Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rasagiline
go back to main search page
Accession:CHEBI:63620 term browser browse the term
Definition:An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
Synonyms:exact_synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
 related_synonym: (1R)-N-propargylindan-1-amine;   (R)-N-2-Propynyl-1-indanamine;   (R)-indan-1-yl-prop-2-ynyl-amine;   Formula=C12H13N;   InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1;   InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N;   RAS;   SMILES=C#CCN[C@@H]1CCc2ccccc12
 xref: CAS:136236-51-6;   DrugBank:DB01367;   KEGG:D08469
 xref_mesh: MESH:C031967
 xref: PMID:20577110;   PMID:21482191;   PMID:21500280;   PMID:21628600;   PMID:21671840;   PMID:21819487;   PMID:21864207;   PMID:21878836;   PMID:21895884;   PMID:21946113;   PMID:21953831;   PMID:21971006;   PMID:21971007;   PMID:22045282;   PMID:22065207;   Reaxys:9194207;   Wikipedia:Rasagiline


show annotations for term's descendants           Sort by:
rasagiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression		 ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein		 CTD PMID:14687604 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO rasagiline results in decreased activity of MAOB protein CTD PMID:21923181 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein] CTD PMID:14687604 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            protective agent 18235
              neuroprotective agent 15712
                rasagiline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        secondary amino compound 6953
                                          secondary amine 1847
                                            rasagiline 3
paths to the root