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G |
Ace2 |
angiotensin converting enzyme 2 |
decreases expression |
ISO |
Acarbose results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
|
NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
Acarbose results in increased expression of ADIPOQ protein |
CTD |
PMID:18290871 |
|
NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 mRNA]; Acarbose inhibits the reaction [Fructose results in increased expression of CCL2 protein] |
CTD |
PMID:17133782 |
|
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression |
ISO |
Acarbose results in decreased expression of CYP2E1 mRNA |
CTD |
PMID:14975757 |
|
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
Acarbose results in decreased expression of FASN mRNA; Acarbose results in decreased expression of FASN protein |
CTD |
PMID:8101498 |
|
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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G |
Ins1 |
insulin I |
increases secretion increases response to substance decreases secretion multiple interactions decreases expression |
ISO |
Acarbose results in increased secretion of INS1 protein Acarbose results in increased susceptibility to INS1 protein Acarbose results in decreased secretion of INS1 protein Acarbose inhibits the reaction [[Dietary Sucrose co-treated with Sodium Chloride, Dietary] results in increased expression of INS1 protein] Acarbose results in decreased expression of INS1 protein |
CTD |
PMID:1767839 PMID:8101498 PMID:9313782 PMID:18290871 |
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NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914
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G |
Lep |
leptin |
decreases expression |
ISO |
Acarbose results in decreased expression of LEP protein |
CTD |
PMID:18290871 |
|
NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
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G |
Mgam |
maltase-glucoamylase |
decreases activity |
ISO EXP |
Acarbose results in decreased activity of MGAM protein |
CTD |
PMID:17585022 PMID:20349118 |
|
NCBI chr 6:40,605,765...40,746,057
Ensembl chr 6:40,605,765...40,746,057
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G |
Npy |
neuropeptide Y |
decreases expression |
ISO |
Acarbose results in decreased expression of NPY protein |
CTD |
PMID:18290871 |
|
NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487
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G |
Ppargc1a |
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
affects response to substance |
ISO |
PPARGC1A protein polymorphism affects the susceptibility to Acarbose |
CTD |
PMID:15592662 |
|
NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
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G |
Slc2a1 |
solute carrier family 2 (facilitated glucose transporter), member 1 |
increases expression |
ISO |
Acarbose results in increased expression of SLC2A1 protein |
CTD |
PMID:11779583 |
|
NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
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G |
Slc2a4 |
solute carrier family 2 (facilitated glucose transporter), member 4 |
increases expression |
ISO |
Acarbose results in increased expression of SLC2A4 mRNA; Acarbose results in increased expression of SLC2A4 protein |
CTD |
PMID:1767839 |
|
NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014
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G |
Sqstm1 |
sequestosome 1 |
affects response to substance |
EXP |
SQSTM1 affects the susceptibility to Acarbose |
CTD |
PMID:19207582 |
|
NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654
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G |
Tnf |
tumor necrosis factor |
decreases expression multiple interactions |
EXP ISO |
Acarbose results in decreased expression of TNF mRNA Acarbose results in decreased expression of TNF mRNA; Acarbose results in decreased expression of TNF protein Acarbose inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA] |
CTD |
PMID:12717270 PMID:14975757 PMID:20703014 |
|
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Casp1 |
caspase 1 |
increases response to substance |
EXP |
CASP1 results in increased susceptibility to Aclarubicin |
CTD |
PMID:9491796 |
|
NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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|
G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
EXP ISO |
Aclarubicin results in increased activity of CASP3 protein acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Aclarubicin results in increased activity of CASP3 protein] |
CTD |
PMID:16215684 PMID:20399885 |
|
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Aclarubicin results in increased activity of CASP8 protein |
CTD |
PMID:20399885 |
|
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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G |
Dffa |
DNA fragmentation factor, alpha subunit |
increases degradation |
ISO |
Aclarubicin results in increased degradation of DFFA protein |
CTD |
PMID:12370496 |
|
NCBI chr 4:149,188,599...149,205,110
Ensembl chr 4:149,188,603...149,205,104
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G |
Gata1 |
GATA binding protein 1 |
multiple interactions increases activity increases expression |
ISO |
Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of GATA1 mRNA] Aclarubicin results in increased activity of GATA1 protein |
CTD |
PMID:10656287 PMID:14623254 |
|
NCBI chr X:7,825,504...7,842,844
Ensembl chr X:7,825,499...7,844,310
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G |
Gstp1 |
glutathione S-transferase, pi 1 |
multiple interactions increases expression |
ISO |
Aclarubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter] Aclarubicin results in increased expression of GSTP1 mRNA; Aclarubicin results in increased expression of GSTP1 protein |
CTD |
PMID:14623254 |
|
NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985
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G |
Hmbs |
hydroxymethylbilane synthase |
increases expression multiple interactions |
ISO |
Aclarubicin results in increased expression of HMBS mRNA Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of HMBS mRNA] |
CTD |
PMID:10656287 |
|
NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525
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G |
Nfe2 |
nuclear factor, erythroid derived 2 |
increases expression multiple interactions |
ISO |
