CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | manganese(II) chloride |
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Accession: | CHEBI:63041
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browse the term
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Definition: | An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure. |
Synonyms: | exact_synonym: | manganese(2+) dichloride |
| related_synonym: | Formula=Cl2Mn; InChI=1S/2ClH.Mn/h2*1H;/q;;+2/p-2; InChIKey=GLFNIEUTAYBVOC-UHFFFAOYSA-L; Mangandichlorid; Manganese bichloride; Manganese(II) chloride (1:2); Manganous chloride; SMILES=Cl[Mn]Cl; dichlorure de manganese; manganese(II) dichloride; manganous dichloride |
| xref: | CAS:7773-01-5 |
| xref_mesh: | MESH:C025340 |
| xref: | MetaCyc:CPD0-2394; PMID:101555; PMID:146543; PMID:19801673; PMID:3143594; PMID:4476198; PMID:4771199; PMID:98204; Reaxys:8128170; Wikipedia:Manganese(II)_chloride |
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1700037C18Rik |
RIKEN cDNA 1700037C18 gene |
increases expression |
ISO |
manganese chloride results in increased expression of C10H16ORF90 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:3,723,662...3,726,553
Ensembl chr16:3,713,043...3,726,553
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2900026A02Rik |
RIKEN cDNA 2900026A02 gene |
increases expression |
ISO |
manganese chloride results in increased expression of KIAA1671 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:113,234,189...113,369,158
Ensembl chr 5:113,234,189...113,369,102
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Abca5 |
ATP-binding cassette, sub-family A member 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ABCA5 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:110,160,195...110,228,542
Ensembl chr11:110,160,195...110,228,542
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Abca9 |
ATP-binding cassette, sub-family A member 9 |
increases expression |
ISO |
manganese chloride results in increased expression of ABCA9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:109,990,919...110,059,532
Ensembl chr11:109,991,575...110,059,022
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Abcb1a |
ATP-binding cassette, sub-family B member 1A |
increases expression |
ISO |
manganese chloride results in increased expression of ABCB1A mRNA |
CTD |
PMID:26745496 |
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NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575
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Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
ISO |
manganese chloride results in increased expression of ABCB1B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315
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Abcc2 |
ATP-binding cassette, sub-family member 2 |
increases expression decreases methylation |
ISO |
manganese chloride results in increased expression of ABCC2 mRNA manganese chloride results in decreased methylation of ABCC2 gene |
CTD |
PMID:28801915 |
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NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
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Abcc8 |
ATP-binding cassette, sub-family C member 8 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein |
CTD |
PMID:32659473 |
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NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457
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Abi2 |
abl interactor 2 |
increases expression |
ISO |
manganese chloride results in increased expression of ABI2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:60,444,927...60,521,104
Ensembl chr 1:60,448,778...60,520,317
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Abitram |
actin binding transcription modulator |
increases expression |
ISO |
manganese chloride results in increased expression of ABITRAM mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:56,802,329...56,809,605
Ensembl chr 4:56,802,345...56,809,601
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Acap1 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ACAP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:69,772,393...69,786,390
Ensembl chr11:69,772,393...69,786,365
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Ace |
angiotensin I converting enzyme |
increases expression |
ISO |
manganese chloride results in increased expression of ACE mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790
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Ache |
acetylcholinesterase |
increases activity increases expression multiple interactions decreases activity |
ISO EXP |
manganese chloride results in increased activity of ACHE protein manganese chloride results in increased expression of ACHE mRNA [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased expression of ACHE mRNA] [manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form |
CTD |
PMID:20503066 PMID:22033861 PMID:22154916 PMID:22192907 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588 More...
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NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
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Aco1 |
aconitase 1 |
increases activity |
ISO |
manganese chloride results in increased activity of ACO1 protein |
CTD |
PMID:15893546 PMID:16545456 PMID:16568477 |
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NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338
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Aco2 |
aconitase 2, mitochondrial |
multiple interactions decreases expression decreases activity |
ISO |
ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein] manganese chloride results in decreased expression of ACO2 mRNA; manganese chloride results in decreased expression of ACO2 protein Iron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein] |
CTD |
PMID:9675333 PMID:16625280 |
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NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334
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Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of ACOT2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647
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Acp5 |
acid phosphatase 5, tartrate resistant |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of ACP5 mRNA manganese chloride results in increased methylation of ACP5 gene |
CTD |
PMID:22281203 PMID:28801915 |
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NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007
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Acr |
acrosin prepropeptide |
increases expression |
ISO |
manganese chloride results in increased expression of ACR mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:89,452,549...89,458,790
Ensembl chr15:89,452,529...89,458,788
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Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
decreases expression |
EXP |
manganese chloride results in decreased expression of ACSL3 mRNA |
CTD |
PMID:15295902 |
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NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460
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Acss2 |
acyl-CoA synthetase short-chain family member 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ACSS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644
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Acta1 |
actin alpha 1, skeletal muscle |
decreases expression |
ISO |
manganese chloride results in decreased expression of ACTA1 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:124,618,497...124,621,514
Ensembl chr 8:124,618,508...124,621,490
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Acta2 |
actin alpha 2, smooth muscle, aorta |
increases expression |
ISO |
manganese chloride results in increased expression of ACTA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990
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Actb |
actin, beta |
decreases expression increases expression |
ISO |
manganese chloride results in decreased expression of ACTB protein manganese chloride results in increased expression of ACTB mRNA |
CTD |
PMID:20452446 |
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NCBI chr 5:142,888,870...142,892,509
Ensembl chr 5:142,888,870...142,892,509
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Acvrl1 |
activin A receptor, type II-like 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ACVRL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217
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Adam19 |
ADAM metallopeptidase domain 19 |
increases expression |
ISO |
manganese chloride results in increased expression of ADAM19 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170
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Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001
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Adamts5 |
ADAM metallopeptidase with thrombospondin type 1 motif 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ADAMTS5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716
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Adcy6 |
adenylate cyclase 6 |
increases expression |
ISO |
manganese chloride results in increased expression of ADCY6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:98,484,982...98,508,119
Ensembl chr15:98,487,854...98,507,957
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Add2 |
adducin 2 |
increases expression |
ISO |
manganese chloride results in increased expression of ADD2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:86,005,663...86,101,391
Ensembl chr 6:86,005,663...86,101,391
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Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
manganese chloride results in increased expression of ADIPOQ mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778
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Adm |
adrenomedullin |
increases expression decreases expression |
ISO |
manganese chloride results in increased expression of ADM mRNA manganese chloride results in decreased expression of ADM mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027
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Adora2a |
adenosine A2a receptor |
increases expression |
ISO |
manganese chloride results in increased expression of ADORA2A mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618
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Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
manganese chloride results in increased expression of AEN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:78,545,675...78,560,957
Ensembl chr 7:78,545,602...78,560,957
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Aff1 |
AF4/FMR2 family, member 1 |
increases expression |
ISO |
manganese chloride results in increased expression of AFF1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:103,840,307...104,003,188
Ensembl chr 5:103,840,240...104,003,188
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Afmid |
arylformamidase |
increases expression |
ISO |
manganese chloride results in increased expression of AFMID mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:117,716,329...117,730,734
Ensembl chr11:117,716,750...117,730,734
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Afp |
alpha fetoprotein |
decreases expression |
ISO |
manganese chloride results in decreased expression of AFP mRNA |
CTD |
PMID:26745496 |
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NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766
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Ahnak2 |
AHNAK nucleoprotein 2 |
increases expression |
ISO |
manganese chloride results in increased expression of AHNAK2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277
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Aicda |
activation-induced cytidine deaminase |
increases expression |
ISO |
manganese chloride results in increased expression of AICDA mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139
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Aif1 |
allograft inflammatory factor 1 |
increases expression |
EXP |
manganese chloride results in increased expression of AIF1 protein |
CTD |
PMID:28595911 |
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NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044
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Akap7 |
A kinase anchor protein 7 |
decreases expression |
ISO |
manganese chloride results in decreased expression of AKAP7 mRNA |
CTD |
PMID:17175027 |
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NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768
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Akr1b1 |
aldo-keto reductase family 1 member B |
increases expression |
ISO |
manganese chloride results in increased expression of AKR1B1 mRNA |
CTD |
PMID:22281203 |
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NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413
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Akt1 |
thymoma viral proto-oncogene 1 |
decreases phosphorylation multiple interactions |
ISO EXP |
manganese chloride results in decreased phosphorylation of AKT1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein] |
CTD |
PMID:30040983 PMID:31676349 |
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NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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Alb |
albumin |
multiple interactions |
ISO |
[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein |
CTD |
PMID:17657459 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression |
ISO |
manganese chloride results in increased expression of ALDH18A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907
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Aldh1a1 |
aldehyde dehydrogenase family 1, subfamily A1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ALDH1A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829
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Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
increases expression |
ISO |
manganese chloride results in increased expression of ALDH4A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:139,348,404...139,377,002
Ensembl chr 4:139,350,177...139,377,001
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Aldoc |
aldolase C, fructose-bisphosphate |
decreases expression |
ISO |
manganese chloride results in decreased expression of ALDOC mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:78,213,899...78,218,607
Ensembl chr11:78,213,794...78,218,607
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Alkal1 |
ALK and LTK ligand 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ALKAL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:6,429,555...6,464,955
Ensembl chr 1:6,429,442...6,464,955
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Amigo3 |
adhesion molecule with Ig like domain 3 |
increases expression |
ISO |
manganese chloride results in increased expression of AMIGO3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:107,930,358...107,932,900
Ensembl chr 9:107,930,358...107,932,900
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Angpt2 |
angiopoietin 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ANGPT2 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 8:18,740,279...18,791,578
Ensembl chr 8:18,740,279...18,791,578
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Angptl4 |
angiopoietin-like 4 |
increases expression |
ISO |
manganese chloride results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:17175027 |
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NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804
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Ankrd28 |
ankyrin repeat domain 28 |
increases expression |
ISO |
manganese chloride results in increased expression of ANKRD28 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:31,418,687...31,552,374
Ensembl chr14:31,420,725...31,552,608
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Ano3 |
anoctamin 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ANO3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:110,485,546...110,780,854
Ensembl chr 2:110,485,546...110,781,268
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Anp32a |
acidic nuclear phosphoprotein 32 family member A |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ANP32A mRNA |
CTD |
PMID:35690225 |
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NCBI chr 9:62,248,637...62,286,084
Ensembl chr 9:62,248,575...62,286,094
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Anxa3 |
annexin A3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ANXA3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825
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Aopep |
aminopeptidase O |
decreases expression |
ISO |
manganese chloride results in decreased expression of AOPEP mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:63,112,707...63,473,910
Ensembl chr13:63,112,707...63,473,910
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Ap3b2 |
adaptor-related protein complex 3, beta 2 subunit |
increases expression |
ISO |
manganese chloride results in increased expression of AP3B2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 7:81,110,147...81,143,722
Ensembl chr 7:81,110,147...81,143,673
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Apbb3 |
amyloid beta precursor protein binding family B member 3 |
increases expression |
ISO |
manganese chloride results in increased expression of APBB3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:36,804,207...36,812,419
Ensembl chr18:36,804,207...36,812,419
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Apc |
APC, WNT signaling pathway regulator |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of APC gene manganese chloride results in decreased expression of APC mRNA |
CTD |
PMID:27913844 |
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NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605
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Apoa2 |
apolipoprotein A-II |
decreases expression |
ISO |
manganese chloride results in decreased expression of APOA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948
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Apold1 |
apolipoprotein L domain containing 1 |
increases expression |
ISO |
manganese chloride results in increased expression of APOLD1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:134,958,964...134,963,799
Ensembl chr 6:134,958,681...134,963,799
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Aqp3 |
aquaporin 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of AQP3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
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Areg |
amphiregulin |
increases expression |
ISO |
manganese chloride results in increased expression of AREG mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291
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Arg1 |
arginase, liver |
increases methylation increases expression multiple interactions |
ISO EXP |
manganese chloride results in increased methylation of ARG1 gene manganese chloride results in increased expression of ARG1 mRNA [manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA |
CTD |
PMID:28801915 PMID:34018660 |
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NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382
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Arhgap24 |
Rho GTPase activating protein 24 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ARHGAP24 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:102,355,043...103,053,743
Ensembl chr 5:102,629,257...103,045,803
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Arhgdia |
Rho GDP dissociation inhibitor alpha |
decreases expression |
ISO |
manganese chloride results in decreased expression of ARHGDIA mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450
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G |
Arhgef10 |
Rho guanine nucleotide exchange factor 10 |
increases expression |
ISO |
manganese chloride results in increased expression of ARHGEF10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085
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G |
Arhgef16 |
Rho guanine nucleotide exchange factor 16 |
increases expression |
ISO |
manganese chloride results in increased expression of ARHGEF16 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:154,362,926...154,384,535
Ensembl chr 4:154,362,943...154,386,133
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G |
Arhgef4 |
Rho guanine nucleotide exchange factor 4 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of ARHGEF4 mRNA manganese chloride results in increased methylation of ARHGEF4 gene |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 1:34,717,263...34,851,819
Ensembl chr 1:34,717,269...34,852,390
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G |
Arhgef6 |
Rac/Cdc42 guanine nucleotide exchange factor 6 |
increases expression |
ISO |
manganese chloride results in increased expression of ARHGEF6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:56,276,845...56,384,119
Ensembl chr X:56,276,845...56,384,089
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G |
Arhgef7 |
Rho guanine nucleotide exchange factor |
decreases expression |
ISO |
manganese chloride results in decreased expression of ARHGEF7 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:11,778,053...11,885,219
Ensembl chr 8:11,777,721...11,885,219
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G |
Arid3a |
AT-rich interaction domain 3A |
increases expression |
ISO |
manganese chloride results in increased expression of ARID3A mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:79,762,877...79,790,852
Ensembl chr10:79,762,877...79,790,852
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G |
Arl4c |
ADP-ribosylation factor-like 4C |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of ARL4C gene manganese chloride results in increased expression of ARL4C mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:88,625,947...88,629,913
Ensembl chr 1:88,600,847...88,629,943
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G |
Arnt |
aryl hydrocarbon receptor nuclear translocator |
multiple interactions |
EXP |
ARNT gene mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein] |
CTD |
PMID:19263519 |
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NCBI chr 3:95,341,674...95,404,551
Ensembl chr 3:95,341,699...95,404,551
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G |
Asb5 |
ankyrin repeat and SOCs box-containing 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ASB5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:55,003,366...55,040,877
Ensembl chr 8:54,982,615...55,040,910
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G |
Asns |
asparagine synthetase |
increases expression |
ISO |
manganese chloride results in increased expression of ASNS mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254
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G |
Ass1 |
argininosuccinate synthetase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ASS1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684
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G |
Aste1 |
asteroid homolog 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ASTE1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:105,272,533...105,285,497
Ensembl chr 9:105,272,591...105,289,428
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G |
Atf1 |
activating transcription factor 1 |
multiple interactions increases phosphorylation |
ISO |
SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein] |
CTD |
PMID:16787641 |
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NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125
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G |
Atf2 |
activating transcription factor 2 |
increases activity increases phosphorylation |
ISO |
manganese chloride results in increased activity of ATF2 protein manganese chloride results in increased phosphorylation of ATF2 protein |
CTD |
PMID:19084589 PMID:20152896 |
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NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA] manganese chloride results in increased expression of ATF4 mRNA; manganese chloride results in increased expression of ATF4 protein |
CTD |
PMID:23934647 PMID:23948121 |
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NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
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G |
Atf6 |
activating transcription factor 6 |
decreases expression increases expression |
ISO |
manganese chloride results in decreased expression of ATF6 mRNA manganese chloride results in increased expression of ATF6 protein |
CTD |
PMID:17175027 PMID:25732873 |
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NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340
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G |
Atm |
ataxia telangiectasia mutated |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATM mRNA |
CTD |
PMID:17175027 |
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NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040
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G |
Atoh8 |
atonal bHLH transcription factor 8 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATOH8 mRNA |
CTD |
PMID:26745496 PMID:28801915 |
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NCBI chr 6:72,183,158...72,212,765
Ensembl chr 6:72,183,161...72,212,561
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G |
Atp1a2 |
ATPase, Na+/K+ transporting, alpha 2 polypeptide |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ATP1A2 protein |
CTD |
PMID:37598760 |
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NCBI chr 1:172,099,276...172,125,631
Ensembl chr 1:172,099,276...172,125,631
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G |
Atp1a3 |
ATPase, Na+/K+ transporting, alpha 3 polypeptide |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which affects the expression of ATP1A3 protein |
CTD |
PMID:37598760 |
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NCBI chr 7:24,677,592...24,705,338
Ensembl chr 7:24,677,592...24,705,383
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G |
Atp2a3 |
ATPase, Ca++ transporting, ubiquitous |
increases methylation |
ISO |
manganese chloride results in increased methylation of ATP2A3 gene |
CTD |
PMID:28801915 |
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NCBI chr11:72,851,995...72,883,869
Ensembl chr11:72,851,995...72,883,870
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G |
Atp2b2 |
ATPase, Ca++ transporting, plasma membrane 2 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of ATP2B2 gene manganese chloride results in decreased expression of ATP2B2 mRNA |
CTD |
PMID:27913844 |
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NCBI chr 6:113,720,803...114,019,574
Ensembl chr 6:113,720,792...114,019,574
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G |
Atp2b4 |
ATPase, Ca++ transporting, plasma membrane 4 |
increases expression |
ISO |
manganese chloride results in increased expression of ATP2B4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779
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G |
Atp5f1c |
ATP synthase F1 subunit gamma |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATP5F1C mRNA |
CTD |
PMID:22281203 |
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NCBI chr 2:10,060,841...10,085,321
Ensembl chr 2:10,060,827...10,085,321
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G |
Atp6v1a |
ATPase, H+ transporting, lysosomal V1 subunit A |
increases expression |
ISO |
manganese chloride results in increased expression of ATP6V1A mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:43,905,765...43,960,055
Ensembl chr16:43,905,765...43,960,068
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G |
Atp6v1e2 |
ATPase, H+ transporting, lysosomal V1 subunit E2 |
decreases expression |
ISO EXP |
manganese chloride results in decreased expression of ATP6V1E2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:87,251,537...87,255,315
Ensembl chr17:87,251,537...87,255,325
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G |
Atp6v1h |
ATPase, H+ transporting, lysosomal V1 subunit H |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA] |
CTD |
PMID:31690173 |
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NCBI chr 1:5,153,201...5,233,438
Ensembl chr 1:5,140,241...5,232,752
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G |
Atp7a |
ATPase, copper transporting, alpha polypeptide |
decreases expression affects localization |
ISO |
manganese chloride results in decreased expression of ATP7A mRNA; manganese chloride results in decreased expression of ATP7A protein manganese chloride affects the localization of ATP7A protein |
CTD |
PMID:24614235 |
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NCBI chr X:105,070,830...105,171,766
Ensembl chr X:105,070,882...105,168,532
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G |
Atp7b |
ATPase, copper transporting, beta polypeptide |
affects localization decreases expression |
ISO |
manganese chloride affects the localization of ATP7B protein manganese chloride results in decreased expression of ATP7B mRNA; manganese chloride results in decreased expression of ATP7B protein |
CTD |
PMID:24614235 |
|
NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321
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G |
Atp8a1 |
ATPase phospholipid transporting 8A1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ATP8A1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:67,775,482...68,004,822
Ensembl chr 5:67,775,483...68,004,777
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G |
Avil |
advillin |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of AVIL gene manganese chloride results in decreased expression of AVIL mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:126,835,933...126,856,857
Ensembl chr10:126,836,578...126,856,863
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G |
Axin2 |
axin 2 |
increases expression |
ISO |
manganese chloride results in increased expression of AXIN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609
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G |
Bach1 |
BTB and CNC homology 1, basic leucine zipper transcription factor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of BACH1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:87,495,842...87,530,234
Ensembl chr16:87,495,833...87,530,234
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G |
Bax |
BCL2-associated X protein |
increases expression multiple interactions |
ISO EXP |
manganese chloride results in increased expression of BAX mRNA; manganese chloride results in increased expression of BAX protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; Estradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein]; Tamoxifen inhibits the reaction [manganese chloride results in increased expression of BAX protein] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; manganese chloride results in increased expression of and affects the localization of BAX protein NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein] |
CTD |
PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:29183790 PMID:30844427 PMID:30951808 PMID:31676349 PMID:33314588 PMID:35690225 More...
