CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 1,1-diol
Accession: CHEBI:63732
browse the term
Definition: Any alcohol in which two hydroxy groups are bonded to the same atom.
Synonyms: related_synonym: 1,1-diols; gem-diol; gem-diols; geminal diol; geminal diols
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Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
ISO EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde
CTD
PMID:18272654 PMID:21334317 PMID:21376711
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions
EXP
Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]
CTD
PMID:7513451
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
multiple interactions
EXP
Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA]
CTD
PMID:7513451
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases chemical synthesis multiple interactions
EXP
CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate [CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate
CTD
PMID:1739413
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein]
CTD
PMID:15219685
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabbr1
gamma-aminobutyric acid type B receptor subunit 1
multiple interactions
ISO
Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein]
CTD
PMID:10683198
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
ISO
Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
multiple interactions
ISO
Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]]
CTD
PMID:10683198
NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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Gast
gastrin
multiple interactions
EXP
Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine]
CTD
PMID:10864877
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Gja1
gap junction protein, alpha 1
decreases expression increases expression
EXP
Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein Chloral Hydrate results in increased expression of GJA1 protein
CTD
PMID:21243523
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Gjb2
gap junction protein, beta 2
decreases expression increases expression
EXP
Chloral Hydrate results in decreased expression of GJB2 mRNA Chloral Hydrate results in increased expression of GJB2 protein
CTD
PMID:21243523
NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
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Glra1
glycine receptor, alpha 1
multiple interactions
ISO
Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein]
CTD
PMID:10683198
NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
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Hmox1
heme oxygenase 1
affects expression
EXP
Chloral Hydrate affects the expression of HMOX1 mRNA
CTD
PMID:22954530
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
Chloral Hydrate results in increased expression of IL1B mRNA Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]
CTD
PMID:15207037 PMID:15207038
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases expression
EXP
Chloral Hydrate results in increased expression of IL6 mRNA
CTD
PMID:15207037 PMID:15207038
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Slc2a1
solute carrier family 2 member 1
multiple interactions
ISO
Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose]
CTD
PMID:18455367
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Tnf
tumor necrosis factor
multiple interactions
ISO
neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
CTD
PMID:32471037
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
affects activity
ISO
Ninhydrin affects the activity of TP53 protein
CTD
PMID:35435491
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions affects activity
ISO
[Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein Saxitoxin affects the activity of ABCB1 protein
CTD
PMID:29128272
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Alb
albumin
decreases expression
ISO
Saxitoxin results in decreased expression of ALB protein
CTD
PMID:29228856
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Arpc5l
actin related protein 2/3 complex, subunit 5-like
decreases expression
ISO
Saxitoxin results in decreased expression of ARPC5L protein
CTD
PMID:29228856
NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538 Ensembl chr 9:22,759,876...22,767,538
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Cfl2
cofilin 2
affects expression
ISO
Saxitoxin affects the expression of CFL2 protein
CTD
PMID:29228856
NCBI chr 6:72,355,664...72,359,709
Ensembl chr 6:72,355,664...72,359,674
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Eno1
enolase 1
affects expression
ISO
Saxitoxin affects the expression of ENO1 protein
CTD
PMID:29228856
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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Hnrnpl
heterogeneous nuclear ribonucleoprotein L
decreases expression
ISO
Saxitoxin results in decreased expression of HNRNPL protein
CTD
PMID:29228856
NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553
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Vdac1
voltage-dependent anion channel 1
decreases expression
ISO
Saxitoxin results in decreased expression of VDAC1 protein
CTD
PMID:29228856
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
increases expression
ISO
Saxitoxin results in increased expression of YWHAB protein
CTD
PMID:29228856
NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
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