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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxytolbutamide
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Accession:CHEBI:63799 term browser browse the term
Definition:A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.
Synonyms:exact_synonym: N-(butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
 related_synonym: 1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea;   Formula=C12H18N2O4S;   Hydroxymethyltolbutamide;   Hydroxytolbutamide;   InChI=1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16);   InChIKey=SJRHYONYKZIRPM-UHFFFAOYSA-N;   Methylhydroxytolbutamide;   SMILES=CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
 xref: CAS:5719-85-7;   HMDB:HMDB0006408
 xref_mesh: MESH:C031014
 xref: PMID:16493553;   Reaxys:2867981


show annotations for term's descendants           Sort by:
4-hydroxytolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 multiple interactions ISO [CYP2C55 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30500380 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO [CYP2C66 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr 1:246,490,888...246,582,199
Ensembl chr 1:248,272,336...248,309,323 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20871
    role 20829
      biological role 20827
        biochemical role 20274
          metabolite 20255
            4-hydroxytolbutamide 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20871
    subatomic particle 20869
      composite particle 20869
        hadron 20869
          baryon 20869
            nucleon 20869
              atomic nucleus 20869
                atom 20869
                  main group element atom 20792
                    p-block element atom 20792
                      carbon group element atom 20725
                        carbon atom 20721
                          organic molecular entity 20721
                            heteroorganic entity 20226
                              organochalcogen compound 19911
                                organooxygen compound 19814
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      carboacyl group 18080
                                        univalent carboacyl group 18080
                                          carbamoyl group 17916
                                            carboxamide 17916
                                              monocarboxylic acid amide 15949
                                                urea 6332
                                                  ureas 6330
                                                    4-hydroxytolbutamide 3
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