996,986
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POLE
DNA polymerase epsilon, catalytic subunit
increases expression
ISO
Lidocaine results in increased expression of POLE mRNA
CTD
PMID:35283115
NCBI chr12:132,623,762...132,687,342
Ensembl chr12:132,623,753...132,687,376
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POLE2
DNA polymerase epsilon 2, accessory subunit
increases expression
ISO
Lidocaine results in increased expression of POLE2 mRNA
CTD
PMID:35283115
NCBI chr14:49,643,555...49,688,214
Ensembl chr14:49,643,555...49,688,422
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POLQ
DNA polymerase theta
increases expression
ISO
Lidocaine results in increased expression of POLQ mRNA
CTD
PMID:35283115
NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,431...121,545,988
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POMC
proopiomelanocortin
multiple interactions
ISO
Lidocaine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]
CTD
PMID:8925284
NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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POSTN
periostin
increases expression
ISO
Lidocaine results in increased expression of POSTN mRNA
CTD
PMID:35283115
NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844
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PPP4R3C
protein phosphatase 4 regulatory subunit 3C
decreases expression
ISO
Lidocaine results in decreased expression of PPP4R3C mRNA
CTD
PMID:35283115
NCBI chr X:27,460,207...27,463,341
Ensembl chr X:27,460,207...27,463,341
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PRC1
protein regulator of cytokinesis 1
increases expression
ISO
Lidocaine results in increased expression of PRC1 mRNA
CTD
PMID:35283115
NCBI chr15:90,966,040...90,994,535
Ensembl chr15:90,966,040...90,995,629
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PRIMPOL
primase and DNA directed polymerase
increases expression
ISO
Lidocaine results in increased expression of PRIMPOL mRNA
CTD
PMID:35283115
NCBI chr 4:184,649,738...184,694,952
Ensembl chr 4:184,649,667...184,694,963
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PRKAA1
protein kinase AMP-activated catalytic subunit alpha 1
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]; MK-8722 promotes the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]
CTD
PMID:37914286
NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
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PRKCB
protein kinase C beta
multiple interactions increases expression
ISO
Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein]
CTD
PMID:30240660
NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
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PRKCG
protein kinase C gamma
multiple interactions
ISO
Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein]
CTD
PMID:19955894
NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652
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PROK2
prokineticin 2
decreases expression
ISO
Lidocaine results in decreased expression of PROK2 mRNA
CTD
PMID:35283115
NCBI chr 3:71,771,655...71,785,148
Ensembl chr 3:71,771,655...71,785,206
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PRPH2
peripherin 2
decreases expression
ISO
Lidocaine results in decreased expression of PRPH2 mRNA
CTD
PMID:35283115
NCBI chr 6:42,696,598...42,722,597
Ensembl chr 6:42,696,598...42,722,597
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PRR11
proline rich 11
increases expression
ISO
Lidocaine results in increased expression of PRR11 mRNA
CTD
PMID:35283115
NCBI chr17:59,155,746...59,206,709
Ensembl chr17:59,155,732...59,206,709
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PRRG4
proline rich and Gla domain 4
increases expression
ISO
Lidocaine results in increased expression of PRRG4 mRNA
CTD
PMID:35283115
NCBI chr11:32,829,789...32,858,120
Ensembl chr11:32,829,927...32,858,120
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PRSS56
serine protease 56
increases expression
ISO
Lidocaine results in increased expression of PRSS56 mRNA
CTD
PMID:35283115
NCBI chr 2:232,520,388...232,525,716
Ensembl chr 2:232,520,388...232,525,716
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PTGES
prostaglandin E synthase
decreases expression
ISO
Lidocaine results in decreased expression of PTGES mRNA
CTD
PMID:35283115
NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042
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PTGS2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Lidocaine results in decreased expression of PTGS2 mRNA
CTD
PMID:35283115
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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PTPN18
protein tyrosine phosphatase non-receptor type 18
increases expression
ISO
Lidocaine results in increased expression of PTPN18 mRNA
CTD
PMID:35283115
NCBI chr 2:130,356,056...130,375,405
Ensembl chr 2:130,356,045...130,375,405
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PTPN6
protein tyrosine phosphatase non-receptor type 6
increases expression
ISO
Lidocaine results in increased expression of PTPN6 mRNA
CTD
PMID:35283115
NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
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PTTG1
PTTG1 regulator of sister chromatid separation, securin
increases expression
ISO
Lidocaine results in increased expression of PTTG1 mRNA
CTD
PMID:35283115
NCBI chr 5:160,421,855...160,428,744
Ensembl chr 5:160,421,855...160,428,739
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PTX3
pentraxin 3
decreases expression
ISO
Lidocaine results in decreased expression of PTX3 mRNA
CTD
PMID:35283115
NCBI chr 3:157,436,850...157,443,633
Ensembl chr 3:157,436,850...157,443,633
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PVR
