pergolide - Ontology Report - Rat Genome Database

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein]

PMID:15081873 PMID:15672541

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Drd1

dopamine receptor D1

increases activity

Pergolide results in increased activity of DRD1 protein

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

Drd2

dopamine receptor D2

increases activity

Pergolide results in increased activity of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

Gdnf

glial cell derived neurotrophic factor

increases expression
increases secretion

Pergolide results in increased expression of GDNF mRNA
Pergolide results in increased secretion of GDNF protein

PMID:12770616

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

Kcna5

potassium voltage-gated channel subfamily A member 5

decreases activity

Pergolide results in decreased activity of KCNA5 protein

NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697

Kcnma1

potassium calcium-activated channel subfamily M alpha 1

decreases activity

EXP

Pergolide results in decreased activity of KCNMA1 protein

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

Msh2

mutS homolog 2

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]

NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938

Nfkb1

nuclear factor kappa B subunit 1

multiple interactions

Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Ngf

nerve growth factor

increases expression
increases secretion

Pergolide results in increased expression of NGF mRNA
Pergolide results in increased secretion of NGF protein

PMID:12770616

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

Rela

RELA proto-oncogene, NF-kB subunit

multiple interactions

Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Slc22a2

solute carrier family 22 member 2

multiple interactions

Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:21599003

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

Tp53

tumor protein p53

multiple interactions

Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein]