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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arsenic trichloride
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Accession:CHEBI:63952 term browser browse the term
Definition:A arsenic molecular entity that consists of a single arsenic atom bearing three chloro substituents.
Synonyms:exact_synonym: arsenous chloride
 related_synonym: Arsenic butter;   Arsenic chloride;   Arsenic(III) chloride;   Arsenic(III) trichloride;   Arsenious chloride;   Arsenous trichloride;   AsCl3;   Butter of arsenic;   Caustic arsenic chloride;   Caustic oil of arsenic;   Chlorure arsenieux;   Chlorure d'arsenic;   Formula=AsCl3;   InChI=1S/AsCl3/c2-1(3)4;   InChIKey=OEYOHULQRFXULB-UHFFFAOYSA-N;   SMILES=Cl[As](Cl)Cl;   Trichloroarsine;   Trichlorure d'arsenic
 xref: CAS:7784-34-1
 xref_mesh: MESH:C050510
 xref: PMID:19071824;   PMID:20306073;   PMID:4475013;   PMID:936786;   Reaxys:3903069;   Wikipedia:Arsenic_trichloride


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arsenic trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases activity
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]
MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]		 CTD PMID:22696236 PMID:25944616 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of APP mRNA CTD PMID:35809665 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6 promoter]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of ATF6 protein; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA] CTD PMID:35625704 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6B promoter]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of and results in increased cleavage of ATF6B protein; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6B mRNA; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6B mRNA] CTD PMID:35625704 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of ATP5F1A mRNA CTD PMID:35809665 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of ATP5F1C mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of ATP5F1C mRNA CTD PMID:35809665 NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of ATP5MC3 mRNA CTD PMID:35809665 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [arsenic trichloride co-treated with antimony trichloride] results in increased expression of CASP12 mRNA CTD PMID:34091186 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO arsenic trichloride promotes the reaction [antimony trichloride results in increased cleavage of CASP3 protein]; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of CASP3 mRNA] CTD PMID:34091186 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein] CTD PMID:21854796 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of CDC20 mRNA CTD PMID:35809665 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [HIF1A protein binds to CEBPB gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to CEBPB gene]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of CEBPB mRNA; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of CEBPB protein CTD PMID:35625704 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of COX7A2 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of COX7A2 mRNA CTD PMID:35809665 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
increases activity
multiple interactions		 ISO arsenic trichloride results in increased expression of CTNNB1 protein
arsenic trichloride results in increased activity of CTNNB1 protein
CAT protein inhibits the reaction [arsenic trichloride results in increased activity of CTNNB1 protein]; CAT protein inhibits the reaction [arsenic trichloride results in increased expression of CTNNB1 protein]		 CTD PMID:21854796 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO antimony trichloride promotes the reaction [arsenic trichloride results in increased expression of DDIT3 protein]; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of DDIT3 mRNA]; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of DDIT3 protein]; IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA] CTD PMID:16283526 PMID:34091186 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of DDIT4 mRNA CTD PMID:35809665 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of DNAJB1 mRNA CTD PMID:35809665 NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of EIF3B mRNA CTD PMID:35809665 NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886 		JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of EIF3I mRNA CTD PMID:35809665 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which affects the expression of EIF4G1 mRNA CTD PMID:35809665 NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA] CTD PMID:16421274 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Elob elongin B multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of ELOB mRNA CTD PMID:35809665 NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of ERN2 mRNA CTD PMID:35625704 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Flna filamin A multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; AKT1 mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]; arsenic trichloride promotes the reaction [AKT1 protein binds to FLNA protein modified form]; arsenic trichloride promotes the reaction [AKT1 protein modified form binds to FLNA protein modified form]; wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein] CTD PMID:25944616 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of FURIN mRNA CTD PMID:35809665 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
affects response to substance
increases expression		 ISO arsenic trichloride promotes the reaction [ELAVL1 protein binds to GADD45A mRNA]; arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]; arsenic trichloride results in increased stability of and results in increased expression of GADD45A mRNA; GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein]; Hydrogen Peroxide promotes the reaction [arsenic trichloride results in increased expression of GADD45A protein]
GADD45A protein affects the susceptibility to arsenic trichloride
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]
arsenic trichloride results in increased expression of GADD45A mRNA; arsenic trichloride results in increased expression of GADD45A protein		 CTD PMID:16283526 PMID:16421274 PMID:16814109 PMID:18942077 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of GADD45B mRNA
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]		 CTD PMID:16283526 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of GADD45G mRNA
IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA]		 CTD PMID:16283526 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO GPX1 protein inhibits the reaction [arsenic trichloride results in increased expression of GADD45A protein] CTD PMID:16814109 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of GSR mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of GSR mRNA CTD PMID:35809665 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of H2AX protein; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of H2AX protein CTD PMID:35809665 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [HIF1A protein binds to CEBPB gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [HIF1A protein binds to HSPA1B promoter] CTD PMID:35625704 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of HMOX1 mRNA
[Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of HMOX1 mRNA		 CTD PMID:19276070 PMID:35809665 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of HSP90B1 mRNA CTD PMID:35809665 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [HIF1A protein binds to HSPA1B promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B promoter]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of HSPA1B protein CTD PMID:35625704 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [arsenic trichloride co-treated with antimony trichloride] results in increased expression of HSPA5 protein
[arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of HSPA5 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of HSPA5 mRNA		 CTD PMID:34091186 PMID:35809665 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of HSPH1 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of HSPH1 mRNA CTD PMID:35809665 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224 		JBrowse link
G Htra4 HtrA serine peptidase 4 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of HTRA4 mRNA CTD PMID:35625704 NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO IKBKB affects the reaction [arsenic trichloride results in increased expression of DDIT3 mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45A protein]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45B mRNA]; IKBKB affects the reaction [arsenic trichloride results in increased expression of GADD45G mRNA] CTD PMID:16283526 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il2 interleukin 2 decreases secretion ISO arsenic trichloride results in decreased secretion of IL2 protein CTD PMID:27714827 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 increases secretion ISO arsenic trichloride results in increased secretion of IL6 protein CTD PMID:22696236 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insr insulin receptor multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of INSR mRNA CTD PMID:35809665 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of MAPK10 mRNA CTD PMID:35625704 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 ISO pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK8 protein]
[arsenic trichloride co-treated with antimony trichloride] results in increased expression of MAPK8 mRNA; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of MAPK8 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased activity of AKT1 protein]; MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]		 CTD PMID:22696236 PMID:24434654 PMID:34091186 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 ISO MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]
MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]		 CTD PMID:22696236 PMID:24434654 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir106a microRNA 106a increases expression ISO arsenic trichloride results in increased expression of MIR106A CTD PMID:21750348 NCBI chr  X:132,422,584...132,422,661
Ensembl chr  X:132,422,584...132,422,661 		JBrowse link
G Mir17 microRNA 17 increases expression ISO arsenic trichloride results in increased expression of MIR17 CTD PMID:21750348 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir190 microRNA 190 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of MIR190A
[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein		 CTD PMID:21750348 NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071 		JBrowse link
G Mir19a microRNA 19a increases expression ISO arsenic trichloride results in increased expression of MIR19A CTD PMID:21750348 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir1b microRNA 1b increases expression ISO arsenic trichloride results in increased expression of MIR1-1 CTD PMID:21750348 NCBI chr 3:167,487,117...167,487,201
Ensembl chr 3:167,487,117...167,487,201 		JBrowse link
G Mir20a microRNA 20a increases expression ISO arsenic trichloride results in increased expression of MIR20A CTD PMID:21750348 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir21 microRNA 21 multiple interactions
affects expression		 ISO MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]; stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA] CTD PMID:24434654 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir92a1 microRNA 92a-1 increases expression ISO arsenic trichloride results in increased expression of MIR92A1 CTD PMID:21750348 NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of MKI67 protein; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of MKI67 protein CTD PMID:35809665 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of COX2 mRNA CTD PMID:35809665 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of COX3 mRNA CTD PMID:35809665 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ND4L mRNA CTD PMID:35809665 NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166 		JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of MT1 mRNA
arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]; Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]		 CTD PMID:19276070 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
affects response to substance
