K-ATP channel agonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	K-ATP channel agonist	go back to main search page
Accession:	CHEBI:64338	browse the term
Definition:	A compound which acts as an agonist at the ATP-sensitive K+ channel.
Synonyms:	related_synonym:	ATP-sensitive K+ channel agonist; ATP-sensitive K+ channel agonists; ATP-sensitive K+ channel opener; ATP-sensitive K+ channel openers; K-ATP channel agonists

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Genes (136)

diazoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

apoptosis inducing factor, mitochondria associated 1

decreases localization
multiple interactions

Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]]; Diazoxide inhibits the reaction [Bleomycin affects the expression of and affects the localization of AIFM1 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]

PMID:21256120 PMID:37783230

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of BAX protein]]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of BAX protein]

PMID:20650802 PMID:37783230

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]]; Diazoxide inhibits the reaction [Bleomycin results in decreased expression of BCL2 protein]

PMID:20650802 PMID:37783230

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
increases expression

5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

caspase 3

multiple interactions
decreases activity

5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin D1

multiple interactions
decreases expression

Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

collagen type I alpha 1 chain

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

catenin beta 1

multiple interactions
decreases expression

Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome c, somatic

decreases secretion
multiple interactions

Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

Fms related receptor tyrosine kinase 1

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

glucagon

multiple interactions

Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glycerol-3-phosphate dehydrogenase 2

multiple interactions

[Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

heme oxygenase 1

multiple interactions

Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

islet amyloid polypeptide

multiple interactions

Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA]

NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920

G

interleukin 10

decreases secretion

Diazoxide results in decreased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 6

decreases secretion

Diazoxide results in decreased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

[Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]; Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of INS1 mRNA]

PMID:10464266 PMID:10780946 PMID:11527545

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

Diazoxide inhibits the reaction [Glucose results in increased secretion of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

potassium inwardly-rectifying channel, subfamily J, member 11

decreases expression

Diazoxide results in decreased expression of KCNJ11 mRNA

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

leptin

multiple interactions
decreases secretion

Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

nicotinamide phosphoribosyltransferase

multiple interactions

Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein]

NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100

G

nuclear factor kappa B subunit 1

multiple interactions
increases activity

5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]

PMID:15795934 PMID:15927086 PMID:16257489

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

pancreatic and duodenal homeobox 1

multiple interactions

Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA]

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

solute carrier family 2 member 2

multiple interactions

Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

transforming growth factor, beta 1

multiple interactions

5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]]; Diazoxide inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

decreases secretion
multiple interactions

Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]

PMID:16257489 PMID:16612254 PMID:18700057 PMID:19012619

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

decreases expression

Diazoxide results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

rottlerin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]

NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065

G

acetyl-CoA acetyltransferase 1

multiple interactions

rottlerin inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

angiotensinogen

multiple interactions

rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

allograft inflammatory factor 1

multiple interactions

rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of AIF1 protein]

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

rottlerin results in decreased phosphorylation of AKT1 protein
rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:15177934 PMID:19393235 PMID:22902833

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

autophagy related 7

multiple interactions
increases expression

3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

BCL2-associated agonist of cell death

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

multiple interactions

rottlerin inhibits the reaction [Doxorubicin results in increased activity of BAK1 protein]

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of BAX protein]; rottlerin inhibits the reaction [Cisplatin affects the localization of BAX protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]
rottlerin results in increased expression of BAX protein

PMID:21633170 PMID:22902833 PMID:25895139 PMID:30366073

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

rottlerin results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]; rottlerin promotes the reaction [Paclitaxel results in decreased expression of BCL2 protein]

PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195 PMID:35995259

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
multiple interactions

rottlerin results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]

PMID:22902833 PMID:25895139 PMID:30366073 PMID:30393195

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

beclin 1

multiple interactions
increases expression

3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 3

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

caspase 3

decreases activity
multiple interactions
increases activity
increases cleavage

rottlerin results in decreased activity of CASP3 protein
rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Dieldrin results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]
rottlerin results in increased activity of CASP3 protein
rottlerin inhibits the reaction [NSC606985 results in increased activity of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]
rottlerin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]

PMID:11880503 PMID:12831855 PMID:19662097 PMID:21362627 PMID:22410117 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 6

multiple interactions

rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 9

multiple interactions
increases cleavage

rottlerin inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of CASP9 protein]; rottlerin inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased cleavage of CASP9 protein]
rottlerin results in increased cleavage of CASP9 protein