PVR cell adhesion molecule
increases expression
ISO
Lidocaine results in increased expression of PVR mRNA
CTD
PMID:35283115
NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162
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PVT1
Pvt1 oncogene
increases expression
ISO
Lidocaine results in increased expression of PVT1 mRNA
CTD
PMID:35283115
NCBI chr 8:127,794,524...128,101,256
Ensembl chr 8:127,794,513...128,188,202
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PYCARD
PYD and CARD domain containing
increases expression
ISO
Lidocaine results in increased expression of PYCARD mRNA
CTD
PMID:35283115
NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
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PYY
peptide YY
increases expression
ISO
Lidocaine results in increased expression of PYY mRNA
CTD
PMID:35283115
NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,733...44,004,469
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PZP
PZP alpha-2-macroglobulin like
increases expression
ISO
Lidocaine results in increased expression of PZP mRNA
CTD
PMID:35283115
NCBI chr12:9,136,472...9,208,395
Ensembl chr12:9,148,840...9,208,395
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QPRT
quinolinate phosphoribosyltransferase
increases expression
ISO
Lidocaine results in increased expression of QPRT mRNA
CTD
PMID:35283115
NCBI chr16:29,679,008...29,698,699
Ensembl chr16:29,663,279...29,698,699
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RAB7B
RAB7B, member RAS oncogene family
increases expression
ISO
Lidocaine results in increased expression of RAB7B mRNA
CTD
PMID:35283115
NCBI chr 1:205,976,740...206,003,395
Ensembl chr 1:205,976,740...206,003,461
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RAB8A
RAB8A, member RAS oncogene family
increases expression
ISO
Lidocaine results in increased expression of RAB8A mRNA
CTD
PMID:35283115
NCBI chr19:16,111,889...16,134,234
Ensembl chr19:16,111,889...16,134,234
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RACGAP1
Rac GTPase activating protein 1
increases expression
ISO
Lidocaine results in increased expression of RACGAP1 mRNA
CTD
PMID:35283115
NCBI chr12:49,989,162...50,033,440
Ensembl chr12:49,976,923...50,033,136
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RAD51
RAD51 recombinase
increases expression
ISO
Lidocaine results in increased expression of RAD51 mRNA
CTD
PMID:35283115
NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340
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RAD54L
RAD54 like
increases expression
ISO
Lidocaine results in increased expression of RAD54L mRNA
CTD
PMID:35283115
NCBI chr 1:46,247,688...46,278,473
Ensembl chr 1:46,246,461...46,278,480
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RASA4B
RAS p21 protein activator 4B
increases expression
ISO
Lidocaine results in increased expression of RASA4 mRNA
CTD
PMID:35283115
NCBI chr 7:102,479,976...102,517,777
Ensembl chr 7:102,479,976...102,517,777
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RBL1
RB transcriptional corepressor like 1
affects expression increases expression
ISO
Lidocaine affects the expression of RBL1 mRNA Lidocaine results in increased expression of RBL1 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr20:36,996,349...37,095,997
Ensembl chr20:36,996,349...37,095,997
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RBL2
RB transcriptional corepressor like 2
affects expression
ISO
Lidocaine affects the expression of RBL2 mRNA
CTD
PMID:18931217
NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648
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RBM47
RNA binding motif protein 47
increases expression
ISO
Lidocaine results in increased expression of RBM47 mRNA
CTD
PMID:35283115
NCBI chr 4:40,423,280...40,630,852
Ensembl chr 4:40,423,267...40,630,875
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RECQL4
RecQ like helicase 4
increases expression
ISO
Lidocaine results in increased expression of RECQL4 mRNA
CTD
PMID:35283115
NCBI chr 8:144,511,288...144,517,833
Ensembl chr 8:144,511,288...144,517,845
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REG3A
regenerating family member 3 alpha
increases expression
ISO
Lidocaine results in increased expression of REG3B mRNA
CTD
PMID:35283115
NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753
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RGS18
regulator of G protein signaling 18
increases expression
ISO
Lidocaine results in increased expression of RGS18 mRNA
CTD
PMID:35283115
NCBI chr 1:192,158,462...192,185,815
Ensembl chr 1:192,158,462...192,185,815
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RPTOR
regulatory associated protein of MTOR complex 1
multiple interactions
ISO
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; dorsomorphin inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]; Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]; MK-8722 promotes the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
CTD
PMID:37914286
NCBI chr17:80,544,838...80,966,368
Ensembl chr17:80,544,819...80,966,371
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RRM1
ribonucleotide reductase catalytic subunit M1
increases expression
ISO
Lidocaine results in increased expression of RRM1 mRNA
CTD
PMID:35283115
NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
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RRM2
ribonucleotide reductase regulatory subunit M2
increases expression
ISO
Lidocaine results in increased expression of RRM2 mRNA
CTD
PMID:35283115
NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725
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RSAD2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
Lidocaine results in increased expression of RSAD2 mRNA
CTD
PMID:35283115
