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G |
Ace2 |
angiotensin converting enzyme 2 |
decreases expression |
ISO |
Acarbose results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
EXP |
Acarbose results in increased expression of ADIPOQ protein |
CTD |
PMID:18290871 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein] |
CTD |
PMID:17133782 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression |
EXP |
Acarbose results in decreased expression of CYP2E1 mRNA |
CTD |
PMID:14975757 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Fasn |
fatty acid synthase |
decreases expression |
EXP |
Acarbose results in decreased expression of FASN mRNA; Acarbose results in decreased expression of FASN protein |
CTD |
PMID:8101498 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Ins1 |
insulin 1 |
increases response to substance decreases secretion decreases expression increases secretion multiple interactions |
EXP |
Acarbose results in increased susceptibility to INS1 protein Acarbose results in decreased secretion of INS1 protein Acarbose results in decreased expression of INS1 protein Acarbose results in increased secretion of INS1 protein Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased expression of INS1 protein] |
CTD |
PMID:1767839 PMID:8101498 PMID:9313782 PMID:18290871 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Lep |
leptin |
decreases expression |
EXP |
Acarbose results in decreased expression of LEP protein |
CTD |
PMID:18290871 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G |
Mgam |
maltase-glucoamylase |
decreases activity |
ISO |
Acarbose results in decreased activity of MGAM protein |
CTD |
PMID:17585022 PMID:20349118 |
|
NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715
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G |
Npy |
neuropeptide Y |
decreases expression |
EXP |
Acarbose results in decreased expression of NPY protein |
CTD |
PMID:18290871 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
affects response to substance |
ISO |
PPARGC1A protein polymorphism affects the susceptibility to Acarbose |
CTD |
PMID:15592662 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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|
G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
EXP |
Acarbose results in increased expression of SLC2A1 protein |
CTD |
PMID:11779583 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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|
G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
EXP |
Acarbose results in increased expression of SLC2A4 mRNA; Acarbose results in increased expression of SLC2A4 protein |
CTD |
PMID:1767839 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Sqstm1 |
sequestosome 1 |
affects response to substance |
ISO |
SQSTM1 affects the susceptibility to Acarbose |
CTD |
PMID:19207582 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
ISO EXP |
Acarbose results in decreased expression of TNF mRNA Acarbose results in decreased expression of TNF mRNA; Acarbose results in decreased expression of TNF protein Acarbose inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA] |
CTD |
PMID:12717270 PMID:14975757 PMID:20703014 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Casp1 |
caspase 1 |
increases response to substance |
ISO |
CASP1 results in increased susceptibility to Aclarubicin |
CTD |
PMID:9491796 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Aclarubicin results in increased activity of CASP3 protein acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Aclarubicin results in increased activity of CASP3 protein] |
CTD |
PMID:16215684 PMID:20399885 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Aclarubicin results in increased activity of CASP8 protein |
CTD |
PMID:20399885 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Dffa |
DNA fragmentation factor subunit alpha |
increases degradation |
ISO |
Aclarubicin results in increased degradation of DFFA protein |
CTD |
PMID:12370496 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Gata1 |
GATA binding protein 1 |
multiple interactions increases activity increases expression |
ISO |
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA] Aclarubicin results in increased activity of GATA1 protein |
CTD |
PMID:10656287 PMID:14623254 |
|
NCBI chr X:14,529,706...14,537,530
Ensembl chr X:14,529,702...14,537,530
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression multiple interactions |
ISO |
Aclarubicin results in increased expression of GSTP1 mRNA; Aclarubicin results in increased expression of GSTP1 protein Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter] |
CTD |
PMID:14623254 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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|
G |
Hmbs |
hydroxymethylbilane synthase |
increases expression multiple interactions |
ISO |
Aclarubicin results in increased expression of HMBS mRNA Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA] |
CTD |
PMID:10656287 |
|
NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:44,673,554...44,680,957
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G |
Nfe2 |
nuclear factor, erythroid 2 |
increases expression multiple interactions |
ISO |
Aclarubicin results in increased expression of NFE2 mRNA Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA] |
CTD |
PMID:10656287 |
|
NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
affects activity |
ISO |
Aclarubicin affects the activity of PARP1 protein |
CTD |
PMID:20399885 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Aclarubicin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Sod1 |
superoxide dismutase 1 |
decreases activity |
ISO |
Aclarubicin results in decreased activity of SOD1 protein |
CTD |
PMID:10656287 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G |
Xiap |
X-linked inhibitor of apoptosis |
increases response to substance |
ISO |
XIAP protein results in increased susceptibility to Aclarubicin |
CTD |
PMID:10815900 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] |
CTD |
PMID:31202640 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
Digitonin results in increased expression of CCNB1 protein |
CTD |
PMID:36030841 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression |
ISO |
Digitonin results in increased expression of CCND1 protein |
CTD |
PMID:36030841 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh5 |
cadherin 5 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] |
CTD |
PMID:31404653 |
|
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
Digitonin results in decreased expression of CDKN1A protein |
CTD |
PMID:36030841 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
decreases expression |
ISO |
Digitonin results in decreased expression of CDKN1B protein |
CTD |
PMID:36030841 |
|
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
Digitonin results in increased expression of CYP2B10 protein |
CTD |
PMID:36030841 |
|