PMID:12626342 PMID:22902833

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin D1

multiple interactions

[sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

multiple interactions

[sorafenib co-treated with rottlerin] results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

CD38 molecule

multiple interactions

rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 mRNA]; rottlerin inhibits the reaction [Tretinoin results in increased expression of CD38 protein]

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

cadherin 1

multiple interactions
increases expression

Paclitaxel promotes the reaction [rottlerin results in increased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 4

multiple interactions

[sorafenib co-treated with rottlerin] results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

multiple interactions

[sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein alpha

multiple interactions

rottlerin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein]; rottlerin inhibits the reaction [NSC606985 results in increased ubiquitination of CEBPA protein]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

claudin 1

affects localization

rottlerin affects the localization of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

claudin 4

multiple interactions

rottlerin results in increased expression of and affects the localization of CLDN4 protein

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

collagen type I alpha 1 chain

multiple interactions

rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 mRNA]; rottlerin inhibits the reaction [Acetaldehyde results in increased expression of COL1A1 protein]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

rottlerin results in decreased activity of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

[rottlerin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

rottlerin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]
rottlerin results in increased expression of DDIT3 protein
rottlerin inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]

PMID:17171638 PMID:22410117 PMID:27658547

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD-box helicase 3, X-linked

increases expression

Rottlerin increases expression of DDX3X mRNA in liver

RGD

NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168

G

eukaryotic translation elongation factor 2

decreases phosphorylation

rottlerin results in decreased phosphorylation of EEF2 protein

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor receptor

multiple interactions

rottlerin inhibits the reaction [irinotecan metabolite results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [irinotecan results in increased phosphorylation of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]

PMID:15177934 PMID:15723263

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E

multiple interactions

rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; rottlerin promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
rottlerin inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]

PMID:12720544 PMID:19771169

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ELAV like RNA binding protein 1

multiple interactions

rottlerin inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]

NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784

G

fibroblast growth factor 1

multiple interactions

rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

multiple interactions

rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of GCLC protein]
rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLC mRNA]; rottlerin inhibits the reaction [Exenatide results in increased expression of GCLC protein]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLC mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]

PMID:24211276 PMID:25773745 PMID:25895139 PMID:27939242 PMID:30393195 More...

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]; rottlerin affects the reaction [Dextromethorphan affects the expression of GCLM mRNA]; rottlerin promotes the reaction [Cocaine results in increased expression of GCLM mRNA]; rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]

PMID:25895139 PMID:30393195 PMID:34740715

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

multiple interactions
increases expression
affects response to substance

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [rottlerin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [rottlerin results in increased expression of GDF15 protein]
rottlerin results in increased expression of GDF15 mRNA; rottlerin results in increased expression of GDF15 protein
GDF15 affects the susceptibility to rottlerin

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glutamic--pyruvic transaminase

multiple interactions

rottlerin inhibits the reaction [Acrolein results in increased secretion of GPT protein]; rottlerin inhibits the reaction [allyl alcohol results in increased secretion of GPT protein]
rottlerin inhibits the reaction [Cocaine results in increased activity of GPT protein]

PMID:12755590 PMID:30393195

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

gastrin releasing peptide

multiple interactions

rottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]

NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061

G

glycogen synthase kinase 3 alpha

decreases expression
multiple interactions

rottlerin results in decreased expression of GSK3A protein
[Cadmium co-treated with rottlerin] results in decreased expression of GSK3A protein

NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

multiple interactions
decreases expression

[Cadmium co-treated with rottlerin] results in decreased expression of GSK3B protein; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of GSK3B protein]
rottlerin results in decreased expression of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hepcidin antimicrobial peptide

decreases expression

rottlerin results in decreased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

heme oxygenase 1

multiple interactions

rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [2-butenal results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; rottlerin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Exenatide results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]
rottlerin inhibits the reaction [Cadmium results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]

PMID:17535857 PMID:18048804 PMID:18357586 PMID:20060010 PMID:21238556 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

rottlerin inhibits the reaction [NSC606985 results in decreased expression of HNRNPK protein]

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heat shock protein family A (Hsp70) member 5

increases expression

rottlerin results in increased expression of HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

5-hydroxytryptamine receptor 1A

multiple interactions

rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A mRNA]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of HTR1A protein]

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

interferon gamma

multiple interactions

rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 12B

multiple interactions

rottlerin promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 2

multiple interactions

rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions
increases expression

rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of IL6 protein]
rottlerin results in increased expression of IL6 protein