decreases response to substance		 ISO arsenic trichloride promotes the reaction [MTF1 protein binds to MT1 protein]; MTF1 protein affects the reaction [arsenic trichloride results in increased expression of MT1 mRNA]; MTF1 protein affects the reaction [Cycloheximide promotes the reaction [arsenic trichloride results in increased expression of MT1 mRNA]]
MTF1 protein affects the susceptibility to arsenic trichloride
MTF1 protein results in decreased susceptibility to arsenic trichloride		 CTD PMID:19276070 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO arsenic trichloride results in increased expression of MYC mRNA; arsenic trichloride results in increased expression of MYC protein CTD PMID:16283526 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO arsenic trichloride results in increased expression of NCF1 protein CTD PMID:21854796 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression ISO arsenic trichloride results in increased expression of NCF2 protein CTD PMID:21854796 NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Ncl nucleolin affects localization
multiple interactions		 ISO arsenic trichloride affects the localization of NCL protein
arsenic trichloride promotes the reaction [NCL protein binds to GADD45A mRNA]		 CTD PMID:16421274 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of NDUFA4 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of NDUFA4 mRNA CTD PMID:35809665 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of NDUFV1 mRNA CTD PMID:35809665 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA]
[arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6 promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to ATF6B promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to CEBPB gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B gene]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to HSPA1B promoter]; [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to UBE2G2 promoter]; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6 mRNA]; NFE2L2 protein affects the reaction [[arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of ATF6B mRNA]		 CTD PMID:19276070 PMID:35625704 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO arsenic trichloride results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [arsenic trichloride results in increased expression of NQO1 mRNA]		 CTD PMID:19276070 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PARK7 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of PARK7 mRNA CTD PMID:35809665 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pfkm phosphofructokinase, muscle multiple interactions ISO [arsenic trichloride co-treated with Ascorbic Acid] results in decreased expression of PFKM mRNA CTD PMID:38160894 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 multiple interactions ISO [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]; [arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein CTD PMID:21750348 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PPP2R1A mRNA CTD PMID:35809665 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PRDX3 mRNA CTD PMID:35809665 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Psma4 proteasome 20S subunit alpha 4 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMA4 mRNA CTD PMID:35809665 NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMA7 mRNA CTD PMID:35809665 NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672 		JBrowse link
G Psmb1 proteasome 20S subunit beta 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB1 mRNA CTD PMID:35809665 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB2 mRNA CTD PMID:35809665 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB4 mRNA CTD PMID:35809665 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB5 mRNA CTD PMID:35809665 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmb6 proteasome 20S subunit beta 6 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB6 mRNA CTD PMID:35809665 NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586 		JBrowse link
G Psmb7 proteasome 20S subunit beta 7 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMB7 mRNA CTD PMID:35809665 NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMC2 mRNA CTD PMID:35809665 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMC4 mRNA CTD PMID:35809665 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMC5 mRNA CTD PMID:35809665 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135 		JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD1 mRNA CTD PMID:35809665 NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211 		JBrowse link
G Psmd11 proteasome 26S subunit, non-ATPase 11 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD11 mRNA CTD PMID:35809665 NCBI chr10:65,433,853...65,479,774
Ensembl chr10:65,433,853...65,479,766 		JBrowse link
G Psmd13 proteasome 26S subunit, non-ATPase 13 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD13 mRNA CTD PMID:35809665 NCBI chr 1:195,964,617...195,976,895
Ensembl chr 1:195,964,138...195,976,905 		JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD14 mRNA CTD PMID:35809665 NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD2 mRNA CTD PMID:35809665 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD4 mRNA CTD PMID:35809665 NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194 		JBrowse link
G Psmd8 proteasome 26S subunit, non-ATPase 8 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of PSMD8 mRNA CTD PMID:35809665 NCBI chr 1:84,474,377...84,481,209
Ensembl chr 1:84,474,378...84,481,209 		JBrowse link
G Rb1 RB transcriptional corepressor 1 increases phosphorylation ISO arsenic trichloride results in increased phosphorylation of RB1 protein CTD PMID:16283526 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions
increases expression
increases phosphorylation		 ISO MAPK9 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; MIR21 mRNA affects the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]; wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]
arsenic trichloride results in increased expression of RIOX2 mRNA; arsenic trichloride results in increased expression of RIOX2 protein		 CTD PMID:24434654 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574 		JBrowse link
