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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EET
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Accession:CHEBI:64007 term browser browse the term
Definition:An icosanoid obtained by formal epoxidation of one of the double bonds of arachidonic acid.
Synonyms:related_synonym: epoxyeicosatrienoic acid;   epoxyeicosatrienoic acids;   epoxyicosatrienoic acid;   epoxyicosatrienoic acids
 xref: PMID:14636671;   PMID:16473964;   PMID:21704394;   PMID:22100745;   PMID:22116511;   PMID:22182836;   PMID:22182838;   PMID:22223859;   PMID:22245571;   PMID:22280237;   PMID:22298653;   PMID:22303912;   Wikipedia:Epoxyeicosatrienoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:131865



show annotations for term's descendants           Sort by:
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Agt angiotensinogen decreases expression
increases cleavage
multiple interactions
EXP
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD PMID:27428043 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions
increases abundance
ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470 PMID:22680237 PMID:24472606 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
ISO TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:28694203 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19878
    role 19848
      biological role 19846
        biochemical role 19550
          metabolite 19538
            EET 13
              11,12-EET + 0
              14,15-EET + 12
              5,6-EET + 2
              8,9-EET + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19878
    subatomic particle 19876
      composite particle 19876
        hadron 19876
          baryon 19876
            nucleon 19876
              atomic nucleus 19876
                atom 19876
                  main group element atom 19815
                    p-block element atom 19815
                      carbon group element atom 19755
                        carbon atom 19752
                          organic molecular entity 19752
                            heteroorganic entity 19509
                              organochalcogen compound 19270
                                organooxygen compound 19186
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18001
                                        fatty acid 16832
                                          unsaturated fatty acid 1682
                                            polyunsaturated fatty acid 847
                                              fatty acid 20:4 364
                                                icosatetraenoic acid 364
                                                  icosa-5,8,11,14-tetraenoic acid 321
                                                    arachidonic acid 321
                                                      EET 13
                                                        11,12-EET + 0
                                                        14,15-EET + 12
                                                        5,6-EET + 2
                                                        8,9-EET + 3
paths to the root