PMID:30366073 PMID:37722575

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 2

decreases expression

rottlerin results in decreased expression of IRS2 protein

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of JUN protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of JUN protein]

PMID:18628248 PMID:20599481

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

low density lipoprotein receptor

multiple interactions

rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase kinase 1

decreases phosphorylation

rottlerin results in decreased phosphorylation of MAP2K1 protein

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

rottlerin results in decreased phosphorylation of MAPK1 protein
[Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK1 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK1 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]

PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

decreases phosphorylation

rottlerin results in decreased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

[Sorafenib co-treated with rottlerin] results in decreased phosphorylation of MAPK3 protein; rottlerin inhibits the reaction [Acetaldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Acrylonitrile results in increased phosphorylation of MAPK3 protein]; rottlerin inhibits the reaction [Curcumin results in increased expression of MAPK3 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
rottlerin results in decreased phosphorylation of MAPK3 protein
rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; rottlerin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; rottlerin promotes the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]

PMID:12720544 PMID:14975926 PMID:15177934 PMID:16959960 PMID:17030193 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

rottlerin inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]

PMID:15917298 PMID:20599481

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

MAPK activated protein kinase 2

decreases activity

rottlerin results in decreased activity of MAPKAPK2 protein

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

MAPK activated protein kinase 5

decreases activity

rottlerin results in decreased activity of MAPKAPK5 protein

NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052

G

myristoylated alanine rich protein kinase C substrate

multiple interactions

rottlerin inhibits the reaction [sodium arsenate results in increased phosphorylation of MARCKS protein]

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

macrophage migration inhibitory factor

multiple interactions
increases expression

rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]
rottlerin results in increased expression of MIF protein

PMID:16872482 PMID:37722575

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

matrix metallopeptidase 12

multiple interactions

rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

multiple interactions

rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions

rottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 mRNA]

PMID:16872482 PMID:20599481

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

rottlerin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

rottlerin inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
rottlerin results in decreased phosphorylation of MTOR protein

PMID:19771169 PMID:22902833

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

neutrophil cytosolic factor 1

multiple interactions

rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to HTR1A protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased phosphorylation of and affects the localization of NCF1 protein]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

multiple interactions

rottlerin inhibits the reaction [Paraquat affects the localization of NCF2 protein]

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

NFE2 like bZIP transcription factor 2

multiple interactions

rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [Acrolein affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [Cadmium Chloride affects the localization of NFE2L2 protein]
rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; [rottlerin co-treated with Dextromethorphan] results in increased activity of and affects the localization of NFE2L2 protein; rottlerin promotes the reaction [Cocaine results in increased activity of and affects the localization of NFE2L2 protein]; rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]

PMID:18048804 PMID:21787730 PMID:24211276 PMID:25773745 PMID:25895139 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

multiple interactions

rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NADPH oxidase 1

multiple interactions

rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]; rottlerin inhibits the reaction [Paraquat results in increased expression of NOX1 protein]

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; rottlerin inhibits the reaction [Cadmium Chloride results in increased expression of NQO1 protein]; rottlerin inhibits the reaction [Plant Extracts results in increased expression of NQO1 protein]

PMID:21787730 PMID:30626086

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

neurotensin

multiple interactions
increases activity

rottlerin affects the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; rottlerin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
rottlerin results in increased activity of NTS protein

PMID:15177934 PMID:18313772

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

occludin

affects localization

rottlerin affects the localization of OCLN protein modified form

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

ornithine decarboxylase 1

multiple interactions

rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein]

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

purinergic receptor P2Y1

multiple interactions

rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; rottlerin inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK3 protein]]

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

rottlerin results in increased cleavage of PARP1 protein
rottlerin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
[rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein

PMID:22902833 PMID:27658547 PMID:35995259

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phospholipase D1

multiple interactions

rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]

NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692

G

phospholipid scramblase 1

multiple interactions

rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 mRNA]; rottlerin inhibits the reaction [IFNA2 protein results in increased expression of PLSCR1 protein]

NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692

G

peroxisome proliferator-activated receptor gamma

multiple interactions

rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

peroxiredoxin 1

multiple interactions

rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; rottlerin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein]

NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856

G

protein kinase C, delta

multiple interactions
decreases activity
decreases phosphorylation
decreases response to substance

