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G |
Ace |
angiotensin I converting enzyme |
multiple interactions increases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein] |
CTD |
PMID:31629013 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
multiple interactions decreases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] |
CTD |
PMID:31629013 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Adra2a |
adrenoceptor alpha 2A |
decreases expression |
ISO |
Pregabalin results in decreased expression of ADRA2A mRNA |
CTD |
PMID:22489711 |
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NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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G |
Agt |
angiotensinogen |
decreases expression multiple interactions |
EXP |
Pregabalin results in decreased expression of AGT protein Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein] |
CTD |
PMID:31629013 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression multiple interactions |
EXP |
Pregabalin results in increased expression of AGTR1 protein Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein] |
CTD |
PMID:31629013 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Pregabalin; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Pregabalin] |
CTD |
PMID:39172838 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Cacna1c |
calcium voltage-gated channel subunit alpha1 C |
affects localization |
EXP |
Pregabalin affects the localization of CACNA1C protein |
CTD |
PMID:22949532 |
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NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
decreases response to substance affects response to substance multiple interactions affects binding decreases expression affects localization |
ISO EXP |
CACNA2D1 gene mutant form results in decreased susceptibility to Pregabalin CACNA2D1 affects the susceptibility to Pregabalin CACNA2D1 protein affects the susceptibility to and affects the activity of Pregabalin; Pregabalin binds to and affects the activity of CACNA2D1 protein Pregabalin binds to and affects the activity of CACNA2D1 protein; Pregabalin results in decreased expression of and affects the localization of CACNA2D1 protein Pregabalin binds to CACNA2D1 protein Pregabalin results in decreased expression of CACNA2D1 mRNA Pregabalin affects the localization of CACNA2D1 protein |
CTD |
PMID:16460711 PMID:17088553 PMID:19339603 PMID:22949532 PMID:24133248 PMID:24269977 More...
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NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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G |
Casp3 |
caspase 3 |
affects expression |
EXP |
Pregabalin affects the expression of CASP3 protein |
CTD |
PMID:21394310 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cnr1 |
cannabinoid receptor 1 |
affects expression |
ISO |
Pregabalin affects the expression of CNR1 mRNA |
CTD |
PMID:22017514 |
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NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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G |
Drd2 |
dopamine receptor D2 |
decreases expression |
ISO |
Pregabalin results in decreased expression of DRD2 mRNA |
CTD |
PMID:22489711 |
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] |
CTD |
PMID:25290014 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Mas1 |
MAS1 proto-oncogene, G protein-coupled receptor |
decreases expression multiple interactions |
EXP |
Pregabalin results in decreased expression of MAS1 protein Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein] |
CTD |
PMID:31629013 |
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NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
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G |
Nppb |
natriuretic peptide B |
increases expression multiple interactions |
EXP |
Pregabalin results in increased expression of NPPB protein Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein] |
CTD |
PMID:31629013 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
P2rx3 |
purinergic receptor P2X 3 |
affects expression |
EXP |
Pregabalin affects the expression of P2RX3 mRNA; Pregabalin affects the expression of P2RX3 protein |
CTD |
PMID:24136739 |
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NCBI chr 3:70,080,850...70,124,664
Ensembl chr 3:70,080,851...70,125,178
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions decreases expression |
EXP |
Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] |
CTD |
PMID:31629013 |
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NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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G |
Psen1 |
presenilin 1 |
multiple interactions |
ISO |
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Pregabalin; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Pregabalin] |
CTD |
PMID:39172838 |
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NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
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G |
Slc1a1 |
solute carrier family 1 member 1 |
multiple interactions increases activity |
EXP |
chelerythrine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; Staurosporine inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein] |
CTD |
PMID:22511482 |
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NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402
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G |
Stx1a |
syntaxin 1A |
affects response to substance |
ISO |
STX1A affects the susceptibility to Pregabalin |
CTD |
PMID:24269977 |
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NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
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G |
Tac1 |
tachykinin, precursor 1 |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Freund's Adjuvant promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; Pregabalin inhibits the reaction [Phorbol 12,13-Dibutyrate promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] |
CTD |
PMID:14499429 |
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NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression |
EXP |
Pregabalin results in increased expression of TGFB1 protein |
CTD |
PMID:25340254 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
increases expression affects expression |
ISO |
Pregabalin results in increased expression of TH mRNA Pregabalin affects the expression of TH mRNA |
CTD |
PMID:22017514 PMID:22489711 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Pregabalin inhibits the reaction [Vincristine results in increased expression of TNF protein] |
CTD |
PMID:26102012 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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