NCBI chr 2:6,865,885...6,898,239
Ensembl chr 2:6,865,557...6,898,239
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S100A11
S100 calcium binding protein A11
increases expression
ISO
Lidocaine results in increased expression of S100A11 mRNA
CTD
PMID:35283115
NCBI chr 1:152,032,506...152,037,004
Ensembl chr 1:152,032,506...152,047,907
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S100A3
S100 calcium binding protein A3
increases expression
ISO
Lidocaine results in increased expression of S100A3 mRNA
CTD
PMID:35283115
NCBI chr 1:153,547,329...153,549,258
Ensembl chr 1:153,547,329...153,549,258
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S100A8
S100 calcium binding protein A8
increases expression decreases expression
ISO
Lidocaine results in increased expression of S100A8 protein Lidocaine results in decreased expression of S100A8 mRNA
CTD
PMID:18382663 PMID:35283115
NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
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S100A9
S100 calcium binding protein A9
increases expression
ISO
Lidocaine results in increased expression of S100A9 protein
CTD
PMID:18382663
NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
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SAPCD2
suppressor APC domain containing 2
increases expression
ISO
Lidocaine results in increased expression of SAPCD2 mRNA
CTD
PMID:35283115
NCBI chr 9:137,062,127...137,070,557
Ensembl chr 9:137,062,127...137,070,557
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SC5D
sterol-C5-desaturase
decreases expression
ISO
Lidocaine results in decreased expression of SC5D mRNA
CTD
PMID:35283115
NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410
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SCGB1A1
secretoglobin family 1A member 1
increases expression
ISO
Lidocaine results in increased expression of SCGB1A1 mRNA
CTD
PMID:35283115
NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195
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SCN4A
sodium voltage-gated channel alpha subunit 4
multiple interactions
EXP
Lidocaine binds to and results in decreased activity of SCN4A protein
CTD
PMID:14662728
NCBI chr17:63,938,554...63,972,918
Ensembl chr17:63,938,554...63,972,918
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SCN5A
sodium voltage-gated channel alpha subunit 5
affects response to substance
EXP
SCN5A protein mutant form affects the susceptibility to Lidocaine
CTD
PMID:18599870
NCBI chr 3:38,548,062...38,649,687
Ensembl chr 3:38,548,057...38,649,743
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SCT
secretin
increases expression
ISO
Lidocaine results in increased expression of SCT mRNA
CTD
PMID:35283115
NCBI chr11:626,309...627,181
Ensembl chr11:626,309...627,181
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SCUBE1
signal peptide, CUB domain and EGF like domain containing 1
increases expression
ISO
Lidocaine results in increased expression of SCUBE1 mRNA
CTD
PMID:35283115
NCBI chr22:43,197,280...43,343,372
Ensembl chr22:43,197,280...43,343,372
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SDF2L1
stromal cell derived factor 2 like 1
increases expression
ISO
Lidocaine results in increased expression of SDF2L1 mRNA
CTD
PMID:35283115
NCBI chr22:21,642,302...21,644,299
Ensembl chr22:21,642,302...21,644,299
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SELL
selectin L
multiple interactions
EXP
Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]
CTD
PMID:9336308
NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
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SEMA5B
semaphorin 5B
increases expression
ISO
Lidocaine results in increased expression of SEMA5B mRNA
CTD
PMID:35283115
NCBI chr 3:122,909,082...123,028,605
Ensembl chr 3:122,909,082...123,028,605
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SGO2
shugoshin 2
increases expression
ISO
Lidocaine results in increased expression of SGO2 mRNA
CTD
PMID:35283115
NCBI chr 2:200,526,142...200,584,096
Ensembl chr 2:200,510,008...200,584,096
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SGSM3
small G protein signaling modulator 3
decreases expression
ISO
Lidocaine results in decreased expression of SGSM3 mRNA
CTD
PMID:35283115
NCBI chr22:40,370,594...40,410,289
Ensembl chr22:40,370,591...40,410,289
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SHC4
SHC adaptor protein 4
increases expression
ISO
Lidocaine results in increased expression of SHC4 mRNA
CTD
PMID:35283115
NCBI chr15:48,823,741...48,963,919
Ensembl chr15:48,823,741...48,963,919
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SHCBP1
SHC binding and spindle associated 1
increases expression
ISO
Lidocaine results in increased expression of SHCBP1 mRNA
CTD
PMID:35283115
NCBI chr16:46,578,591...46,621,379
Ensembl chr16:46,578,591...46,621,379
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SHMT1
serine hydroxymethyltransferase 1
increases expression
ISO
Lidocaine results in increased expression of SHMT1 mRNA
CTD
PMID:35283115
NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550
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SIRT4
sirtuin 4
decreases expression
ISO
Lidocaine results in decreased expression of SIRT4 mRNA
CTD
PMID:35283115
NCBI chr12:120,291,780...120,313,249
Ensembl chr12:120,302,316...120,313,249
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SKA1
spindle and kinetochore associated complex subunit 1
increases expression
ISO
Lidocaine results in increased expression of SKA1 mRNA
CTD
PMID:35283115
NCBI chr18:50,375,046...50,394,168
Ensembl chr18:50,375,040...50,394,168
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SKA3
spindle and kinetochore associated complex subunit 3
increases expression
ISO
Lidocaine results in increased expression of SKA3 mRNA
