manganese(II) chloride - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	manganese(II) chloride	go back to main search page
Accession:	CHEBI:63041	browse the term
Definition:	An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Synonyms:	exact_synonym:	manganese(2+) dichloride
	related_synonym:	Formula=Cl2Mn; InChI=1S/2ClH.Mn/h2*1H;/q;;+2/p-2; InChIKey=GLFNIEUTAYBVOC-UHFFFAOYSA-L; Mangandichlorid; Manganese bichloride; Manganese(II) chloride (1:2); Manganous chloride; SMILES=Cl[Mn]Cl; dichlorure de manganese; manganese(II) dichloride; manganous dichloride
	xref:	CAS:7773-01-5
	xref_mesh:	MESH:C025340
	xref:	MetaCyc:CPD0-2394; PMID:101555; PMID:146543; PMID:19801673; PMID:3143594; PMID:4476198; PMID:4771199; PMID:98204; Reaxys:8128170; Wikipedia:Manganese(II)_chloride

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Genes (1172)

manganese(II) chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA A630001G21 gene like

increases expression

manganese chloride results in increased expression of A630001G21RIKL mRNA

NCBI chr 9:86,381,777...86,405,385
Ensembl chr 9:86,383,201...86,405,361

G

ATP binding cassette subfamily A member 5

decreases expression

manganese chloride results in decreased expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

G

ATP binding cassette subfamily A member 9

increases expression

manganese chloride results in increased expression of ABCA9 mRNA

NCBI chr10:95,077,615...95,137,751
Ensembl chr10:95,079,058...95,139,608

G

ATP binding cassette subfamily B member 1A

increases expression

manganese chloride results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression

manganese chloride results in increased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

increases expression
decreases methylation

manganese chloride results in increased expression of ABCC2 mRNA
manganese chloride results in decreased methylation of ABCC2 gene

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 8

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

abl-interactor 2

increases expression

manganese chloride results in increased expression of ABI2 mRNA

NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699

G

actin binding transcription modulator

increases expression

manganese chloride results in increased expression of ABITRAM mRNA

NCBI chr 5:71,505,848...71,524,224
Ensembl chr 5:71,505,813...71,511,890

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

increases expression

manganese chloride results in increased expression of ACAP1 mRNA

NCBI chr10:54,605,323...54,619,472
Ensembl chr10:54,605,323...54,619,472

G

angiotensin I converting enzyme

increases expression

manganese chloride results in increased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

increases activity
increases expression
multiple interactions
decreases activity

manganese chloride results in increased activity of ACHE protein
manganese chloride results in increased expression of ACHE mRNA
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Lycopene inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased activity of ACHE protein]; Silymarin inhibits the reaction [manganese chloride results in increased expression of ACHE mRNA]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form

PMID:20503066 PMID:22033861 PMID:22154916 PMID:22192907 PMID:30738988 More...

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

aconitase 1

increases activity

manganese chloride results in increased activity of ACO1 protein

PMID:15893546 PMID:16545456 PMID:16568477

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

multiple interactions
decreases expression
decreases activity

ferric ammonium citrate inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]
manganese chloride results in decreased expression of ACO2 mRNA; manganese chloride results in decreased expression of ACO2 protein
Iron inhibits the reaction [manganese chloride results in decreased activity of ACO2 protein]

PMID:9675333 PMID:16625280

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA thioesterase 2

increases expression

manganese chloride results in increased expression of ACOT2 mRNA

NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245

G

acid phosphatase 5, tartrate resistant

increases expression
increases methylation

manganese chloride results in increased expression of ACP5 mRNA
manganese chloride results in increased methylation of ACP5 gene

PMID:22281203 PMID:28801915

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

acrosin

increases expression

manganese chloride results in increased expression of ACR mRNA

NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474

G

acyl-CoA synthetase long-chain family member 3

decreases expression

manganese chloride results in decreased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

acyl-CoA synthetase short-chain family member 2

decreases expression

manganese chloride results in decreased expression of ACSS2 mRNA

NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675

G

actin, alpha 1, skeletal muscle

decreases expression

manganese chloride results in decreased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

increases expression

manganese chloride results in increased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

decreases expression
increases expression

manganese chloride results in decreased expression of ACTB protein
manganese chloride results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

activin A receptor like type 1

increases expression

manganese chloride results in increased expression of ACVRL1 mRNA

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

ADAM metallopeptidase domain 19

increases expression

manganese chloride results in increased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases expression

manganese chloride results in decreased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

ADAM metallopeptidase with thrombospondin type 1 motif, 5

decreases expression

manganese chloride results in decreased expression of ADAMTS5 mRNA

NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205

G

adenylate cyclase 6

increases expression

manganese chloride results in increased expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adducin 2

increases expression

manganese chloride results in increased expression of ADD2 mRNA

NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505

G

adiponectin, C1Q and collagen domain containing

increases expression

manganese chloride results in increased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenomedullin

increases expression
decreases expression

manganese chloride results in increased expression of ADM mRNA
manganese chloride results in decreased expression of ADM mRNA

PMID:17175027 PMID:28801915

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adenosine A2a receptor

increases expression

manganese chloride results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

apoptosis enhancing nuclease

increases expression

manganese chloride results in increased expression of AEN mRNA

NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523

G

ALF transcription elongation factor 1

increases expression

manganese chloride results in increased expression of AFF1 mRNA

NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729

G

arylformamidase

increases expression

manganese chloride results in increased expression of AFMID mRNA

NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718

G

alpha-fetoprotein

decreases expression

manganese chloride results in decreased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

AHNAK nucleoprotein 2

increases expression

manganese chloride results in increased expression of AHNAK2 mRNA

NCBI chr 6:131,830,668...131,876,311

G

activation-induced cytidine deaminase

increases expression

manganese chloride results in increased expression of AICDA mRNA

NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972

G

allograft inflammatory factor 1

increases expression

manganese chloride results in increased expression of AIF1 protein

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

A-kinase anchoring protein 7

decreases expression

manganese chloride results in decreased expression of AKAP7 mRNA

NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797

G

aldo-keto reductase family 1 member B1

increases expression

manganese chloride results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

manganese chloride results in decreased phosphorylation of AKT1 protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]

PMID:30040983 PMID:31676349

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions

[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate co-treated with Mercuric Chloride co-treated with chromium trioxide co-treated with nickel chloride co-treated with manganese chloride co-treated with ferric chloride] results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 18 family, member A1

increases expression

manganese chloride results in increased expression of ALDH18A1 mRNA

NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

manganese chloride results in decreased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 4 family, member A1

increases expression

manganese chloride results in increased expression of ALDH4A1 mRNA

NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345

G

aldolase, fructose-bisphosphate A

increases expression

manganese chloride results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

decreases expression

manganese chloride results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

ALK and LTK ligand 1

increases expression

manganese chloride results in increased expression of ALKAL1 mRNA

NCBI chr 5:13,019,729...13,049,913
Ensembl chr 5:13,019,429...13,049,948

G

adhesion molecule with Ig like domain 3

increases expression

manganese chloride results in increased expression of AMIGO3 mRNA

NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555

G

angiopoietin 2

decreases expression

manganese chloride results in decreased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

angiopoietin-like 4

increases expression

manganese chloride results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

ankyrin repeat domain 28

increases expression

manganese chloride results in increased expression of ANKRD28 mRNA

NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249

G

anoctamin 3

increases expression

manganese chloride results in increased expression of ANO3 mRNA

NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154

G

acidic nuclear phosphoprotein 32 family member A

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ANP32A mRNA

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

annexin A3

decreases expression

manganese chloride results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

aminopeptidase O

decreases expression

manganese chloride results in decreased expression of AOPEP mRNA

NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331

G

adaptor related protein complex 3 subunit beta 2

increases expression

manganese chloride results in increased expression of AP3B2 mRNA

NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191

G

amyloid beta precursor protein binding family B member 3

increases expression

manganese chloride results in increased expression of APBB3 mRNA

NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094

G

APC regulator of WNT signaling pathway

decreases expression
increases methylation

manganese chloride results in decreased expression of APC mRNA
manganese chloride results in increased methylation of APC gene

