Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nebivolol
go back to main search page
Accession:CHEBI:64022 term browser browse the term
Definition:A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Synonyms:related_synonym: (1RS,1'RS)-1,1'-[(2RS,2'SR)-bis(6-fluorochroman-2-yl)]-2,2'-iminodiethanol;   (1RS,1'RS)-2,2'-iminobis{1-[(2RS,2'SR)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol};   dl-nebivolol;   nebivololum
 xref: CAS:118457-14-0;   DrugBank:DB04861
 xref_mesh: MESH:D000068577
 xref: Patent:US4654362;   Reaxys:4789059;   kegg.drug:D05127;   pubmed:17661735;   pubmed:18078016;   pubmed:18083889;   pubmed:18221115;   pubmed:18786089;   pubmed:19443516;   pubmed:19815121;   pubmed:20620250;   pubmed:23314750;   wikipedia.en:Nebivolol


show annotations for term's descendants           Sort by:
nebivolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions
affects binding 		ISO
EXP 		Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nebivolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Nebivolol inhibits the reaction [Epinephrine results in increased activity of ADRB1 protein]
Nebivolol binds to ADRB1 protein
Nebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]; Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein] 		CTD PMID:2462161 PMID:12535855 PMID:30155694 NCBI chr 1:265,777,103...265,780,114
Ensembl chr 1:265,766,079...265,849,237 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Nebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in decreased expression of VASP protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF1 mRNA]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of RAC1 protein] CTD PMID:16940222 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Ar androgen receptor increases expression
multiple interactions 		EXP
ISO 		Nebivolol results in increased expression of AR protein
Nebivolol binds to and results in decreased activity of AR protein 		CTD PMID:19962728 PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP [Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein] CTD PMID:30291735 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Cat catalase multiple interactions EXP Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]] CTD PMID:30291735 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
decreases secretion 		ISO Nebivolol results in decreased expression of CCL2 mRNA
Nebivolol results in decreased secretion of CCL2 protein 		CTD PMID:17310107 PMID:17467819 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:16940222 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA] CTD PMID:16940222 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
increases activity
increases expression 		ISO Dactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA]
Nebivolol results in increased activity of DDAH2 protein
Nebivolol results in increased expression of DDAH2 mRNA; Nebivolol results in increased expression of DDAH2 protein 		CTD PMID:17977009 NCBI chr20:3,766,115...3,769,161
Ensembl chr20:3,766,120...3,769,183 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO Nebivolol results in increased expression of DHCR24 mRNA CTD PMID:17467819 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Edn1 endothelin 1 decreases secretion
decreases expression 		ISO Nebivolol results in decreased secretion of EDN1 protein
Nebivolol results in decreased expression of EDN1 mRNA 		CTD PMID:11078433 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nebivolol binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 affects activity
multiple interactions 		ISO Nebivolol affects the activity of ESR2 protein
Nebivolol binds to and results in decreased activity of ESR2 protein 		CTD PMID:19330906 PMID:25752796 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Nebivolol results in decreased expression of ICAM1 mRNA CTD PMID:17310107 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Nebivolol results in decreased expression of IL1A mRNA CTD PMID:17467819 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Mrgprx2 MAS related GPR family member X2 affects binding ISO Nebivolol binds to MRGPRX2 protein CTD PMID:39285676 NCBI chr 1:107,252,467...107,271,809 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF1 mRNA] CTD PMID:16940222 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:28,121,366...28,131,079 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein affects the localization of NCF2 protein]; Nebivolol inhibits the reaction [AGT protein results in increased expression of NCF2 protein] CTD PMID:16940222 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:67,505,375...67,536,149 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Nebivolol results in increased expression of NFE2L2 CTD PMID:23886954 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nos3 nitric oxide synthase 3 increases activity
increases expression
multiple interactions 		ISO
EXP 		Nebivolol results in increased activity of NOS3 protein
Nebivolol results in increased expression of NOS3
[Nebivolol co-treated with Flutamide] results in increased expression of NOS3 protein
Nebivolol results in increased expression of NOS3 protein 		CTD PMID:17977009 PMID:19962728 PMID:23886954 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein] CTD PMID:16940222 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Nppb natriuretic peptide B increases expression ISO Nebivolol results in increased expression of NPPB protein CTD PMID:18192850 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310 		JBrowse link
G Pdgfa platelet derived growth factor subunit A decreases expression ISO Nebivolol results in decreased expression of PDGFA mRNA CTD PMID:17467819 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Nebivolol results in decreased expression of PDGFB mRNA CTD PMID:17310107 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Nebivolol binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression 		ISO 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of PPARGC1A protein] CTD PMID:23886954 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Nebivolol results in decreased expression of PTGS2 mRNA CTD PMID:17467819 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in increased expression of RAC1 protein] CTD PMID:16940222 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Ren renin multiple interactions EXP Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein] CTD PMID:12806161 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Sele selectin E decreases expression ISO Nebivolol results in decreased expression of SELE mRNA CTD PMID:17310107 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903 		JBrowse link
G Selp selectin P decreases expression ISO Nebivolol results in decreased expression of SELP mRNA CTD PMID:17310107 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:79,009,475...79,044,987 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression 		ISO 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein] CTD PMID:23886954 NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression 		ISO
EXP 		3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol affects the expression of SOD2 protein]
Nebivolol inhibits the reaction [Daunorubicin results in decreased secretion of SOD2 protein] 		CTD PMID:18194856 PMID:23886954 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Nebivolol results in increased expression of TFAM CTD PMID:23886954 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Nebivolol binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Nebivolol results in decreased expression of TNFAIP6 mRNA CTD PMID:17467819 NCBI chr 3:56,911,398...56,930,797
Ensembl chr 3:56,911,252...56,930,796 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP Nebivolol inhibits the reaction [Daunorubicin results in increased expression of TNNT2 protein] CTD PMID:18194856 NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Nebivolol inhibits the reaction [AGT protein results in decreased expression of VASP protein]; Nebivolol inhibits the reaction [Phorbol Esters results in decreased phosphorylation of VASP protein] CTD PMID:16940222 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Nebivolol results in decreased expression of VCAM1 mRNA CTD PMID:17310107 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 increases expression ISO Nebivolol results in increased expression of VIPR1 mRNA CTD PMID:17467819 NCBI chr 8:130,181,219...130,217,098
Ensembl chr 8:130,187,731...130,217,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      chemical substance 14602
        mixture 13915
          racemate 12303
            nebivolol 41
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  oxacycle 18273
                                    benzopyran 10790
                                      1-benzopyran 10376
                                        chromanes 4074
                                          2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] 41
                                            (R,S,S,S)-nebivolol 41
                                              nebivolol 41
paths to the root