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NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322
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G |
Bcl2 |
B cell leukemia/lymphoma 2 |
decreases expression multiple interactions increases nitrosation increases expression |
ISO EXP |
manganese chloride results in decreased expression of BCL2 mRNA; manganese chloride results in decreased expression of BCL2 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BCL2 protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; manganese chloride results in decreased expression of and affects the localization of BCL2 protein manganese chloride results in increased nitrosation of BCL2 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 mRNA; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased nitrosation of BCL2 protein] manganese chloride results in increased expression of BCL2 mRNA manganese chloride results in increased expression of BCL2 protein |
CTD |
PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:28801915 PMID:28856835 PMID:29183790 PMID:30578841 PMID:30844427 PMID:30951808 PMID:31676349 PMID:33314588 PMID:38503349 More...
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NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004
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G |
Bcl2l1 |
BCL2-like 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of BCL2L1 protein |
CTD |
PMID:27107493 |
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NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
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G |
Bcl2l11 |
BCL2 like 11 |
increases expression decreases expression |
ISO |
manganese chloride results in increased expression of BCL2L11 protein manganese chloride results in decreased expression of BCL2L11 mRNA |
CTD |
PMID:25732873 PMID:28801915 |
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NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
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G |
Bcl6b |
B cell CLL/lymphoma 6, member B |
increases expression |
ISO |
manganese chloride results in increased expression of BCL6B mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:70,114,953...70,120,624
Ensembl chr11:70,114,954...70,120,624
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G |
Bdkrb2 |
bradykinin receptor, beta 2 |
increases expression |
ISO |
manganese chloride results in increased expression of BDKRB2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496
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G |
Bdnf |
brain derived neurotrophic factor |
decreases expression increases methylation increases expression multiple interactions |
EXP ISO |
manganese chloride results in decreased expression of BDNF mRNA manganese chloride results in increased methylation of BDNF gene manganese chloride results in increased expression of BDNF mRNA [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA] |
CTD |
PMID:25698507 PMID:28801915 PMID:30951808 PMID:32659473 |
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NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
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G |
Becn1 |
beclin 1, autophagy related |
increases expression multiple interactions decreases expression affects expression |
ISO |
manganese chloride results in increased expression of BECN1 protein wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein] manganese chloride results in decreased expression of BECN1 protein corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] manganese chloride affects the expression of BECN1 protein |
CTD |
PMID:23604964 PMID:28856835 PMID:30578841 PMID:30672645 |
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NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
increases expression |
ISO |
manganese chloride results in increased expression of BHLHE40 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886
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G |
Bid |
BH3 interacting domain death agonist |
increases cleavage multiple interactions increases expression |
ISO |
manganese chloride results in increased cleavage of BID protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein] manganese chloride results in increased expression of BID protein; manganese chloride results in increased expression of BID protein modified form |
CTD |
PMID:21704098 PMID:28378122 |
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NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions decreases expression |
ISO |
Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of BIRC5 mRNA] |
CTD |
PMID:24464479 |
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NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569
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G |
Birc7 |
baculoviral IAP repeat-containing 7 |
increases expression |
ISO |
manganese chloride results in increased expression of BIRC7 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803
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G |
Bloc1s3 |
biogenesis of lysosomal organelles complex-1, subunit 3 |
increases expression |
ISO |
manganese chloride results in increased expression of BLOC1S3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:19,239,708...19,242,295
Ensembl chr 7:19,238,411...19,242,292
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G |
Blvra |
biliverdin reductase A |
increases expression |
ISO |
manganese chloride results in increased expression of BLVRA mRNA |
CTD |
PMID:22281203 |
|
NCBI chr 2:126,912,549...126,939,004
Ensembl chr 2:126,912,585...126,939,004
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G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of BMAL1 mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333
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G |
Bmf |
BCL2 modifying factor |
decreases expression |
ISO |
manganese chloride results in decreased expression of BMF mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
EXP |
manganese chloride results in increased expression of BMP4 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
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G |
Bnip3 |
BCL2/adenovirus E1B interacting protein 3 |
multiple interactions affects response to substance |
EXP |
[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cycloheximide inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; manganese chloride results in increased expression of and affects the localization of BNIP3 protein BNIP3 protein affects the susceptibility to manganese chloride |
CTD |
PMID:19442826 |
|
NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
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G |
Bpifb6 |
BPI fold containing family B, member 6 |
increases expression |
ISO |
manganese chloride results in increased expression of BPIFB6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:153,742,308...153,754,715
Ensembl chr 2:153,742,308...153,754,715
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G |
Bsn |
bassoon |
increases expression |
ISO |
manganese chloride results in increased expression of BSN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:107,973,221...108,067,618
Ensembl chr 9:107,973,221...108,067,583
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G |
Bub1 |
BUB1, mitotic checkpoint serine/threonine kinase |
decreases expression |
ISO |
manganese chloride results in decreased expression of BUB1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785
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G |
C1qtnf4 |
C1q and tumor necrosis factor related protein 4 |
increases expression |
ISO |
manganese chloride results in increased expression of C1QTNF4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:90,713,132...90,720,870
Ensembl chr 2:90,716,204...90,720,869
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G |
C2cd4b |
C2 calcium-dependent domain containing 4B |
increases expression |
ISO |
manganese chloride results in increased expression of C2CD4B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 9:67,623,506...67,668,215
Ensembl chr 9:67,666,719...67,668,212
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G |
Cables1 |
CDK5 and Abl enzyme substrate 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CABLES1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:11,972,600...12,078,681
Ensembl chr18:11,972,277...12,078,687
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G |
Calcoco2 |
calcium binding and coiled-coil domain 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CALCOCO2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:95,990,195...96,015,362
Ensembl chr11:95,990,152...96,002,790
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G |
Cald1 |
caldesmon 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CALD1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408
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G |
Caly |
calcyon neuron-specific vesicular protein |
increases expression |
ISO |
manganese chloride results in increased expression of CALY mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:139,649,793...139,662,485
Ensembl chr 7:139,649,793...139,662,461
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2, beta |
increases expression |
EXP |
manganese chloride results in increased expression of CAMKK2 mRNA |
CTD |
PMID:15295902 |
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NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472
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G |
Camkv |
CaM kinase-like vesicle-associated |
decreases expression |
ISO |
manganese chloride results in decreased expression of CAMKV mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:107,813,097...107,826,882
Ensembl chr 9:107,812,873...107,826,890
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G |
Camp |
cathelicidin antimicrobial peptide |
increases expression |
ISO |
manganese chloride results in increased expression of CAMP mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:109,676,445...109,678,524
Ensembl chr 9:109,676,447...109,678,685
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G |
Camta2 |
calmodulin binding transcription activator 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CAMTA2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:70,560,288...70,578,966
Ensembl chr11:70,560,289...70,578,931
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G |
Capn5 |
calpain 5 |
increases expression |
ISO |
manganese chloride results in increased expression of CAPN5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:97,770,766...97,828,148
Ensembl chr 7:97,770,766...97,827,481
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G |
Car5b |
carbonic anhydrase 5b, mitochondrial |
decreases expression |
ISO |
manganese chloride results in decreased expression of CAR5B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:162,759,818...162,811,006
Ensembl chr X:162,759,818...162,810,993
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G |
Car8 |
carbonic anhydrase 8 |
increases expression |
ISO |
manganese chloride results in increased expression of CAR8 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 4:8,141,491...8,239,226
Ensembl chr 4:8,143,362...8,239,041
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G |
Card14 |
caspase recruitment domain family, member 14 |
increases methylation |
ISO |
manganese chloride results in increased methylation of CARD14 gene |
CTD |
PMID:27913844 |
|
NCBI chr11:119,197,923...119,236,205
Ensembl chr11:119,198,594...119,236,201
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G |
Card9 |
caspase recruitment domain family, member 9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CARD9 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:26,242,199...26,250,957
Ensembl chr 2:26,242,188...26,250,930
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G |
Casp12 |
caspase 12 |
multiple interactions increases expression increases cleavage |
ISO EXP |
Deferoxamine promotes the reaction [manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein]; manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein manganese chloride results in increased expression of CASP12 mRNA; manganese chloride results in increased expression of CASP12 protein SNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein] manganese chloride results in increased cleavage of CASP12 protein Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP12 protein] |
CTD |
PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:26064043 PMID:28801915 More...
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NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032
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G |
Casp2 |
caspase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CASP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions increases expression increases activity increases methylation |
EXP ISO |
manganese chloride results in increased cleavage of CASP3 protein [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of CASP3 protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; Quercetin inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 protein] manganese chloride results in increased expression of CASP3 mRNA; manganese chloride results in increased expression of CASP3 protein; manganese chloride results in increased expression of CASP3 protein modified form [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein] Deferoxamine promotes the reaction [manganese chloride results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein] manganese chloride results in increased methylation of CASP3 gene |
CTD |
PMID:16787641 PMID:17483122 PMID:18178165 PMID:19815061 PMID:23764342 PMID:24464479 PMID:25416158 PMID:25732873 PMID:26064043 PMID:27913844 PMID:28040552 PMID:28378122 PMID:28778520 PMID:30844427 PMID:30991096 PMID:31676349 PMID:32574669 PMID:33314588 More...
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NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
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G |
Casp4 |
caspase 4, apoptosis-related cysteine peptidase |
increases expression |
ISO |
manganese chloride results in increased expression of CASP4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783
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G |
Casp8 |
caspase 8 |
increases cleavage multiple interactions |
ISO |
manganese chloride results in increased cleavage of CASP8 protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] |
CTD |
PMID:21704098 PMID:28378122 |
|
NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions increases cleavage |
EXP ISO |
manganese chloride results in increased activity of CASP9 protein PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein] SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein] manganese chloride results in increased cleavage of CASP9 protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein] |
CTD |
PMID:16787641 PMID:17483122 PMID:21704098 PMID:25416158 PMID:28378122 |
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NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
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G |
Cat |
catalase |
decreases activity multiple interactions decreases expression |
ISO EXP |
manganese chloride results in decreased activity of CAT protein [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; [Plant Extracts co-treated with manganese chloride] results in increased expression of CAT protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of CAT protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of CAT protein] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CAT protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Quercetin inhibits the reaction [manganese chloride results in decreased activity of CAT protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of CAT protein] |
CTD |
PMID:20503066 PMID:22033861 PMID:22192907 PMID:26064043 PMID:28040552 PMID:29183790 PMID:30844427 PMID:32445656 PMID:33314588 PMID:38129942 More...