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apolipoprotein A2

decreases expression

manganese chloride results in decreased expression of APOA2 mRNA

NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355

G

apolipoprotein L2

increases expression

manganese chloride results in increased expression of APOL2 mRNA

NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558

G

apolipoprotein L domain containing 1

increases expression

manganese chloride results in increased expression of APOLD1 mRNA

NCBI chr 4:167,768,437...167,825,706
Ensembl chr 4:167,818,271...167,825,706

G

aquaporin 3 (Gill blood group)

decreases expression

manganese chloride results in decreased expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

amphiregulin

increases expression

manganese chloride results in increased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 1

increases expression
increases methylation
multiple interactions

manganese chloride results in increased expression of ARG1 mRNA
manganese chloride results in increased methylation of ARG1 gene
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA

PMID:28801915 PMID:34018660

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GTPase activating protein 24

decreases expression

manganese chloride results in decreased expression of ARHGAP24 mRNA

NCBI chr14:6,800,624...7,183,877
Ensembl chr14:6,800,631...7,183,823

G

Rho GDP dissociation inhibitor alpha

decreases expression

manganese chloride results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

Rho guanine nucleotide exchange factor 10

increases expression

manganese chloride results in increased expression of ARHGEF10 mRNA

NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173

G

Rho guanine nucleotide exchange factor 16

increases expression

manganese chloride results in increased expression of ARHGEF16 mRNA

NCBI chr 5:164,843,656...164,866,212
Ensembl chr 5:164,844,161...164,866,212

G

Rho guanine nucleotide exchange factor 4

increases expression
increases methylation

manganese chloride results in increased expression of ARHGEF4 mRNA
manganese chloride results in increased methylation of ARHGEF4 gene

PMID:17175027 PMID:28801915

NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075

G

Rac/Cdc42 guanine nucleotide exchange factor 6

increases expression

manganese chloride results in increased expression of ARHGEF6 mRNA

NCBI chr X:135,145,447...135,264,636
Ensembl chr X:135,146,786...135,275,304

G

Rho guanine nucleotide exchange factor 7

decreases expression

manganese chloride results in decreased expression of ARHGEF7 mRNA

NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697

G

AT-rich interaction domain 3A

increases expression

manganese chloride results in increased expression of ARID3A mRNA

NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599

G

ADP ribosylation factor like GTPase 4C

increases methylation
increases expression

manganese chloride results in increased methylation of ARL4C gene
manganese chloride results in increased expression of ARL4C mRNA

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ARNT gene mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

ankyrin repeat and SOCS box-containing 5

decreases expression

manganese chloride results in decreased expression of ASB5 mRNA

NCBI chr16:37,237,869...37,305,207
Ensembl chr16:37,235,405...37,278,109

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

manganese chloride results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

argininosuccinate synthase 1

increases expression

manganese chloride results in increased expression of ASS1 mRNA

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

asteroid homolog 1

increases expression

manganese chloride results in increased expression of ASTE1 mRNA

NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430

G

activating transcription factor 1

increases phosphorylation
multiple interactions

manganese chloride results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of ATF1 protein]

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 2

increases activity
increases phosphorylation

manganese chloride results in increased activity of ATF2 protein
manganese chloride results in increased phosphorylation of ATF2 protein

PMID:19084589 PMID:20152896

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

activating transcription factor 4

multiple interactions
increases expression

manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of ATF4 mRNA]
manganese chloride results in increased expression of ATF4 mRNA; manganese chloride results in increased expression of ATF4 protein

PMID:23934647 PMID:23948121

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

decreases expression
increases expression

manganese chloride results in decreased expression of ATF6 mRNA
manganese chloride results in increased expression of ATF6 protein

PMID:17175027 PMID:25732873

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

ATM serine/threonine kinase

decreases expression

manganese chloride results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

atonal bHLH transcription factor 8

decreases expression

manganese chloride results in decreased expression of ATOH8 mRNA

PMID:26745496 PMID:28801915

NCBI chr 4:104,259,992...104,292,168
Ensembl chr 4:104,259,992...104,292,168

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of ATP1A2 protein

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] which affects the expression of ATP1A3 protein

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases methylation

manganese chloride results in increased methylation of ATP2A3 gene

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATPase plasma membrane Ca2+ transporting 2

increases methylation
decreases expression

manganese chloride results in increased methylation of ATP2B2 gene
manganese chloride results in decreased expression of ATP2B2 mRNA

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

ATPase plasma membrane Ca2+ transporting 4

increases expression

manganese chloride results in increased expression of ATP2B4 mRNA

NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246

G

ATP synthase F1 subunit gamma

decreases expression

manganese chloride results in decreased expression of ATP5F1C mRNA

NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367

G

ATPase H+ transporting V1 subunit A

increases expression

manganese chloride results in increased expression of ATP6V1A mRNA

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

ATPase H+ transporting V1 subunit E2

decreases expression

manganese chloride results in decreased expression of ATP6V1E2 mRNA

NCBI chr 6:7,667,359...7,673,711
Ensembl chr 6:7,667,564...7,672,626

G

ATPase H+ transporting V1 subunit H

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ATP6V1H mRNA]

NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962

G

ATPase copper transporting alpha

decreases expression
affects localization

manganese chloride results in decreased expression of ATP7A mRNA; manganese chloride results in decreased expression of ATP7A protein
manganese chloride affects the localization of ATP7A protein

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

affects localization
decreases expression

manganese chloride affects the localization of ATP7B protein
manganese chloride results in decreased expression of ATP7B mRNA; manganese chloride results in decreased expression of ATP7B protein

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

ATPase phospholipid transporting 8A1

decreases expression

manganese chloride results in decreased expression of ATP8A1 mRNA

NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611

G

advillin

decreases expression
increases methylation

manganese chloride results in decreased expression of AVIL mRNA
manganese chloride results in increased methylation of AVIL gene

NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071

G

axin 2

increases expression

manganese chloride results in increased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

BTB domain and CNC homolog 1

increases expression

manganese chloride results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

manganese chloride results in increased expression of BAX mRNA; manganese chloride results in increased expression of BAX protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; Estradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein]; Tamoxifen inhibits the reaction [manganese chloride results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; manganese chloride results in increased expression of and affects the localization of BAX protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]

PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:29183790 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions
increases nitrosation
increases expression

manganese chloride results in decreased expression of BCL2 mRNA; manganese chloride results in decreased expression of BCL2 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; [Plant Extracts co-treated with manganese chloride] affects the expression of BCL2 protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of BCL2 protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; manganese chloride results in decreased expression of and affects the localization of BCL2 protein
manganese chloride results in increased nitrosation of BCL2 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 mRNA; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased expression of and results in decreased phosphorylation of BCL2 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride results in increased nitrosation of BCL2 protein]
manganese chloride results in increased expression of BCL2 mRNA
manganese chloride results in increased expression of BCL2 protein

PMID:17623882 PMID:21704098 PMID:25732873 PMID:26064043 PMID:28801915 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

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Bcl2-like 1

decreases expression

manganese chloride results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

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Bcl2-like 11

increases expression
decreases expression

manganese chloride results in increased expression of BCL2L11 protein
manganese chloride results in decreased expression of BCL2L11 mRNA

PMID:25732873 PMID:28801915

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL6B, transcription repressor

increases expression

manganese chloride results in increased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

bradykinin receptor B2

increases expression

manganese chloride results in increased expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

decreases expression
increases expression
increases methylation
multiple interactions

manganese chloride results in decreased expression of BDNF mRNA
manganese chloride results in increased expression of BDNF mRNA
manganese chloride results in increased methylation of BDNF gene
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]

PMID:25698507 PMID:28801915 PMID:30951808 PMID:32659473

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

increases expression
multiple interactions
decreases expression
affects expression

manganese chloride results in increased expression of BECN1 protein
wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]
manganese chloride results in decreased expression of BECN1 protein
corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]]
manganese chloride affects the expression of BECN1 protein

PMID:23604964 PMID:28856835 PMID:30578841 PMID:30672645

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

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basic helix-loop-helix family, member e40

increases expression

manganese chloride results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

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BH3 interacting domain death agonist

increases cleavage
increases expression
multiple interactions

manganese chloride results in increased cleavage of BID protein
manganese chloride results in increased expression of BID protein; manganese chloride results in increased expression of BID protein modified form
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of BID protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein]

PMID:21704098 PMID:28378122

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of BIRC5 mRNA]

