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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amisulpride
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Accession:CHEBI:64045 term browser browse the term
Definition:A member of the class of benzamides resulting from the formal condensation of the carboxy group of 4-amino-5-(ethylsulfonyl)-2-methoxybenzoic acid with the primary amino group of 2-(aminomethyl)-1-ethylpyrrolidine. It is a potent, selective dopamine D2 and D3 receptor antagonist. It is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects.
Synonyms:exact_synonym: 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
 related_synonym: 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;   4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide;   Aminosultopride;   Formula=C17H27N3O4S;   InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21);   InChIKey=NTJOBXMMWNYJFB-UHFFFAOYSA-N;   SMILES=CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC;   amisulprida;   amisulpridum
 xref: CAS:71675-85-9;   DrugBank:DB06288;   Drug_Central:179;   HMDB:HMDB0015633;   KEGG:D07310;   LINCS:LSM-1669
 xref_mesh: MESH:D000077582
 xref: PMID:21176108;   PMID:21647545;   PMID:21663752;   PMID:21746752;   PMID:21822161;   PMID:21845006;   PMID:21852060;   PMID:21886905;   PMID:21888613;   PMID:21969105;   PMID:22035899;   PMID:22059694;   PMID:22121864;   PMID:22241281;   PMID:22250612;   Patent:BE872585;   Patent:US4401822;   Reaxys:6876191;   Wikipedia:Amisulpride


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amisulpride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Amisulpride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Amisulpride binds to DRD2 protein CTD PMID:12191584 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Prl prolactin increases secretion
multiple interactions
increases expression 		ISO
EXP 		Amisulpride results in increased secretion of PRL protein
Bromocriptine inhibits the reaction [Amisulpride results in increased secretion of PRL protein]; carmoxirole inhibits the reaction [Amisulpride results in increased secretion of PRL protein]
Amisulpride results in increased expression of PRL protein 		CTD PMID:12106810 PMID:14966260 PMID:14997280 PMID:15665803 PMID:16938372 More... NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 decreases expression ISO Amisulpride results in decreased expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:143,139,672...143,213,609
Ensembl chr 6:143,144,523...143,213,609 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        xenobiotic 19525
          amisulpride 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      carboacyl group 18089
                                        univalent carboacyl group 18071
                                          carbamoyl group 17906
                                            carboxamide 17925
                                              monocarboxylic acid amide 15956
                                                arenecarboxamide 8280
                                                  benzamides 8285
                                                    amisulpride 4
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