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
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G |
Etv2 |
ETS variant transcription factor 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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G |
Hexb |
hexosaminidase subunit beta |
multiple interactions increases activity |
ISO |
1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [Digitonin results in increased activity of HEXB protein] |
CTD |
PMID:36860548 |
|
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression |
ISO |
Digitonin results in decreased expression of HIF1A protein |
CTD |
PMID:34717917 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G |
Nek2 |
NIMA-related kinase 2 |
increases expression |
ISO |
Digitonin results in increased expression of NEK2 protein |
CTD |
PMID:36030841 |
|
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
decreases expression |
ISO |
Digitonin results in decreased expression of RBL2 protein |
CTD |
PMID:36030841 |
|
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
ISO |
Digitonin results in increased expression of SLCO1A4 protein |
CTD |
PMID:36030841 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Spn |
sialophorin |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions |
EXP |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] |
CTD |
PMID:27317372 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression |
ISO EXP |
dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein |
CTD |
PMID:24680847 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] |
CTD |
PMID:27317372 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Acadm |
acyl-CoA dehydrogenase medium chain |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] |
CTD |
PMID:24146112 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
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G |
Acads |
acyl-CoA dehydrogenase short chain |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] |
CTD |
PMID:24146112 |
|
NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
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G |
Acox1 |
acyl-CoA oxidase 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] |
CTD |
PMID:24146112 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] |
CTD |
PMID:24146112 |
|
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] |
CTD |
PMID:35481609 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases expression |
ISO |
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein] dioscin results in decreased expression of AKT1 mRNA |
CTD |
PMID:25111127 PMID:29990575 PMID:35481609 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] |
CTD |
PMID:24146112 |
|
NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
decreases expression |
ISO |
dioscin results in decreased expression of APAF1 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] |
CTD |
PMID:24146112 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
dioscin results in increased expression of BAD mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions increases expression |
ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein] dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein] dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein |
CTD |
PMID:22334414 PMID:22939915 PMID:33359023 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression decreases expression |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] dioscin results in increased expression of BCL2 protein dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
ISO |
[Acetaminophen co-treated with dioscin] results in increased expression of BID protein dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein |
CTD |
PMID:22334414 PMID:22939915 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
ISO |
dioscin results in increased expression of BIRC5 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases expression increases activity |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein] dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein] dioscin results in increased activity of CASP3 protein |
CTD |
PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
increases expression |
ISO |
dioscin results in increased expression of CASP7 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions decreases expression increases expression |
ISO |
dioscin results in increased activity of CASP8 protein dioscin results in decreased expression of and results in increased cleavage of CASP8 protein dioscin results in decreased expression of CASP8 mRNA dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions decreases expression increases expression |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein] dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein |
CTD |
PMID:24146112 PMID:29990575 PMID:33359023 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein |
CTD |
PMID:33359023 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein |
CTD |
PMID:29990575 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
increases expression decreases expression |
ISO |
dioscin results in increased expression of CCND1 mRNA dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein |
CTD |
PMID:33359023 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein |
CTD |
PMID:29990575 |
|
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein |
CTD |
PMID:33359023 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK4 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein |
CTD |
PMID:33359023 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein |
CTD |
PMID:33359023 |
|
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein |
CTD |
PMID:33359023 |
|
NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
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G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein |
CTD |
PMID:33359023 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
decreases expression |
ISO |
dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein |
CTD |
PMID:29990575 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Ctnnb1 |
catenin beta 1 |
increases expression multiple interactions |
ISO |
dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA] |
CTD |
PMID:24742230 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
dioscin results in increased expression of CYCS mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] |
CTD |
PMID:22939915 PMID:24146112 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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|
G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
increases expression |
ISO |
dioscin results in increased expression of DIABLO mRNA |
CTD |
PMID:29990575 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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|
G |
Esr1 |
estrogen receptor 1 |
increases expression multiple interactions |
ISO |
dioscin results in increased expression of ESR1 protein fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein] |