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

baculoviral IAP repeat-containing 7

increases expression

manganese chloride results in increased expression of BIRC7 mRNA

NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606

G

biogenesis of lysosomal organelles complex-1, subunit 3

increases expression

manganese chloride results in increased expression of BLOC1S3 mRNA

NCBI chr 1:79,155,873...79,158,247
Ensembl chr 1:79,155,693...79,158,505

G

biliverdin reductase A

increases expression

manganese chloride results in increased expression of BLVRA mRNA

NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033

G

basic helix-loop-helix ARNT like 1

decreases expression

manganese chloride results in decreased expression of BMAL1 mRNA

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

Bcl2 modifying factor

decreases expression

manganese chloride results in decreased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

bone morphogenetic protein 4

increases expression

manganese chloride results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

BCL2 interacting protein 3

multiple interactions
affects response to substance

[N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cycloheximide inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein]; manganese chloride results in increased expression of and affects the localization of BNIP3 protein
BNIP3 protein affects the susceptibility to manganese chloride

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BPI fold containing family B, member 6

increases expression

manganese chloride results in increased expression of BPIFB6 mRNA

NCBI chr 3:142,381,478...142,395,304
Ensembl chr 3:142,381,374...142,395,308

G

bassoon (presynaptic cytomatrix protein)

increases expression

manganese chloride results in increased expression of BSN mRNA

NCBI chr 8:108,784,849...108,875,819
Ensembl chr 8:108,788,542...108,875,819

G

butyrophilin-like 5

decreases expression

manganese chloride results in decreased expression of BTNL5 mRNA

NCBI chr20:4,366,780...4,376,385
Ensembl chr20:4,365,793...4,376,385

G

butyrophilin-like 7

decreases expression

manganese chloride results in decreased expression of BTNL7 mRNA

NCBI chr20:4,301,078...4,313,522
Ensembl chr20:4,301,854...4,313,274

G

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

manganese chloride results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

similar to human chromosome 16 open reading frame 90

increases expression

manganese chloride results in increased expression of C10H16ORF90 mRNA

NCBI chr10:11,618,867...11,632,151
Ensembl chr10:11,618,348...11,629,910

G

C1q and TNF related 4

increases expression

manganese chloride results in increased expression of C1QTNF4 mRNA

NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139

G

C2 calcium-dependent domain containing 4B

increases expression

manganese chloride results in increased expression of C2CD4B mRNA

NCBI chr 8:68,372,793...68,396,477
Ensembl chr 8:68,384,847...68,396,328

G

complement component 4 binding protein, alpha

decreases expression

manganese chloride results in decreased expression of C4BPA mRNA

NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205

G

complement C5

decreases expression

manganese chloride results in decreased expression of C5 mRNA

NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994

G

complement C5 like 1

increases methylation
decreases expression

manganese chloride results in increased methylation of C5L1 gene
manganese chloride results in decreased expression of C5L1 mRNA

NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054

G

Cdk5 and Abl enzyme substrate 1

decreases expression

manganese chloride results in decreased expression of CABLES1 mRNA

NCBI chr18:3,076,556...3,181,181
Ensembl chr18:3,075,524...3,181,181

G

calcium binding and coiled-coil domain 2

increases expression

manganese chloride results in increased expression of CALCOCO2 mRNA

NCBI chr10:81,055,467...81,069,298

G

caldesmon 1

increases expression

manganese chloride results in increased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calcyon neuron-specific vesicular protein

increases expression

manganese chloride results in increased expression of CALY mRNA

NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551

G

calcium/calmodulin-dependent protein kinase kinase 2

increases expression

manganese chloride results in increased expression of CAMKK2 mRNA

NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279

G

CaM kinase-like vesicle-associated

decreases expression

manganese chloride results in decreased expression of CAMKV mRNA

NCBI chr 8:108,626,821...108,641,169
Ensembl chr 8:108,626,821...108,641,169

G

cathelicidin antimicrobial peptide

increases expression

manganese chloride results in increased expression of CAMP mRNA

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

calmodulin binding transcription activator 2

increases expression

manganese chloride results in increased expression of CAMTA2 mRNA

NCBI chr10:55,383,450...55,401,838
Ensembl chr10:55,383,450...55,401,558

G

calpain 5

increases expression

manganese chloride results in increased expression of CAPN5 mRNA

NCBI chr 1:152,416,252...152,472,923
Ensembl chr 1:152,416,252...152,472,923

G

carbonic anhydrase 5B

decreases expression

manganese chloride results in decreased expression of CAR5B mRNA

NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837

G

carbonic anhydrase 8

increases expression

manganese chloride results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

caspase recruitment domain family, member 14

increases methylation

manganese chloride results in increased methylation of CARD14 gene

NCBI chr10:104,572,059...104,601,606
Ensembl chr10:104,566,424...104,601,905

G

caspase recruitment domain family, member 9

decreases expression

manganese chloride results in decreased expression of CARD9 mRNA

NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237

G

caspase 12

multiple interactions
increases expression
increases cleavage

Deferoxamine promotes the reaction [manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein]; manganese chloride results in increased cleavage of and results in increased activity of CASP12 protein
manganese chloride results in increased expression of CASP12 mRNA; manganese chloride results in increased expression of CASP12 protein
SNCA protein promotes the reaction [manganese chloride results in increased expression of CASP12 protein]
manganese chloride results in increased cleavage of CASP12 protein
Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP12 protein]

PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:26064043 More...

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 2

increases expression

manganese chloride results in increased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases cleavage
multiple interactions
increases expression
increases activity
increases methylation

manganese chloride results in increased cleavage of CASP3 protein
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [manganese chloride results in increased expression of CASP3 protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Lithium Chloride inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]; Quercetin inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [manganese chloride results in increased expression of CASP3 protein]
manganese chloride results in increased expression of CASP3 mRNA; manganese chloride results in increased expression of CASP3 protein; manganese chloride results in increased expression of CASP3 protein modified form
[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; Plant Extracts inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]
Deferoxamine promotes the reaction [manganese chloride results in increased activity of CASP3 protein]; SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]
manganese chloride results in increased methylation of CASP3 gene

PMID:16787641 PMID:17483122 PMID:18178165 PMID:19815061 PMID:23764342 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

manganese chloride results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 8

increases cleavage
multiple interactions

manganese chloride results in increased cleavage of CASP8 protein
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein]

PMID:21704098 PMID:28378122

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions
increases cleavage

manganese chloride results in increased activity of CASP9 protein
PRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]
SNCA protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]
manganese chloride results in increased cleavage of CASP9 protein
bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]

PMID:16787641 PMID:17483122 PMID:21704098 PMID:25416158 PMID:28378122

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

decreases activity
multiple interactions
decreases expression

manganese chloride results in decreased activity of CAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; [Plant Extracts co-treated with manganese chloride] results in increased expression of CAT protein; Estradiol inhibits the reaction [manganese chloride results in decreased expression of CAT protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of CAT protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CAT protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Quercetin inhibits the reaction [manganese chloride results in decreased activity of CAT protein]; Silymarin inhibits the reaction [manganese chloride results in decreased activity of CAT protein]

PMID:20503066 PMID:22033861 PMID:22192907 PMID:26064043 PMID:28040552 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

ciliogenesis associated TTC17 interacting protein

increases expression

manganese chloride results in increased expression of CATIP mRNA

NCBI chr 9:75,945,960...75,953,618
Ensembl chr 9:75,945,961...75,953,607

G

cation channel sperm associated auxiliary subunit delta

increases expression

manganese chloride results in increased expression of CATSPERD mRNA

NCBI chr 9:1,459,967...1,498,342
Ensembl chr 9:1,460,001...1,498,344

G

caveolin 2

decreases expression

manganese chloride results in decreased expression of CAV2 mRNA

NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244

G

CACN subunit beta associated regulatory protein

increases expression

manganese chloride results in increased expression of DOS mRNA

NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204

G

cystathionine beta synthase

decreases expression

manganese chloride results in decreased expression of CBS mRNA

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

coiled-coil domain containing 15

increases expression

manganese chloride results in increased expression of CCDC15 mRNA

NCBI chr 8:36,991,147...37,068,849
Ensembl chr 8:36,998,867...37,068,919

G

coiled-coil domain containing 175

increases expression

manganese chloride results in increased expression of CCDC175 mRNA

NCBI chr 6:90,661,948...90,745,015
Ensembl chr 6:90,662,269...90,744,963

G

coiled-coil domain containing 96

increases expression

manganese chloride results in increased expression of CCDC96 mRNA

NCBI chr14:74,276,568...74,279,072
Ensembl chr14:74,276,960...74,278,888

G

C-C motif chemokine ligand 17

increases expression

manganese chloride results in increased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

increases expression

manganese chloride results in increased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 2

multiple interactions
decreases secretion

manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]
manganese chloride results in decreased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