CTD
PMID:35283115
NCBI chr13:21,153,595...21,176,552
Ensembl chr13:21,153,595...21,176,552
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SLAMF7
SLAM family member 7
increases expression
ISO
Lidocaine results in increased expression of SLAMF7 mRNA
CTD
PMID:35283115
NCBI chr 1:160,739,057...160,754,821
Ensembl chr 1:160,739,057...160,754,821
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SLAMF9
SLAM family member 9
increases expression
ISO
Lidocaine results in increased expression of SLAMF9 mRNA
CTD
PMID:35283115
NCBI chr 1:159,951,492...159,983,984
Ensembl chr 1:159,951,492...159,954,237
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SLC10A6
solute carrier family 10 member 6
increases expression
ISO
Lidocaine results in increased expression of SLC10A6 mRNA
CTD
PMID:35283115
NCBI chr 4:86,823,468...86,849,384
Ensembl chr 4:86,823,468...86,849,384
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SLC13A3
solute carrier family 13 member 3
decreases expression
ISO
Lidocaine results in decreased expression of SLC13A3 mRNA
CTD
PMID:35283115
NCBI chr20:46,557,828...46,684,485
Ensembl chr20:46,557,823...46,684,467
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SLC22A1
solute carrier family 22 member 1
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:21641380
NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
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SLC22A16
solute carrier family 22 member 16
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:15963465
NCBI chr 6:110,424,687...110,476,613
Ensembl chr 6:110,424,687...110,476,641
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SLC22A2
solute carrier family 22 member 2
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
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SLC22A3
solute carrier family 22 member 3
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:21641380
NCBI chr 6:160,348,378...160,452,577
Ensembl chr 6:160,348,378...160,452,577
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SLC22A4
solute carrier family 22 member 4
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:21641380
NCBI chr 5:132,294,394...132,344,190
Ensembl chr 5:132,294,394...132,344,190
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SLC22A5
solute carrier family 22 member 5
multiple interactions
EXP
Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
CTD
PMID:21641380
NCBI chr 5:132,369,710...132,395,612
Ensembl chr 5:132,369,710...132,395,613
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SLC26A2
solute carrier family 26 member 2
decreases expression
ISO
Lidocaine results in decreased expression of SLC26A2 mRNA
CTD
PMID:35283115
NCBI chr 5:149,960,758...149,987,400
Ensembl chr 5:149,960,758...149,993,455
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SLC28A1
solute carrier family 28 member 1
decreases expression
ISO
Lidocaine results in decreased expression of SLC28A1 mRNA
CTD
PMID:35283115
NCBI chr15:84,884,662...84,975,649
Ensembl chr15:84,884,654...84,945,798
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SLC39A12
solute carrier family 39 member 12
increases expression
ISO
Lidocaine results in increased expression of SLC39A12 mRNA
CTD
PMID:35283115
NCBI chr10:17,951,918...18,043,285
Ensembl chr10:17,951,839...18,043,292
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SLC41A2
solute carrier family 41 member 2
decreases expression
ISO
Lidocaine results in decreased expression of SLC41A2 mRNA
CTD
PMID:35283115
NCBI chr12:104,801,801...104,958,746
Ensembl chr12:104,801,801...104,958,744
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SLC6A2
solute carrier family 6 member 2
multiple interactions
ISO
Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
CTD
PMID:16725121
NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645
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SLC7A7
solute carrier family 7 member 7
increases expression
ISO
Lidocaine results in increased expression of SLC7A7 mRNA
CTD
PMID:35283115
NCBI chr14:22,773,222...22,819,791
Ensembl chr14:22,773,222...22,829,820
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SLCO2B1
solute carrier organic anion transporter family member 2B1
increases expression
ISO
Lidocaine results in increased expression of SLCO2B1 mRNA
CTD
PMID:35283115
NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
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SMC2
structural maintenance of chromosomes 2
increases expression
ISO
Lidocaine results in increased expression of SMC2 mRNA
CTD
PMID:35283115
NCBI chr 9:104,088,263...104,141,419
Ensembl chr 9:104,094,260...104,141,419
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SNX20
sorting nexin 20
increases expression
ISO
Lidocaine results in increased expression of SNX20 mRNA
CTD
PMID:35283115
NCBI chr16:50,666,300...50,681,312
Ensembl chr16:50,666,300...50,681,353
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SOAT1
sterol O-acyltransferase 1
increases expression
ISO
Lidocaine results in increased expression of SOAT1 mRNA
CTD
PMID:35283115
NCBI chr 1:179,293,797...179,358,680
Ensembl chr 1:179,293,714...179,358,680
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SPATA45
spermatogenesis associated 45
increases expression
ISO
Lidocaine results in increased expression of PYHIN1 mRNA
CTD
PMID:35283115
NCBI chr 1:212,830,141...212,847,649
Ensembl chr 1:212,830,141...212,847,649
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SPC24
SPC24 component of NDC80 kinetochore complex
increases expression
ISO
Lidocaine results in increased expression of SPC24 mRNA
CTD
PMID:35283115
NCBI chr19:11,145,493...11,155,782
Ensembl chr19:11,131,520...11,155,807
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SPC25
SPC25 component of NDC80 kinetochore complex
