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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 4.2.1.22 (cystathionine beta-synthase) inhibitor
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Accession:CHEBI:63157 term browser browse the term
Definition:An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of cystathionine beta-synthase (EC 4.2.1.22).
Synonyms:related_synonym: EC 4.2.1.22 inhibitor;   EC 4.2.1.22 inhibitors;   L-serine hydro-lyase (adding homocysteine) inhibitor;   L-serine hydro-lyase (adding homocysteine) inhibitors;   L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitor;   L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitors;   beta-thionase inhibitor;   beta-thionase inhibitors;   cystathionine beta-synthase (EC 4.2.1.22) inhibitors;   cystathionine-beta-synthase inhibitor;   cystathionine-beta-synthase inhibitors;   cysteine synthase inhibitor;   cysteine synthase inhibitors;   methylcysteine synthase inhibitor;   methylcysteine synthase inhibitors;   serine sulfhydrase inhibitor;   serine sulfhydrase inhibitors;   serine sulfhydrylase inhibitor;   serine sulfhydrylase inhibitors


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vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383 		JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 501
    role 501
      biological role 501
        biochemical role 459
          enzyme inhibitor 370
            EC 4.* (lyase) inhibitor 8
              EC 4.2.* (C-O lyase) inhibitor 3
                EC 4.2.1.* (hydro-lyases) inhibitor 3
                  EC 4.2.1.22 (cystathionine beta-synthase) inhibitor 3
                    (aminooxy)acetic acid 0
                    hydroxylamine + 3
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