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C-C motif chemokine ligand 5

increases expression

manganese chloride results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

increases expression

manganese chloride results in increased expression of CCL7 mRNA

PMID:17175027 PMID:28801915

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 2

increases expression
increases methylation

manganese chloride results in increased expression of CCN2 mRNA
manganese chloride results in increased methylation of CCN2 gene

PMID:17467022 PMID:28801915

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin A1

increases expression

manganese chloride results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

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cyclin B1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 protein

PMID:34822792 PMID:38503349

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression
multiple interactions

manganese chloride results in decreased expression of CCNB2 mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein]

PMID:17175027 PMID:34822792

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNE1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin G1

increases expression

manganese chloride results in increased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd28 molecule

multiple interactions

[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; manganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein]

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD44 molecule

increases expression

manganese chloride results in increased expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd48 molecule

increases expression

manganese chloride results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

Cd6 molecule

decreases expression

manganese chloride results in decreased expression of CD6 mRNA

NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634

G

CD74 molecule

increases expression

manganese chloride results in increased expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

CD86 molecule

increases expression

manganese chloride results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CD8 subunit beta

increases expression

manganese chloride results in increased expression of CD8B mRNA; manganese chloride results in increased expression of CD8B1 mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

CDC42 effector protein 3

increases expression

manganese chloride results in increased expression of CDC42EP3 mRNA

NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721

G

cadherin-related family member 4

decreases expression

manganese chloride results in decreased expression of CDHR4 mRNA

NCBI chr 8:108,682,594...108,690,358
Ensembl chr 8:108,682,613...108,690,367

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
affects localization

Cycloheximide inhibits the reaction [manganese chloride results in increased expression of CDKN1A protein]
manganese chloride results in increased expression of CDKN1A mRNA; manganese chloride results in increased expression of CDKN1A protein
manganese chloride affects the localization of CDKN1A protein

PMID:22542671 PMID:28801915

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

manganese chloride results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2B

increases expression

manganese chloride results in increased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cyclin-dependent kinase inhibitor 2C

decreases expression

manganese chloride results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

cyclin-dependent kinase inhibitor 3

decreases expression

manganese chloride results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

cerebral dopamine neurotrophic factor

increases expression

manganese chloride results in increased expression of CDNF mRNA

NCBI chr17:74,714,564...74,728,639
Ensembl chr17:74,713,564...74,728,639

G

chromodomain Y-like 2

increases expression

manganese chloride results in increased expression of CDYL2 mRNA

NCBI chr19:44,591,734...44,783,258
Ensembl chr19:44,597,459...44,783,022

G

CCAAT/enhancer binding protein delta

increases expression

manganese chloride results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

cadherin, EGF LAG seven-pass G-type receptor 1

increases expression

manganese chloride results in increased expression of CELSR1 mRNA

NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164

G

centrosomal protein 112

increases expression

manganese chloride results in increased expression of CEP112 mRNA

NCBI chr10:93,366,059...93,833,133
Ensembl chr10:93,366,136...93,833,131

G

centrosomal protein 128

decreases expression

manganese chloride results in decreased expression of CEP128 mRNA

NCBI chr 6:109,951,009...110,328,686
Ensembl chr 6:109,951,061...110,328,713

G

ceramide synthase 1

increases expression

manganese chloride results in increased expression of CERS1 mRNA

NCBI chr16:19,097,309...19,112,519
Ensembl chr16:19,104,466...19,112,519

G

ceramide synthase 6

increases expression

manganese chloride results in increased expression of CERS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

G

CASP8 and FADD-like apoptosis regulator

increases expression

manganese chloride results in increased expression of CFLAR mRNA

NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034

G

CF transmembrane conductance regulator

increases expression

manganese chloride results in increased expression of CFTR mRNA

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cell growth regulator with EF hand domain 1

increases expression

manganese chloride results in increased expression of CGREF1 mRNA

NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852

G

cholesterol 25-hydroxylase

increases expression

manganese chloride results in increased expression of CH25H mRNA

NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195

G

choline O-acetyltransferase

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

CHM like Rab escort protein

increases expression

manganese chloride results in increased expression of CHML mRNA

NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862

G

charged multivesicular body protein 4B

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of CHMP4B protein

NCBI chr 3:143,170,859...143,211,376
Ensembl chr 3:143,170,902...143,210,844

G

cholinergic receptor nicotinic alpha 7 subunit

decreases expression

manganese chloride results in decreased expression of CHRNA7 protein

NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240

G

carbohydrate sulfotransferase 10

increases expression

manganese chloride results in increased expression of CHST10 mRNA

NCBI chr 9:41,092,805...41,122,737
Ensembl chr 9:41,092,808...41,122,503

G

carbohydrate sulfotransferase 5

increases expression

manganese chloride results in increased expression of CHST5 mRNA

NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
increases phosphorylation

15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

class II, major histocompatibility complex, transactivator

increases expression

manganese chloride results in increased expression of CIITA mRNA

NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440

G

cytokine inducible SH2-containing protein

increases expression

manganese chloride results in increased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

decreases expression

manganese chloride results in decreased expression of CITED1 mRNA

NCBI chr X:67,350,376...67,355,072
Ensembl chr X:67,350,373...67,355,162

G

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 like 1

decreases expression

manganese chloride results in decreased expression of CITED1L1 mRNA

NCBI chr 1:204,760,742...204,761,351

G

CDC28 protein kinase regulatory subunit 2

decreases expression

manganese chloride results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 23

increases expression

manganese chloride results in increased expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

G

claudin 4

increases expression

manganese chloride results in increased expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 9

decreases expression

manganese chloride results in decreased expression of CLDN9 mRNA

NCBI chr10:12,714,137...12,715,568

G

claudin domain containing 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CLDND1 mRNA

NCBI chr11:41,883,120...41,889,471
Ensembl chr11:41,883,134...41,889,354

G

C-type lectin domain family 4, member F

increases methylation

manganese chloride results in increased methylation of CLEC4F gene

NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775

G

clock circadian regulator

decreases expression

manganese chloride results in decreased expression of CLOCK mRNA

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

cytidine/uridine monophosphate kinase 2

increases expression
increases methylation

manganese chloride results in increased expression of CMPK2 mRNA
manganese chloride results in increased methylation of CMPK2 gene

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

connector enhancer of kinase suppressor of Ras 1

increases expression

manganese chloride results in increased expression of CNKSR1 mRNA

NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212

G

CCR4-NOT transcription complex, subunit 2

decreases expression

manganese chloride results in decreased expression of CNOT2 mRNA

NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575

G

CCR4-NOT transcription complex, subunit 6-like

increases expression

manganese chloride results in increased expression of CNOT6L mRNA

NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203

G

contactin 4

decreases expression

manganese chloride results in decreased expression of CNTN4 mRNA

NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090

G

collagen type XII alpha 1 chain

decreases expression

manganese chloride results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

G

collagen type XV alpha 1 chain

increases expression

manganese chloride results in increased expression of COL15A1 mRNA

NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591

G

collagen type XVII alpha 1 chain

increases expression

manganese chloride results in increased expression of COL17A1 mRNA

NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632

G

collagen type XVIII alpha 1 chain

increases expression

manganese chloride results in increased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type IV alpha 5 chain

decreases expression

manganese chloride results in decreased expression of COL4A5 mRNA

NCBI chr X:105,118,762...105,322,699
Ensembl chr X:105,118,820...105,322,692

G

collagen type V alpha 2 chain

increases expression

manganese chloride results in increased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VI alpha 1 chain

increases expression

manganese chloride results in increased expression of COL6A1 mRNA

NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597

G

collagen type VII alpha 1 chain

increases expression

manganese chloride results in increased expression of COL7A1 mRNA

NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252

G

collagen type VIII alpha 1 chain

increases expression

manganese chloride results in increased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

collectin subfamily member 10

decreases expression

manganese chloride results in decreased expression of COLEC10 mRNA

NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675

G

collectin sub-family member 12

decreases expression

manganese chloride results in decreased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

COPI coat complex subunit gamma 2

increases expression

manganese chloride results in increased expression of COPG2 mRNA

NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618

G

cytochrome c oxidase subunit 6A2

increases expression

manganese chloride results in increased expression of COX6A2 mRNA

NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274

G

complexin 2

increases expression

manganese chloride results in increased expression of CPLX2 mRNA

NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855

G

carboxypeptidase M

decreases expression

manganese chloride results in decreased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