CTD |
PMID:24742230 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] |
CTD |
PMID:24742230 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
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|
G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein |
CTD |
PMID:22334414 PMID:33359023 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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|
G |
Faslg |
Fas ligand |
increases expression |
ISO |
dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein |
CTD |
PMID:22334414 PMID:29990575 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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|
G |
Foxo1 |
forkhead box O1 |
increases expression |
ISO |
dioscin results in increased expression of FOXO1 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] |
CTD |
PMID:27317372 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] |
CTD |
PMID:24146112 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein] dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] |
CTD |
PMID:24146112 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] |
CTD |
PMID:35481609 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]] dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] |
CTD |
PMID:35481609 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] |
CTD |
PMID:35481609 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA] dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver] dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]] |
CTD RGD |
PMID:24146112 PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] |
CTD |
PMID:25111127 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] |
CTD |
PMID:28082111 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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|
G |
Krt18 |
keratin 18 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] |
CTD |
PMID:22939915 PMID:24146112 |
|
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
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|
G |
Lrp5 |
LDL receptor related protein 5 |
multiple interactions increases expression |
ISO |
fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] |
CTD |
PMID:24742230 |
|
NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:200,814,250...200,917,581
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|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24146112 PMID:25111127 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24146112 PMID:25111127 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases expression |
ISO |
dioscin results in increased expression of MAPK8 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases expression |
ISO |
dioscin results in increased expression of MAPK9 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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|
G |
Mdh1 |
malate dehydrogenase 1 |
multiple interactions |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] |
CTD |
PMID:22939915 |
|
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
ISO |
dioscin results in decreased expression of MTOR mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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|
G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] |
CTD |
PMID:35481609 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]] dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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|
G |
Nfkbia |
NFKB inhibitor alpha |
decreases degradation |
ISO |
dioscin results in decreased degradation of NFKBIA protein |
CTD |
PMID:24680847 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions increases expression |
EXP |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA] dioscin results in increased expression of NR0B2 mRNA |
CTD |
PMID:27317372 |
|
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]] dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein dioscin results in increased expression of PARP1 mRNA |
CTD |
PMID:24146112 PMID:29990575 PMID:33359023 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G |
Pik3cb |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
decreases expression |
ISO |
dioscin results in decreased expression of PIK3CB mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
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|
G |
Pnp |
purine nucleoside phosphorylase |
multiple interactions |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] |
CTD |
PMID:22939915 |
|
NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986
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|
G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] |
CTD |
PMID:24146112 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] |
CTD |
PMID:22939915 |
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NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkab1 |
protein kinase AMP-activated non-catalytic subunit beta 1 |
increases expression |
ISO |
dioscin results in increased expression of PRKAB1 mRNA |
CTD |
PMID:29990575 |
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NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Ptk2 |
protein tyrosine kinase 2 |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] |
CTD |
PMID:25111127 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] |
CTD |
PMID:28082111 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Rgn |
regucalcin |
multiple interactions |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] |
CTD |
PMID:22939915 |
|
NCBI chr X:4,172,537...4,190,112
Ensembl chr X:1,619,032...1,634,450
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
dioscin results in decreased expression of RPS6KB1 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
EXP |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] |
CTD |
PMID:27317372 |
|
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
EXP |
dioscin results in increased expression of SLCO1A2 mRNA |
CTD |
PMID:27317372 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions increases expression |
EXP |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein] dioscin results in increased expression of SLCO1B2 mRNA |
CTD |
PMID:27317372 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] |
CTD |
PMID:25111127 |
|
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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G |
Suox |
sulfite oxidase |
multiple interactions |
ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] |
CTD |
PMID:22939915 |
|
NCBI chr 7:1,103,149...1,107,156
Ensembl chr 7:1,103,151...1,107,038
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein] dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:35481609 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA] dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver] dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]] |
CTD RGD |
PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 PMID:35481609 PMID:29091898 More...