Aclarubicin results in increased expression of NFE2 mRNA Acetylcysteine inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA]; Quercetin inhibits the reaction [Aclarubicin results in increased expression of NFE2 mRNA] |
CTD |
PMID:10656287 |
|
NCBI chr15:103,156,640...103,166,809
Ensembl chr15:103,156,639...103,166,830
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|
G |
Parp1 |
poly (ADP-ribose) polymerase family, member 1 |
affects activity |
ISO |
Aclarubicin affects the activity of PARP1 protein |
CTD |
PMID:20399885 |
|
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
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G |
Slc22a2 |
solute carrier family 22 (organic cation transporter), member 2 |
multiple interactions |
ISO |
Aclarubicin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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G |
Sod1 |
superoxide dismutase 1, soluble |
decreases activity |
ISO |
Aclarubicin results in decreased activity of SOD1 protein |
CTD |
PMID:10656287 |
|
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
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G |
Xiap |
X-linked inhibitor of apoptosis |
increases response to substance |
ISO |
XIAP protein results in increased susceptibility to Aclarubicin |
CTD |
PMID:10815900 |
|
NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP |
ganglioside, GD1b analog inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites]; ganglioside, GD1b inhibits the reaction [[lipopolysaccharide, E. coli O26-B6 results in increased activity of NOS2 protein] which results in increased secretion of Nitrites] |
CTD |
PMID:31202640 |
|
NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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|
G |
Ccnb1 |
cyclin B1 |
increases expression |
EXP |
Digitonin results in increased expression of CCNB1 protein |
CTD |
PMID:36030841 |
|
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
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|
G |
Ccnd1 |
cyclin D1 |
increases expression |
EXP |
Digitonin results in increased expression of CCND1 protein |
CTD |
PMID:36030841 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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|
G |
Cdh5 |
cadherin 5 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein] |
CTD |
PMID:31404653 |
|
NCBI chr 8:104,828,247...104,871,136
Ensembl chr 8:104,828,257...104,871,143
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G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
decreases expression |
EXP |
Digitonin results in decreased expression of CDKN1A protein |
CTD |
PMID:36030841 |
|
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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G |
Cdkn1b |
cyclin dependent kinase inhibitor 1B |
decreases expression |
EXP |
Digitonin results in decreased expression of CDKN1B protein |
CTD |
PMID:36030841 |
|
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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|
G |
Cyp2b10 |
cytochrome P450, family 2, subfamily b, polypeptide 10 |
increases expression |
EXP |
Digitonin results in increased expression of CYP2B10 protein |
CTD |
PMID:36030841 |
|
NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
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|
G |
Cyp3a11 |
cytochrome P450, family 3, subfamily a, polypeptide 11 |
increases expression |
EXP |
Digitonin results in increased expression of CYP3A11 protein |
CTD |
PMID:36030841 |
|
NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774
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G |
Etv2 |
ets variant 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 7:30,333,041...30,335,934
Ensembl chr 7:30,333,041...30,335,277
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014
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|
G |
Hexb |
hexosaminidase B |
multiple interactions increases activity |
EXP |
1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [Digitonin results in increased activity of HEXB protein] |
CTD |
PMID:36860548 |
|
NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865
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G |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
decreases expression |
ISO |
Digitonin results in decreased expression of HIF1A protein |
CTD |
PMID:34717917 |
|
NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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G |
Nek2 |
NIMA (never in mitosis gene a)-related expressed kinase 2 |
increases expression |
EXP |
Digitonin results in increased expression of NEK2 protein |
CTD |
PMID:36030841 |
|
NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162
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G |
Rbl2 |
RB transcriptional corepressor like 2 |
decreases expression |
EXP |
Digitonin results in decreased expression of RBL2 protein |
CTD |
PMID:36030841 |
|
NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472
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|
G |
Slc22a2 |
solute carrier family 22 (organic cation transporter), member 2 |
multiple interactions |
ISO |
Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
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|
G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
EXP |
Digitonin results in increased expression of SLCO1A4 protein |
CTD |
PMID:36030841 |
|
NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
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G |
Spn |
sialophorin |
multiple interactions |
ISO |
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein] |
CTD |
PMID:31404653 |
|
NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995
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|
G |
Abcb11 |
ATP-binding cassette, sub-family B member 11 |
multiple interactions |
ISO |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 protein] |
CTD |
PMID:27317372 |
|
NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
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G |
Abcb1a |
ATP-binding cassette, sub-family B member 1A |
decreases expression |
ISO |
dioscin results in decreased expression of ABCB1 mRNA; dioscin results in decreased expression of ABCB1 protein |
CTD |
PMID:24680847 |
|
NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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G |
Abcc2 |
ATP-binding cassette, sub-family member 2 |
multiple interactions |
ISO |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 mRNA]; dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC2 protein] |