CRACD like

increases expression

manganese chloride results in increased expression of CRACDL mRNA

NCBI chr 9:39,834,321...39,950,763
Ensembl chr 9:39,834,833...39,951,086

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

manganese chloride results in increased phosphorylation of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [manganese chloride results in increased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]

PMID:16787641 PMID:30951808 PMID:31676349 PMID:32659473

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein-like 2

increases expression

manganese chloride results in increased expression of CREBL2 mRNA

NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292

G

CRK proto-oncogene, adaptor protein

increases expression

manganese chloride results in increased expression of CRK mRNA

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

cryptochrome circadian regulator 1

decreases expression

manganese chloride results in decreased expression of CRY1 mRNA

NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091

G

crystallin, alpha A

increases methylation

manganese chloride results in increased methylation of CRYAA gene

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

crystallin, alpha B

decreases expression

manganese chloride results in decreased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin, beta A4

increases expression

manganese chloride results in increased expression of CRYBA4 mRNA

NCBI chr12:44,378,734...44,393,226
Ensembl chr12:44,378,737...44,393,221

G

colony stimulating factor 2

multiple interactions
increases expression

manganese chloride promotes the reaction [SNCA protein results in increased expression of CSF2 mRNA]
manganese chloride results in increased expression of CSF2 mRNA

PMID:28539244 PMID:28801915

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression

manganese chloride results in increased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

chondroitin sulfate proteoglycan 4

increases expression
increases methylation

manganese chloride results in increased expression of CSPG4 mRNA
manganese chloride results in increased methylation of CSPG4 gene

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

cysteine and glycine rich protein 3

increases expression

manganese chloride results in increased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

cleavage stimulation factor subunit 2

increases expression

manganese chloride results in increased expression of CSTF2 mRNA

NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476

G

catenin alpha 1

decreases expression

manganese chloride results in decreased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

decreases expression
multiple interactions

manganese chloride results in decreased expression of CTNNB1 mRNA
Lithium Chloride inhibits the reaction [manganese chloride results in decreased expression of CTNNB1 protein]

PMID:17175027 PMID:24464479

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

catenin delta 1

increases expression

manganese chloride results in increased expression of CTNND1 mRNA

NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516

G

cathepsin 7 like 2

increases expression

manganese chloride results in increased expression of CTS7L2 mRNA

NCBI chr17:3,903,602...3,907,088
Ensembl chr17:3,903,602...3,906,568

G

cathepsin D

increases expression
affects localization
multiple interactions

manganese chloride results in increased expression of CTSD protein
manganese chloride affects the localization of CTSD protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CTSD protein

PMID:28378122 PMID:31690173

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin W

increases expression

manganese chloride results in increased expression of CTSW mRNA

NCBI chr 1:202,772,395...202,777,021
Ensembl chr 1:202,772,572...202,775,964

G

C-X3-C motif chemokine ligand 1

increases expression

manganese chloride results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

increases methylation
increases expression

manganese chloride results in increased methylation of CXCL1 gene
manganese chloride results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

increases expression

manganese chloride results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

manganese chloride results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 14

increases expression

manganese chloride results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

increases expression

manganese chloride results in increased expression of CXCL2 mRNA

PMID:17175027 PMID:28801915

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

manganese chloride results in increased expression of CXCL3 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

increases expression

manganese chloride results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

CXXC finger protein 1

increases methylation
decreases expression

manganese chloride results in increased methylation of CXXC1 gene
manganese chloride results in decreased expression of CXXC1 mRNA

NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551

G

cytochrome c, somatic

multiple interactions
affects localization

BNIP3 protein affects the reaction [manganese chloride affects the localization of CYCS protein]; Cyclosporine inhibits the reaction [manganese chloride affects the localization of CYCS protein]
SNCA protein inhibits the reaction [manganese chloride affects the localization of CYCS protein]

PMID:19442826 PMID:25416158

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions
decreases expression
increases expression

manganese chloride inhibits the reaction [CYP11A1 protein results in increased chemical synthesis of Progesterone]
manganese chloride results in decreased expression of CYP11A1 protein
manganese chloride results in increased expression of CYP11A1 mRNA

PMID:12699903 PMID:25981801 PMID:28801915

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

manganese chloride results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases methylation
decreases expression

manganese chloride results in increased methylation of CYP4F4 gene
manganese chloride results in decreased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

CYFIP related Rac1 interactor A

increases methylation
increases expression

manganese chloride results in increased methylation of CYRIA gene
manganese chloride results in increased expression of CYRIA mRNA

NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668

G

dachshund family transcription factor 2

increases expression

manganese chloride results in increased expression of DACH2 mRNA

NCBI chr X:78,718,963...79,018,023
Ensembl chr X:78,451,593...79,017,592

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

manganese chloride results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

dopamine beta-hydroxylase

increases methylation

manganese chloride results in increased methylation of DBH gene

NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248

G

D-box binding PAR bZIP transcription factor

increases expression

manganese chloride results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

decapping mRNA 1B

increases expression

manganese chloride results in increased expression of DCP1B mRNA

NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

Deferoxamine promotes the reaction [manganese chloride results in increased expression of DDIT3 protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of DDIT3 protein]
manganese chloride results in increased expression of DDIT3 mRNA; manganese chloride results in increased expression of DDIT3 protein

PMID:23764342 PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEXD/H-box helicase 60

increases expression

manganese chloride results in increased expression of DDX60 mRNA

NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526

G

defensin beta 29

increases methylation
increases expression

manganese chloride results in increased methylation of DEFB29 gene
manganese chloride results in increased expression of DEFB29 mRNA

NCBI chr 3:141,004,098...141,009,379
Ensembl chr 3:141,004,098...141,005,557

G

DEPP autophagy regulator 1

increases expression

manganese chloride results in increased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

dehydrogenase/reductase 3

decreases expression

manganese chloride results in decreased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dihydrolipoamide dehydrogenase

decreases expression

manganese chloride results in decreased expression of DLD protein

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

G

delta like non-canonical Notch ligand 1

increases methylation
decreases expression

manganese chloride results in increased methylation of DLK1 gene
manganese chloride results in decreased expression of DLK1 mRNA

NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522

G

delta like canonical Notch ligand 4

increases expression

manganese chloride results in increased expression of DLL4 mRNA

NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931

G

dermokine

increases expression

manganese chloride results in increased expression of DMKN mRNA

NCBI chr 1:86,013,237...86,031,243
Ensembl chr 1:86,014,188...86,030,006

G

dynein axonemal heavy chain 14

decreases expression

manganese chloride results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

G

dynein, axonemal, intermediate chain 2

decreases expression

manganese chloride results in decreased expression of DNAI2 mRNA

NCBI chr10:99,759,966...99,793,379
Ensembl chr10:99,759,966...99,793,378

G

DnaJ heat shock protein family (Hsp40) member C12

increases expression

manganese chloride results in increased expression of DNAJC12 mRNA

NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521

G

DnaJ heat shock protein family (Hsp40) member C16

increases expression

manganese chloride results in increased expression of DNAJC16 mRNA

NCBI chr 5:154,073,372...154,106,246
Ensembl chr 5:154,075,261...154,106,136

G

dynamin 1-like

increases expression
multiple interactions

manganese chloride results in increased expression of DNM1L mRNA; manganese chloride results in increased expression of DNM1L protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L protein]]; manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]; Resveratrol inhibits the reaction [manganese chloride promotes the reaction [PPARGC1A protein binds to DNM1L promoter]]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L mRNA]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

manganese chloride results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

double C2 domain alpha

increases expression

manganese chloride results in increased expression of DOC2A mRNA

NCBI chr 1:181,457,415...181,462,528
Ensembl chr 1:181,458,390...181,462,030

G

dipeptidase 1

decreases expression

manganese chloride results in decreased expression of DPEP1 mRNA

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dipeptidase 2

increases expression

manganese chloride results in increased expression of DPEP2 mRNA

NCBI chr19:33,883,557...33,896,487
Ensembl chr19:33,885,478...33,891,954

G

diphthamide biosynthesis 1

increases expression

manganese chloride results in increased expression of DPH1 mRNA

NCBI chr10:60,028,081...60,039,764
Ensembl chr10:60,026,048...60,039,850

G

dipeptidylpeptidase 4

increases expression

manganese chloride results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dihydropyrimidinase-like 3

decreases expression
increases expression

manganese chloride results in decreased expression of DPYSL3 mRNA
manganese chloride results in increased expression of DPYSL3 mRNA