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NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
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G |
Catip |
ciliogenesis associated TTC17 interacting protein |
increases expression |
ISO |
manganese chloride results in increased expression of CATIP mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:74,401,272...74,408,482
Ensembl chr 1:74,401,267...74,408,480
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G |
Catsperd |
cation channel sperm associated auxiliary subunit delta |
increases expression |
ISO |
manganese chloride results in increased expression of CATSPERD mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:56,933,917...56,971,456
Ensembl chr17:56,935,143...56,971,456
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G |
Cav2 |
caveolin 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CAV2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:17,281,184...17,289,129
Ensembl chr 6:17,281,184...17,289,114
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|
G |
Cbarp |
calcium channel, voltage-dependent, beta subunit associated regulatory protein |
increases expression |
ISO |
manganese chloride results in increased expression of DOS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:79,966,268...79,976,189
Ensembl chr10:79,966,285...79,976,669
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G |
Cbs |
cystathionine beta-synthase |
decreases expression |
ISO |
manganese chloride results in decreased expression of CBS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212
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G |
Ccdc15 |
coiled-coil domain containing 15 |
increases expression |
ISO |
manganese chloride results in increased expression of CCDC15 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:37,178,758...37,262,508
Ensembl chr 9:37,187,131...37,259,728
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G |
Ccdc175 |
coiled-coil domain containing 175 |
increases expression |
ISO |
manganese chloride results in increased expression of CCDC175 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:72,148,066...72,231,803
Ensembl chr12:72,148,074...72,231,803
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G |
Ccdc96 |
coiled-coil domain containing 96 |
increases expression |
ISO |
manganese chloride results in increased expression of CCDC96 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:36,641,932...36,645,515
Ensembl chr 5:36,641,932...36,645,516
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
increases expression |
ISO |
manganese chloride results in increased expression of CCL17 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:95,535,996...95,538,666
Ensembl chr 8:95,537,081...95,538,664
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
increases expression |
ISO |
manganese chloride results in increased expression of CCL19 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:42,754,525...42,756,558
Ensembl chr 4:42,754,525...42,756,577
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases secretion |
ISO EXP |
manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein] manganese chloride results in decreased secretion of CCL2 protein |
CTD |
PMID:23329836 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
ISO |
manganese chloride results in increased expression of CCL5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
increases expression |
ISO |
manganese chloride results in increased expression of CCL7 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351
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G |
Ccn2 |
cellular communication network factor 2 |
increases expression increases methylation |
EXP ISO |
manganese chloride results in increased expression of CCN2 mRNA manganese chloride results in increased methylation of CCN2 gene |
CTD |
PMID:17467022 PMID:28801915 |
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NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581
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G |
Ccna1 |
cyclin A1 |
increases expression |
ISO |
manganese chloride results in increased expression of CCNA1 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
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G |
Ccnb1 |
cyclin B1 |
multiple interactions |
EXP ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 protein |
CTD |
PMID:34822792 PMID:38503349 |
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NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078
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G |
Ccnb2 |
cyclin B2 |
decreases expression multiple interactions |
ISO EXP |
manganese chloride results in decreased expression of CCNB2 mRNA [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein] |
CTD |
PMID:17175027 PMID:34822792 |
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NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of CCND1 mRNA |
CTD |
PMID:38503349 |
|
NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNE1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNE1 protein |
CTD |
PMID:38503349 |
|
NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
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G |
Ccng1 |
cyclin G1 |
increases expression |
ISO |
manganese chloride results in increased expression of CCNG1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138
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G |
Cd28 |
CD28 antigen |
multiple interactions |
ISO |
[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; manganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein] |
CTD |
PMID:8662792 |
|
NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518
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G |
Cd44 |
CD44 antigen |
increases expression |
ISO |
manganese chloride results in increased expression of CD44 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010
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G |
Cd48 |
CD48 antigen |
increases expression |
ISO |
manganese chloride results in increased expression of CD48 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:171,508,989...171,532,825
Ensembl chr 1:171,509,577...171,532,826
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G |
Cd6 |
CD6 antigen |
decreases expression |
ISO |
manganese chloride results in decreased expression of CD6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:10,766,703...10,807,427
Ensembl chr19:10,766,705...10,807,422
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G |
Cd74 |
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
increases expression |
ISO |
manganese chloride results in increased expression of CD74 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724
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G |
Cd86 |
CD86 antigen |
increases expression |
ISO |
manganese chloride results in increased expression of CD86 protein |
CTD |
PMID:15737199 |
|
NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
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G |
Cd8b1 |
CD8 subunit beta 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CD8B mRNA; manganese chloride results in increased expression of CD8B1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 6:71,299,772...71,314,476
Ensembl chr 6:71,299,772...71,314,478
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|
G |
Cdc42ep3 |
CDC42 effector protein 3 |
increases expression |
ISO |
manganese chloride results in increased expression of CDC42EP3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:79,641,152...79,662,520
Ensembl chr17:79,641,156...79,662,520
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G |
Cdhr4 |
cadherin-related family member 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDHR4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:107,869,656...107,876,880
Ensembl chr 9:107,869,696...107,876,883
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G |
Cdkn1a |
cyclin dependent kinase inhibitor 1A |
multiple interactions increases expression affects localization |
ISO |
Cycloheximide inhibits the reaction [manganese chloride results in increased expression of CDKN1A protein] manganese chloride results in increased expression of CDKN1A mRNA; manganese chloride results in increased expression of CDKN1A protein manganese chloride affects the localization of CDKN1A protein |
CTD |
PMID:22542671 PMID:28801915 |
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NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
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G |
Cdkn1c |
cyclin dependent kinase inhibitor 1C |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDKN1C mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787
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G |
Cdkn2b |
cyclin dependent kinase inhibitor 2B |
increases expression |
ISO |
manganese chloride results in increased expression of CDKN2B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276
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G |
Cdkn2c |
cyclin dependent kinase inhibitor 2C |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDKN2C mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 4:109,518,073...109,523,953
Ensembl chr 4:109,518,073...109,524,386
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G |
Cdkn3 |
cyclin dependent kinase inhibitor 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CDKN3 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126
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G |
Cdnf |
cerebral dopamine neurotrophic factor |
increases expression |
ISO |
manganese chloride results in increased expression of CDNF mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:3,514,102...3,527,413
Ensembl chr 2:3,514,067...3,527,413
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|
G |
Cdyl2 |
chromodomain protein, Y chromosome-like 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CDYL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:117,295,462...117,459,730
Ensembl chr 8:117,301,139...117,459,730
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G |
Cebpd |
CCAAT/enhancer binding protein delta |
increases expression |
ISO |
manganese chloride results in increased expression of CEBPD mRNA |
CTD |
PMID:17175027 |
|
NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895
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G |
Celsr1 |
cadherin, EGF LAG seven-pass G-type receptor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CELSR1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr15:85,782,959...85,918,424
Ensembl chr15:85,783,130...85,918,404
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G |
Cep112 |
centrosomal protein 112 |
increases expression |
ISO |
manganese chloride results in increased expression of CEP112 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:108,316,041...108,751,441
Ensembl chr11:108,316,018...108,751,441
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G |
Cep128 |
centrosomal protein 128 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CEP128 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr12:90,965,264...91,351,207
Ensembl chr12:90,965,266...91,351,183
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G |
Cers1 |
ceramide synthase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CERS1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:70,768,425...70,784,238
Ensembl chr 8:70,768,425...70,784,242
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G |
Cers6 |
ceramide synthase 6 |
increases expression |
ISO |
manganese chloride results in increased expression of CERS6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:68,691,489...68,944,628
Ensembl chr 2:68,691,785...68,944,626
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
manganese chloride results in increased expression of CFLAR mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043
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G |
Cftr |
cystic fibrosis transmembrane conductance regulator |
increases expression |
ISO |
manganese chloride results in increased expression of CFTR mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767
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|
G |
Cgref1 |
cell growth regulator with EF hand domain 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CGREF1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:31,090,487...31,102,771
Ensembl chr 5:31,090,487...31,102,935
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G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
ISO |
manganese chloride results in increased expression of CH25H mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:34,451,183...34,452,548
Ensembl chr19:34,451,178...34,452,564
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G |
Chat |
choline O-acetyltransferase |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein |
CTD |
PMID:30738988 |
|
NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946
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G |
Chml |
choroideremia-like |
increases expression |
ISO |
manganese chloride results in increased expression of CHML mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:175,509,803...175,520,198
Ensembl chr 1:175,509,803...175,520,467
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G |
Chmp4b |
charged multivesicular body protein 4B |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of CHMP4B protein |
CTD |
PMID:35690225 |
|
NCBI chr 2:154,498,949...154,536,703
Ensembl chr 2:154,493,625...154,536,705
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|
G |
Chrna7 |
cholinergic receptor, nicotinic, alpha polypeptide 7 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CHRNA7 protein |
CTD |
PMID:25874029 |
|
NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317
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|
G |
Chst10 |
carbohydrate sulfotransferase 10 |
increases expression |
ISO |
manganese chloride results in increased expression of CHST10 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:38,902,948...38,937,256
Ensembl chr 1:38,902,948...38,937,242
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|
G |
Chuk |
conserved helix-loop-helix ubiquitous kinase |
multiple interactions increases phosphorylation |
ISO |
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein] |
CTD |
PMID:22245093 |
|
NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919
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|
G |
Ciita |
class II transactivator |
increases expression |
ISO |
manganese chloride results in increased expression of CIITA mRNA |
CTD |
PMID:28801915 |
|
NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282
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G |
Cish |
cytokine inducible SH2-containing protein |
increases expression |
ISO |
manganese chloride results in increased expression of CISH mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
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|
G |
Cited1 |
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CITED1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:101,290,984...101,295,787
Ensembl chr X:101,290,987...101,295,787
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G |
Cks2 |
CDC28 protein kinase regulatory subunit 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CKS2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696
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|
G |
Cldn23 |
claudin 23 |
increases expression |
ISO |
manganese chloride results in increased expression of CLDN23 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 8:36,291,863...36,293,713
Ensembl chr 8:36,291,866...36,293,713
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|
G |
Cldn4 |
claudin 4 |
increases expression |
ISO |
manganese chloride results in increased expression of CLDN4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788
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|
G |
Cldn9 |
claudin 9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CLDN9 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:23,901,558...23,903,000
Ensembl chr17:23,901,558...23,903,000
|
|
G |
Cldnd1 |
claudin domain containing 1 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CLDND1 mRNA |
CTD |
PMID:35690225 |
|
NCBI chr16:58,548,269...58,554,610
Ensembl chr16:58,548,273...58,554,614
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|
G |
Clec4f |
C-type lectin domain family 4, member f |
increases methylation |
ISO |
manganese chloride results in increased methylation of CLEC4F gene |
CTD |
PMID:28801915 |
|
NCBI chr 6:83,621,524...83,633,098
Ensembl chr 6:83,621,524...83,633,169
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|
G |
Clock |
clock circadian regulator |
decreases expression |
ISO |
manganese chloride results in decreased expression of CLOCK mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639
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|
G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of CMPK2 mRNA manganese chloride results in increased methylation of CMPK2 gene |
CTD |
PMID:28801915 |
|
NCBI chr12:26,519,121...26,529,836
Ensembl chr12:26,519,203...26,529,836
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|
G |
Cnksr1 |
connector enhancer of kinase suppressor of Ras 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CNKSR1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:133,955,352...133,965,737
Ensembl chr 4:133,955,352...133,965,710
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|
G |
Cnot2 |
CCR4-NOT transcription complex, subunit 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CNOT2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr10:116,321,065...116,418,891
Ensembl chr10:116,321,066...116,417,416
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|
G |
Cnot6l |
CCR4-NOT transcription complex, subunit 6-like |
increases expression |
ISO |
manganese chloride results in increased expression of CNOT6L mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:96,218,192...96,312,044
Ensembl chr 5:96,218,192...96,312,030
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G |
Cntn4 |
contactin 4 |
decreases expression |
EXP |
manganese chloride results in decreased expression of CNTN4 mRNA |
CTD |
PMID:15295902 |
|
NCBI chr 6:105,654,505...106,677,102
Ensembl chr 6:105,654,621...106,676,271
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|
G |
Col12a1 |
collagen, type XII, alpha 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of COL12A1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 9:79,506,269...79,628,423
Ensembl chr 9:79,506,273...79,626,113
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|
G |
Col15a1 |
collagen, type XV, alpha 1 |
increases expression |
ISO |
manganese chloride results in increased expression of COL15A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:47,207,744...47,313,165
Ensembl chr 4:47,208,161...47,313,167
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|
G |
Col17a1 |
collagen, type XVII, alpha 1 |
increases expression |
ISO |
manganese chloride results in increased expression of COL17A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:47,634,783...47,680,460
Ensembl chr19:47,634,783...47,680,533
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|
G |
Col18a1 |
collagen, type XVIII, alpha 1 |
increases expression |
EXP |
manganese chloride results in increased expression of COL18A1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382
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|
G |
Col4a5 |
collagen, type IV, alpha 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of COL4A5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:140,258,367...140,472,232
Ensembl chr X:140,258,381...140,472,230
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|
G |
Col5a2 |
collagen, type V, alpha 2 |
increases expression |
ISO |
manganese chloride results in increased expression of COL5A2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
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|
G |
Col6a1 |
collagen, type VI, alpha 1 |
increases expression |
ISO |
manganese chloride results in increased expression of COL6A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002
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|
G |
Col7a1 |
collagen, type VII, alpha 1 |
increases expression |
ISO |
manganese chloride results in increased expression of COL7A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:108,782,654...108,813,943
Ensembl chr 9:108,782,654...108,813,943
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|
G |
Col8a1 |
collagen, type VIII, alpha 1 |
increases expression |
ISO |
manganese chloride results in increased expression of COL8A1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100
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|
G |
Colec10 |
collectin sub-family member 10 |
decreases expression |
ISO |
manganese chloride results in decreased expression of COLEC10 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:54,274,170...54,329,755
Ensembl chr15:54,274,170...54,329,754
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|
G |
Colec12 |
collectin sub-family member 12 |
decreases expression |
ISO |
manganese chloride results in decreased expression of COLEC12 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644
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|
G |
Copg2 |
coatomer protein complex, subunit gamma 2 |
increases expression |
ISO |
manganese chloride results in increased expression of COPG2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:30,747,552...30,873,712
Ensembl chr 6:30,747,553...30,873,729
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|
G |
Cox6a2 |
cytochrome c oxidase subunit 6A2 |
increases expression |
ISO |
manganese chloride results in increased expression of COX6A2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:127,804,607...127,805,538
Ensembl chr 7:127,804,607...127,805,559
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|
G |
Cplx2 |
complexin 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CPLX2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:54,455,447...54,531,736
Ensembl chr13:54,519,162...54,531,730
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|
G |
Cpm |
carboxypeptidase M |
decreases expression |
ISO |
manganese chloride results in decreased expression of CPM mRNA |
CTD |
PMID:17175027 |
|
NCBI chr10:117,465,405...117,523,257
Ensembl chr10:117,465,405...117,523,257
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|
G |
Cracdl |
capping protein inhibiting regulator of actin like |
increases expression |
ISO |
manganese chloride results in increased expression of CRACDL mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:37,650,758...37,758,905
Ensembl chr 1:37,650,758...37,759,166
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G |
Creb1 |
cAMP responsive element binding protein 1 |
increases phosphorylation multiple interactions |
ISO EXP |
manganese chloride results in increased phosphorylation of CREB1 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein] [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:16787641 PMID:30951808 PMID:31676349 PMID:32659473 |
|
NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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|
G |
Crebl2 |
cAMP responsive element binding protein-like 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CREBL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:134,807,090...134,835,894
Ensembl chr 6:134,807,117...134,835,894
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|
G |
Crk |
v-crk avian sarcoma virus CT10 oncogene homolog |
increases expression |
ISO |
manganese chloride results in increased expression of CRK mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734
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|
G |
Cry1 |
cryptochrome circadian regulator 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CRY1 mRNA |
CTD |
PMID:28511934 |
|
NCBI chr10:84,967,564...85,020,918
Ensembl chr10:84,967,564...85,020,928
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G |
Cryaa |
crystallin, alpha A |
increases methylation |
ISO |
manganese chloride results in increased methylation of CRYAA gene |
CTD |
PMID:28801915 |
|
NCBI chr17:31,896,905...31,900,704
Ensembl chr17:31,896,781...31,900,707
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|
G |
Cryab |
crystallin, alpha B |
decreases expression |
ISO |
manganese chloride results in decreased expression of CRYAB mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936
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G |
Cryba4 |
crystallin, beta A4 |
increases expression |
ISO |
manganese chloride results in increased expression of CRYBA4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:112,394,358...112,411,411
Ensembl chr 5:112,394,359...112,400,384
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|
G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
multiple interactions increases expression |
ISO |
manganese chloride promotes the reaction [SNCA protein results in increased expression of CSF2 mRNA] manganese chloride results in increased expression of CSF2 mRNA |
CTD |
PMID:28539244 PMID:28801915 |
|
NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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G |
Csf3 |
colony stimulating factor 3 (granulocyte) |
increases expression |
ISO |
manganese chloride results in increased expression of CSF3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455
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G |
Cspg4 |
chondroitin sulfate proteoglycan 4 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of CSPG4 mRNA manganese chloride results in increased methylation of CSPG4 gene |
CTD |
PMID:28801915 |
|
NCBI chr 9:56,772,388...56,807,154
Ensembl chr 9:56,772,317...56,807,154
