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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metolazone
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Accession:CHEBI:64354 term browser browse the term
Definition:A quinazoline that consists of 1,2,3,4-tetrahydroquinazolin-4-one bearing additional methyl, 2-tolyl, sulfamyl and chloro substituents at positions 2, 3, 6 and 7 respectively. A quinazoline diuretic, with properties similar to thiazide diuretics.
Synonyms:exact_synonym: 7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
 related_synonym: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;   7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide;   Formula=C16H16ClN3O3S;   InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23);   InChIKey=AQCHWTWZEMGIFD-UHFFFAOYSA-N;   SMILES=CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O;   Zaroxolyn;   metolazona;   metolazonum
 alt_id: CHEBI:6903
 xref: CAS:17560-51-9;   DrugBank:DB00524;   Drug_Central:1783;   KEGG:D00431;   LINCS:LSM-1680
 xref_mesh: MESH:D008788
 xref: PMID:12671341;   PMID:15095363;   PMID:1593359;   PMID:16189620;   PMID:16538931;   PMID:16717105;   PMID:16908225;   PMID:1886511;   PMID:1928234;   PMID:1946137;   PMID:2071258;   PMID:21387350;   PMID:21886902;   PMID:8199745;   PMID:8205244;   PMID:8870895;   PMID:9089428;   Patent:US2008139593;   Patent:US3360518;   Reaxys:965506;   Wikipedia:Metolazone



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metolazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Metolazone results in increased activity of NR1I2 protein
[Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            diuretic 4108
              metolazone 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19347
                              oxoacid 18782
                                chalcogen oxoacid 13784
                                  sulfur oxoacid 13573
                                    sulfonic acid 11618
                                      sulfonic acid derivative 11618
                                        sulfonamide 5307
                                          metolazone 2
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