The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
CYP2C8 protein results in decreased degradation of vanoxerine [Quercetin results in decreased activity of CYP2C8 protein] which results in decreased degradation of vanoxerine
CYP2E1 protein results in decreased degradation of vanoxerine [Chlorzoxazone results in decreased activity of CYP2E1 protein] which results in decreased degradation of vanoxerine
[Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine; [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine CYP3A4 protein results in decreased degradation of vanoxerine
vanoxerine binds to SLC6A3 protein vanoxerine results in decreased activity of SLC6A3 protein vanoxerine affects the reaction [Cocaine affects the expression of SLC6A3 protein] SLC6A3 protein affects the susceptibility to vanoxerine vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]] SLC6A3 gene mutant form results in decreased susceptibility to vanoxerine [vanoxerine results in decreased activity of SLC6A3 protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium; vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]