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|
G |
Csrp3 |
cysteine and glycine-rich protein 3 |
increases expression |
ISO |
manganese chloride results in increased expression of CSRP3 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 7:48,480,146...48,497,799
Ensembl chr 7:48,480,146...48,497,781
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|
G |
Cstf2 |
cleavage stimulation factor, 3' pre-RNA subunit 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CSTF2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:132,959,925...132,987,571
Ensembl chr X:132,959,936...132,987,568
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|
G |
Ctnna1 |
catenin alpha 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CTNNA1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr18:35,251,955...35,387,829
Ensembl chr18:35,251,912...35,387,832
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|
G |
Ctnnb1 |
catenin beta 1 |
decreases expression multiple interactions |
ISO |
manganese chloride results in decreased expression of CTNNB1 mRNA Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of CTNNB1 protein] |
CTD |
PMID:17175027 PMID:24464479 |
|
NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
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|
G |
Ctnnd1 |
catenin delta 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CTNND1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:84,417,440...84,489,321
Ensembl chr 2:84,430,415...84,481,109 Ensembl chr 2:84,430,415...84,481,109
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G |
Ctsd |
cathepsin D |
increases expression affects localization multiple interactions |
ISO EXP |
manganese chloride results in increased expression of CTSD protein manganese chloride affects the localization of CTSD protein [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CTSD protein |
CTD |
PMID:28378122 PMID:31690173 |
|
NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775
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G |
Ctsw |
cathepsin W |
increases expression |
ISO |
manganese chloride results in increased expression of CTSW mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:5,515,071...5,518,558
Ensembl chr19:5,515,071...5,518,535
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|
G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
increases expression |
ISO |
manganese chloride results in increased expression of CX3CL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055
|
|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of CXCL1 mRNA manganese chloride results in increased methylation of CXCL1 gene |
CTD |
PMID:28801915 |
|
NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL10 mRNA |
CTD |
PMID:27427241 |
|
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CXCL12 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL14 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364
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|
G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
increases expression affects expression |
ISO |
manganese chloride results in increased expression of CXCL8 mRNA manganese chloride affects the expression of CXCL8 mRNA |
CTD |
PMID:19815061 PMID:27427241 |
|
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL2 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
|
NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
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|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
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G |
Cxcl5 |
C-X-C motif chemokine ligand 5 |
increases expression |
ISO |
manganese chloride results in increased expression of CXCL6 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483
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G |
Cxxc1 |
CXXC finger protein 1 |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of CXXC1 mRNA manganese chloride results in increased methylation of CXXC1 gene |
CTD |
PMID:27913844 |
|
NCBI chr18:74,349,283...74,354,564
Ensembl chr18:74,349,195...74,354,567
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G |
Cycs |
cytochrome c, somatic |
multiple interactions affects localization |
EXP ISO |
BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cyclosporine inhibits the reaction [manganese chloride affects the localization of CYCS protein] SNCA protein inhibits the reaction [manganese chloride affects the localization of CYCS protein] |
CTD |
PMID:19442826 PMID:25416158 |
|
NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518
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|
G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions decreases expression increases expression |
ISO |
manganese chloride inhibits the reaction [CYP11A1 protein results in increased chemical synthesis of Progesterone] manganese chloride results in decreased expression of CYP11A1 protein manganese chloride results in increased expression of CYP11A1 mRNA |
CTD |
PMID:12699903 PMID:25981801 PMID:28801915 |
|
NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
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G |
Cyp26b1 |
cytochrome P450, family 26, subfamily b, polypeptide 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of CYP26B1 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 6:84,548,396...84,570,890
Ensembl chr 6:84,548,396...84,570,890
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G |
Cyria |
CYFIP related Rac1 interactor A |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of CYRIA mRNA manganese chloride results in increased methylation of CYRIA gene |
CTD |
PMID:28801915 |
|
NCBI chr12:12,312,136...12,430,966
Ensembl chr12:12,312,140...12,430,966
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G |
Dach2 |
dachshund family transcription factor 2 |
increases expression |
ISO |
manganese chloride results in increased expression of DACH2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr X:112,207,177...112,746,083
Ensembl chr X:112,207,207...112,746,083
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G |
Dact1 |
dishevelled-binding antagonist of beta-catenin 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DACT1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:71,356,658...71,366,881
Ensembl chr12:71,356,658...71,366,881
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G |
Dbh |
dopamine beta hydroxylase |
increases methylation |
ISO |
manganese chloride results in increased methylation of DBH gene |
CTD |
PMID:27913844 |
|
NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212
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G |
Dbp |
D site albumin promoter binding protein |
increases expression |
ISO |
manganese chloride results in increased expression of DBP mRNA |
CTD |
PMID:28511934 |
|
NCBI chr 7:45,354,658...45,359,579
Ensembl chr 7:45,354,512...45,359,627
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G |
Dcp1b |
decapping mRNA 1B |
increases expression |
ISO |
manganese chloride results in increased expression of DCP1B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:119,152,214...119,198,575
Ensembl chr 6:119,152,214...119,198,577
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
Deferoxamine promotes the reaction [manganese chloride results in increased expression of DDIT3 protein] [manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 protein] manganese chloride results in increased expression of DDIT3 mRNA; manganese chloride results in increased expression of DDIT3 protein |
CTD |
PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
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NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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G |
Ddx60 |
DExD/H box helicase 60 |
increases expression |
ISO |
manganese chloride results in increased expression of DDX60 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:62,381,155...62,491,278
Ensembl chr 8:62,381,121...62,491,278
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G |
Defb29 |
defensin beta 29 |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of DEFB29 gene manganese chloride results in increased expression of DEFB29 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:152,380,634...152,381,961
Ensembl chr 2:152,380,634...152,382,018
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G |
Depp1 |
DEPP1 autophagy regulator |
increases expression |
ISO |
manganese chloride results in increased expression of DEPP1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DHRS3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779
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G |
Dld |
dihydrolipoamide dehydrogenase |
decreases expression |
ISO |
manganese chloride results in decreased expression of DLD protein |
CTD |
PMID:25981801 |
|
NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of DLK1 mRNA manganese chloride results in increased methylation of DLK1 gene |
CTD |
PMID:27913844 |
|
NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262
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G |
Dll4 |
delta like canonical Notch ligand 4 |
increases expression |
EXP |
manganese chloride results in increased expression of DLL4 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443
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G |
Dmkn |
dermokine |
increases expression |
ISO |
manganese chloride results in increased expression of DMKN mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:30,463,181...30,480,491
Ensembl chr 7:30,463,181...30,480,488
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G |
Dnah14 |
dynein, axonemal, heavy chain 14 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DNAH14 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 1:181,404,158...181,642,306
Ensembl chr 1:181,404,124...181,643,339
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G |
Dnai2 |
dynein axonemal intermediate chain 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DNAI2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:114,614,634...114,648,715
Ensembl chr11:114,618,234...114,648,715
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G |
Dnajc12 |
DnaJ heat shock protein family (Hsp40) member C12 |
increases expression |
ISO |
manganese chloride results in increased expression of DNAJC12 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:63,218,222...63,244,619
Ensembl chr10:63,218,222...63,246,355
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G |
Dnajc16 |
DnaJ heat shock protein family (Hsp40) member C16 |
increases expression |
ISO |
manganese chloride results in increased expression of DNAJC16 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:141,487,498...141,518,255
Ensembl chr 4:141,487,500...141,518,242
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G |
Dnm1l |
dynamin 1-like |
increases expression multiple interactions |
EXP |
manganese chloride results in increased expression of DNM1L mRNA; manganese chloride results in increased expression of DNM1L protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L protein]]; manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]; Resveratrol inhibits the reaction [manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L mRNA]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L protein] |
CTD |
PMID:34738708 |
|
NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823
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G |
Dnph1 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DNPH1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr17:46,807,715...46,810,544
Ensembl chr17:46,807,637...46,810,550
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G |
Doc2a |
double C2, alpha |
increases expression |
ISO |
manganese chloride results in increased expression of DOC2A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:126,446,525...126,451,877
Ensembl chr 7:126,446,588...126,451,877
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G |
Dpep1 |
dipeptidase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DPEP1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:123,913,069...123,928,551
Ensembl chr 8:123,912,981...123,928,551
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G |
Dpep2 |
dipeptidase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of DPEP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:106,711,577...106,732,658
Ensembl chr 8:106,711,576...106,718,391 Ensembl chr 8:106,711,576...106,718,391
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G |
Dph1 |
diphthamide biosynthesis 1 |
increases expression |
ISO |
manganese chloride results in increased expression of DPH1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:75,068,469...75,081,309
Ensembl chr11:75,068,469...75,082,067
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G |
Dpp4 |
dipeptidylpeptidase 4 |
increases expression |
ISO |
manganese chloride results in increased expression of DPP4 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 2:62,160,417...62,242,635
Ensembl chr 2:62,160,417...62,242,575
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression increases expression |
EXP ISO |
manganese chloride results in decreased expression of DPYSL3 mRNA manganese chloride results in increased expression of DPYSL3 mRNA |
CTD |
PMID:22407947 PMID:25698507 PMID:28801915 |
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NCBI chr18:43,454,044...43,571,354
Ensembl chr18:43,454,049...43,571,351
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G |
Dr1 |
down-regulator of transcription 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of DR1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:108,416,763...108,428,387
Ensembl chr 5:108,416,763...108,428,392
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G |
Drd1 |
dopamine receptor D1 |
decreases expression multiple interactions increases expression |
EXP ISO |
manganese chloride results in decreased expression of DRD1 protein Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] manganese chloride results in increased expression of DRD1 [manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein |
CTD |
PMID:22479410 PMID:23458069 PMID:23604964 PMID:24969583 |
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NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions increases expression decreases expression |
ISO EXP |
[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein; manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone] manganese chloride results in increased expression of DRD2; manganese chloride results in increased expression of DRD2 protein; manganese chloride results in increased expression of DRD2 protein alternative form manganese chloride results in decreased expression of DRD2 protein Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein] |
CTD |
PMID:21484877 PMID:22479410 PMID:23458069 PMID:24969583 |
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NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477
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G |
Dscaml1 |
DS cell adhesion molecule like 1 |
increases expression |
ISO |
manganese chloride results in increased expression of DSCAML1 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 9:45,338,735...45,665,011
Ensembl chr 9:45,337,926...45,665,010
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G |
Dspp |
dentin sialophosphoprotein |
increases expression |
ISO |
manganese chloride results in increased expression of DSPP mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:104,318,569...104,327,993
Ensembl chr 5:104,318,578...104,327,993
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G |
Dtx1 |
deltex 1, E3 ubiquitin ligase |
increases expression |
ISO |
manganese chloride results in increased expression of DTX1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:120,818,268...120,850,879
Ensembl chr 5:120,818,267...120,849,992
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G |
Dusp13b |
dual specificity phosphatase 13B |
increases expression |
ISO |
manganese chloride results in increased expression of DUSP13B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr14:21,783,463...21,792,947
Ensembl chr14:21,783,462...21,792,947
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G |
Dusp2 |
dual specificity phosphatase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of DUSP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296
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G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
ISO |
manganese chloride results in increased expression of DUSP4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of DUSP5 mRNA manganese chloride results in increased methylation of DUSP5 gene |
CTD |
PMID:28801915 |
|
NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of DUSP6 gene manganese chloride results in increased expression of DUSP6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
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G |
Dynlt4 |
dynein light chain Tctex-type 4 |
increases expression |
ISO |
manganese chloride results in increased expression of DYNLT4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:116,981,734...116,985,935
Ensembl chr 4:116,983,991...116,985,935
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G |
Eaf2 |
ELL associated factor 2 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of EAF2 mRNA manganese chloride results in increased methylation of EAF2 gene |
CTD |
PMID:28801915 |
|
NCBI chr16:36,613,246...36,695,275
Ensembl chr16:36,613,246...36,695,365
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G |
Ebi3 |
Epstein-Barr virus induced gene 3 |
increases expression |
ISO |
manganese chloride results in increased expression of EBI3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022
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G |
Ecrg4 |
ECRG4 augurin precursor |
decreases expression |
ISO |
manganese chloride results in decreased expression of ECRG4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:43,769,762...43,781,724
Ensembl chr 1:43,769,762...43,781,738
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G |
Edn1 |
endothelin 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of EDN1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein |
CTD |
PMID:2354210 |
|
NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965
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G |
Egfl7 |
EGF-like domain 7 |
increases expression |
EXP |
manganese chloride results in increased expression of EGFL7 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 2:26,471,095...26,482,694
Ensembl chr 2:26,470,026...26,483,132
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G |
Egfr |
epidermal growth factor receptor |
multiple interactions increases activity increases expression |
ISO |
[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein manganese chloride results in increased activity of EGFR protein manganese chloride results in increased expression of EGFR mRNA |
CTD |
PMID:2354210 PMID:28801915 |
|
NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
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G |
Egln3 |
egl-9 family hypoxia-inducible factor 3 |
increases expression |
ISO |
manganese chloride results in increased expression of EGLN3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
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G |
Egr1 |
early growth response 1 |
increases expression |
ISO EXP |
manganese chloride results in increased expression of EGR1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
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G |
Egr2 |
early growth response 2 |
increases expression |
EXP ISO |
manganese chloride results in increased expression of EGR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018
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G |
Egr3 |
early growth response 3 |
increases expression |
ISO |
manganese chloride results in increased expression of EGR3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr14:70,314,766...70,320,062
Ensembl chr14:70,314,652...70,320,063
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G |
Eif1ad |
eukaryotic translation initiation factor 1A domain containing |
increases expression |
ISO |
manganese chloride results in increased expression of EIF1AD mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:5,416,841...5,421,546
Ensembl chr19:5,416,769...5,421,554
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions |
ISO |
manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:23934647 |
|
NCBI chr 3:58,433,252...58,464,922
Ensembl chr 3:58,433,242...58,464,922
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] |
CTD |
PMID:32574669 |
|
NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation increases expression |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]; manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein] manganese chloride results in increased phosphorylation of EIF2AK3 protein manganese chloride results in increased expression of EIF2AK3 protein |
CTD |
PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
|
NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229
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G |
Eif2s1 |
eukaryotic translation initiation factor 2, subunit 1 alpha |
increases phosphorylation multiple interactions |
ISO |
manganese chloride results in increased phosphorylation of EIF2S1 protein [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:23764342 PMID:23948121 PMID:32574669 |
|
NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation multiple interactions |
ISO |
manganese chloride results in decreased phosphorylation of EIF4EBP1 protein corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of EIF4EBP1 protein] |
CTD |
PMID:30578841 |
|
NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702
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G |
Elf1 |
E74 like ETS transcription factor 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ELF1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr14:79,718,619...79,819,916
Ensembl chr14:79,718,634...79,819,934
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G |
Elk3 |
ELK3, member of ETS oncogene family |
increases expression |
EXP |
manganese chloride results in increased expression of ELK3 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr10:93,083,277...93,147,021
Ensembl chr10:93,083,276...93,146,997
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G |
Elmod3 |
ELMO/CED-12 domain containing 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ELMOD3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:72,542,905...72,575,396
Ensembl chr 6:72,542,905...72,575,396
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ELOVL6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144
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G |
Eml2 |
echinoderm microtubule associated protein like 2 |
increases expression |
ISO |
manganese chloride results in increased expression of EML2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:18,910,322...18,940,407
Ensembl chr 7:18,910,346...18,940,407
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of ENC1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:97,377,613...97,389,548
Ensembl chr13:97,377,613...97,389,542
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G |
Eng |
endoglin |
increases expression |
EXP |
manganese chloride results in increased expression of ENG mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681
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G |
Eno2 |
enolase 2, gamma neuronal |
increases expression decreases expression multiple interactions |
ISO EXP |
manganese chloride results in increased expression of ENO2 mRNA manganese chloride results in decreased expression of ENO2 protein Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] |
CTD |
PMID:22281203 PMID:24969583 |
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NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636
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G |
Eomes |
eomesodermin |
decreases expression |
EXP |
manganese chloride results in decreased expression of EOMES mRNA; manganese chloride results in decreased expression of EOMES protein |
CTD |
PMID:25698507 |
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NCBI chr 9:118,307,259...118,315,176
Ensembl chr 9:118,307,280...118,315,200
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G |
Epas1 |
endothelial PAS domain protein 1 |
increases expression |
EXP |
manganese chloride results in increased expression of EPAS1 mRNA |
CTD |
PMID:17467022 |
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NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838
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G |
Epdr1 |
ependymin related 1 |
increases expression |
ISO |
manganese chloride results in increased expression of EPDR1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:19,775,878...19,804,000
Ensembl chr13:19,775,876...19,804,097
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G |
Epha2 |
Eph receptor A2 |
increases expression |
ISO |
manganese chloride results in increased expression of EPHA2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:141,028,532...141,056,695
Ensembl chr 4:141,028,551...141,056,695
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G |
Epha4 |
Eph receptor A4 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of EPHA4 gene manganese chloride results in decreased expression of EPHA4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725
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G |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of ERAP1 mRNA |
CTD |
PMID:17467022 |
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NCBI chr13:74,787,692...74,841,321
Ensembl chr13:74,787,687...74,841,320
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G |