PMID:22407947 PMID:25698507 PMID:28801915

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

down-regulator of transcription 1

decreases expression

manganese chloride results in decreased expression of DR1 mRNA

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

G

dopamine receptor D1

decreases expression
multiple interactions
increases expression

manganese chloride results in decreased expression of DRD1 protein
Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein]
manganese chloride results in increased expression of DRD1
[manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein

PMID:22479410 PMID:23458069 PMID:23604964 PMID:24969583

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions
increases expression
decreases expression

[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein; manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]
manganese chloride results in increased expression of DRD2; manganese chloride results in increased expression of DRD2 protein; manganese chloride results in increased expression of DRD2 protein alternative form
manganese chloride results in decreased expression of DRD2 protein
Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]

PMID:21484877 PMID:22479410 PMID:23458069 PMID:24969583

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

DS cell adhesion molecule-like 1

increases expression

manganese chloride results in increased expression of DSCAML1 mRNA

NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320

G

dentin sialophosphoprotein

increases expression

manganese chloride results in increased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

deltex E3 ubiquitin ligase 1

increases expression

manganese chloride results in increased expression of DTX1 mRNA

NCBI chr12:35,849,647...35,880,835
Ensembl chr12:35,849,617...35,880,838

G

dual specificity phosphatase 13B

increases expression

manganese chloride results in increased expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

dual specificity phosphatase 2

increases expression

manganese chloride results in increased expression of DUSP2 mRNA

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 4

increases expression

manganese chloride results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 5

increases expression
increases methylation

manganese chloride results in increased expression of DUSP5 mRNA
manganese chloride results in increased methylation of DUSP5 gene

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

increases methylation
increases expression

manganese chloride results in increased methylation of DUSP6 gene
manganese chloride results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dynein light chain Tctex-type 4

increases expression

manganese chloride results in increased expression of DYNLT4 mRNA

NCBI chr 5:130,605,437...130,607,224
Ensembl chr 5:130,605,399...130,607,666

G

ELL associated factor 2

increases expression
increases methylation

manganese chloride results in increased expression of EAF2 mRNA
manganese chloride results in increased methylation of EAF2 gene

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

Epstein-Barr virus induced 3

increases expression

manganese chloride results in increased expression of EBI3 mRNA

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

ECRG4 augurin precursor

decreases expression

manganese chloride results in decreased expression of ECRG4 mRNA

NCBI chr 9:45,992,954...46,012,605
Ensembl chr 9:45,992,954...46,012,595

G

endothelin 1

decreases expression

manganese chloride results in decreased expression of EDN1 mRNA

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor

multiple interactions

[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

EGF-like-domain, multiple 7

increases expression

manganese chloride results in increased expression of EGFL7 mRNA

NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879

G

epidermal growth factor receptor

multiple interactions
increases activity
increases expression

[manganese chloride co-treated with EGF protein] results in increased activity of EGFR protein
manganese chloride results in increased activity of EGFR protein
manganese chloride results in increased expression of EGFR mRNA

PMID:2354210 PMID:28801915

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

increases expression

manganese chloride results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

increases expression

manganese chloride results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

manganese chloride results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

increases expression

manganese chloride results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 1A domain containing

increases expression

manganese chloride results in increased expression of EIF1AD mRNA

NCBI chr 1:202,674,362...202,679,662
Ensembl chr 1:202,674,185...202,679,658

G

eukaryotic translation initiation factor 2A

multiple interactions

manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2A protein]

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2-alpha kinase 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation
increases expression

[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]; manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein; SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]
manganese chloride results in increased phosphorylation of EIF2AK3 protein
manganese chloride results in increased expression of EIF2AK3 protein

PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation
multiple interactions

manganese chloride results in increased phosphorylation of EIF2S1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein; manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]

PMID:23764342 PMID:23948121 PMID:32574669

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

E74 like ETS transcription factor 1

decreases expression

manganese chloride results in decreased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

ETS transcription factor ELK3

increases expression

manganese chloride results in increased expression of ELK3 mRNA

NCBI chr 7:27,768,582...27,831,088
Ensembl chr 7:27,768,599...27,804,084

G

ELMO domain containing 3

increases expression

manganese chloride results in increased expression of ELMOD3 mRNA

NCBI chr 4:104,614,665...104,653,122
Ensembl chr 4:104,614,676...104,653,053

G

ELOVL fatty acid elongase 6

decreases expression

manganese chloride results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

EMAP like 2

increases expression

manganese chloride results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

ectodermal-neural cortex 1

decreases expression

manganese chloride results in decreased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

endoglin

increases expression

manganese chloride results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 2

increases expression
decreases expression
multiple interactions

manganese chloride results in increased expression of ENO2 mRNA
manganese chloride results in decreased expression of ENO2 protein
Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein]

PMID:22281203 PMID:24969583

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

eomesodermin

decreases expression

manganese chloride results in decreased expression of EOMES mRNA; manganese chloride results in decreased expression of EOMES protein

NCBI chr 8:118,181,340...118,189,186
Ensembl chr 8:118,181,777...118,188,316

G

endothelial PAS domain protein 1

increases expression

manganese chloride results in increased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

ependymin related 1

increases expression

manganese chloride results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

Eph receptor A2

increases expression

manganese chloride results in increased expression of EPHA2 mRNA

NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117

G

Eph receptor A4

increases methylation
decreases expression

manganese chloride results in increased methylation of EPHA4 gene
manganese chloride results in decreased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

endoplasmic reticulum aminopeptidase 1

increases expression

manganese chloride results in increased expression of ERAP1 mRNA

NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

manganese chloride results in decreased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

epiregulin

increases expression

manganese chloride results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

glutamate-rich 1

increases expression

manganese chloride results in increased expression of ERICH1 mRNA

NCBI chr16:75,501,322...75,569,129
Ensembl chr16:75,501,384...75,569,128

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases phosphorylation

SNCA protein promotes the reaction [manganese chloride results in increased phosphorylation of ERN1 protein]

PMID:23934647 PMID:25732873

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

ERBB receptor feedback inhibitor 1

increases expression

manganese chloride results in increased expression of ERRFI1 mRNA

NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282

G

estrogen receptor 1

multiple interactions
decreases expression

Estradiol inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [manganese chloride results in decreased expression of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ETS variant transcription factor 3

increases expression

manganese chloride results in increased expression of ETV3 mRNA

NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314

G

ETS variant transcription factor 4

increases expression

manganese chloride results in increased expression of ETV4 mRNA

NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974

G

ETS variant transcription factor 5

increases expression

manganese chloride results in increased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

eva-1 homolog C

increases expression

manganese chloride results in increased expression of EVA1C mRNA

NCBI chr11:30,089,510...30,163,596
Ensembl chr11:30,089,365...30,163,596

G

exocyst complex component 6

decreases expression

manganese chloride results in decreased expression of EXOC6 mRNA

NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015

G

EYA transcriptional coactivator and phosphatase 4

decreases expression

manganese chloride results in decreased expression of EYA4 mRNA

NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976

G

F2R like trypsin receptor 1

increases expression

manganese chloride results in increased expression of F2RL1 mRNA

NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226

G

fatty acid 2-hydroxylase

increases expression
decreases expression

manganese chloride results in increased expression of FA2H mRNA
manganese chloride results in decreased expression of FA2H mRNA

PMID:26745496 PMID:28801915

NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153

G

fatty acid desaturase 2

decreases expression

manganese chloride results in decreased expression of FADS2 mRNA

NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789

G

family with sequence similarity 107, member A

decreases expression

manganese chloride results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

family with sequence similarity 171, member B

increases expression

manganese chloride results in increased expression of FAM171B mRNA

NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127

G

family with sequence similarity 180, member A

decreases expression

manganese chloride results in decreased expression of FAM180A mRNA

NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047

G

family with sequence similarity 210, member A

increases expression

manganese chloride results in increased expression of FAM210A mRNA

NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171

G

family with sequence similarity 210, member B

increases expression

manganese chloride results in increased expression of FAM210B mRNA

NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397

G

family with sequence similarity 219, member A

increases expression

manganese chloride results in increased expression of FAM219A mRNA

NCBI chr 5:56,679,272...56,729,959
Ensembl chr 5:56,680,613...56,729,924

G

family with sequence similarity 227, member A

increases expression

manganese chloride results in increased expression of FAM227A mRNA

NCBI chr 7:111,174,362...111,216,513
Ensembl chr 7:111,174,362...111,216,483

G

family with sequence similarity 229, member B

increases expression

manganese chloride results in increased expression of FAM229B mRNA

NCBI chr20:42,538,853...42,552,355
Ensembl chr20:42,538,868...42,552,248

G

FA complementation group F

decreases expression

manganese chloride results in decreased expression of FANCF mRNA

NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923

G

Fas cell surface death receptor

increases expression

manganese chloride results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

increases expression
multiple interactions

manganese chloride results in increased expression of FASLG protein
bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; CA 074 methyl ester inhibits the reaction [manganese chloride results in increased expression of FASLG protein]; pepstatin inhibits the reaction [manganese chloride results in increased expression of FASLG protein]

