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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:propafenone
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Accession:CHEBI:63619 term browser browse the term
Definition:An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Synonyms:exact_synonym: 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
 related_synonym: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone;   2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone;   Formula=C21H27NO3;   InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3;   InChIKey=JWHAUXFOSRPERK-UHFFFAOYSA-N;   SMILES=CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1;   propafenona;   propafenonum
 alt_id: CHEBI:8465
 xref: CAS:54063-53-5;   DrugBank:DB01182;   Drug_Central:2291;   KEGG:C07381;   KEGG:D08435;   LINCS:LSM-1416
 xref_mesh: MESH:D011405
 xref: PMID:8777484;   Patent:DE2001431;   Reaxys:2175182;   Wikipedia:Propafenone
 cyclic_relationship: is_conjugate_base_of CHEBI:63650


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propafenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Propafenone binds to and results in decreased activity of ADRB1 protein CTD PMID:6141285 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Propafenone binds to and results in decreased activity of ADRB2 protein CTD PMID:6141285 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Casp3 caspase 3 increases activity ISO Propafenone results in increased activity of CASP3 protein CTD PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Propafenone results in increased activity of CASP7 protein CTD PMID:22700542 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Propafenone results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Propafenone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance
increases metabolic processing		 ISO CYP2D6 protein mutant form affects the susceptibility to Propafenone
CYP2D6 protein results in increased metabolism of Propafenone		 CTD PMID:12421483 PMID:35442037 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
affects activity
decreases activity		 ISO Propafenone analog binds to and results in decreased activity of KCNH2 protein; Propafenone binds to and results in decreased activity of KCNH2 protein; Propafenone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Propafenone affects the activity of KCNH2 protein
Propafenone results in decreased activity of KCNH2 protein		 CTD PMID:16278312 PMID:18724381 PMID:21158687 PMID:21175572 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Propafenone inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:258,374,671...258,388,945
Ensembl chr 1:258,374,671...258,388,945 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Propafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Propafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            cardiovascular drug 8644
              anti-arrhythmia drug 1540
                propafenone 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        secondary amino compound 6954
                                          propafenone 12
paths to the root