Ercc6l |
excision repair cross-complementing rodent repair deficiency complementation group 6 like |
decreases expression |
ISO |
manganese chloride results in decreased expression of ERCC6L mRNA |
CTD |
PMID:17175027 |
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NCBI chr X:101,186,426...101,200,697
Ensembl chr X:101,185,322...101,200,697
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G |
Ereg |
epiregulin |
increases expression |
ISO |
manganese chloride results in increased expression of EREG mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 5:91,222,476...91,241,508
Ensembl chr 5:91,222,481...91,241,505
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G |
Erich1 |
glutamate rich 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ERICH1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:14,075,051...14,140,393
Ensembl chr 8:14,077,561...14,140,301
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G |
Ern1 |
endoplasmic reticulum to nucleus signalling 1 |
multiple interactions increases phosphorylation |
ISO |
SNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:23934647 PMID:25732873 |
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NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
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G |
Errfi1 |
ERBB receptor feedback inhibitor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of ERRFI1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349
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G |
Esr1 |
estrogen receptor 1 (alpha) |
decreases expression multiple interactions |
EXP |
manganese chloride results in decreased expression of ESR1 protein Estradiol inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein] |
CTD |
PMID:29183790 |
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NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614
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G |
Etv3 |
ets variant 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ETV3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:87,432,891...87,447,463
Ensembl chr 3:87,432,714...87,447,463
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G |
Etv4 |
ets variant 4 |
increases expression |
ISO |
manganese chloride results in increased expression of ETV4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:101,660,573...101,677,963
Ensembl chr11:101,660,568...101,676,197
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G |
Etv5 |
ets variant 5 |
increases expression |
ISO |
manganese chloride results in increased expression of ETV5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:22,200,063...22,258,320
Ensembl chr16:22,200,059...22,258,469
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G |
Eva1c |
eva-1 homolog C |
increases expression |
ISO |
manganese chloride results in increased expression of EVA1C mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:90,623,607...90,701,997
Ensembl chr16:90,623,607...90,701,997
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G |
Exoc6 |
exocyst complex component 6 |
decreases expression |
ISO |
manganese chloride results in decreased expression of EXOC6 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr19:37,525,181...37,672,499
Ensembl chr19:37,509,327...37,672,507
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G |
Eya4 |
EYA transcriptional coactivator and phosphatase 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of EYA4 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr10:22,978,861...23,226,785
Ensembl chr10:22,978,862...23,226,684
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G |
F2rl1 |
F2R like trypsin receptor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of F2RL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735
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G |
Fa2h |
fatty acid 2-hydroxylase |
increases expression decreases expression |
ISO |
manganese chloride results in increased expression of FA2H mRNA manganese chloride results in decreased expression of FA2H mRNA |
CTD |
PMID:26745496 PMID:28801915 |
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NCBI chr 8:112,071,770...112,120,453
Ensembl chr 8:112,071,767...112,120,456
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G |
Fads2 |
fatty acid desaturase 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FADS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110
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G |
Fam107a |
family with sequence similarity 107, member A |
decreases expression |
ISO |
manganese chloride results in decreased expression of FAM107A mRNA |
CTD |
PMID:26745496 |
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NCBI chr14:14,152,166...14,173,503
Ensembl chr14:14,151,750...14,173,499
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G |
Fam171b |
family with sequence similarity 171, member B |
increases expression |
ISO |
manganese chloride results in increased expression of FAM171B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:83,642,889...83,713,878
Ensembl chr 2:83,642,980...83,713,830
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G |
Fam180a |
family with sequence similarity 180, member A |
decreases expression |
ISO |
manganese chloride results in decreased expression of FAM180A mRNA |
CTD |
PMID:26745496 |
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NCBI chr 6:35,289,678...35,303,076
Ensembl chr 6:35,289,603...35,303,076
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G |
Fam210a |
family with sequence similarity 210, member A |
increases expression |
ISO |
manganese chloride results in increased expression of FAM210A mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:68,393,248...68,433,404
Ensembl chr18:68,393,258...68,433,404
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G |
Fam210b |
family with sequence similarity 210, member B |
increases expression |
ISO |
manganese chloride results in increased expression of FAM210B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:172,187,444...172,197,669
Ensembl chr 2:172,187,485...172,197,669
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G |
Fam219a |
family with sequence similarity 219, member A |
increases expression |
ISO |
manganese chloride results in increased expression of FAM219A mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:41,517,691...41,569,538
Ensembl chr 4:41,517,691...41,569,538
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G |
Fam227a |
family with sequence similarity 227, member A |
increases expression |
ISO |
manganese chloride results in increased expression of FAM227A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:79,493,777...79,543,157
Ensembl chr15:79,496,518...79,543,157
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G |
Fam229b |
family with sequence similarity 229, member B |
increases expression |
ISO |
manganese chloride results in increased expression of FAM229B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:38,994,800...39,009,936
Ensembl chr10:38,994,800...39,009,910
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G |
Fancf |
Fanconi anemia, complementation group F |
decreases expression |
ISO |
manganese chloride results in decreased expression of FANCF mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:51,510,325...51,512,015
Ensembl chr 7:51,510,325...51,512,015
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
manganese chloride results in increased expression of FAS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
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G |
Fasl |
Fas ligand |
increases expression multiple interactions |
ISO |
manganese chloride results in increased expression of FASLG protein bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of FASLG protein] |
CTD |
PMID:21704098 PMID:28378122 |
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NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
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G |
Fasn |
fatty acid synthase |
decreases expression |
ISO |
manganese chloride results in decreased expression of FASN mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373
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G |
Fat2 |
FAT atypical cadherin 2 |
increases methylation |
ISO |
manganese chloride results in increased methylation of FAT2 gene |
CTD |
PMID:28801915 |
|
NCBI chr11:55,141,435...55,228,331
Ensembl chr11:55,141,435...55,227,390
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G |
Fat4 |
FAT atypical cadherin 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FAT4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:38,939,867...39,066,134
Ensembl chr 3:38,941,089...39,066,134
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G |
Fbln2 |
fibulin 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FBLN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 6:91,189,442...91,249,522
Ensembl chr 6:91,189,437...91,249,522
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G |
Fbn1 |
fibrillin 1 |
increases expression |
ISO |
manganese chloride results in increased expression of FBN1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913
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G |
Fbp2 |
fructose bisphosphatase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FBP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236
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G |
Fbxl2 |
F-box and leucine-rich repeat protein 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FBXL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:113,787,625...113,855,871
Ensembl chr 9:113,792,705...113,875,259
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G |
Fbxl4 |
F-box and leucine-rich repeat protein 4 |
increases expression |
ISO |
manganese chloride results in increased expression of FBXL4 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:22,357,526...22,434,091
Ensembl chr 4:22,357,543...22,434,091
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G |
Fcgr1 |
Fc receptor, IgG, high affinity I |
decreases expression |
ISO |
manganese chloride results in decreased expression of FCGR1A mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 3:96,190,225...96,201,285
Ensembl chr 3:96,190,225...96,201,285
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G |
Fcgr4 |
Fc receptor, IgG, low affinity IV |
increases expression |
ISO |
manganese chloride results in increased expression of FCGR3A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330
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G |
Fdps |
farnesyl diphosphate synthetase |
decreases expression |
ISO |
manganese chloride results in decreased expression of FDPS mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
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G |
Fez1 |
fasciculation and elongation protein zeta 1 |
increases expression |
ISO |
manganese chloride results in increased expression of FEZ1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 9:36,732,694...36,790,220
Ensembl chr 9:36,733,160...36,790,220
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G |
Fez2 |
fasciculation and elongation protein zeta 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FEZ2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:78,676,641...78,725,581
Ensembl chr17:78,676,641...78,725,581
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G |
Fgf2 |
fibroblast growth factor 2 |
decreases expression increases methylation |
EXP ISO |
manganese chloride results in decreased expression of FGF2 mRNA manganese chloride results in increased methylation of FGF2 gene |
CTD |
PMID:28801915 |
|
NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
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G |
Fgf20 |
fibroblast growth factor 20 |
increases expression |
ISO |
manganese chloride results in increased expression of FGF20 mRNA |
CTD |
PMID:28986288 |
|
NCBI chr 8:40,732,206...40,740,060
Ensembl chr 8:40,732,207...40,761,372
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G |
Fgfbp1 |
fibroblast growth factor binding protein 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FGFBP1 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121
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G |
Fgfr2 |
fibroblast growth factor receptor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FGFR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079
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G |
Fhip2b |
FHF complex subunit HOOK interacting protein 2B |
increases expression |
ISO |
manganese chloride results in increased expression of FHIP2B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr14:70,820,733...70,837,309
Ensembl chr14:70,820,736...70,837,275
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G |
Fhl1 |
four and a half LIM domains 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FHL1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr X:55,776,569...55,838,704
Ensembl chr X:55,777,147...55,838,706
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
EXP |
manganese chloride results in increased expression of FIS1 protein |
CTD |
PMID:34738708 |
|
NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088
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G |
Flcn |
folliculin |
increases expression |
ISO |
manganese chloride results in increased expression of FLCN mRNA |
CTD |
PMID:17175027 |
|
NCBI chr11:59,682,234...59,706,138
Ensembl chr11:59,682,234...59,700,842
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G |
Flrt2 |
fibronectin leucine rich transmembrane protein 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FLRT2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:95,658,780...95,751,989
Ensembl chr12:95,659,000...95,751,989
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G |
Flt1 |
FMS-like tyrosine kinase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of FLT1 mRNA |
CTD |
PMID:17467022 |
|
NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821
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G |
Flvcr2 |
feline leukemia virus subgroup C cellular receptor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FLVCR2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:85,793,313...85,860,359
Ensembl chr12:85,793,313...85,860,359
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G |
Fmo2 |
flavin containing monooxygenase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FMO2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:162,701,886...162,726,327
Ensembl chr 1:162,701,886...162,726,295
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G |
Fmo5 |
flavin containing monooxygenase 5 |
decreases methylation increases expression |
ISO |
manganese chloride results in decreased methylation of FMO5 gene manganese chloride results in increased expression of FMO5 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598
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G |
Fn1 |
fibronectin 1 |
multiple interactions increases expression |
ISO |
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; manganese chloride results in increased expression of and results in increased secretion of FN1 protein; Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; phenyl-N-tert-butylnitrone inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] |
CTD |
PMID:19524604 |
|
NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
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G |
Fos |
FBJ osteosarcoma oncogene |
increases expression decreases expression |
ISO EXP |
manganese chloride results in increased expression of FOS protein manganese chloride results in decreased expression of FOS protein |
CTD |
PMID:9751194 PMID:25698507 |
|
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
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G |
Fosl1 |
fos-like antigen 1 |
increases expression |
ISO |
manganese chloride results in increased expression of FOSL1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
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G |
Foxn4 |
forkhead box N4 |
increases expression |
ISO |
manganese chloride results in increased expression of FOXN4 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 5:114,392,225...114,412,486
Ensembl chr 5:114,392,225...114,411,868
|
|
G |
Foxp2 |
forkhead box P2 |
increases expression |
ISO |
manganese chloride results in increased expression of FOXP2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 6:14,901,348...15,441,976
Ensembl chr 6:14,901,348...15,441,976
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|
G |
Frem3 |
Fras1 related extracellular matrix protein 3 |
increases expression |
ISO |
manganese chloride results in increased expression of FREM3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 8:81,337,668...81,422,186
Ensembl chr 8:81,337,709...81,421,985
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|
G |
Frmd4a |
FERM domain containing 4A |
increases expression |
ISO |
manganese chloride results in increased expression of FRMD4A mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:4,022,461...4,618,854
Ensembl chr 2:4,022,528...4,618,854
|
|
G |
Fscn2 |
fascin actin-bundling protein 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FSCN2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:120,250,991...120,258,999
Ensembl chr11:120,252,360...120,258,994
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|
G |
Fshb |
follicle stimulating hormone beta |
decreases expression multiple interactions |
ISO |
manganese chloride results in decreased expression of FSHB protein Quercetin inhibits the reaction [manganese chloride results in decreased expression of FSHB protein] |
CTD |
PMID:28040552 |
|
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
|
|
G |
Fstl3 |
follistatin-like 3 |
increases expression |
ISO |
manganese chloride results in increased expression of FSTL3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464
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|
G |
Fth1 |
ferritin heavy polypeptide 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FTH1 mRNA; manganese chloride results in decreased expression of FTH1 protein |
CTD |
PMID:15893546 PMID:15922012 PMID:16545456 PMID:16568477 |
|
NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462
|
|
G |
Ftl1 |
ferritin light polypeptide 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of FTL mRNA |
CTD |
PMID:15893546 |
|
NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308
|
|
G |
Fut1 |
fucosyltransferase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of FUT1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 7:45,266,862...45,270,483
Ensembl chr 7:45,266,713...45,270,483
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G |
Fut2 |
fucosyltransferase 2 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of FUT2 gene manganese chloride results in decreased expression of FUT2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:45,298,015...45,315,818
Ensembl chr 7:45,298,015...45,315,818
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G |
Fxyd2 |
FXYD domain-containing ion transport regulator 2 |
increases expression |
ISO |
manganese chloride results in increased expression of FXYD2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576
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G |
G0s2 |
G0/G1 switch gene 2 |
increases expression |
ISO |
manganese chloride results in increased expression of G0S2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:192,954,468...192,955,496
Ensembl chr 1:192,954,469...192,955,525
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G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
multiple interactions decreases expression |
ISO |
[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein manganese chloride results in decreased expression of GABBR2 mRNA [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein |
CTD |
PMID:18771689 PMID:32659473 |
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NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions decreases expression increases expression |
ISO |
[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein manganese chloride results in decreased expression of GABRA1 mRNA manganese chloride results in increased expression of GABRA1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein |
CTD |
PMID:18771689 PMID:32659473 |
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NCBI chr11:42,021,766...42,073,893
Ensembl chr11:42,021,766...42,073,757
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G |
Gabrb3 |
GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GABRB3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:57,240,266...57,478,550
Ensembl chr 7:57,069,440...57,478,550
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G |
Gabrg2 |
gamma-aminobutyric acid type A receptor, subunit gamma 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GABRG2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:41,801,017...41,891,684
Ensembl chr11:41,801,030...41,891,684
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G |
Gad1 |
glutamate decarboxylase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GAD1 mRNA |
CTD |
PMID:12106697 |
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NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358
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G |
Gadd45a |
growth arrest and DNA-damage-inducible 45 alpha |
decreases expression |
ISO |
manganese chloride results in decreased expression of GADD45A mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
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G |
Gal |
galanin and GMAP prepropeptide |
increases expression |
ISO |
manganese chloride results in increased expression of GAL mRNA |
CTD |
PMID:17175027 |
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NCBI chr19:3,459,915...3,464,544
Ensembl chr19:3,459,915...3,464,544
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G |
Gale |
galactose-4-epimerase, UDP |
decreases expression |
ISO |
manganese chloride results in decreased expression of GALE mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:135,690,550...135,695,489
Ensembl chr 4:135,691,038...135,695,489
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G |
Garin1b |
golgi associated RAB2 interactor 1B |
increases expression |
ISO |
manganese chloride results in increased expression of GARIN1B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:29,313,468...29,336,021
Ensembl chr 6:29,319,139...29,336,018
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G |
Gbe1 |
1,4-alpha-glucan branching enzyme 1 |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of GBE1 mRNA manganese chloride results in increased methylation of GBE1 gene |
CTD |
PMID:27913844 |
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NCBI chr16:70,110,837...70,366,608
Ensembl chr16:70,110,837...70,366,604
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G |
Gbp5 |
guanylate binding protein 5 |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of GBP5 gene manganese chloride results in increased expression of GBP5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105
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G |
Gcdh |
glutaryl-Coenzyme A dehydrogenase |
decreases expression |
ISO |
manganese chloride results in decreased expression of GCDH mRNA |
CTD |
PMID:22281203 |
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NCBI chr 8:85,613,016...85,629,378
Ensembl chr 8:85,613,022...85,620,550
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G |
Gcfc2 |
GC-rich sequence DNA binding factor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GCFC2 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 6:81,887,543...81,936,079
Ensembl chr 6:81,900,650...81,936,896
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G |
Gcgr |
glucagon receptor |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of GCGR mRNA manganese chloride results in increased methylation of GCGR gene |
CTD |
PMID:28801915 |
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NCBI chr11:120,420,011...120,429,815
Ensembl chr11:120,421,525...120,429,812
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G |
Gch1 |
GTP cyclohydrolase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GCH1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870
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G |
Gclm |
glutamate-cysteine ligase, modifier subunit |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GCLM mRNA |
CTD |
PMID:38503349 |
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NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
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G |
Gdap2 |
ganglioside-induced differentiation-associated-protein 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GDAP2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 3:100,069,843...100,117,909
Ensembl chr 3:100,069,697...100,114,297
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
manganese chloride results in increased expression of GDF15 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106
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G |
Gdnf |
glial cell line derived neurotrophic factor |
increases methylation |
ISO |
manganese chloride results in increased methylation of GDNF gene |
CTD |
PMID:27913844 |
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NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056
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G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression multiple interactions |
ISO EXP |
manganese chloride results in decreased expression of GFAP protein manganese chloride results in increased expression of GFAP protein Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein] |
CTD |
PMID:12009774 PMID:12106697 PMID:24060432 PMID:24969583 PMID:25288107 PMID:28539244 More...