CTD |
PMID:27317372 |
|
NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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G |
Acadm |
acyl-Coenzyme A dehydrogenase, medium chain |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADM protein] |
CTD |
PMID:24146112 |
|
NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269
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G |
Acads |
acyl-Coenzyme A dehydrogenase, short chain |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACADS protein] |
CTD |
PMID:24146112 |
|
NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405
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G |
Acox1 |
acyl-Coenzyme A oxidase 1, palmitoyl |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL1 protein] |
CTD |
PMID:24146112 |
|
NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088
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G |
Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein] |
CTD |
PMID:24146112 |
|
NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152
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G |
Acta2 |
actin alpha 2, smooth muscle, aorta |
multiple interactions |
EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of ACTA2 protein] |
CTD |
PMID:35481609 |
|
NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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G |
Akt1 |
thymoma viral proto-oncogene 1 |
multiple interactions decreases expression |
ISO EXP |
dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased phosphorylation of AKT1 protein] dioscin results in decreased expression of AKT1 mRNA |
CTD |
PMID:25111127 PMID:29990575 PMID:35481609 |
|
NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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G |
Aldh7a1 |
aldehyde dehydrogenase family 7, member A1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of ALDH7A1 protein] |
CTD |
PMID:24146112 |
|
NCBI chr18:56,657,794...56,706,112
Ensembl chr18:56,642,759...56,706,023
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
decreases expression |
ISO |
dioscin results in decreased expression of APAF1 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632
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|
G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of ATF6 protein] |
CTD |
PMID:24146112 |
|
NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
dioscin results in increased expression of BAD mRNA |
CTD |
PMID:33359023 |
|
NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267
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|
G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions increases expression |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of BAK1 protein] dioscin results in increased expression of BAK1 mRNA; dioscin results in increased expression of BAK1 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:29990575 PMID:33359023 |
|
NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
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G |
Bax |
BCL2-associated X protein |
multiple interactions increases expression |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of BAX protein] dioscin results in increased expression of BAX mRNA; dioscin results in increased expression of BAX protein |
CTD |
PMID:22334414 PMID:22939915 PMID:33359023 |
|
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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|
G |
Bbc3 |
BCL2 binding component 3 |
increases expression |
ISO |
dioscin results in increased expression of BBC3 mRNA; dioscin results in increased expression of BBC3 protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130
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|
G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions decreases expression increases expression |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] dioscin results in decreased expression of BCL2 mRNA; dioscin results in decreased expression of BCL2 protein dioscin results in increased expression of BCL2 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:24742230 PMID:29990575 PMID:33359023 |
|
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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|
G |
Bcl2l1 |
BCL2-like 1 |
decreases expression |
ISO |
dioscin results in decreased expression of BCL2L1 mRNA; dioscin results in decreased expression of BCL2L1 protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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|
G |
Bid |
BH3 interacting domain death agonist |
multiple interactions decreases expression |
EXP ISO |
[Acetaminophen co-treated with dioscin] results in increased expression of BID protein dioscin results in decreased expression of BID mRNA; dioscin results in decreased expression of BID protein |
CTD |
PMID:22334414 PMID:22939915 |
|
NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
increases expression |
ISO |
dioscin results in increased expression of BIRC5 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
|
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases expression increases activity |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of CASP3 protein] dioscin results in decreased expression of CASP3 mRNA; dioscin results in decreased expression of CASP3 protein benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [dioscin results in increased expression of CASP3 protein] dioscin results in increased expression of CASP3 mRNA; dioscin results in increased expression of CASP3 protein dioscin results in increased activity of CASP3 protein |
CTD |
PMID:22334414 PMID:24146112 PMID:29990575 PMID:33359023 |
|
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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|
G |
Casp7 |
caspase 7 |
increases expression |
ISO |
dioscin results in increased expression of CASP7 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776
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|
G |
Casp8 |
caspase 8 |
increases activity decreases expression multiple interactions increases expression |
ISO |
dioscin results in increased activity of CASP8 protein dioscin results in decreased expression of CASP8 mRNA dioscin results in decreased expression of and results in increased cleavage of CASP8 protein dioscin results in increased expression of CASP8 mRNA; dioscin results in increased expression of CASP8 protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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|