increases expression
ISO
Lidocaine results in increased expression of SPC25 mRNA
CTD
PMID:35283115
NCBI chr 2:168,861,521...168,890,430
Ensembl chr 2:168,834,132...168,913,371
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SPI1
Spi-1 proto-oncogene
increases expression
ISO
Lidocaine results in increased expression of SPI1 mRNA
CTD
PMID:35283115
NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369
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SPINK2
serine peptidase inhibitor Kazal type 2
increases expression
ISO
Lidocaine results in increased expression of SPINK2 mRNA
CTD
PMID:35283115
NCBI chr 4:56,809,860...56,821,869
Ensembl chr 4:56,809,860...56,821,742
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SPP1
secreted phosphoprotein 1
increases expression
ISO
Lidocaine results in increased expression of SPP1 mRNA
CTD
PMID:35283115
NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
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SRD5A2
steroid 5 alpha-reductase 2
decreases expression
ISO
Lidocaine results in decreased expression of SRD5A2 mRNA
CTD
PMID:35283115
NCBI chr 2:31,522,480...31,663,009
Ensembl chr 2:31,522,480...31,580,938
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ST14
ST14 transmembrane serine protease matriptase
increases expression
ISO
Lidocaine results in increased expression of ST14 mRNA
CTD
PMID:35283115
NCBI chr11:130,159,782...130,210,362
Ensembl chr11:130,159,782...130,210,362
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STAP1
signal transducing adaptor family member 1
increases expression
ISO
Lidocaine results in increased expression of STAP1 mRNA
CTD
PMID:35283115
NCBI chr 4:67,558,727...67,607,337
Ensembl chr 4:67,558,727...67,607,337
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STAT6
signal transducer and activator of transcription 6
increases expression
ISO
Lidocaine results in increased expression of STAT6 mRNA
CTD
PMID:35283115
NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
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STEAP4
STEAP4 metalloreductase
decreases expression
ISO
Lidocaine results in decreased expression of STEAP4 mRNA
CTD
PMID:35283115
NCBI chr 7:88,270,892...88,306,894
Ensembl chr 7:88,270,892...88,306,894
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STIL
STIL centriolar assembly protein
increases expression
ISO
Lidocaine results in increased expression of STIL mRNA
CTD
PMID:35283115
NCBI chr 1:47,250,139...47,314,896
Ensembl chr 1:47,250,139...47,314,892
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STKLD1
serine/threonine kinase like domain containing 1
decreases expression
ISO
Lidocaine results in decreased expression of STKLD1 mRNA
CTD
PMID:35283115
NCBI chr 9:133,376,366...133,406,096
Ensembl chr 9:133,376,366...133,406,096
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STMN1
stathmin 1
increases expression
ISO
Lidocaine results in increased expression of STMN1 mRNA; Lidocaine results in increased expression of STMN1 protein
CTD
PMID:27018092
NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
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STXBP2
syntaxin binding protein 2
increases expression
ISO
Lidocaine results in increased expression of STXBP2 mRNA
CTD
PMID:35283115
NCBI chr19:7,629,793...7,647,873
Ensembl chr19:7,636,772...7,647,873
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SULT1A1
sulfotransferase family 1A member 1
increases sulfation
EXP
SULT1A1 protein results in increased sulfation of Lidocaine metabolite
CTD
PMID:10460806
NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044
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SULT1B1
sulfotransferase family 1B member 1
increases sulfation
EXP
SULT1B1 protein results in increased sulfation of Lidocaine metabolite
CTD
PMID:10460806
NCBI chr 4:69,721,167...69,760,620
Ensembl chr 4:69,721,167...69,787,961
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SYK
spleen associated tyrosine kinase
increases expression
ISO
Lidocaine results in increased expression of SYK mRNA
CTD
PMID:35283115
NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549
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SYPL2
synaptophysin like 2
increases expression
ISO
Lidocaine results in increased expression of SYPL2 mRNA
CTD
PMID:35283115
NCBI chr 1:109,466,546...109,482,134
Ensembl chr 1:109,466,546...109,482,134
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TAC1
tachykinin precursor 1
increases expression
ISO
Lidocaine results in increased expression of TAC1 mRNA
CTD
PMID:35283115
NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
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TACC3
transforming acidic coiled-coil containing protein 3
increases expression
ISO
Lidocaine results in increased expression of TACC3 mRNA
CTD
PMID:35283115
NCBI chr 4:1,721,521...1,745,171
Ensembl chr 4:1,712,858...1,745,171
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TAGAP
T cell activation RhoGTPase activating protein
increases expression
ISO
Lidocaine results in increased expression of TAGAP mRNA
CTD
PMID:35283115
NCBI chr 6:159,034,481...159,044,991
Ensembl chr 6:159,034,468...159,095,823
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TCF19
transcription factor 19
increases expression
ISO
Lidocaine results in increased expression of TCF19 mRNA
CTD
PMID:35283115
NCBI chr 6:31,158,589...31,164,215
Ensembl chr 6:31,158,331...31,167,159
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TCHHL1
trichohyalin like 1
decreases expression
ISO
Lidocaine results in decreased expression of TCHHL1 mRNA
CTD
PMID:35283115
NCBI chr 1:152,084,141...152,089,064
Ensembl chr 1:152,084,141...152,089,064
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TCIM