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NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GJA1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609
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G |
Gja5 |
gap junction protein, alpha 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GJA5 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 3:96,939,718...96,960,950
Ensembl chr 3:96,812,009...96,984,732
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G |
Gja8 |
gap junction protein, alpha 8 |
increases expression |
ISO |
manganese chloride results in increased expression of GJA8 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:96,820,882...96,833,367
Ensembl chr 3:96,820,882...96,833,336
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G |
Gjb5 |
gap junction protein, beta 5 |
increases expression |
ISO |
manganese chloride results in increased expression of GJB5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:127,248,600...127,251,957
Ensembl chr 4:127,248,602...127,251,974
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G |
Gkn3 |
gastrokine 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GKN3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:87,360,301...87,365,917
Ensembl chr 6:87,360,238...87,365,917
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G |
Gldn |
gliomedin |
decreases expression |
ISO |
manganese chloride results in decreased expression of GLDN mRNA |
CTD |
PMID:26745496 |
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NCBI chr 9:54,193,770...54,249,061
Ensembl chr 9:54,193,770...54,249,070
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G |
Glis1 |
GLIS family zinc finger 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GLIS1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:107,283,840...107,492,258
Ensembl chr 4:107,291,788...107,492,258
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G |
Glis2 |
GLIS family zinc finger 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GLIS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:4,412,217...4,443,076
Ensembl chr16:4,412,577...4,442,788
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G |
Glt8d2 |
glycosyltransferase 8 domain containing 2 |
increases expression |
ISO |
manganese chloride results in increased expression of GLT8D2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:82,486,262...82,529,846
Ensembl chr10:82,486,267...82,526,484
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G |
Glul |
glutamate-ammonia ligase |
decreases expression multiple interactions |
ISO |
manganese chloride results in decreased expression of GLUL mRNA; manganese chloride results in decreased expression of GLUL protein Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA] |
CTD |
PMID:19615351 |
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NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
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G |
Gm4984 |
predicted pseudogene 4984 |
increases expression |
ISO |
manganese chloride results in increased expression of MPC1L mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:12,518,492...12,519,064
Ensembl chr X:12,518,542...12,518,901
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G |
Gnb4 |
guanine nucleotide binding protein (G protein), beta 4 |
increases expression |
ISO |
manganese chloride results in increased expression of GNB4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:32,632,736...32,670,813
Ensembl chr 3:32,634,481...32,670,734
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G |
Gnrh1 |
gonadotropin releasing hormone 1 |
increases expression multiple interactions increases secretion |
ISO |
manganese chloride results in increased expression of GNRH1 mRNA 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; [manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein; [manganese chloride results in increased chemical synthesis of Cyclic GMP] which results in increased secretion of GNRH1 protein; Bicuculline promotes the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Dopamine affects the reaction [manganese chloride results in increased secretion of GNRH1 protein]; gamma-Aminobutyric Acid inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] |
CTD |
PMID:17110411 PMID:17290048 PMID:18603625 PMID:21402727 |
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NCBI chr14:67,982,717...67,986,889
Ensembl chr14:67,982,630...67,986,888
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G |
Gpnmb |
glycoprotein (transmembrane) nmb |
increases expression |
ISO |
manganese chloride results in increased expression of GPNMB mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863
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G |
Gpr18 |
G protein-coupled receptor 18 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GPR18 mRNA |
CTD |
PMID:26745496 |
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NCBI chr14:122,148,846...122,153,300
Ensembl chr14:122,148,665...122,153,193
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G |
Gpr34 |
G protein-coupled receptor 34 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GPR34 mRNA |
CTD |
PMID:26745496 |
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NCBI chr X:13,489,777...13,507,098
Ensembl chr X:13,498,328...13,507,097
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions decreases expression increases activity |
EXP ISO |
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein] manganese chloride results in increased activity of GPX1 protein [Cadmium Chloride co-treated with lead acetate co-treated with manganese chloride] results in increased activity of GPX1 protein |
CTD |
PMID:24969583 PMID:25288107 PMID:27599793 |
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NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542
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G |
Grik3 |
glutamate receptor, ionotropic, kainate 3 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of GRIK3 gene manganese chloride results in decreased expression of GRIK3 mRNA |
CTD |
PMID:27913844 PMID:28801915 |
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NCBI chr 4:125,384,025...125,607,966
Ensembl chr 4:125,384,493...125,607,966
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G |
Grin1 |
glutamate receptor, ionotropic, NMDA1 (zeta 1) |
decreases expression |
ISO |
manganese chloride results in decreased expression of GRIN1 mRNA; manganese chloride results in decreased expression of GRIN1 protein |
CTD |
PMID:20175136 |
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NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
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G |
Grin2a |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
decreases expression |
ISO |
manganese chloride results in decreased expression of GRIN2A mRNA; manganese chloride results in decreased expression of GRIN2A protein |
CTD |
PMID:20175136 |
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NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
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G |
Grin2b |
glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
decreases expression |
ISO |
manganese chloride results in decreased expression of GRIN2B mRNA; manganese chloride results in decreased expression of GRIN2B protein |
CTD |
PMID:20175136 |
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NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions increases activity decreases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased phosphorylation of GSK3B protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased activity of GSK3B protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]; manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein |
CTD |
PMID:20937724 PMID:24464479 |
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NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
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G |
Gskip |
GSK3B interacting protein |
increases expression |
ISO |
manganese chloride results in increased expression of GSKIP mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:105,651,611...105,669,317
Ensembl chr12:105,651,088...105,669,282
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G |
Gspt2 |
G1 to S phase transition 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GSPT2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr X:93,679,675...93,682,168
Ensembl chr X:93,679,675...93,686,850
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G |
Gsr |
glutathione reductase |
decreases expression multiple interactions |
ISO EXP |
manganese chloride results in decreased expression of GSR mRNA manganese chloride results in decreased expression of GSR protein [manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein] |
CTD |
PMID:17175027 PMID:24969583 PMID:25288107 PMID:32445656 |
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NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
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G |
Gsto1 |
glutathione S-transferase omega 1 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GSTO1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GSTO1 protein |
CTD |
PMID:38129942 |
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NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229
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G |
Gtf2h1 |
general transcription factor II H, polypeptide 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of GTF2H1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:46,445,518...46,473,224
Ensembl chr 7:46,445,527...46,473,224
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G |
H1f1 |
H1.1 linker histone, cluster member |
decreases expression |
ISO |
manganese chloride results in decreased expression of H1F1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:23,947,651...23,948,395
Ensembl chr13:23,947,649...23,948,389
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases expression |
ISO |
manganese chloride results in decreased expression of H1F2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350
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G |
H2bc27 |
H2B clustered histone 27 |
decreases expression |
ISO |
manganese chloride results in decreased expression of H2BU1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:58,839,737...58,840,198
Ensembl chr11:58,839,746...58,840,359
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G |
H2bc4 |
H2B clustered histone 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HIST1H2BC mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891
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G |
H2bc8 |
H2B clustered histone 8 |
decreases expression |
ISO |
manganese chloride results in decreased expression of H2BC8 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:23,755,574...23,756,037
Ensembl chr13:23,755,570...23,756,187
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G |
H3c1 |
H3 clustered histone 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of H3C1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression multiple interactions |
ISO EXP |
manganese chloride results in decreased expression of HAMP mRNA [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of HAMP protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HAMP protein |
CTD |
PMID:20635692 PMID:34590183 |
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NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457
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G |
Hapln3 |
hyaluronan and proteoglycan link protein 3 |
increases expression |
ISO |
manganese chloride results in increased expression of HAPLN3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:78,766,775...78,783,100
Ensembl chr 7:78,764,850...78,780,766
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G |
Hat1 |
histone aminotransferase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HAT1 protein |
CTD |
PMID:29155171 |
|
NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966
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G |
Hc |
hemolytic complement |
decreases expression |
ISO |
manganese chloride results in decreased expression of C5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450
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G |
Hdac1 |
histone deacetylase 1 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]] |
CTD |
PMID:34800614 |
|
NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of HDAC2 mRNA |
CTD |
PMID:29155171 |
|
NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885
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G |
Hdac3 |
histone deacetylase 3 |
increases expression multiple interactions |
ISO |
manganese chloride results in increased expression of HDAC3 mRNA; manganese chloride results in increased expression of HDAC3 protein [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]] |
CTD |
PMID:29155171 PMID:34800614 |
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NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069
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G |
Hdac4 |
histone deacetylase 4 |
increases expression |
ISO |
manganese chloride results in increased expression of HDAC4 mRNA; manganese chloride results in increased expression of HDAC4 protein |
CTD |
PMID:29155171 |
|
NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421
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G |
Hdgfl3 |
HDGF like 3 |
increases expression |
ISO |
manganese chloride results in increased expression of HDGFL3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:81,531,004...81,587,227
Ensembl chr 7:81,530,999...81,584,221
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G |
Heatr3 |
HEAT repeat containing 3 |
increases expression |
ISO |
manganese chloride results in increased expression of HEATR3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:88,864,453...88,901,656
Ensembl chr 8:88,864,483...88,898,655
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G |
Heph |
hephaestin |
increases expression |
ISO |
manganese chloride results in increased expression of HEPH mRNA |
CTD |
PMID:17175027 |
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NCBI chr X:95,499,042...95,618,091
Ensembl chr X:95,498,965...95,618,091
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G |
Hexd |
hexosaminidase D |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA |
CTD |
PMID:35690225 |
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NCBI chr11:121,095,187...121,113,485
Ensembl chr11:121,095,259...121,113,481
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G |
Hey1 |
hairy/enhancer-of-split related with YRPW motif 1 |
increases expression |
ISO |
manganese chloride results in increased expression of HEY1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316
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G |
Hfe |
homeostatic iron regulator |
multiple interactions decreases response to substance |
EXP |
HFE gene mutant form inhibits the reaction [manganese chloride results in decreased activity of SOD1 protein] HFE gene mutant form results in decreased susceptibility to manganese chloride |
CTD |
PMID:25874029 |
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NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837
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G |
Hif1a |
hypoxia inducible factor 1, alpha subunit |
increases expression multiple interactions decreases hydroxylation increases stability decreases degradation decreases expression |
ISO EXP |
manganese chloride results in increased expression of HIF1A mRNA; manganese chloride results in increased expression of HIF1A protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased degradation of HIF1A protein; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased hydroxylation of HIF1A protein; Ascorbic Acid inhibits the reaction [manganese chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [manganese chloride results in increased stability of HIF1A protein]; HIF1A mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; VHL protein affects the reaction [manganese chloride results in increased expression of HIF1A protein] manganese chloride results in decreased degradation of HIF1A protein manganese chloride results in decreased expression of HIF1A mRNA [[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A protein |
CTD |
PMID:17175027 PMID:17467022 PMID:19074761 PMID:19263519 PMID:20152896 PMID:28801915 PMID:34590183 More...
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NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
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G |
Hif1an |
hypoxia-inducible factor 1, alpha subunit inhibitor |
decreases expression |
ISO |
manganese chloride results in decreased expression of HIF1AN mRNA |
CTD |
PMID:17175027 |
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NCBI chr19:44,551,293...44,564,713
Ensembl chr19:44,551,289...44,564,713
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G |
Hilpda |
hypoxia inducible lipid droplet associated |
increases expression |
ISO |
manganese chloride results in increased expression of HILPDA mRNA |
CTD |
PMID:22281203 |
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NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445
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G |
Hipk3 |
homeodomain interacting protein kinase 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HIPK3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:104,256,826...104,324,834
Ensembl chr 2:104,256,826...104,324,791
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G |
Hmbox1 |
homeobox containing 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HMBOX1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:65,049,049...65,187,354
Ensembl chr14:65,049,049...65,187,320
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G |
Hmcn2 |
hemicentin 2 |
increases expression |
ISO |
manganese chloride results in increased expression of HMCN2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:31,204,273...31,350,751
Ensembl chr 2:31,204,427...31,350,750
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G |
Hmgb1 |
high mobility group box 1 |
increases expression multiple interactions |
ISO |
manganese chloride results in increased expression of HMGB1 mRNA corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]; manganese chloride results in increased expression of and affects the localization of HMGB1 protein |
CTD |
PMID:30578841 |
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NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
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G |
Hmgcs2 |
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HMGCS2 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054
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G |
Hmox1 |
heme oxygenase 1 |
affects response to substance multiple interactions increases expression |
EXP ISO |
HMOX1 protein affects the susceptibility to manganese chloride 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]; manganese chloride promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 protein] HMOX1 protein inhibits the reaction [manganese chloride results in increased abundance of Hydrogen Peroxide]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein] manganese chloride results in increased expression of HMOX1 mRNA; manganese chloride results in increased expression of HMOX1 protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 mRNA |
CTD |
PMID:21107535 PMID:21384399 PMID:21963524 PMID:22281203 PMID:25288107 PMID:29054681 PMID:30040983 PMID:32574669 PMID:38503349 More...
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Hoxb9 |
homeobox B9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HOXB9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:96,162,156...96,167,421
Ensembl chr11:96,162,283...96,167,421
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G |
Hoxd4 |
homeobox D4 |
increases expression |
ISO |
manganese chloride results in increased expression of HOXD4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:74,552,322...74,559,504
Ensembl chr 2:74,542,273...74,559,504
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G |
Hpx |
hemopexin |
decreases expression |
ISO |
manganese chloride results in decreased expression of HPX mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344
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G |
Hrh1 |
histamine receptor H1 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of HRH1 gene |
CTD |
PMID:27913844 |
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NCBI chr 6:114,374,897...114,459,432
Ensembl chr 6:114,374,897...114,460,257
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G |
Hrk |
harakiri, BCL2 interacting protein (contains only BH3 domain) |
increases expression decreases methylation |
ISO |
manganese chloride results in increased expression of HRK mRNA manganese chloride results in decreased methylation of HRK gene |
CTD |
PMID:28801915 |
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NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of HSD11B1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383
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G |
Hsp90b1 |
heat shock protein 90, beta (Grp94), member 1 |
multiple interactions increases expression |
ISO |
SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein] manganese chloride results in increased expression of HSP90B1 mRNA; manganese chloride results in increased expression of HSP90B1 protein |
CTD |
PMID:23934647 PMID:23948121 |
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NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373
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G |
Hspa4l |
heat shock protein 4 like |
increases expression |
ISO |
manganese chloride results in increased expression of HSPA4L mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:40,698,664...40,750,538
Ensembl chr 3:40,699,814...40,750,538
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G |
Hspa5 |
heat shock protein 5 |
multiple interactions increases expression |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein] manganese chloride results in increased expression of HSPA5 mRNA; manganese chloride results in increased expression of HSPA5 protein |
CTD |
PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669 |
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NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
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G |
Hspb8 |
heat shock protein 8 |
decreases expression |
ISO |
manganese chloride results in decreased expression of HSPB8 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923
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G |
Htra1 |
HtrA serine peptidase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of HTRA1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390
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G |
Htt |
huntingtin |
affects response to substance |
EXP |
HTT affects the susceptibility to manganese chloride |
CTD |
PMID:22363539 |
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NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions decreases expression |
ISO |
manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased expression of ICAM1 protein] manganese chloride results in decreased expression of ICAM1 protein |
CTD |
PMID:23329836 |
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NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
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G |
Id1 |
inhibitor of DNA binding 1, HLH protein |
increases expression |
EXP |
manganese chloride results in increased expression of ID1 mRNA |
CTD |
PMID:17467022 |
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NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression decreases expression |
ISO |
manganese chloride results in increased expression of ID2 mRNA manganese chloride results in decreased expression of ID2 mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
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G |
Idh3g |
isocitrate dehydrogenase 3 (NAD+), gamma |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of IDH3G mRNA |
CTD |
PMID:35690225 |
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NCBI chr X:72,822,569...72,830,471
Ensembl chr X:72,822,569...72,830,503
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G |
Ifi204 |
interferon activated gene 204 |
decreases expression |
ISO |
manganese chloride results in decreased expression of IFI204 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:173,574,859...173,594,606
Ensembl chr 1:173,574,859...173,594,509
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G |
Ifi211 |
interferon activated gene 211 |
decreases expression |
ISO |
manganese chloride results in decreased expression of IFI204 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:173,723,907...173,740,650
Ensembl chr 1:173,723,911...173,740,612
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G |
Ifng |
interferon gamma |
increases expression multiple interactions |
ISO EXP |
manganese chloride results in increased expression of IFNG protein manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]] |
CTD |
PMID:16168523 PMID:20798247 |
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NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
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G |
Ift70a1 |
intraflagellar transport 70A1 |
increases expression |
ISO |
manganese chloride results in increased expression of IFT70A1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:75,809,450...75,812,311
Ensembl chr 2:75,808,591...75,812,311
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G |
Igf1 |
insulin-like growth factor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of IGF1 mRNA |
CTD |
PMID:21402727 |
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NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
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G |
Igf1r |
insulin-like growth factor I receptor |
increases expression decreases expression |
ISO |
manganese chloride results in increased expression of IGF1R protein manganese chloride results in decreased expression of IGF1R mRNA |
CTD |
PMID:19276553 PMID:21402727 |
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NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416
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G |
Igf2 |
insulin-like growth factor 2 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of IGF2 gene |
CTD |
PMID:27913844 |
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NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553
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G |
Igf2r |
insulin-like growth factor 2 receptor |
decreases expression |
ISO |
manganese chloride results in decreased expression of IGF2R mRNA |
CTD |
PMID:19276553 |
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NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551
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G |
Igfbp5 |
insulin-like growth factor binding protein 5 |
increases expression |
ISO |
manganese chloride results in increased expression of IGFBP5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043
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G |
Ikbkb |
inhibitor of kappaB kinase beta |
multiple interactions |
EXP ISO |
IKBKB gene mutant form results in increased susceptibility to [manganese chloride results in increased abundance of Manganese] [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:32692843 PMID:34310962 |
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NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
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G |
Il12a |
interleukin 12a |
increases expression multiple interactions |
ISO EXP |
manganese chloride results in increased expression of IL12A mRNA manganese chloride results in increased expression of [IL12A protein binds to IL12B protein] manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:17175027 PMID:28539244 |
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NCBI chr 3:68,597,977...68,605,881
Ensembl chr 3:68,597,977...68,605,880
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G |
Il12b |
interleukin 12b |
increases expression multiple interactions |
EXP ISO |
manganese chloride results in increased expression of IL12B mRNA manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]] manganese chloride results in increased expression of [IL12A protein binds to IL12B protein] |
CTD |
PMID:28539244 |
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NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860
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G |
Il18 |
interleukin 18 |
multiple interactions increases expression |
EXP |
acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA] |
CTD |
PMID:28539244 |
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NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
manganese chloride results in increased expression of IL1A mRNA |
CTD |
PMID:25219578 |
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NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
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G |
Il1b |
interleukin 1 beta |
increases expression multiple interactions decreases expression |
ISO EXP |
manganese chloride results in increased expression of IL1B protein [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein] [Lipopolysaccharides co-treated with manganese chloride] results in increased expression of IL1B protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA] manganese chloride results in decreased expression of IL1B mRNA [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B mRNA; [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B protein |
CTD |
PMID:15601679 PMID:18836210 PMID:27427241 PMID:28539244 PMID:33314588 PMID:34018660 More...
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il1r1 |
interleukin 1 receptor, type I |
increases expression |
ISO |
manganese chloride results in increased expression of IL1R1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417
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G |
Il1r2 |
interleukin 1 receptor, type II |
increases expression |
ISO |
manganese chloride results in increased expression of IL1R2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391
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G |
Il1rl1 |
interleukin 1 receptor-like 1 |
decreases expression increases expression |
ISO |
manganese chloride results in decreased expression of IL1RL1 mRNA manganese chloride results in increased expression of IL1RL1 mRNA |
CTD |
PMID:26745496 PMID:28801915 |
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NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression |
ISO |
manganese chloride results in increased expression of IL1RN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
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G |
Il23a |
interleukin 23, alpha subunit p19 |
increases expression |
ISO |
manganese chloride results in increased expression of IL23A mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621
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G |
Il36rn |
interleukin 36 receptor antagonist |
increases expression |
ISO |
manganese chloride results in increased expression of IL36RN mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:24,166,966...24,172,444
Ensembl chr 2:24,166,966...24,173,438
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G |
Il4 |
interleukin 4 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 protein |
CTD |
PMID:34018660 |
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NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression decreases expression increases secretion |
EXP ISO |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 protein; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Lipopolysaccharides promotes the reaction [manganese chloride results in increased expression of IL6 protein]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]] manganese chloride results in increased expression of IL6 mRNA manganese chloride results in increased expression of IL6 mRNA; manganese chloride results in increased expression of IL6 protein manganese chloride results in decreased expression of IL6 mRNA manganese chloride results in increased secretion of IL6 protein manganese chloride promotes the reaction [SNCA protein results in increased expression of IL6 mRNA] |
CTD |
PMID:15601679 PMID:17065364 PMID:19815061 PMID:21963524 PMID:25219578 PMID:27427241 PMID:28539244 PMID:34018660 More...