G |
Casp9 |
caspase 9 |
multiple interactions decreases expression increases expression |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of CASP9 protein] dioscin results in decreased expression of CASP9 mRNA; dioscin results in decreased expression of CASP9 protein dioscin results in increased expression of CASP9 mRNA; dioscin results in increased expression of CASP9 protein |
CTD |
PMID:24146112 PMID:29990575 PMID:33359023 |
|
NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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|
G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNA2 mRNA; dioscin results in decreased expression of CCNA2 protein |
CTD |
PMID:33359023 |
|
NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299
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|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNB1 mRNA; dioscin results in decreased expression of CCNB1 protein |
CTD |
PMID:29990575 |
|
NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
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|
G |
Ccnd1 |
cyclin D1 |
increases expression decreases expression |
ISO |
dioscin results in increased expression of CCND1 mRNA dioscin results in decreased expression of CCND1 mRNA; dioscin results in decreased expression of CCND1 protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
dioscin results in decreased expression of CCNE1 mRNA; dioscin results in decreased expression of CCNE1 protein |
CTD |
PMID:33359023 |
|
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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|
G |
Cdk1 |
cyclin dependent kinase 1 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK1 mRNA; dioscin results in decreased expression of CDK1 protein |
CTD |
PMID:29990575 |
|
NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768
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|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK2 mRNA; dioscin results in decreased expression of CDK2 protein |
CTD |
PMID:33359023 |
|
NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900
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|
G |
Cdk4 |
cyclin dependent kinase 4 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK4 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789
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G |
Cdk6 |
cyclin dependent kinase 6 |
decreases expression |
ISO |
dioscin results in decreased expression of CDK6 mRNA; dioscin results in decreased expression of CDK6 protein |
CTD |
PMID:33359023 |
|
NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008
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G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
increases expression |
ISO |
dioscin results in increased expression of CDKN1A mRNA; dioscin results in increased expression of CDKN1A protein |
CTD |
PMID:29990575 PMID:33359023 |
|
NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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|
G |
Cdkn1b |
cyclin dependent kinase inhibitor 1B |
increases expression |
ISO |
dioscin results in increased expression of CDKN1B mRNA; dioscin results in increased expression of CDKN1B protein |
CTD |
PMID:33359023 |
|
NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
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G |
Cdkn2a |
cyclin dependent kinase inhibitor 2A |
increases expression |
ISO |
dioscin results in increased expression of CDKN2A mRNA; dioscin results in increased expression of CDKN2A protein |
CTD |
PMID:33359023 |
|
NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890
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|
G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
dioscin results in decreased expression of CHEK1 mRNA; dioscin results in decreased expression of CHEK1 protein |
CTD |
PMID:33359023 |
|
NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361
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|
G |
Chek2 |
checkpoint kinase 2 |
decreases expression |
ISO |
dioscin results in decreased expression of CHEK2 mRNA; dioscin results in decreased expression of CHEK2 protein |
CTD |
PMID:29990575 |
|
NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011
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|
G |
Cpt1a |
carnitine palmitoyltransferase 1a, liver |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733
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|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions increases expression |
EXP ISO |
fulvestrant inhibits the reaction [dioscin results in increased expression of CTNNB1 mRNA] dioscin results in increased expression of CTNNB1 protein dioscin results in increased expression of CTNNB1 mRNA; dioscin results in increased expression of CTNNB1 protein |
CTD |
PMID:24742230 |
|
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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|
G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
dioscin results in increased expression of CYCS mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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|
G |
Cyp2c65 |
cytochrome P450, family 2, subfamily c, polypeptide 65 |
increases expression |
ISO |
dioscin results in increased expression of CYP2C9 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of and results in increased activity of CYP2E1 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] |
CTD |
PMID:22939915 PMID:24146112 |
|
NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
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|
G |
Dgat1 |
diacylglycerol O-acyltransferase 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT1 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr15:76,386,215...76,396,167
Ensembl chr15:76,386,215...76,396,153
|
|
G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA] |
CTD |
PMID:24146112 |
|
NCBI chr 7:98,802,870...98,831,920
Ensembl chr 7:98,802,865...98,831,926
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|
G |
Diablo |
diablo, IAP-binding mitochondrial protein |
increases expression |
ISO |
dioscin results in increased expression of DIABLO mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239
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|
G |
Esr1 |
estrogen receptor 1 (alpha) |
increases expression multiple interactions |
EXP ISO |
dioscin results in increased expression of ESR1 protein fulvestrant inhibits the reaction [dioscin results in increased expression of ESR1 protein] |