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RGD:15090820 |
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfrsf11b |
TNF receptor superfamily member 11B |
increases expression multiple interactions |
ISO |
dioscin results in increased expression of TNFRSF11B mRNA fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA] |
CTD |
PMID:24742230 |
|
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
ISO |
dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
increases expression |
ISO |
dioscin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:29990575 PMID:33359023 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Tnfsf11 |
TNF superfamily member 11 |
decreases expression multiple interactions |
ISO |
dioscin results in decreased expression of TNFSF11 mRNA fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] |
CTD |
PMID:24742230 |
|
NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO EXP |
dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein] dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tradd |
TNFRSF1A-associated via death domain |
increases expression |
ISO |
dioscin results in increased expression of TRADD mRNA |
CTD |
PMID:29990575 PMID:33359023 |
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NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Traf1 |
TNF receptor-associated factor 1 |
increases expression |
ISO |
dioscin results in increased expression of TRAF1 protein |
CTD |
PMID:22334414 |
|
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] |
CTD |
PMID:25111127 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G |
Wee1 |
WEE1 G2 checkpoint kinase |
increases expression |
ISO |
dioscin results in increased expression of WEE1 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
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G |
Atp7b |
ATPase copper transporting beta |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] |
CTD |
PMID:38761876 |
|
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein] |
CTD |
PMID:38761876 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein] |
CTD |
PMID:38761876 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein] |
CTD |
PMID:38761876 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
eritoran inhibits the reaction [Azathioprine results in increased expression of GPT protein]; eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein] |
CTD |
PMID:24184165 PMID:24747151 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsdmd |
gasdermin D |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein] |
CTD |
PMID:38761876 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein] |
CTD |
PMID:38761876 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Mlkl |
mixed lineage kinase domain like pseudokinase |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein] |
CTD |
PMID:38761876 |
|
NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] |
CTD |
PMID:38761876 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein] |
CTD |
PMID:38761876 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein] |
CTD |
PMID:38761876 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
ISO |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein] |
CTD |
PMID:38761876 |
|
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] |
CTD |
PMID:38761876 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
F10 |
coagulation factor X |
decreases activity |
ISO |
fondaparinux results in decreased activity of F10 protein |
CTD |
PMID:16084352 |
|
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression multiple interactions |
ISO |
Lipid A results in increased expression of CCL3 mRNA anacetrapib inhibits the reaction [Lipid A results in increased expression of CCL3 mRNA] |
CTD |
PMID:20448206 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG protein Lipid A results in increased expression of IFNG mRNA; Lipid A results in increased expression of IFNG protein |
CTD |
PMID:16299289 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G |
Il12a |
interleukin 12A |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12A mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein] Lipid A results in increased expression of IL12A mRNA |
CTD |
PMID:16299289 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12B mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12B mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein] Lipid A results in increased expression of IL12B mRNA |
CTD |
PMID:16299289 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il15 |
interleukin 15 |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL15 mRNA Lipid A results in increased expression of IL15 mRNA |
CTD |
PMID:16299289 |
|
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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G |
Il18 |
interleukin 18 |
increases expression |
ISO |
Lipid A results in increased expression of IL18 mRNA |
CTD |
PMID:16299289 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
anacetrapib inhibits the reaction [Lipid A results in increased expression of IL6 mRNA] |
CTD |
PMID:20448206 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
anacetrapib inhibits the reaction [Lipid A results in increased expression of TNF mRNA] |
CTD |
PMID:20448206 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA] madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:37087747 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA] |
CTD |
PMID:37087747 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein] |
CTD |
PMID:37087747 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
madecassoside results in decreased activity of CYP2C19 protein |
CTD |
PMID:21349323 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
madecassoside results in decreased activity of CYP3A4 protein |
CTD |
PMID:21349323 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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|
G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] |
CTD |
PMID:37087747 |
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NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] |
CTD |
PMID:37087747 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] |
CTD |
PMID:37087747 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 protein] |
CTD |
PMID:37087747 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:37087747 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:37087747 |
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NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] |
CTD |
PMID:37087747 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein] |
CTD |
PMID:20923188 |
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] |
CTD |
PMID:20923188 |
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:20923188 |
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NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased secretion of NOS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] |
CTD |
PMID:20923188 PMID:21397503 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] |
CTD |
PMID:20923188 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:20923188 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G |
Ren |
renin |
decreases activity |
ISO |
soyasaponin I results in decreased activity of REN protein |
CTD |
PMID:19060406 PMID:20460744 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
St3gal4 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
decreases expression |
ISO |
soyasaponin I results in decreased expression of ST3GAL4 mRNA |
CTD |
PMID:15661230 |
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NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] |
CTD |
PMID:20923188 |
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
affects binding |
ISO |
sucrose octasulfate binds to FGFR2 protein |
CTD |
PMID:15047176 |
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NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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