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Il7 |
interleukin 7 |
increases expression |
ISO |
manganese chloride results in increased expression of IL7 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
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G |
Ins2 |
insulin II |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein] |
CTD |
PMID:31555879 |
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NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
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G |
Insig1 |
insulin induced gene 1 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of INSIG1 gene manganese chloride results in decreased expression of INSIG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660
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G |
Insr |
insulin receptor |
decreases expression increases phosphorylation increases expression |
ISO |
manganese chloride results in decreased expression of INSR mRNA manganese chloride results in increased phosphorylation of INSR protein manganese chloride results in increased expression of INSR mRNA |
CTD |
PMID:2475105 PMID:19276553 PMID:28801915 |
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NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
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G |
Ints2 |
integrator complex subunit 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of INTS2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:86,101,507...86,148,912
Ensembl chr11:86,101,507...86,148,401
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G |
Ipo11 |
importin 11 |
decreases expression |
ISO |
manganese chloride results in decreased expression of IPO11 mRNA |
CTD |
PMID:17175027 |
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NCBI chr13:106,930,947...107,073,466
Ensembl chr13:106,930,947...107,073,466
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G |
Iqcg |
IQ motif containing G |
increases expression |
ISO |
manganese chloride results in increased expression of IQCG mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:32,834,640...32,876,617
Ensembl chr16:32,833,053...32,876,588
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G |
Iqgap1 |
IQ motif containing GTPase activating protein 1 |
increases expression |
ISO |
manganese chloride results in increased expression of IQGAP1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:80,361,331...80,453,288
Ensembl chr 7:80,361,331...80,475,722
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G |
Ireb2 |
iron responsive element binding protein 2 |
decreases activity increases activity |
ISO |
manganese chloride results in decreased activity of IREB2 protein manganese chloride results in increased activity of IREB2 protein |
CTD |
PMID:15893546 PMID:16568477 |
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NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814
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G |
Irf2 |
interferon regulatory factor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of IRF2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:47,192,751...47,300,493
Ensembl chr 8:47,192,767...47,300,493
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G |
Ism1 |
isthmin 1, angiogenesis inhibitor |
increases expression |
ISO |
manganese chloride results in increased expression of ISM1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:139,515,169...139,600,500
Ensembl chr 2:139,520,098...139,600,501
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G |
Itga10 |
integrin, alpha 10 |
increases expression |
ISO |
manganese chloride results in increased expression of ITGA10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 3:96,552,900...96,571,835
Ensembl chr 3:96,552,900...96,571,835
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G |
Itga2b |
integrin alpha 2b |
multiple interactions |
EXP |
manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein] |
CTD |
PMID:20971947 |
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NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948
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G |
Itga3 |
integrin alpha 3 |
increases expression |
ISO |
manganese chloride results in increased expression of ITGA3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627
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G |
Itga8 |
integrin alpha 8 |
increases expression increases methylation |
ISO |
manganese chloride results in increased expression of ITGA8 mRNA manganese chloride results in increased methylation of ITGA8 gene |
CTD |
PMID:28801915 |
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NCBI chr 2:12,111,443...12,306,755
Ensembl chr 2:12,111,443...12,306,733
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G |
Itgam |
integrin alpha M |
increases expression |
ISO |
manganese chloride results in increased expression of ITGAM protein |
CTD |
PMID:12106697 |
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NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663
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G |
Itgav |
integrin alpha V |
multiple interactions |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] |
CTD |
PMID:15213856 |
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NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260
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G |
Itgb3 |
integrin beta 3 |
multiple interactions |
EXP ISO |
manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] |
CTD |
PMID:15213856 PMID:20971947 |
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NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302
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G |
Itgb5 |
integrin beta 5 |
increases expression |
ISO |
manganese chloride results in increased expression of ITGB5 mRNA |
CTD |
PMID:17175027 |
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NCBI chr16:33,650,021...33,769,708
Ensembl chr16:33,650,035...33,769,708
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G |
Itgb6 |
integrin beta 6 |
decreases methylation increases expression increases methylation |
ISO |
manganese chloride results in decreased methylation of ITGB6 gene manganese chloride results in increased expression of ITGB6 mRNA manganese chloride results in increased methylation of ITGB6 gene |
CTD |
PMID:27913844 PMID:28801915 |
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NCBI chr 2:60,428,636...60,553,005
Ensembl chr 2:60,428,636...60,552,987
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G |
Itih1 |
inter-alpha trypsin inhibitor, heavy chain 1 |
multiple interactions |
ISO |
manganese chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein] |
CTD |
PMID:16768462 |
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NCBI chr14:30,651,137...30,665,246
Ensembl chr14:30,651,137...30,665,246
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G |
Itih2 |
inter-alpha trypsin inhibitor, heavy chain 2 |
multiple interactions |
ISO |
manganese chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein] |
CTD |
PMID:16768462 |
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NCBI chr 2:10,099,408...10,135,492
Ensembl chr 2:10,099,404...10,136,207
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G |
Jun |
jun proto-oncogene |
multiple interactions increases phosphorylation |
ISO |
manganese chloride results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein] |
CTD |
PMID:9751194 PMID:15342272 |
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NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Kcng1 |
potassium voltage-gated channel, subfamily G, member 1 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:168,102,037...168,123,453
Ensembl chr 2:168,102,037...168,123,656
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G |
Kcnh4 |
potassium voltage-gated channel, subfamily H (eag-related), member 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KCNH4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:100,631,204...100,650,941
Ensembl chr11:100,631,202...100,650,768
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G |
Kcnh6 |
potassium voltage-gated channel, subfamily H (eag-related), member 6 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNH6 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:105,898,871...105,926,421
Ensembl chr11:105,898,950...105,925,375
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G |
Kcnip3 |
Kv channel interacting protein 3, calsenilin |
increases expression |
ISO |
manganese chloride results in increased expression of KCNIP3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014
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G |
Kcnj11 |
potassium inwardly rectifying channel, subfamily J, member 11 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein |
CTD |
PMID:32659473 |
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NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188
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G |
Kcnj3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNJ3 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 2:55,301,814...55,488,157
Ensembl chr 2:55,325,982...55,488,157
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G |
Kcnj8 |
potassium inwardly-rectifying channel, subfamily J, member 8 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein |
CTD |
PMID:32659473 |
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NCBI chr 6:142,510,563...142,517,340
Ensembl chr 6:142,510,563...142,517,340
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G |
Kcnk12 |
potassium channel, subfamily K, member 12 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KCNK12 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:88,049,100...88,106,329
Ensembl chr17:88,053,229...88,105,422
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G |
Kcnq1 |
potassium voltage-gated channel, subfamily Q, member 1 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNQ1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:142,660,614...142,980,787
Ensembl chr 7:142,660,099...142,980,779
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G |
Kcnq2 |
potassium voltage-gated channel, subfamily Q, member 2 |
increases expression |
ISO |
manganese chloride results in increased expression of KCNQ2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:180,717,372...180,777,368
Ensembl chr 2:180,717,372...180,777,093
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G |
Keap1 |
kelch-like ECH-associated protein 1 |
affects expression multiple interactions |
EXP |
manganese chloride affects the expression of KEAP1 protein Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein] |
CTD |
PMID:25288107 |
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NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657
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G |
Kera |
keratocan |
increases expression |
ISO |
manganese chloride results in increased expression of KERA mRNA |
CTD |
PMID:26745496 |
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NCBI chr10:97,442,873...97,449,555
Ensembl chr10:97,442,741...97,449,554
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G |
Kif3b |
kinesin family member 3B |
increases expression |
ISO |
manganese chloride results in increased expression of KIF3B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:153,132,028...153,175,310
Ensembl chr 2:153,133,333...153,175,310
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G |
Kif5c |
kinesin family member 5C |
increases expression |
ISO |
manganese chloride results in increased expression of KIF5C mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790
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G |
Kiss1r |
KISS1 receptor |
increases expression |
ISO |
manganese chloride results in increased expression of KISS1R mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:79,752,786...79,759,922
Ensembl chr10:79,752,805...79,758,107
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G |
Klf2 |
Kruppel-like transcription factor 2 (lung) |
increases expression |
ISO |
manganese chloride results in increased expression of KLF2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:73,072,906...73,075,498
Ensembl chr 8:73,072,877...73,075,500
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G |
Klf4 |
Kruppel-like transcription factor 4 (gut) |
increases expression |
ISO |
manganese chloride results in increased expression of KLF4 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466
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G |
Klf5 |
Kruppel-like transcription factor 5 |
decreases expression decreases methylation increases expression |
EXP ISO |
manganese chloride results in decreased expression of KLF5 mRNA manganese chloride results in decreased methylation of KLF5 gene manganese chloride results in increased expression of KLF5 mRNA |
CTD |
PMID:17467022 PMID:28801915 |
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NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472
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G |
Klf9 |
Kruppel-like transcription factor 9 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KLF9 mRNA |
CTD |
PMID:17175027 |
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NCBI chr19:23,118,590...23,145,493
Ensembl chr19:23,118,590...23,145,498
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G |
Klhdc8a |
kelch domain containing 8A |
increases expression |
ISO |
manganese chloride results in increased expression of KLHDC8A mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:132,226,352...132,236,216
Ensembl chr 1:132,226,364...132,235,095
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G |
Kng1 |
kininogen 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KNG1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828
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G |
Krt7 |
keratin 7 |
increases expression |
ISO |
manganese chloride results in increased expression of KRT7 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,310,284...101,325,687
Ensembl chr15:101,308,924...101,328,194
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G |
Krt76 |
keratin 76 |
increases expression |
ISO |
manganese chloride results in increased expression of KRT76 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,792,786...101,801,355
Ensembl chr15:101,792,786...101,801,355
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G |
Krt79 |
keratin 79 |
decreases expression |
ISO |
manganese chloride results in decreased expression of KRT79 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,837,767...101,848,759
Ensembl chr15:101,837,767...101,848,759
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G |
Krt81 |
keratin 81 |
increases expression |
ISO |
manganese chloride results in increased expression of KRT81 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,356,942...101,361,646
Ensembl chr15:101,356,942...101,361,632
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G |
Krt87 |
keratin 87 |
increases expression |
ISO |
manganese chloride results in increased expression of KRT83 mRNA |
CTD |
PMID:28801915 |
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NCBI chr15:101,329,371...101,336,685
Ensembl chr15:101,328,919...101,336,685
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G |
Lacc1 |
laccase domain containing 1 |
increases expression |
ISO |
manganese chloride results in increased expression of LACC1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein] |
CTD |
PMID:31690173 |
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NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338
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G |
Lamp2 |
lysosomal-associated membrane protein 2 |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP2 protein |
CTD |
PMID:31690173 |
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NCBI chr X:37,488,524...37,545,337
Ensembl chr X:37,490,234...37,545,331
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G |
Lcat |
lecithin cholesterol acyltransferase |
increases expression |
ISO |
manganese chloride results in increased expression of LCAT mRNA |
CTD |
PMID:28801915 |
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NCBI chr 8:106,666,183...106,670,034
Ensembl chr 8:106,666,183...106,670,014
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G |
Lck |
lymphocyte protein tyrosine kinase |
multiple interactions |
ISO |
[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein] |
CTD |
PMID:8662792 |
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NCBI chr 4:129,442,142...129,467,415
Ensembl chr 4:129,442,137...129,467,434
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G |
Ldlrad4 |
low density lipoprotein receptor class A domain containing 4 |
increases expression |
ISO |
manganese chloride results in increased expression of LDLRAD4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:68,065,345...68,393,621
Ensembl chr18:68,066,328...68,401,701
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G |
Lefty2 |
left-right determination factor 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LEFTY2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr 1:180,720,673...180,726,672
Ensembl chr 1:180,720,673...180,726,668
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G |
Lgals3 |
lectin, galactose binding, soluble 3 |
increases expression |
ISO |
manganese chloride results in increased expression of LGALS3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617
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G |
Lgi4 |
leucine-rich repeat LGI family, member 4 |
increases expression |
ISO |
manganese chloride results in increased expression of LGI4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:30,758,360...30,770,347
Ensembl chr 7:30,758,767...30,770,360
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G |
Lgr4 |
leucine-rich repeat-containing G protein-coupled receptor 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LGR4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:109,747,919...109,844,602
Ensembl chr 2:109,747,992...109,844,602
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G |
Lhb |
luteinizing hormone beta |
decreases expression multiple interactions |
ISO |
manganese chloride results in decreased expression of LHB protein Quercetin inhibits the reaction [manganese chloride results in decreased expression of LHB protein] |
CTD |
PMID:28040552 |
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NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
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G |
Lhfpl2 |
lipoma HMGIC fusion partner-like 2 |
increases expression |
ISO |
manganese chloride results in increased expression of LHFPL2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr13:94,193,659...94,331,918
Ensembl chr13:94,194,304...94,331,917
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G |
Lhx1 |
LIM homeobox protein 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LHX1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:84,408,801...84,416,360
Ensembl chr11:84,409,110...84,416,361
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G |
Lif |
leukemia inhibitory factor |
increases expression |
ISO |
manganese chloride results in increased expression of LIF mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514
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G |
Lman2 |
lectin, mannose-binding 2 |
increases expression |
ISO |
manganese chloride results in increased expression of LMAN2 mRNA |
CTD |
PMID:17175027 |
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NCBI chr13:55,491,646...55,510,596
Ensembl chr13:55,491,646...55,510,596
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G |
Lmod2 |
leiomodin 2 (cardiac) |
decreases expression |
ISO |
manganese chloride results in decreased expression of LMOD2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:24,597,770...24,605,413
Ensembl chr 6:24,597,761...24,605,413
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G |
Lox |
lysyl oxidase |
decreases expression |
ISO |
manganese chloride results in decreased expression of LOX mRNA |
CTD |
PMID:28801915 |
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NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
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G |
Lpar1 |
lysophosphatidic acid receptor 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LPAR1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898
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G |
Lpcat4 |
lysophosphatidylcholine acyltransferase 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LPCAT4 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:112,070,186...112,077,456
Ensembl chr 2:112,069,813...112,077,456
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G |
Lpin1 |
lipin 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LPIN1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967
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G |
Lrat |
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) |
increases expression |
ISO |
manganese chloride results in increased expression of LRAT mRNA |
CTD |
PMID:26745496 |
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NCBI chr 3:82,799,889...82,811,281
Ensembl chr 3:82,799,886...82,811,280
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G |
Lrp2 |
low density lipoprotein receptor-related protein 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of LRP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409
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G |
Lrp8 |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
increases expression |
EXP |
manganese chloride results in increased expression of LRP8 mRNA |
CTD |
PMID:22407947 |
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NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037
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G |
Lrrc10b |
leucine rich repeat containing 10B |
increases methylation |
ISO |
manganese chloride results in increased methylation of LRRC10B gene |
CTD |
PMID:28801915 |
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NCBI chr19:10,432,735...10,434,811
Ensembl chr19:10,432,735...10,434,837
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G |
Lrrc15 |
leucine rich repeat containing 15 |
increases expression |
ISO |
manganese chloride results in increased expression of LRRC15 mRNA |
CTD |
PMID:28801915 |
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NCBI chr16:30,088,120...30,102,072
Ensembl chr16:30,088,120...30,102,074
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G |
Lrrc8b |
leucine rich repeat containing 8 family, member B |
increases expression |
ISO |
manganese chloride results in increased expression of LRRC8B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:105,563,072...105,637,945
Ensembl chr 5:105,563,641...105,637,940
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G |
Lrrk1 |
leucine-rich repeat kinase 1 |
increases expression |
ISO |
manganese chloride results in increased expression of LRRK1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 7:65,908,493...66,038,089
Ensembl chr 7:65,876,660...66,038,098
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G |
Lsm2 |
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LSM2 mRNA |
CTD |
PMID:35690225 |
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NCBI chr17:35,200,830...35,204,867
Ensembl chr17:35,200,838...35,204,867
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G |
Ly6g5b |
lymphocyte antigen 6 family member G5B |
increases expression |
ISO |
manganese chloride results in increased expression of LY6G5B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:35,332,920...35,337,534
Ensembl chr17:35,332,924...35,334,404
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of LYN gene |
CTD |
PMID:27913844 |
|
NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122
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G |
Lypd6b |
LY6/PLAUR domain containing 6B |
decreases expression |
ISO |
manganese chloride results in decreased expression of LYPD6B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:49,677,380...49,838,861
Ensembl chr 2:49,677,700...49,838,861
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G |
Lyrm7 |
LYR motif containing 7 |
increases expression |
ISO |
manganese chloride results in increased expression of LYRM7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:54,717,692...54,751,738
Ensembl chr11:54,717,692...54,751,742
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G |
Lyrm9 |
LYR motif containing 9 |
increases expression |
ISO |
manganese chloride results in increased expression of LYRM9 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:78,717,421...78,734,725
Ensembl chr11:78,717,410...78,737,696
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G |
Macrod2 |
mono-ADP ribosylhydrolase 2 |
increases expression |
ISO |
manganese chloride results in increased expression of MACROD2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:140,237,223...142,234,886
Ensembl chr 2:140,237,229...142,234,886
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G |
Madcam1 |
mucosal vascular addressin cell adhesion molecule 1 |
increases expression |
ISO |
manganese chloride results in increased expression of MADCAM1 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:79,500,393...79,504,376
Ensembl chr10:79,500,393...79,504,371
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G |
Maff |
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) |
increases expression |
ISO |
manganese chloride results in increased expression of MAFF mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276
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G |
Mall |
mal, T cell differentiation protein-like |
decreases expression |
ISO |
manganese chloride results in decreased expression of MALL mRNA |
CTD |
PMID:26745496 |
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NCBI chr 2:127,546,310...127,571,817
Ensembl chr 2:127,546,306...127,571,852
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA] |
CTD |
PMID:31690173 |
|
NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499
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G |
Map2 |
microtubule-associated protein 2 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MAP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742
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G |
Map2k3 |
mitogen-activated protein kinase kinase 3 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of MAP2K3 gene |
CTD |
PMID:27913844 |
|
NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637
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G |
Map2k4 |
mitogen-activated protein kinase kinase 4 |
increases phosphorylation |
ISO |
manganese chloride results in increased phosphorylation of MAP2K4 protein |
CTD |
PMID:9751194 PMID:15342272 |
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NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123
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G |
Map3k11 |
mitogen-activated protein kinase kinase kinase 11 |
increases phosphorylation |
ISO |
manganese chloride results in increased phosphorylation of MAP3K11 protein |
CTD |
PMID:15342272 |
|
NCBI chr19:5,738,764...5,752,893
Ensembl chr19:5,738,770...5,752,893
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G |
Map3k7 |
mitogen-activated protein kinase kinase kinase 7 |
increases methylation |
ISO |
manganese chloride results in increased methylation of MAP3K7 gene |
CTD |
PMID:27913844 |
|
NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467
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G |
Map4k3 |
mitogen-activated protein kinase kinase kinase kinase 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MAP4K3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr17:80,887,942...81,039,118
Ensembl chr17:80,887,941...81,035,914
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G |
Map7 |
microtubule-associated protein 7 |
increases expression |
ISO |
manganese chloride results in increased expression of MAP7 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:20,024,666...20,157,336
Ensembl chr10:20,024,217...20,157,336
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G |
Map7d2 |
MAP7 domain containing 2 |
increases methylation decreases expression |
ISO |
manganese chloride results in increased methylation of MAP7D2 gene manganese chloride results in decreased expression of MAP7D2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr X:158,197,488...158,281,954
Ensembl chr X:158,197,568...158,281,753
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions increases activity increases phosphorylation decreases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein] manganese chloride results in increased activity of MAPK1 protein manganese chloride results in decreased phosphorylation of MAPK1 protein [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein] |
CTD |
PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 PMID:20937724 PMID:23811825 PMID:24324973 PMID:25981801 PMID:30040983 PMID:31676349 PMID:31690173 PMID:32574669 More...
