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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:moxifloxacin
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Accession:CHEBI:63611 term browser browse the term
Definition:A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.
Synonyms:exact_synonym: 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid;   Formula=C21H24FN3O4;   InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1;   InChIKey=FABPRXSRWADJSP-MEDUHNTESA-N;   SMILES=[H][C@@]12CCCN[C@]1([H])CN(C2)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1
 alt_id: CHEBI:7007
 xref: CAS:151096-09-2;   DrugBank:DB00218;   Drug_Central:1854;   KEGG:C07663;   KEGG:D08237;   LINCS:LSM-5746
 xref_mesh: MESH:C104727
 xref: Patent:EP550903;   Reaxys:8365827;   VSDB:2983;   Wikipedia:Moxifloxacin
 cyclic_relationship: is_conjugate_base_of CHEBI:63699


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moxifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO moxifloxacin results in decreased expression of IFNG protein CTD PMID:16006447 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO moxifloxacin results in decreased secretion of IL1B protein CTD PMID:16352735 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 decreases expression ISO moxifloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 PMID:27553911 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK1 protein CTD PMID:16352735 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK3 protein CTD PMID:16352735 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion 		ISO Moxifloxacin results in increased secretion of MMP1 protein
Moxifloxacin results in decreased secretion of MMP1 protein 		CTD PMID:24890593 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression 		EXP Moxifloxacin results in increased activity of MMP2 protein
Moxifloxacin results in increased expression of MMP2 mRNA 		CTD PMID:21058936 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion
increases secretion 		ISO Moxifloxacin results in decreased secretion of MMP3 protein
Moxifloxacin results in increased secretion of MMP3 protein 		CTD PMID:24890593 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion
increases activity
increases expression 		ISO
EXP 		Moxifloxacin results in decreased secretion of MMP9 protein
Moxifloxacin results in increased activity of MMP9 protein
Moxifloxacin results in increased expression of MMP9 mRNA 		CTD PMID:21058936 PMID:24890593 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO moxifloxacin results in decreased expression of RELA protein CTD PMID:16352735 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO moxifloxacin results in decreased secretion of TNF protein CTD PMID:16352735 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:169,713,195...169,796,330
Ensembl chr 3:169,713,130...169,796,327 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20873
    role 20805
      biological role 20829
        antimicrobial agent 18576
          quinolone antibiotic 2112
            moxifloxacin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 20873
    subatomic particle 20871
      composite particle 20871
        hadron 20871
          baryon 20871
            nucleon 20871
              atomic nucleus 20871
                atom 20871
                  main group element atom 20794
                    p-block element atom 20794
                      carbon group element atom 20727
                        carbon atom 20722
                          organic molecular entity 20722
                            heteroorganic entity 20226
                              organochalcogen compound 19910
                                organooxygen compound 19813
                                  carbon oxoacid 19160
                                    carboxylic acid 19157
                                      aromatic carboxylic acid 14033
                                        quinolinemonocarboxylic acid 107
                                          moxifloxacin 17
paths to the root