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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glucocorticoid receptor agonist
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Accession:CHEBI:63562 term browser browse the term
Definition:An agonist that selectively binds to and activates a glucocorticoid receptor.
Synonyms:related_synonym: glucocorticoid receptor agonists


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dexamethasone phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]; dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747 		JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLK mRNA] CTD PMID:36996615 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031 		JBrowse link
G Blnk B-cell linker multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of BLNK protein] CTD PMID:36996615 NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:25447644 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd19 CD19 molecule multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of CD19 protein] CTD PMID:36996615 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Cd22 CD22 molecule multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of CD22 mRNA] CTD PMID:36996615 NCBI chr 1:86,116,376...86,132,782
Ensembl chr 1:86,117,459...86,132,322 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fcgr2b Fc gamma receptor 2B multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA] CTD PMID:36996615 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fcrla Fc receptor-like A multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of FCRLA mRNA] CTD PMID:36996615 NCBI chr13:83,160,453...83,170,170
Ensembl chr13:83,160,398...83,170,762 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in decreased expression of IL10 protein] CTD PMID:36996615 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]; dexamethasone 21-phosphate inhibits the reaction [IL1B protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]] CTD PMID:17931716 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:36996615 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [dexamethasone 21-phosphate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of MS4A1 protein] CTD PMID:36996615 NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO dexamethasone 21-phosphate results in increased cleavage of PARP1 protein CTD PMID:25447644 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pou2af1 POU class 2 homeobox associating factor 1 multiple interactions EXP dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of POU2AF1 mRNA] CTD PMID:36996615 NCBI chr 8:51,521,813...51,548,819
Ensembl chr 8:51,474,015...51,548,819 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO dexamethasone 21-phosphate inhibits the reaction [IL1B protein affects the localization of RELA protein]
dexamethasone 21-phosphate affects the localization of RELA protein		 CTD PMID:17931716 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpinb1a serpin family B member 1A multiple interactions EXP
ISO		 dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1A protein modified form
dexamethasone 21-phosphate results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form		 CTD PMID:25447644 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 dexamethasone 21-phosphate inhibits the reaction [TNF protein promotes the reaction [kallidin, des-Arg(10)- binds to BDKRB1 protein]]
dexamethasone 21-phosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]		 CTD PMID:17931716 PMID:36996615 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19901
    role 19871
      biological role 19869
        pharmacological role 19101
          agonist 18631
            glucocorticoid receptor agonist 20
              dexamethasone phosphate 20
              dexamethasone sodium phosphate 0
              methylprednisolone suleptanate 0
              prednisolone phosphate 0
              prednisolone sodium phosphate 0
              tixocortol + 0
              tixocortol pivalate 0
              vamorolone 0
paths to the root