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]; rottlerin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [IFNA2 protein results in increased phosphorylation of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [NSC606985 results in increased activity of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; [rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to Methamphetamine; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [NCF1 protein binds to PRKCD protein]]; rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [PRKCD protein binds to HTR1A protein]]; rottlerin inhibits the reaction [Dextromethorphan promotes the reaction [PRKCD protein modified form binds to GRIN2B protein]]; rottlerin inhibits the reaction [Dextromethorphan results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [p-Chloroamphetamine results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein results in increased phosphorylation of FGF1 protein]; rottlerin inhibits the reaction [trimethyltin results in increased expression of and results in increased cleavage of PRKCD protein]
[rottlerin results in decreased activity of PRKCD protein] which results in decreased susceptibility to 2-methylcyclopentadienyl manganese tricarbonyl; rottlerin inhibits the reaction [2-methylcyclopentadienyl manganese tricarbonyl results in increased cleavage of and results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [Cadmium results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [manganese chloride results in increased activity of PRKCD protein]; rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]]; rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of LDLR protein]]; rottlerin inhibits the reaction [sodium arsenite results in increased phosphorylation of PRKCD protein]
rottlerin results in decreased phosphorylation of PRKCD protein
PRKCD protein results in decreased susceptibility to rottlerin

PMID:11880503 PMID:12720544 PMID:15574884 PMID:15681813 PMID:15949478 More...

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, theta

decreases activity

rottlerin results in decreased activity of PRKCQ protein

NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704

G

prolactin

multiple interactions

rottlerin inhibits the reaction [PRL protein results in increased activity of ODC1 protein]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

multiple interactions

rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 mRNA]; rottlerin inhibits the reaction [Acrolein results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]
rottlerin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased expression of PTGS2 protein]

PMID:17363696 PMID:17640750 PMID:19084589 PMID:30366073

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases phosphorylation

rottlerin results in decreased phosphorylation of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RB transcriptional corepressor 1

decreases phosphorylation

rottlerin results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

ribosomal protein S6 kinase B1

multiple interactions
decreases activity

rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]
rottlerin results in decreased activity of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S6 kinase B2

multiple interactions
decreases activity

rottlerin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein]
rottlerin results in decreased activity of RPS6KB2 protein

NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078

G

RUNX family transcription factor 2

multiple interactions

rottlerin inhibits the reaction [FGF2 protein results in increased activity of RUNX2 protein]; rottlerin inhibits the reaction [FGF2 protein results in increased expression of RUNX2 mRNA]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

solute carrier family 18 member A2

multiple interactions

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein]

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 6 member 3

multiple interactions

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of DAT protein]

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

rottlerin results in decreased expression of SNAI1 protein
rottlerin promotes the reaction [Paclitaxel results in decreased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 2

multiple interactions

rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

steroid sulfatase

multiple interactions

rottlerin inhibits the reaction [Tretinoin results in increased activity of STS protein]

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

transcription factor AP-2 alpha

multiple interactions

rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

trefoil factor 1

multiple interactions

[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [benz(a)anthracene results in increased expression of TFF1 mRNA]]

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor alpha

multiple interactions

rottlerin inhibits the reaction [irinotecan metabolite results in increased secretion of TGFA protein]; rottlerin inhibits the reaction [irinotecan results in increased secretion of TGFA protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

tyrosine hydroxylase

multiple interactions

rottlerin inhibits the reaction [manganese chloride results in decreased activity of TH protein]
[rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased activity of TH protein]; [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in decreased expression of TH protein]

PMID:21310168 PMID:22512859

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tight junction protein 1

affects localization

rottlerin affects the localization of TJP1 protein

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

rottlerin inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

tyrosinase

decreases expression

rottlerin results in decreased expression of TYR mRNA; rottlerin results in decreased expression of TYR protein

NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207

G

UL16 binding protein 1

multiple interactions
increases expression

rottlerin inhibits the reaction [TFAP2A protein binds to ULBP1 promoter]
rottlerin results in increased expression of ULBP1 mRNA

PMID:21499124 PMID:21951556

NCBI chr 1:1,694,255...1,716,160

G

vascular endothelial growth factor A

multiple interactions

rottlerin inhibits the reaction [VEGFA protein results in increased abundance of phosphatidylbutanol]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression
multiple interactions

rottlerin results in decreased expression of VIM protein
rottlerin promotes the reaction [Paclitaxel results in decreased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-linked inhibitor of apoptosis

decreases expression

rottlerin results in decreased expression of XIAP protein

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
role	19837
biological role	19835
pharmacological role	19069
agonist	18596
K-ATP channel agonist	136
diazoxide	30
rottlerin	115

paths to the root