PMID:21704098 PMID:28378122

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

manganese chloride results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FAT atypical cadherin 2

increases methylation

manganese chloride results in increased methylation of FAT2 gene

NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216

G

FAT atypical cadherin 4

decreases expression

manganese chloride results in decreased expression of FAT4 mRNA

NCBI chr 2:121,927,266...122,056,700
Ensembl chr 2:121,927,942...122,056,707

G

fibulin 2

increases expression

manganese chloride results in increased expression of FBLN2 mRNA

NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948

G

fibrillin 1

increases expression

manganese chloride results in increased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fructose-bisphosphatase 2

increases expression

manganese chloride results in increased expression of FBP2 mRNA

NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698

G

F-box and leucine-rich repeat protein 2

increases expression

manganese chloride results in increased expression of FBXL2 mRNA

NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066

G

F-box and leucine-rich repeat protein 4

increases expression

manganese chloride results in increased expression of FBXL4 mRNA

NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443

G

Fc gamma receptor 1A

decreases expression

manganese chloride results in decreased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

Fc gamma receptor 3A

increases expression

manganese chloride results in increased expression of FCGR3A mRNA

NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921

G

farnesyl diphosphate synthase

decreases expression

manganese chloride results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

farnesyl diphosphate synthase, pseudogene 4

decreases expression

manganese chloride results in decreased expression of FDPS-PS4 mRNA

NCBI chr 8:18,816,786...18,818,020

G

farnesyl diphosphate synthase like 1

decreases expression

manganese chloride results in decreased expression of RGD1560208 mRNA

NCBI chr 2:179,060,261...179,060,762

G

fasciculation and elongation protein zeta 1

increases expression

manganese chloride results in increased expression of FEZ1 mRNA

NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683

G

fasciculation and elongation protein zeta 2

increases expression

manganese chloride results in increased expression of FEZ2 mRNA

NCBI chr 6:16,654,572...16,694,628
Ensembl chr 6:16,654,614...16,694,626

G

fibroblast growth factor 2

decreases expression
increases methylation

manganese chloride results in decreased expression of FGF2 mRNA
manganese chloride results in increased methylation of FGF2 gene

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 20

increases expression

manganese chloride results in increased expression of FGF20 mRNA

NCBI chr16:52,030,549...52,038,201
Ensembl chr16:52,010,194...52,038,204

G

fibroblast growth factor binding protein 1

decreases expression

manganese chloride results in decreased expression of FGFBP1 mRNA

NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496

G

fibroblast growth factor receptor 2

decreases expression

manganese chloride results in decreased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

FHF complex subunit HOOK interacting protein 2B

increases expression

manganese chloride results in increased expression of FHIP2B mRNA

NCBI chr15:45,656,641...45,674,603
Ensembl chr15:45,656,647...45,674,105

G

four and a half LIM domains 1

decreases expression

manganese chloride results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

fission, mitochondrial 1

increases expression

manganese chloride results in increased expression of FIS1 protein

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

folliculin

increases expression

manganese chloride results in increased expression of FLCN mRNA

NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769

G

fibronectin leucine rich transmembrane protein 2

increases expression

manganese chloride results in increased expression of FLRT2 mRNA

NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785

G

Fms related receptor tyrosine kinase 1

increases expression

manganese chloride results in increased expression of FLT1 mRNA

NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626

G

FLVCR choline and putative heme transporter 2

decreases expression

manganese chloride results in decreased expression of FLVCR2 mRNA

NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353

G

flavin containing dimethylaniline monoxygenase 2

increases expression

manganese chloride results in increased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 5

decreases methylation
increases expression

manganese chloride results in decreased methylation of FMO5 gene
manganese chloride results in increased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

fibronectin 1

multiple interactions
increases expression

[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; manganese chloride results in increased expression of and results in increased secretion of FN1 protein; Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]; phenyl-N-tert-butylnitrone inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
decreases expression

manganese chloride results in increased expression of FOS protein
manganese chloride results in decreased expression of FOS protein

PMID:9751194 PMID:25698507

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

increases expression

manganese chloride results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box N4

increases expression

manganese chloride results in increased expression of FOXN4 mRNA

NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921

G

forkhead box P2

increases expression

manganese chloride results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

FRAS1 related extracellular matrix 3

increases expression

manganese chloride results in increased expression of FREM3 mRNA

NCBI chr19:27,308,469...27,366,771
Ensembl chr19:27,308,469...27,366,771

G

FERM domain containing 4A

increases expression

manganese chloride results in increased expression of FRMD4A mRNA

NCBI chr17:73,667,787...74,258,487
Ensembl chr17:73,667,789...74,258,687

G

fascin actin-bundling protein 2, retinal

decreases expression

manganese chloride results in decreased expression of FSCN2 mRNA

NCBI chr10:105,634,783...105,641,322
Ensembl chr10:105,634,783...105,641,322

G

follicle stimulating hormone subunit beta

multiple interactions
decreases expression

Quercetin inhibits the reaction [manganese chloride results in decreased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follistatin like 3

increases expression

manganese chloride results in increased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

ferritin heavy chain 1

decreases expression

manganese chloride results in decreased expression of FTH1 mRNA; manganese chloride results in decreased expression of FTH1 protein

PMID:15893546 PMID:15922012 PMID:16545456 PMID:16568477

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

ferritin light chain 1

decreases expression

manganese chloride results in decreased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

fucosyltransferase 1

increases expression

manganese chloride results in increased expression of FUT1 mRNA

NCBI chr 1:96,086,934...96,090,352
Ensembl chr 1:96,086,635...96,090,616

G

fucosyltransferase 2

decreases expression
increases methylation

manganese chloride results in decreased expression of FUT2 mRNA
manganese chloride results in increased methylation of FUT2 gene

NCBI chr 1:96,119,549...96,139,567
Ensembl chr 1:96,119,371...96,140,360

G

FXYD domain-containing ion transport regulator 2

increases expression

manganese chloride results in increased expression of FXYD2 mRNA

NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203

G

G0/G1switch 2

increases expression

manganese chloride results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions
decreases expression

[Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 mRNA; [Iron deficiency co-treated with manganese chloride] results in decreased expression of GABBR2 protein
manganese chloride results in decreased expression of GABBR2 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein

PMID:18771689 PMID:32659473

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions
decreases expression
increases expression

[Iron deficiency co-treated with manganese chloride] results in increased expression of GABRA1 protein
manganese chloride results in decreased expression of GABRA1 mRNA
manganese chloride results in increased expression of GABRA1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein

PMID:18771689 PMID:32659473

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

decreases expression

manganese chloride results in decreased expression of GABRB3 mRNA

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

manganese chloride results in increased expression of GABRG2 mRNA

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glutamate decarboxylase 1

decreases expression

manganese chloride results in decreased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

growth arrest and DNA-damage-inducible, alpha

decreases expression

manganese chloride results in decreased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

galanin and GMAP prepropeptide

increases expression

manganese chloride results in increased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

UDP-galactose-4-epimerase

decreases expression

manganese chloride results in decreased expression of GALE mRNA

NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388

G

golgi associated RAB2 interactor 1B

increases expression

manganese chloride results in increased expression of GARIN1B mRNA

NCBI chr 4:57,915,184...57,938,593
Ensembl chr 4:57,920,790...57,938,591

G

1,4-alpha-glucan branching enzyme 1

increases methylation
decreases expression

manganese chloride results in increased methylation of GBE1 gene
manganese chloride results in decreased expression of GBE1 mRNA

NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210

G

guanylate binding protein 5

increases methylation
increases expression

manganese chloride results in increased methylation of GBP5 gene
manganese chloride results in increased expression of GBP5 mRNA

NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061

G

glutaryl-CoA dehydrogenase

decreases expression

manganese chloride results in decreased expression of GCDH mRNA

NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681

G

GC-rich sequence DNA-binding factor 2

decreases expression

manganese chloride results in decreased expression of GCFC2 mRNA

NCBI chr 4:114,481,613...114,519,268
Ensembl chr 4:114,481,607...114,519,962

G

glucagon receptor

decreases expression
increases methylation

manganese chloride results in decreased expression of GCGR mRNA
manganese chloride results in increased methylation of GCGR gene

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

GTP cyclohydrolase 1

decreases expression

manganese chloride results in decreased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

ganglioside-induced differentiation-associated-protein 2

increases expression

manganese chloride results in increased expression of GDAP2 mRNA

NCBI chr 2:187,528,514...187,585,270
Ensembl chr 2:187,528,513...187,585,270

G

growth differentiation factor 15

increases expression

manganese chloride results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glial cell derived neurotrophic factor

increases methylation

manganese chloride results in increased methylation of GDNF gene

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

decreases expression
increases expression
multiple interactions

manganese chloride results in decreased expression of GFAP protein
manganese chloride results in increased expression of GFAP protein
Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]

PMID:12009774 PMID:12106697 PMID:24060432 PMID:24969583 PMID:25288107 More...