CTD |
PMID:24742230 |
|
NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
|
|
G |
Esr2 |
estrogen receptor 2 (beta) |
increases expression multiple interactions |
ISO EXP |
dioscin results in increased expression of ESR2 protein fulvestrant inhibits the reaction [dioscin results in increased expression of ESR2 protein] |
CTD |
PMID:24742230 |
|
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
|
|
G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
dioscin results in increased expression of FADD mRNA; dioscin results in increased expression of FADD protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
|
NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200
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|
G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
dioscin results in increased expression of FAS mRNA; dioscin results in increased expression of FAS protein |
CTD |
PMID:22334414 PMID:33359023 |
|
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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|
G |
Fasl |
Fas ligand |
increases expression |
ISO |
dioscin results in increased expression of FASLG mRNA; dioscin results in increased expression of FASLG protein |
CTD |
PMID:22334414 PMID:29990575 |
|
NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
|
|
G |
Foxo1 |
forkhead box O1 |
increases expression |
ISO |
dioscin results in increased expression of FOXO1 mRNA |
CTD |
PMID:33359023 |
|
NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642
|
|
G |
Gpt |
glutamic pyruvic transaminase, soluble |
multiple interactions |
ISO |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] |
CTD |
PMID:27317372 |
|
NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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|
G |
Gsr |
glutathione reductase |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of GSR protein] |
CTD |
PMID:24146112 |
|
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein] dioscin inhibited the reaction [thioacetamide decreased expression of Hmox1 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
|
|
G |
Hspa5 |
heat shock protein 5 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] |
CTD |
PMID:24146112 |
|
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Icam1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
|
|
G |
Il13 |
interleukin 13 |
multiple interactions |
EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL13 protein] |
CTD |
PMID:35481609 |
|
NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]] dioscin inhibited the reaction [thioacetamide increased expression of IL-1b mRNA in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
|
|
G |
Il4 |
interleukin 4 |
multiple interactions |
EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL4 protein] |
CTD |
PMID:35481609 |
|
NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of IL5 protein] |
CTD |
PMID:35481609 |
|
NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA] dioscin inhibited the reaction [thioacetamide increased expression of IL-6 mRNA in liver] dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]] |
CTD RGD |
PMID:24146112 PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
|
|
G |
Kdr |
kinase insert domain protein receptor |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein] |
CTD |
PMID:25111127 |
|
NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118
|
|
G |
Keap1 |
kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
dioscin inhibits the reaction [Doxorubicin results in increased expression of KEAP1 protein] |
CTD |
PMID:28082111 |
|
NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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|
G |
Krt18 |
keratin 18 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of KRT18 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of KRT18 protein] |
CTD |
PMID:22939915 PMID:24146112 |
|
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
|
|
G |
Lrp5 |
low density lipoprotein receptor-related protein 5 |
multiple interactions increases expression |
EXP |
fulvestrant inhibits the reaction [dioscin results in increased expression of LRP5 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] |
CTD |
PMID:24742230 |
|
NCBI chr19:3,634,825...3,736,574
Ensembl chr19:3,634,828...3,736,564
|
|
G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24146112 PMID:25111127 |
|
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
|
|
G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein] dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24146112 PMID:25111127 |
|
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases expression |
ISO |
dioscin results in increased expression of MAPK8 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases expression |
ISO |
dioscin results in increased expression of MAPK9 mRNA |
CTD |
PMID:29990575 |
|
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
|
|
G |
Mdh1 |
malate dehydrogenase 1, NAD (soluble) |
multiple interactions |
EXP |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of MDH1 protein] |
CTD |
PMID:22939915 |
|
NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
|
|
G |
Mtor |
mechanistic target of rapamycin kinase |
decreases expression |
ISO |
dioscin results in decreased expression of MTOR mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140
|
|
G |
Muc5ac |
mucin 5, subtypes A and C, tracheobronchial/gastric |
multiple interactions |
EXP |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of MUC5AC mRNA] |
CTD |
PMID:35481609 |
|
NCBI chr 7:141,342,695...141,372,964
Ensembl chr 7:141,342,709...141,372,968
|
|
G |
Nfe2l2 |
nuclear factor, erythroid derived 2, like 2 |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of and affects the localization of NFE2L2 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]] dioscin inhibited the reaction [thioacetamide decreased expression of Nfe2L2 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
|
|
G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Nfkb1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308
|
|
G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
decreases degradation |
ISO |
dioscin results in decreased degradation of NFKBIA protein |
CTD |
PMID:24680847 |
|
NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
|
|
G |
Nqo1 |
NAD(P)H dehydrogenase, quinone 1 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide decreased expression of Nqo1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