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk11 |
mitogen-activated protein kinase 11 |
increases expression |
ISO |
manganese chloride results in increased expression of MAPK11 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr15:89,026,685...89,033,809
Ensembl chr15:89,026,689...89,033,831
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G |
Mapk14 |
mitogen-activated protein kinase 14 |
increases phosphorylation increases expression |
ISO EXP |
manganese chloride results in increased phosphorylation of MAPK14 protein manganese chloride results in increased expression of MAPK14 mRNA |
CTD |
PMID:15737199 PMID:17467022 |
|
NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions increases activity increases phosphorylation decreases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein] manganese chloride results in increased activity of MAPK3 protein manganese chloride results in decreased phosphorylation of MAPK3 protein [manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein] NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein] |
CTD |
PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 PMID:20937724 PMID:23811825 PMID:24324973 PMID:25981801 PMID:30040983 PMID:31676349 PMID:31690173 PMID:32574669 More...
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases activity increases phosphorylation increases methylation multiple interactions |
ISO |
manganese chloride results in increased activity of MAPK8 protein manganese chloride results in increased phosphorylation of MAPK8 protein manganese chloride results in increased methylation of MAPK8 gene [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19084589 PMID:20152896 PMID:24324973 PMID:27913844 PMID:30951808 PMID:32574669 More...
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NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases activity increases phosphorylation |
ISO |
manganese chloride results in increased activity of MAPK9 protein manganese chloride results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:19084589 PMID:20152896 |
|
NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein] |
CTD |
PMID:20937724 |
|
NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916
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G |
Masp1 |
MBL associated serine protease 1 |
decreases methylation |
ISO |
manganese chloride results in decreased methylation of MASP1 gene |
CTD |
PMID:27913844 |
|
NCBI chr16:23,261,778...23,340,127
Ensembl chr16:23,268,167...23,339,565
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G |
Matn3 |
matrilin 3 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MATN3 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr12:8,997,929...9,022,028
Ensembl chr12:8,997,929...9,022,028
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G |
Mbp |
myelin basic protein |
increases expression |
ISO |
manganese chloride results in increased expression of MBP mRNA |
CTD |
PMID:17175027 |
|
NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762
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G |
Mcf2l |
mcf.2 transforming sequence-like |
increases expression |
EXP |
manganese chloride results in increased expression of MCF2L mRNA |
CTD |
PMID:15295902 |
|
NCBI chr 8:12,923,806...13,070,502
Ensembl chr 8:12,923,806...13,070,905
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G |
Mchr1 |
melanin-concentrating hormone receptor 1 |
increases expression |
ISO |
manganese chloride results in increased expression of MCHR1 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr15:81,119,700...81,123,165
Ensembl chr15:81,119,700...81,123,165
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G |
Mcl1 |
myeloid cell leukemia sequence 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MCL1 protein |
CTD |
PMID:27107493 |
|
NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
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G |
Mcm4 |
minichromosome maintenance complex component 4 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MCM4 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
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G |
Mcm5 |
minichromosome maintenance complex component 5 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MCM5 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 8:75,836,096...75,855,067
Ensembl chr 8:75,836,197...75,855,067
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G |
Mcoln3 |
mucolipin 3 |
increases expression |
ISO |
manganese chloride results in increased expression of MCOLN3 mRNA |
CTD |
PMID:26745496 |
|
NCBI chr 3:145,799,032...145,847,563
Ensembl chr 3:145,823,205...145,847,561
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G |
Mdh1 |
malate dehydrogenase 1, NAD (soluble) |
multiple interactions |
EXP |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MDH1 mRNA |
CTD |
PMID:35690225 |
|
NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367
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G |
Mdm2 |
transformed mouse 3T3 cell double minute 2 |
increases expression |
ISO |
manganese chloride results in increased expression of MDM2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663
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G |
Me3 |
malic enzyme 3, NADP(+)-dependent, mitochondrial |
increases expression |
ISO |
manganese chloride results in increased expression of ME3 mRNA |
CTD |
PMID:17175027 |
|
NCBI chr 7:89,281,492...89,503,423
Ensembl chr 7:89,281,600...89,503,567
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G |
Medag |
mesenteric estrogen dependent adipogenesis |
increases expression |
ISO |
manganese chloride results in increased expression of MEDAG mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:149,335,214...149,355,188
Ensembl chr 5:149,335,214...149,355,188
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G |
Mef2c |
myocyte enhancer factor 2C |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of MEF2C mRNA manganese chloride results in increased methylation of MEF2C gene |
CTD |
PMID:28801915 |
|
NCBI chr13:83,652,136...83,815,197
Ensembl chr13:83,652,153...83,815,199
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G |
Mepe |
matrix extracellular phosphoglycoprotein with ASARM motif (bone) |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of MEPE gene manganese chloride results in increased expression of MEPE mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 5:104,473,195...104,486,477
Ensembl chr 5:104,473,195...104,486,477
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G |
Metap2 |
methionine aminopeptidase 2 |
multiple interactions increases activity |
ISO |
manganese chloride inhibits the reaction [Triazoles results in decreased activity of METAP2 protein] manganese chloride results in increased activity of METAP2 protein |
CTD |
PMID:12718546 |
|
NCBI chr10:93,694,351...93,732,952
Ensembl chr10:93,694,351...93,732,955
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G |
Mfap2 |
microfibrillar-associated protein 2 |
decreases methylation decreases expression |
ISO |
manganese chloride results in decreased methylation of MFAP2 gene manganese chloride results in decreased expression of MFAP2 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 4:140,737,735...140,743,284
Ensembl chr 4:140,737,729...140,743,295
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G |
Mfn2 |
mitofusin 2 |
decreases expression multiple interactions |
EXP |
manganese chloride results in decreased expression of MFN2 mRNA; manganese chloride results in decreased expression of MFN2 protein 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in decreased expression of MFN2 protein]]; Resveratrol inhibits the reaction [manganese chloride results in decreased expression of MFN2 protein] |
CTD |
PMID:28539244 PMID:34738708 |
|
NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161
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G |
Mfsd6 |
major facilitator superfamily domain containing 6 |
increases expression |
ISO |
manganese chloride results in increased expression of MFSD6 mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 1:52,695,463...52,766,495
Ensembl chr 1:52,695,445...52,766,621
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G |
Mga |
MAX gene associated |
increases expression |
ISO |
manganese chloride results in increased expression of MGA mRNA |
CTD |
PMID:28801915 |
|
NCBI chr 2:119,702,974...119,800,610
Ensembl chr 2:119,727,709...119,800,062
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G |
Mgat1 |
mannoside acetylglucosaminyltransferase 1 |
increases expression |
EXP |
manganese chloride results in increased expression of MGAT1 mRNA |
CTD |
PMID:15295902 |
|
NCBI chr11:49,135,018...49,153,854
Ensembl chr11:49,135,018...49,153,857
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G |
Mgat5b |
mannoside acetylglucosaminyltransferase 5, isoenzyme B |
increases expression |
ISO |
manganese chloride results in increased expression of MGAT5B mRNA |
CTD |
PMID:28801915 |
|
NCBI chr11:116,809,629...116,877,770
Ensembl chr11:116,809,689...116,877,774
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
increases methylation increases expression |
ISO |
manganese chloride results in increased methylation of MGMT gene manganese chloride results in increased expression of MGMT mRNA |
CTD |
PMID:27913844 PMID:28801915 |
|
NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995
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G |
Mgp |
matrix Gla protein |
increases expression |
ISO |
manganese chloride results in increased expression of MGP mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MGST1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753
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G |
Mgst3 |
microsomal glutathione S-transferase 3 |
increases expression |
ISO |
manganese chloride results in increased expression of MGST3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 1:167,199,535...167,221,410
Ensembl chr 1:167,199,535...167,221,410
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G |
Mia |
MIA SH3 domain containing |
increases expression |
ISO |
manganese chloride results in increased expression of MIA mRNA |
CTD |
PMID:17175027 PMID:28801915 |
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NCBI chr 7:26,879,166...26,880,574
Ensembl chr 7:26,879,167...26,880,582
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G |
Mical1 |
microtubule associated monooxygenase, calponin and LIM domain containing 1 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MICAL1 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:41,351,693...41,363,026
Ensembl chr10:41,352,310...41,363,028
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G |
Mir107 |
microRNA 107 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR107 mRNA |
CTD |
PMID:28986288 |
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NCBI chr19:34,798,087...34,798,173
Ensembl chr19:34,798,087...34,798,173
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G |
Mir125b-1 |
microRNA 125b-1 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR125B1 mRNA |
CTD |
PMID:31555879 |
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NCBI chr 9:41,493,222...41,493,298
Ensembl chr 9:41,493,222...41,493,298
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G |
Mir134 |
microRNA 134 |
increases expression |
ISO |
manganese chloride results in increased expression of MIR134 mRNA |
CTD |
PMID:28986288 |
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NCBI chr12:109,700,573...109,700,643
Ensembl chr12:109,700,573...109,700,643
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G |
Mir139 |
microRNA 139 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR139 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 7:101,124,583...101,124,650
Ensembl chr 7:101,124,583...101,124,650
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G |
Mir143 |
microRNA 143 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR143 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR143 mRNA |
CTD |
PMID:38503349 |
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NCBI chr18:61,782,267...61,782,329
Ensembl chr18:61,782,267...61,782,329
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G |
Mir146b |
microRNA 146b |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR146B mRNA |
CTD |
PMID:28986288 |
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NCBI chr19:46,331,201...46,331,309
Ensembl chr19:46,331,201...46,331,309
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G |
Mir150 |
microRNA 150 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR150 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR150 mRNA |
CTD |
PMID:38503349 |
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NCBI chr 7:44,771,181...44,771,245
Ensembl chr 7:44,771,181...44,771,245
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G |
Mir15a |
microRNA 15a |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR15A mRNA |
CTD |
PMID:28986288 |
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NCBI chr14:61,869,476...61,869,559
Ensembl chr14:61,869,476...61,869,559
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G |
Mir221 |
microRNA 221 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR221 mRNA |
CTD |
PMID:38503349 |
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NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627
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G |
Mir298 |
microRNA 298 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR298 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 2:174,109,297...174,109,378
Ensembl chr 2:174,109,297...174,109,378
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G |
Mir29a |
microRNA 29a |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR29A mRNA |
CTD |
PMID:28986288 |
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NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682
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G |
Mir31 |
microRNA 31 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR31 mRNA |
CTD |
PMID:38503349 |
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NCBI chr 4:88,828,794...88,828,899
Ensembl chr 4:88,828,794...88,828,899
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G |
Mir320 |
microRNA 320 |
increases expression |
ISO |
manganese chloride results in increased expression of MIR320A mRNA |
CTD |
PMID:28986288 |
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NCBI chr14:70,680,950...70,681,031
Ensembl chr14:70,680,950...70,681,031
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G |
Mir328 |
microRNA 328 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR328 mRNA |
CTD |
PMID:28986288 |
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NCBI chr 8:106,034,996...106,035,092
Ensembl chr 8:106,034,996...106,035,092
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G |
Mir409 |
microRNA 409 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR409 mRNA |
CTD |
PMID:28986288 |
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NCBI chr12:109,709,592...109,709,670
Ensembl chr12:109,709,592...109,709,670
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G |
Mir433 |
microRNA 433 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR433 mRNA |
CTD |
PMID:28986288 |
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NCBI chr12:109,558,149...109,558,272
Ensembl chr12:109,558,149...109,558,272
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G |
Mir582 |
microRNA 582 |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR582 mRNA |
CTD |
PMID:31555879 |
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NCBI chr13:109,461,278...109,461,358
Ensembl chr13:109,461,278...109,461,358
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G |
Mir98 |
microRNA 98 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MIR98 mRNA |
CTD |
PMID:28986288 |
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NCBI chr X:150,696,210...150,696,317
Ensembl chr X:150,696,210...150,696,317
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G |
Mir99a |
microRNA 99a |
multiple interactions |
ISO |
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR99A mRNA |
CTD |
PMID:38503349 |
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NCBI chr16:77,395,824...77,395,888
Ensembl chr16:77,395,824...77,395,888
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G |
Mirlet7b |
microRNA let7b |
increases expression |
ISO |
manganese chloride results in increased expression of MIRLET7B mRNA |
CTD |
PMID:28986288 |
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NCBI chr15:85,591,520...85,591,604
Ensembl chr15:85,591,520...85,591,604
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G |
Mirlet7e |
microRNA let7e |
increases expression |
ISO |
manganese chloride results in increased expression of MIRLET7E mRNA |
CTD |
PMID:28986288 |
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NCBI chr17:18,050,614...18,050,706
Ensembl chr17:18,050,614...18,050,706
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G |
Mmab |
methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) |
decreases expression |
ISO |
manganese chloride results in decreased expression of MMAB mRNA |
CTD |
PMID:28801915 |
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NCBI chr 5:114,569,095...114,582,134
Ensembl chr 5:114,569,095...114,582,121
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G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression |
ISO |
manganese chloride results in increased expression of MMP13 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
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G |
Mmp14 |
matrix metallopeptidase 14 (membrane-inserted) |
decreases expression increases methylation |
ISO |
manganese chloride results in decreased expression of MMP14 mRNA manganese chloride results in increased methylation of MMP14 gene |
CTD |
PMID:28801915 |
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NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821
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G |
Mmp24 |
matrix metallopeptidase 24 |
increases expression |
ISO |
manganese chloride results in increased expression of MMP24 mRNA |
CTD |
PMID:28801915 |
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NCBI chr 2:155,617,262...155,660,286
Ensembl chr 2:155,617,262...155,660,286
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G |
Mmp3 |
matrix metallopeptidase 3 |
increases expression |
ISO |
manganese chloride results in increased expression of MMP3 mRNA |
CTD |
PMID:26745496 |
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NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of MMP9 protein]; manganese chloride results in increased expression of and results in increased secretion of MMP9 protein; resveratrol inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of MMP9 protein]; resveratrol inhibits the reaction [manganese chloride results in increased expression of MMP9 mRNA] |
CTD |
PMID:23811825 |
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NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770
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G |
Mob3b |
MOB kinase activator 3B |
increases expression |
ISO |
manganese chloride results in increased expression of MOB3B mRNA |
CTD |
PMID:28801915 |
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NCBI chr 4:34,949,074...35,157,490
Ensembl chr 4:34,949,074...35,157,484
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G |
Mon2 |
MON2 homolog, regulator of endosome to Golgi trafficking |
decreases expression |
ISO |
manganese chloride results in decreased expression of MON2 mRNA |
CTD |
PMID:28801915 |
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NCBI chr10:122,827,965...122,913,684
Ensembl chr10:122,827,965...122,912,410
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G |
Mpo |
myeloperoxidase |
multiple interactions increases activity |
ISO |
diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; manganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]] [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of MPO protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of MPO protein]; Quercetin inhibits the reaction [manganese chloride results in increased activity of MPO protein] |
CTD |
PMID:22906169 PMID:28040552 PMID:30844427 PMID:33314588 |
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NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
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G |
Mpp3 |
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) |
increases expression |
ISO |
manganese chloride results in increased expression of MPP3 mRNA |
CTD |
PMID:28801915 |
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NCBI chr11:101,890,488...101,925,854
Ensembl chr11:101,890,478...101,919,287
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G |
Mrps10 |
mitochondrial ribosomal protein S10 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MRPS10 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:47,679,803...47,692,343
Ensembl chr17:47,679,812...47,692,342
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G |
Ms4a6c |
membrane-spanning 4-domains, subfamily A, member 6C |
increases expression |
ISO |
manganese chloride results in increased expression of MS4A6A mRNA |
CTD |
PMID:28801915 |
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NCBI chr19:11,446,718...11,464,433
Ensembl chr19:11,446,730...11,459,556
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G |
Msh5 |
mutS homolog 5 |
increases expression |
ISO |
manganese chloride results in increased expression of MSH5 mRNA |
CTD |
PMID:28801915 |
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NCBI chr17:35,247,581...35,267,842
Ensembl chr17:35,247,581...35,265,721
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G |
Msh6 |
mutS homolog 6 |
decreases expression |
ISO |
manganese chloride results in decreased expression of MSH6 mRNA |
CTD |
PMID:17175027 |
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NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320
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G |
Msx2 |
msh homeobox 2 |
decreases expression |
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