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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lapachol
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Accession:CHEBI:6377 term browser browse the term
Definition:A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.
Synonyms:exact_synonym: 2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione
 related_synonym: 2-hydroxy-3-(3-methyl-2-buten-1-yl)-1,4-naphthalenedione;   2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione;   2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone;   2-hydroxy-3-(3-methylbut-2-en-1-yl)-1,4-dihydronaphthalene-1,4-dione;   Bethabarra wood;   C.I. 75490;   C.I. natural yellow 16;   Formula=C15H14O3;   InChI=1S/C15H14O3/c1-9(2)7-8-12-13(16)10-5-3-4-6-11(10)14(17)15(12)18/h3-7,18H,8H2,1-2H3;   InChIKey=CIEYTVIYYGTCCI-UHFFFAOYSA-N;   Ipe-tobacco wood;   SMILES=CC(C)=CCC1=C(O)C(=O)C2=C(C=CC=C2)C1=O;   Surinam greenheart wood;   Taigu wood;   greenhartin;   lapachol wood;   taiguic acid;   tecomin
 xref: CAS:84-79-7;   Chemspider:10770962;   HMDB:HMDB0253978;   KEGG:C10366;   KNApSAcK:C00002835
 xref_mesh: MESH:C008252
 xref: PMID:11180522;   PMID:30797783;   PMID:30896339;   PMID:31183610;   PMID:31935485;   PMID:32318101;   PMID:32712193;   PMID:33019942;   PMID:33254016;   PMID:33275860;   Wikipedia:Lapachol


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lapachol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase decreases activity ISO
EXP 		lapachol results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:54,460,636...54,483,049
Ensembl chr19:54,468,690...54,514,496 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO lapachol affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        anti-inflammatory agent 16834
          lapachol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbonyl compound 19440
                                    ketone 17484
                                      cyclic ketone 16126
                                        quinone 9948
                                          naphthoquinone 1486
                                            1,4-naphthoquinones 1475
                                              hydroxy-1,4-naphthoquinone 165
                                                lapachol 2
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