|
|
G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
multiple interactions increases expression |
ISO |
dioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA] dioscin results in increased expression of NR0B2 mRNA |
CTD |
PMID:27317372 |
|
NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847
|
|
G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
multiple interactions |
ISO |
dioscin inhibits the reaction [Doxorubicin results in decreased expression of NR1H4 protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]] dioscin inhibited the reaction [thioacetamide decreased expression of Nr1h4 protein in liver] |
CTD RGD |
PMID:28082111 PMID:29091898 |
RGD:15090820 |
NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase family, member 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
dioscin inhibits the reaction [Ethanol results in increased expression of PARP1 protein] dioscin results in decreased expression of PARP1 mRNA; dioscin results in decreased expression of PARP1 protein dioscin results in increased expression of PARP1 mRNA |
CTD |
PMID:24146112 PMID:29990575 PMID:33359023 |
|
NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819
|
|
G |
Pik3cb |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
decreases expression |
ISO |
dioscin results in decreased expression of PIK3CB mRNA |
CTD |
PMID:29990575 |
|
NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674
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G |
Pnp2 |
purine-nucleoside phosphorylase 2 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of PNP protein] |
CTD |
PMID:22939915 |
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NCBI chr14:51,193,598...51,202,206
Ensembl chr14:51,193,449...51,202,206
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO EXP |
dioscin inhibits the reaction [Ethanol results in decreased expression of PPARA protein] |
CTD |
PMID:24146112 |
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NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020
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G |
Prdx1 |
peroxiredoxin 1 |
multiple interactions |
EXP |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of PRDX1 protein] |
CTD |
PMID:22939915 |
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NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019
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G |
Prkaa1 |
protein kinase, AMP-activated, alpha 1 catalytic subunit |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide decreased expression of Prkaa1 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
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G |
Prkab1 |
protein kinase, AMP-activated, beta 1 non-catalytic subunit |
increases expression |
ISO |
dioscin results in increased expression of PRKAB1 mRNA |
CTD |
PMID:29990575 |
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NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
dioscin inhibited the reaction [thioacetamide increased expression of Ptgs2 protein in liver] |
RGD |
PMID:29091898 |
RGD:15090820 |
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Ptk2 |
PTK2 protein tyrosine kinase 2 |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein] |
CTD |
PMID:25111127 |
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NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
ISO |
dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of RELA protein]] |
CTD |
PMID:28082111 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Rgn |
regucalcin |
multiple interactions |
EXP |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of RGN protein] |
CTD |
PMID:22939915 |
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NCBI chr X:20,413,980...20,428,328
Ensembl chr X:20,416,026...20,428,328
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G |
Rps6kb1 |
ribosomal protein S6 kinase, polypeptide 1 |
decreases expression |
ISO |
dioscin results in decreased expression of RPS6KB1 mRNA |
CTD |
PMID:29990575 |
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NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631
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G |
Slc10a1 |
solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
multiple interactions |
ISO |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA] |
CTD |
PMID:27317372 |
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NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
ISO |
dioscin results in increased expression of SLCO1A2 mRNA |
CTD |
PMID:27317372 |
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NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925
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G |
Slco1b2 |
solute carrier organic anion transporter family, member 1b2 |
multiple interactions increases expression |
ISO |
dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein] dioscin results in increased expression of SLCO1B2 mRNA |
CTD |
PMID:27317372 |
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NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372
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G |
Src |
Rous sarcoma oncogene |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] |
CTD |
PMID:25111127 |
|
NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782
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G |
Suox |
sulfite oxidase |
multiple interactions |
EXP |
dioscin inhibits the reaction [Acetaminophen results in decreased expression of SUOX protein] |
CTD |
PMID:22939915 |
|
NCBI chr10:128,505,756...128,509,787
Ensembl chr10:128,505,763...128,509,942
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TGFB1 protein] dioscin inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:35481609 |
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NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP ISO |
dioscin inhibits the reaction [[Ovalbumin co-treated with Aluminum Hydroxide] results in increased expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA] dioscin inhibited the reaction [thioacetamide increased expression of Tnfa mRNA in liver] dioscin results in increased expression of TNF mRNA; dioscin results in increased expression of TNF protein dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NR1H4 protein affects the reaction [dioscin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]] |
CTD RGD |
PMID:22334414 PMID:24146112 PMID:28082111 PMID:29990575 PMID:33359023 PMID:35481609 PMID:29091898 More...