G Rps12 ribosomal protein S12 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS12 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS12 mRNA CTD PMID:35809665 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Rps13 ribosomal protein S13 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS13 mRNA CTD PMID:35809665 NCBI chr 1:170,572,925...170,575,355
Ensembl chr 1:170,572,921...170,575,355
Ensembl chr 3:170,572,921...170,575,355 		JBrowse link
G Rps15 ribosomal protein S15 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS15 mRNA CTD PMID:35809665 NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450 		JBrowse link
G Rps18 ribosomal protein S18 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS18 mRNA CTD PMID:35809665 NCBI chr20:4,931,427...4,935,538
Ensembl chr20:4,931,768...4,938,315 		JBrowse link
G Rps19 ribosomal protein S19 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS19 mRNA CTD PMID:35809665 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508 		JBrowse link
G Rps2 ribosomal protein S2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS2 mRNA CTD PMID:35809665 NCBI chr10:13,747,316...13,749,165
Ensembl chr10:13,747,301...13,749,163 		JBrowse link
G Rps20 ribosomal protein S20 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS20 mRNA CTD PMID:35809665 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475 		JBrowse link
G Rps24 ribosomal protein S24 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS24 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS24 mRNA CTD PMID:35809665 NCBI chr16:89,538...94,267
Ensembl chr16:89,604...94,279 		JBrowse link
G Rps25 ribosomal protein s25 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS25 mRNA CTD PMID:35809665 NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271 		JBrowse link
G Rps27 ribosomal protein S27 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS27 mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS27 mRNA CTD PMID:35809665 NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964 		JBrowse link
G Rps27a ribosomal protein S27a multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of RPS27A mRNA CTD PMID:35809665 NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011
Ensembl chr 5:103,285,734...103,288,011 		JBrowse link
G Rps4x ribosomal protein S4, X-linked multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS4X mRNA CTD PMID:35809665 NCBI chr  X:67,298,522...67,302,965
Ensembl chr  X:67,298,525...67,303,019
Ensembl chr 4:67,298,525...67,303,019 		JBrowse link
G Rps5 ribosomal protein S5 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS5 mRNA CTD PMID:35809665 NCBI chr 1:73,538,776...73,543,073
Ensembl chr 1:73,538,776...73,543,073 		JBrowse link
G Rps7 ribosomal protein S7 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS7 mRNA CTD PMID:35809665 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145 		JBrowse link
G Rps9 ribosomal protein S9 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of RPS9 mRNA CTD PMID:35809665 NCBI chr 1:65,511,723...65,515,076
Ensembl chr 1:65,511,723...65,515,123 		JBrowse link
G Scap SREBF chaperone multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of SCAP mRNA CTD PMID:35625704 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [arsenic trichloride co-treated with Ascorbic Acid] results in decreased expression of SLC2A1 mRNA CTD PMID:38160894 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
affects phosphorylation		 ISO arsenic trichloride results in increased phosphorylation of STAT3 protein
pyrazolanthrone inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 protein]; STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein]
MAPK8 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]; MAPK9 gene mutant form inhibits the reaction [arsenic trichloride results in increased phosphorylation of STAT3 protein]
arsenic trichloride affects the phosphorylation of STAT3 protein		 CTD PMID:22696236 PMID:24434654 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tln2 talin 2 increases expression ISO arsenic trichloride results in increased expression of TLN2 mRNA; arsenic trichloride results in increased expression of TLN2 protein CTD PMID:21750348 NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219 		JBrowse link
G Tp53 tumor protein p53 increases phosphorylation
multiple interactions		 ISO arsenic trichloride results in increased phosphorylation of TRP53 protein
arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of TRP53 mRNA]; arsenic trichloride promotes the reaction [antimony trichloride results in increased expression of TRP53 protein]		 CTD PMID:16283526 PMID:34091186 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein] CTD PMID:21750348 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of UBA52 mRNA CTD PMID:35809665 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807 		JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of UBC mRNA CTD PMID:35809665 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] promotes the reaction [NFE2L2 protein binds to UBE2G2 promoter]; [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of UBE2G2 protein CTD PMID:35625704 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of UCHL1 mRNA CTD PMID:35809665 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of UQCRC1 mRNA CTD PMID:35809665 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein multiple interactions ISO [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of UQCRH mRNA; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of UQCRH mRNA CTD PMID:35809665 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO STAT3 mutant form inhibits the reaction [arsenic trichloride results in increased expression of VEGFA protein] CTD PMID:22696236 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [arsenic trichloride co-treated with antimony trichloride] results in increased expression of XBP1 mRNA; arsenic trichloride inhibits the reaction [antimony trichloride results in increased expression of XBP1 protein] CTD PMID:34091186 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        aetiopathogenetic role 19224
          genotoxin 17671
            arsenic trichloride 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      p-block molecular entity 19817
                        pnictogen molecular entity 19078
                          pnictogen halide 121
                            arsenic trichloride 121
paths to the root