transcriptional and immune response regulator
increases expression
ISO
Lidocaine results in increased expression of TCIM mRNA
CTD
PMID:35283115
NCBI chr 8:40,153,482...40,155,310
Ensembl chr 8:40,153,482...40,155,310
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TEC
tec protein tyrosine kinase
increases expression
ISO
Lidocaine results in increased expression of TEC mRNA
CTD
PMID:35283115
NCBI chr 4:48,135,783...48,269,838
Ensembl chr 4:48,135,783...48,269,838
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TENT5A
terminal nucleotidyltransferase 5A
increases expression
ISO
Lidocaine results in increased expression of FAM46A mRNA
CTD
PMID:35283115
NCBI chr 6:81,745,730...81,752,681
Ensembl chr 6:81,491,439...81,752,774
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TENT5C
terminal nucleotidyltransferase 5C
increases expression
ISO
Lidocaine results in increased expression of FAM46C mRNA
CTD
PMID:35283115
NCBI chr 1:117,606,048...117,628,389
Ensembl chr 1:117,606,048...117,628,389
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TEX56P
testis expressed 56, pseudogene
increases expression
ISO
Lidocaine results in increased expression of TEX56P mRNA
CTD
PMID:35283115
NCBI chr 6:4,079,209...4,130,765
Ensembl chr 6:4,087,534...4,122,032 Ensembl chr 6:4,087,534...4,122,032
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TFF3
trefoil factor 3
increases expression
ISO
Lidocaine results in increased expression of TFF3 mRNA
CTD
PMID:35283115
NCBI chr21:42,311,667...42,315,409
Ensembl chr21:42,311,667...42,315,409
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TGFA
transforming growth factor alpha
decreases expression
ISO
Lidocaine results in decreased expression of TGFA protein
CTD
PMID:18382663
NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
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TGFB1
transforming growth factor beta 1
increases expression
ISO
Lidocaine results in increased expression of TGFB1 mRNA
CTD
PMID:35283115
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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TGIF2
TGFB induced factor homeobox 2
increases expression
ISO
Lidocaine results in increased expression of TGIF2 mRNA
CTD
PMID:35283115
NCBI chr20:36,573,464...36,593,950
Ensembl chr20:36,573,488...36,593,950
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THBS2
thrombospondin 2
increases expression
ISO
Lidocaine results in increased expression of THBS2 mRNA
CTD
PMID:35283115
NCBI chr 6:169,215,785...169,253,846
Ensembl chr 6:169,215,780...169,254,050
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THBS4
thrombospondin 4
increases expression
ISO
Lidocaine results in increased expression of THBS4 mRNA
CTD
PMID:35283115
NCBI chr 5:79,991,332...80,083,287
Ensembl chr 5:79,991,311...80,083,287
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TICAM2
TIR domain containing adaptor molecule 2
increases expression
ISO
Lidocaine results in increased expression of TICAM2 mRNA
CTD
PMID:35283115
NCBI chr 5:115,578,496...115,602,479
Ensembl chr 5:115,578,496...115,602,479
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TICRR
TOPBP1 interacting checkpoint and replication regulator
increases expression
ISO
Lidocaine results in increased expression of TICRR mRNA
CTD
PMID:35283115
NCBI chr15:89,575,469...89,628,023
Ensembl chr15:89,575,469...89,631,056
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TIFAB
TIFA inhibitor
increases expression
ISO
Lidocaine results in increased expression of TIFAB mRNA
CTD
PMID:35283115
NCBI chr 5:135,444,226...135,452,351
Ensembl chr 5:135,444,226...135,452,351
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TK1
thymidine kinase 1
increases expression
ISO
Lidocaine results in increased expression of TK1 mRNA
CTD
PMID:35283115
NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233
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TLN1
talin 1
increases expression
ISO
Lidocaine results in increased expression of TLN1 mRNA
CTD
PMID:35283115
NCBI chr 9:35,696,948...35,732,195
Ensembl chr 9:35,696,948...35,732,195
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TLR3
toll like receptor 3
increases expression
ISO
Lidocaine results in increased expression of TLR3 mRNA
CTD
PMID:35283115
NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073
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TLR4
toll like receptor 4
increases expression
ISO
Lidocaine results in increased expression of TLR4 mRNA
CTD
PMID:35283115
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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TLR8
toll like receptor 8
increases expression
ISO
Lidocaine results in increased expression of TLR8 mRNA
CTD
PMID:35283115
NCBI chr X:12,906,620...12,923,169
Ensembl chr X:12,906,620...12,923,169
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TLR9
toll like receptor 9
increases expression
ISO
Lidocaine results in increased expression of TLR9 mRNA
CTD
PMID:35283115
NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645
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TMEM119
transmembrane protein 119
increases expression
ISO
Lidocaine results in increased expression of TMEM119 mRNA
CTD
PMID:35283115
NCBI chr12:108,589,851...108,598,084
Ensembl chr12:108,589,851...108,598,320
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TMEM176B
transmembrane protein 176B
increases expression
ISO
Lidocaine results in increased expression of TMEM176B mRNA
CTD
PMID:35283115
NCBI chr 7:150,791,301...150,801,360
Ensembl chr 7:150,791,285...150,801,360
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TMPRSS7
transmembrane serine protease 7
decreases expression
ISO
Lidocaine results in decreased expression of TMPRSS7 mRNA
CTD
PMID:35283115
NCBI chr 3:112,034,736...112,081,269