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RGD:15090820 |
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Tnfrsf11b |
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) |
multiple interactions increases expression |
EXP |
fulvestrant inhibits the reaction [dioscin results in increased expression of TNFRSF11B mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFRSF11B mRNA] |
CTD |
PMID:24742230 |
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NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
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G |
Tnfrsf1a |
tumor necrosis factor receptor superfamily, member 1a |
increases expression |
ISO |
dioscin results in increased expression of TNFRSF1A mRNA; dioscin results in increased expression of TNFRSF1A protein |
CTD |
PMID:22334414 PMID:29990575 PMID:33359023 |
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NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447
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G |
Tnfrsf25 |
tumor necrosis factor receptor superfamily, member 25 |
increases expression |
ISO |
dioscin results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:29990575 PMID:33359023 |
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NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576
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G |
Tnfsf11 |
tumor necrosis factor (ligand) superfamily, member 11 |
decreases expression multiple interactions |
EXP |
dioscin results in decreased expression of TNFSF11 mRNA fulvestrant inhibits the reaction [dioscin results in increased expression of TNFSF11 mRNA]; LRP5 protein affects the reaction [dioscin results in increased expression of TNFSF11 mRNA] |
CTD |
PMID:24742230 |
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NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
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G |
Tradd |
TNFRSF1A-associated via death domain |
increases expression |
ISO |
dioscin results in increased expression of TRADD mRNA |
CTD |
PMID:29990575 PMID:33359023 |
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NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241
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G |
Traf1 |
TNF receptor-associated factor 1 |
increases expression |
ISO |
dioscin results in increased expression of TRAF1 protein |
CTD |
PMID:22334414 |
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NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784
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G |
Trp53 |
transformation related protein 53 |
multiple interactions increases expression |
EXP ISO |
dioscin inhibits the reaction [Acetaminophen results in increased expression of TRP53 protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TRP53 protein] dioscin results in increased expression of TP53 mRNA; dioscin results in increased expression of TP53 protein |
CTD |
PMID:22334414 PMID:22939915 PMID:24146112 PMID:29990575 |
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NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of KDR protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of PTK2 protein]; dioscin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] |
CTD |
PMID:25111127 |
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NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
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G |
Wee1 |
WEE 1 homolog 1 (S. pombe) |
increases expression |
ISO |
dioscin results in increased expression of WEE1 mRNA |
CTD |
PMID:29990575 |
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NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493
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G |
Atp7b |
ATPase, copper transporting, beta polypeptide |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] |
CTD |
PMID:38761876 |
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NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
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G |
Bax |
BCL2-associated X protein |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein] |
CTD |
PMID:38761876 |
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein] |
CTD |
PMID:38761876 |
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein] |
CTD |
PMID:38761876 |
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NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein] |
CTD |
PMID:38761876 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein] |
CTD |
PMID:38761876 |
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NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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G |
Gpt |
glutamic pyruvic transaminase, soluble |
multiple interactions |
EXP |
eritoran inhibits the reaction [Azathioprine results in increased expression of GPT protein]; eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein] |
CTD |
PMID:24184165 PMID:24747151 |
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NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
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G |
Gsdmd |
gasdermin D |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein] |
CTD |
PMID:38761876 |
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NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL1B protein] |
CTD |
PMID:38761876 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of IL6 protein] |
CTD |
PMID:38761876 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Mlkl |
mixed lineage kinase domain-like |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein] |
CTD |
PMID:38761876 |
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NCBI chr 8:112,037,879...112,065,081
Ensembl chr 8:112,038,429...112,064,809
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G |
Myd88 |
myeloid differentiation primary response gene 88 |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of MYD88 protein] |
CTD |
PMID:38761876 |
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NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in decreased expression of BCL2 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP1 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of CASP8 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased cleavage of GSDMD protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of MLKL protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of BAX protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] |
CTD |
PMID:38761876 |
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NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of PTGS2 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of RELA protein] |
CTD |
PMID:38761876 |
|
NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
EXP |
eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of and results in increased phosphorylation of RIPK3 protein] |
