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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:topiramate
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Accession:CHEBI:63631 term browser browse the term
Definition:A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.
Synonyms:related_synonym: 2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate;   2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose sulfamate;   Formula=C12H21NO8S;   InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1;   InChIKey=KJADKKWYZYXHBB-XBWDGYHZSA-N;   McN-4853;   RWJ-17021;   SMILES=CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1;   TPM;   Topamax;   tipiramate;   tipiramato;   topiramato;   topiramatum
 alt_id: CHEBI:9633
 xref: CAS:97240-79-4;   DrugBank:DB00273;   Drug_Central:2706;   KEGG:C07502;   KEGG:D00537;   LINCS:LSM-5435
 xref_mesh: MESH:C052342
 xref: PDBeChem:TOR;   PMID:22233396;   PMID:22249827;   Patent:US4513006;   Reaxys:5988957;   Wikipedia:Topiramate


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topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 EXP Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression EXP topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion		 ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein		 CTD PMID:12927809 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Agxt alanine--glyoxylate aminotransferase increases expression EXP topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of AKT1 mRNA] CTD PMID:29753867 PMID:34266355 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Capn6 calpain 6 increases expression EXP topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:107,380,774...107,405,489
Ensembl chr  X:107,380,774...107,405,489 		JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity		 ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein		 CTD PMID:17826101 PMID:21314129 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions		 EXP topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
Topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 mRNA]		 CTD PMID:19148780 PMID:29753867 PMID:34266355 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chka choline kinase alpha decreases expression EXP topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression EXP topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression		 ISO Topiramate results in increased activity of CYP3A4 protein
Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein		 CTD PMID:14636322 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Topiramate inhibits the reaction [Morphine increases expression of Gria protein in the nucleus accumbens] RGD PMID:34390773 RGD:405818276 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance
affects binding		 ISO
EXP		 GRIK1 gene SNP affects the susceptibility to topiramate
topiramate binds to Grik1 protein		 CTD
RGD		 PMID:19331489 PMID:12904467 RGD:731146 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569 		JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase multiple interactions EXP [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Me1 malic enzyme 1 decreases expression EXP topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy neuropeptide Y increases expression EXP topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pick1 protein interacting with PRKCA 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Pld1 phospholipase D1 increases expression EXP topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression EXP topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression EXP topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression EXP topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions EXP Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of RPS6 mRNA] CTD PMID:34266355 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Topiramate affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression EXP topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc6a6 solute carrier family 6 member 6 decreases expression EXP topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression EXP topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849 		JBrowse link
G Sqle squalene epoxidase decreases expression EXP topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression		 ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA		 CTD PMID:22017514 PMID:22489711 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biophysical role 14048
          membrane transport modulator 13884
            sodium channel modulator 6715
              sodium channel blocker 4656
                topiramate 83
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      chalcogen 19569
                        oxygen atom 19541
                          oxygen molecular entity 19541
                            hydroxides 19347
                              oxoacid 18782
                                chalcogen oxoacid 13784
                                  sulfur oxoacid 13573
                                    sulfonic acid 11618
                                      sulfonic acid derivative 11618
                                        sulfamic acids 89
                                          sulfamic acid 89
                                            sulfamate ester 84
                                              topiramate 83
paths to the root