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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:13,14-dihydro-15-keto-PGF2alpha
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Accession:CHEBI:63976 term browser browse the term
Definition:A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha.
Synonyms:exact_synonym: (5Z,9alpha,11alpha)-9,11-dihydroxy-15-oxoprost-5-en-1-oic acid
 related_synonym: 13,14-Dihydro-15-ketoprostaglandin F2alpha;   13,14-dihydro-15-keto-Prostaglandin F2a;   15-Keto-13,14-dihydroprostaglandin F2-alpha;   15-Keto-13,14-dihydroprostaglandin F2alpha;   9S,11S-dihydroxy-15-oxo-5Z-prostenoic acid;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19-/m1/s1;   InChIKey=VKTIONYPMSCHQI-XAGFEHLVSA-N;   PGFM;   SMILES=CCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   dhk-PGF2alpha
 xref: CAS:27376-76-7;   HMDB:HMDB0004685;   LIPID_MAPS_instance:LMFA03010027
 xref_mesh: MESH:C008228
 xref: PMID:20961606;   PMID:21228218;   PMID:21615801;   PMID:21653895;   PMID:21741578;   PMID:21924479;   PMID:21940119;   PMID:22192399;   Patent:US5397797;   Reaxys:6227023
 cyclic_relationship: is_conjugate_acid_of CHEBI:133374


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13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions		 ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha		 CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            13,14-dihydro-15-keto-PGF2alpha 1
              13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      monocarboxylic acid 18000
                                        fatty acid 16833
                                          fatty acid derivative 8980
                                            icosanoid 471
                                              prostanoid 407
                                                prostaglandin 399
                                                  prostaglandins F 102
                                                    prostaglandins Falpha 101
                                                      prostaglandin F2alpha 87
                                                        13,14-dihydro-15-keto-PGF2alpha 1
                                                          13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
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