Ensembl chr 3:112,034,736...112,081,269
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TMPRSS9
transmembrane serine protease 9
increases expression
ISO
Lidocaine results in increased expression of TMPRSS9 mRNA
CTD
PMID:35283115
NCBI chr19:2,360,265...2,426,261
Ensembl chr19:2,360,238...2,426,261
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TNC
tenascin C
increases expression
ISO
Lidocaine results in increased expression of TNC mRNA
CTD
PMID:35283115
NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207
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TNF
tumor necrosis factor
multiple interactions
EXP ISO
Lidocaine inhibits the reaction [TNF protein results in increased cleavage of SELL protein]; Lidocaine inhibits the reaction [TNF protein results in increased expression of [ITGAM protein binds to ITGB2 protein]] Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Lidocaine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
CTD
PMID:9336308 PMID:32471037
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFAIP8L2
TNF alpha induced protein 8 like 2
increases expression
ISO
Lidocaine results in increased expression of TNFAIP8L2 mRNA
CTD
PMID:35283115
NCBI chr 1:151,156,649...151,159,749
Ensembl chr 1:151,156,649...151,159,749
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TNFRSF12A
TNF receptor superfamily member 12A
increases expression
ISO
Lidocaine results in increased expression of TNFRSF12A mRNA
CTD
PMID:35283115
NCBI chr16:3,020,368...3,022,383
Ensembl chr16:3,018,445...3,022,383
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TNNI2
troponin I2, fast skeletal type
increases expression
ISO
Lidocaine results in increased expression of TNNI2 mRNA
CTD
PMID:35283115
NCBI chr11:1,838,981...1,841,678
Ensembl chr11:1,838,981...1,841,680
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TOP6BL
TOP6B like initiator of meiotic double strand breaks
decreases expression
ISO
Lidocaine results in decreased expression of TOP6BL mRNA
CTD
PMID:35283115
NCBI chr11:66,744,769...66,843,516
Ensembl chr11:66,744,451...66,843,516
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TP53
tumor protein p53
affects expression decreases expression
ISO
Lidocaine affects the expression of TRP53 mRNA Lidocaine results in decreased expression of TP53 mRNA
CTD
PMID:18931217 PMID:35283115
NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
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TPBGL
trophoblast glycoprotein like
increases expression
ISO
Lidocaine results in increased expression of TPBGL mRNA
CTD
PMID:35283115
NCBI chr11:75,240,774...75,243,704
Ensembl chr11:75,240,774...75,243,704
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TPH1
tryptophan hydroxylase 1
increases expression
ISO
Lidocaine results in increased expression of TPH1 mRNA
CTD
PMID:35283115
NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269
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TPX2
TPX2 microtubule nucleation factor
increases expression
ISO
Lidocaine results in increased expression of TPX2 mRNA
CTD
PMID:35283115
NCBI chr20:31,739,290...31,801,800
Ensembl chr20:31,739,271...31,801,805
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TRAIP
TRAF interacting protein
increases expression
ISO
Lidocaine results in increased expression of TRAIP mRNA
CTD
PMID:35283115
NCBI chr 3:49,828,601...49,856,564
Ensembl chr 3:49,828,601...49,856,574
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TRAM2
translocation associated membrane protein 2
increases expression
ISO
Lidocaine results in increased expression of TRAM2 mRNA
CTD
PMID:35283115
NCBI chr 6:52,497,408...52,577,060
Ensembl chr 6:52,497,408...52,577,060
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TRAV12-3
T cell receptor alpha variable 12-3
decreases expression
ISO
Lidocaine results in decreased expression of TRAV12-3 mRNA
CTD
PMID:35283115
NCBI chr14:21,965,507...21,966,061
Ensembl chr14:21,965,451...21,966,061
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TRIM7
tripartite motif containing 7
decreases expression
ISO
Lidocaine results in decreased expression of TRIM7 mRNA
CTD
PMID:35283115
NCBI chr 5:181,193,924...181,205,196
Ensembl chr 5:181,193,924...181,205,293
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TRIP13
thyroid hormone receptor interactor 13
increases expression
ISO
Lidocaine results in increased expression of TRIP13 mRNA
CTD
PMID:35283115
NCBI chr 5:892,884...919,348
Ensembl chr 5:892,884...919,357
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TROAP
trophinin associated protein
increases expression
ISO
Lidocaine results in increased expression of TROAP mRNA
CTD
PMID:35283115
NCBI chr12:49,323,255...49,331,731
Ensembl chr12:49,323,236...49,331,731
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TRPA1
transient receptor potential cation channel subfamily A member 1
increases activity
ISO
Lidocaine results in increased activity of TRPA1 protein
CTD
PMID:18172555
NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584
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TRPV1
transient receptor potential cation channel subfamily V member 1
increases activity multiple interactions
EXP ISO
Lidocaine results in increased activity of TRPV1 protein 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]; Lidocaine promotes the reaction [TRPV1 protein results in increased abundance of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; oxophenylarsine inhibits the reaction [Lidocaine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]]; oxophenylarsine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Lidocaine results in increased activity of TRPV1 protein] TRPV1 protein affects the reaction [Lidocaine results in increased secretion of CALCA protein]
CTD
PMID:18172555
NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
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TTK
TTK protein kinase
increases expression
ISO
Lidocaine results in increased expression of TTK mRNA
CTD
PMID:35283115
NCBI chr 6:80,004,649...80,042,527
Ensembl chr 6:80,003,887...80,042,527
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TYMS
thymidylate synthetase
increases expression
ISO
Lidocaine results in increased expression of TYMS mRNA
CTD
PMID:35283115
NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
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TYROBP
transmembrane immune signaling adaptor TYROBP
increases expression
ISO
Lidocaine results in increased expression of TYROBP mRNA
CTD
PMID:35283115
NCBI chr19:35,904,403...35,908,295
Ensembl chr19:35,904,401...35,908,295
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UBD
ubiquitin D
decreases expression
ISO
Lidocaine results in decreased expression of UBD mRNA
CTD
PMID:35283115
NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732
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UBE2C
ubiquitin conjugating enzyme E2 C
increases expression
ISO
Lidocaine results in increased expression of UBE2C mRNA
CTD
PMID:35283115
NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957
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UBE2T
ubiquitin conjugating enzyme E2 T
increases expression
ISO
Lidocaine results in increased expression of UBE2T mRNA
CTD
PMID:35283115
NCBI chr 1:202,331,657...202,341,936
Ensembl chr 1:202,331,544...202,341,984
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UBL7
ubiquitin like 7
decreases expression
ISO
Lidocaine results in decreased expression of UBL7 protein
CTD
PMID:27018092
NCBI chr15:74,445,977...74,461,188
Ensembl chr15:74,445,977...74,461,182
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UCHL1
ubiquitin C-terminal hydrolase L1
multiple interactions decreases expression
ISO EXP
NGF protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]; NNAT protein inhibits the reaction [Lidocaine results in decreased expression of UCHL1 protein]
CTD
PMID:34193770
NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
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UCN
urocortin
increases expression
ISO
Lidocaine results in increased expression of UCN mRNA
CTD
PMID:35283115
NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445
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UCP2
uncoupling protein 2
increases expression
ISO
Lidocaine results in increased expression of UCP2 mRNA
CTD
PMID:35283115
NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843
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UNC5CL
unc-5 family C-terminal like
increases expression
ISO
Lidocaine results in increased expression of UNC5CL mRNA
CTD
PMID:35283115
NCBI chr 6:41,026,895...41,039,221
Ensembl chr 6:41,026,895...41,039,221
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UNC93B1
unc-93 homolog B1, TLR signaling regulator
increases expression
ISO
Lidocaine results in increased expression of UNC93B1 mRNA
CTD
PMID:35283115
NCBI chr11:67,991,100...68,004,097
Ensembl chr11:67,991,100...68,004,982
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USP18
ubiquitin specific peptidase 18
increases expression
ISO
Lidocaine results in increased expression of USP18 mRNA
CTD
PMID:35283115
NCBI chr22:18,150,170...18,177,397
Ensembl chr22:18,149,843...18,177,397
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UTS2
urotensin 2
increases expression
ISO
Lidocaine results in increased expression of UTS2 mRNA
CTD
PMID:35283115
NCBI chr 1:7,847,612...7,913,249
Ensembl chr 1:7,843,083...7,853,512
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VAV1
vav guanine nucleotide exchange factor 1
increases expression
ISO
Lidocaine results in increased expression of VAV1 mRNA
CTD
PMID:35283115
NCBI chr19:6,772,708...6,857,361
Ensembl chr19:6,772,708...6,857,366
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VCAN
versican
increases expression
ISO
Lidocaine results in increased expression of VCAN mRNA
CTD
PMID:35283115
NCBI chr 5:83,471,744...83,582,302
Ensembl chr 5:83,471,618...83,582,303
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VGF
VGF nerve growth factor inducible
increases expression
ISO
Lidocaine results in increased expression of VGF mRNA
CTD
PMID:35283115
NCBI chr 7:101,162,509...101,169,952
Ensembl chr 7:101,162,509...101,165,569
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WDFY4
WDFY family member 4
increases expression
ISO
Lidocaine results in increased expression of WDFY4 mRNA
CTD
PMID:35283115
NCBI chr10:48,684,873...48,982,956
Ensembl chr10:48,684,873...48,982,956
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ZBP1
Z-DNA binding protein 1
increases expression
ISO
Lidocaine results in increased expression of ZBP1 mRNA
CTD
PMID:35283115
NCBI chr20:57,603,852...57,620,426
Ensembl chr20:57,603,846...57,620,576
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ZC3HAV1
zinc finger CCCH-type containing, antiviral 1
increases expression
ISO
Lidocaine results in increased expression of ZC3HAV1 mRNA
CTD
PMID:35283115
NCBI chr 7:139,043,515...139,109,720
Ensembl chr 7:139,043,515...139,132,122
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ZNF281
zinc finger protein 281
decreases expression
ISO
Lidocaine results in decreased expression of ZFP281 mRNA
CTD
PMID:35283115
NCBI chr 1:200,404,951...200,410,036
Ensembl chr 1:200,404,940...200,410,056
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ZNF597
zinc finger protein 597
decreases expression
ISO
Lidocaine results in decreased expression of ZFP597 mRNA
CTD
PMID:35283115
NCBI chr16:3,432,414...3,443,504
Ensembl chr16:3,432,414...3,443,504
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