CTD |
PMID:38761876 |
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NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TLR4 protein]; eritoran inhibits the reaction [NLRP3 mutant form results in increased expression of TLR4 protein] |
CTD |
PMID:38761876 |
|
NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
eritoran inhibits the reaction [ATP7B mutant form results in increased expression of TNF protein] |
CTD |
PMID:38761876 |
|
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
F10 |
coagulation factor X |
decreases activity |
ISO |
fondaparinux results in decreased activity of F10 protein |
CTD |
PMID:16084352 |
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NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression multiple interactions |
EXP |
Lipid A results in increased expression of CCL3 mRNA anacetrapib inhibits the reaction [Lipid A results in increased expression of CCL3 mRNA] |
CTD |
PMID:20448206 |
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NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181
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G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of CXCL8 protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of CXCL8 protein Lipid A results in increased expression of CXCL8 protein |
CTD |
PMID:16299289 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG protein Lipid A results in increased expression of IFNG mRNA; Lipid A results in increased expression of IFNG protein |
CTD |
PMID:16299289 |
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Il12a |
interleukin 12a |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12A mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein] Lipid A results in increased expression of IL12A mRNA |
CTD |
PMID:16299289 |
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NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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G |
Il12b |
interleukin 12b |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12B mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12B mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein] Lipid A results in increased expression of IL12B mRNA |
CTD |
PMID:16299289 |
|
NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il15 |
interleukin 15 |
multiple interactions increases expression |
ISO |
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL15 mRNA Lipid A results in increased expression of IL15 mRNA |
CTD |
PMID:16299289 |
|
NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851
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G |
Il18 |
interleukin 18 |
increases expression |
ISO |
Lipid A results in increased expression of IL18 mRNA |
CTD |
PMID:16299289 |
|
NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression |
EXP |
anacetrapib inhibits the reaction [Lipid A results in increased expression of IL6 mRNA] |
CTD |
PMID:20448206 |
|
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
EXP |
anacetrapib inhibits the reaction [Lipid A results in increased expression of TNF mRNA] |
CTD |
PMID:20448206 |
|
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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|
|
G |
Bax |
BCL2-associated X protein |
multiple interactions |
EXP ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of BAX protein] |
CTD |
PMID:37087747 |
|
NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA] |
CTD |
PMID:37087747 |
|
NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
madecassoside inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein] |
CTD |
PMID:37087747 |
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Cyp2c38 |
cytochrome P450, family 2, subfamily c, polypeptide 38 |
decreases activity |
ISO |
madecassoside results in decreased activity of CYP2C19 protein |
CTD |
PMID:21349323 |
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NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
madecassoside inhibits the reaction [Cisplatin results in increased expression of HAVCR1 mRNA] |
CTD |
PMID:37087747 |
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NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] |
CTD |
PMID:37087747 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] |
CTD |
PMID:37087747 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 mRNA]; madecassoside inhibits the reaction [Cisplatin results in increased expression of LCN2 protein] |
CTD |
PMID:37087747 |
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NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP |
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:37087747 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk14 |
mitogen-activated protein kinase 14 |
multiple interactions |
EXP |
madecassoside inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:37087747 |
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NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
madecassoside inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] |
CTD |
PMID:37087747 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein] |
CTD |
PMID:20923188 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein] |
CTD |
PMID:20923188 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:20923188 |
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NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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G |
Nos2 |
nitric oxide synthase 2, inducible |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased secretion of NOS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] |
CTD |
PMID:20923188 PMID:21397503 |
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NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] |
CTD |
PMID:20923188 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:20923188 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Ren1 |
renin 1 structural |
decreases activity |
ISO |
soyasaponin I results in decreased activity of REN protein |
CTD |
PMID:19060406 PMID:20460744 |
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NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063
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G |
St3gal4 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
decreases expression |
ISO |
soyasaponin I results in decreased expression of ST3GAL4 mRNA |
CTD |
PMID:15661230 |
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NCBI chr 9:34,957,872...35,028,160
Ensembl chr 9:34,957,872...35,030,564
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] |
CTD |
PMID:20923188 |
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
affects binding |
ISO |
sucrose octasulfate binds to FGFR2 protein |
CTD |
PMID:15047176 |
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NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
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