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, alpha 1

decreases expression

manganese chloride results in decreased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, alpha 5

decreases expression

manganese chloride results in decreased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gap junction protein, alpha 8

increases expression

manganese chloride results in increased expression of GJA8 mRNA

NCBI chr 2:184,490,840...184,492,456
Ensembl chr 2:184,490,840...184,492,456

G

gap junction protein, beta 5

increases expression

manganese chloride results in increased expression of GJB5 mRNA

NCBI chr 5:139,680,670...139,683,588
Ensembl chr 5:139,680,671...139,683,583

G

gastrokine 3

decreases expression

manganese chloride results in decreased expression of GKN3 mRNA

NCBI chr 4:119,828,859...119,833,924
Ensembl chr 4:119,829,005...119,834,842

G

gliomedin

decreases expression

manganese chloride results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

GLIS family zinc finger 1

decreases expression

manganese chloride results in decreased expression of GLIS1 mRNA

NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141

G

GLIS family zinc finger 2

increases expression

manganese chloride results in increased expression of GLIS2 mRNA

NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578

G

glycosyltransferase 8 domain containing 2

increases expression

manganese chloride results in increased expression of GLT8D2 mRNA

NCBI chr 7:21,029,534...21,081,081
Ensembl chr 7:21,029,525...21,081,080

G

glutamate-ammonia ligase

decreases expression
multiple interactions

manganese chloride results in decreased expression of GLUL mRNA; manganese chloride results in decreased expression of GLUL protein
Riluzole inhibits the reaction [manganese chloride results in decreased expression of and results in decreased activity of GLUL protein]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of GLUL mRNA]

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

G protein subunit beta 4

increases expression

manganese chloride results in increased expression of GNB4 mRNA

NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579

G

gonadotropin releasing hormone 1

increases expression
multiple interactions
increases secretion

manganese chloride results in increased expression of GNRH1 mRNA
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; [manganese chloride co-treated with Calcium Chloride] results in increased secretion of GNRH1 protein; [manganese chloride results in increased chemical synthesis of Cyclic GMP] which results in increased secretion of GNRH1 protein; Bicuculline promotes the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Dopamine affects the reaction [manganese chloride results in increased secretion of GNRH1 protein]; gamma-Aminobutyric Acid inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Haloperidol inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]; Methylene Blue inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein]

PMID:17110411 PMID:17290048 PMID:18603625 PMID:21402727

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

glycoprotein nmb

increases expression

manganese chloride results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor 18

decreases expression

manganese chloride results in decreased expression of GPR18 mRNA

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

G

G protein-coupled receptor 34

decreases expression

manganese chloride results in decreased expression of GPR34 mRNA

NCBI chr X:9,104,829...9,113,796
Ensembl chr X:9,104,565...9,148,601

G

glutathione peroxidase 1

multiple interactions
decreases expression
increases activity

Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]
manganese chloride results in increased activity of GPX1 protein
[Cadmium Chloride co-treated with lead acetate co-treated with manganese chloride] results in increased activity of GPX1 protein

PMID:24969583 PMID:25288107 PMID:27599793

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutamate ionotropic receptor kainate type subunit 3

increases methylation
decreases expression

manganese chloride results in increased methylation of GRIK3 gene
manganese chloride results in decreased expression of GRIK3 mRNA

PMID:27913844 PMID:28801915

NCBI chr 5:137,767,865...137,989,617
Ensembl chr 5:137,767,865...137,984,307

G

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

manganese chloride results in decreased expression of GRIN1 mRNA; manganese chloride results in decreased expression of GRIN1 protein

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

manganese chloride results in decreased expression of GRIN2A mRNA; manganese chloride results in decreased expression of GRIN2A protein

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

manganese chloride results in decreased expression of GRIN2B mRNA; manganese chloride results in decreased expression of GRIN2B protein

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

gasdermin D like 1

increases expression

manganese chloride results in increased expression of GSDMDL1 mRNA

NCBI chr 7:95,620,052...95,630,546
Ensembl chr 7:95,620,061...95,630,532

G

glycogen synthase kinase 3 beta

multiple interactions
increases activity
decreases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased phosphorylation of GSK3B protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased activity of GSK3B protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; Lithium Chloride inhibits the reaction [manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein]; manganese chloride results in decreased phosphorylation of and results in increased activity of GSK3B protein

PMID:20937724 PMID:24464479

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

GSK3B interacting protein

increases expression

manganese chloride results in increased expression of GSKIP mRNA

NCBI chr 6:124,586,087...124,609,106
Ensembl chr 6:124,586,070...124,609,100

G

G1 to S phase transition 2

decreases expression

manganese chloride results in decreased expression of GSPT2 mRNA

NCBI chr X:59,587,237...59,589,758
Ensembl chr X:59,587,276...59,594,162

G

glutathione-disulfide reductase

decreases expression
multiple interactions

manganese chloride results in decreased expression of GSR mRNA
manganese chloride results in decreased expression of GSR protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]

PMID:17175027 PMID:24969583 PMID:25288107 PMID:32445656

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase omega 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GSTO1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GSTO1 protein

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

general transcription factor IIH subunit 1

decreases expression

manganese chloride results in decreased expression of GTF2H1 mRNA

NCBI chr 1:97,321,417...97,349,455
Ensembl chr 1:97,321,394...97,349,455

G

H1.1 linker histone, cluster member

decreases expression

manganese chloride results in decreased expression of H1F1 mRNA

NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011

G

H1.2 linker histone, cluster member

decreases expression

manganese chloride results in decreased expression of H1F2 mRNA

NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635

G

H2B clustered histone 8

decreases expression

manganese chloride results in decreased expression of H2BC8 mRNA

NCBI chr17:42,708,658...42,709,408

G

H2B.U histone 1

decreases expression

manganese chloride results in decreased expression of H2BU1 mRNA

NCBI chr10:43,732,737...43,733,484
Ensembl chr10:43,732,864...43,736,277

G

H3 clustered histone 1

decreases expression

manganese chloride results in decreased expression of H3C1 mRNA

NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856
Ensembl chr17:41,368,386...41,368,856

G

hepcidin antimicrobial peptide

decreases expression
multiple interactions

manganese chloride results in decreased expression of HAMP mRNA
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of HAMP protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HAMP protein

PMID:20635692 PMID:34590183

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

hyaluronan and proteoglycan link protein 3

increases expression

manganese chloride results in increased expression of HAPLN3 mRNA

NCBI chr 1:133,046,465...133,064,665
Ensembl chr 1:133,046,467...133,080,177

G

histone acetyltransferase 1

decreases expression

manganese chloride results in decreased expression of HAT1 protein

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

histone deacetylase 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

histone deacetylase 2

increases expression

manganese chloride results in increased expression of HDAC2 mRNA

NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609

G

histone deacetylase 3

increases expression
multiple interactions

manganese chloride results in increased expression of HDAC3 mRNA; manganese chloride results in increased expression of HDAC3 protein
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]

PMID:29155171 PMID:34800614

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

G

histone deacetylase 4

increases expression

manganese chloride results in increased expression of HDAC4 mRNA; manganese chloride results in increased expression of HDAC4 protein

NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164

G

HDGF like 3

increases expression

manganese chloride results in increased expression of HDGFL3 mRNA

NCBI chr 1:135,822,600...135,876,719
Ensembl chr 1:135,827,549...135,876,719

G

HEAT repeat containing 3

increases expression

manganese chloride results in increased expression of HEATR3 mRNA

NCBI chr19:18,892,477...18,930,502
Ensembl chr19:18,893,144...18,930,509

G

hephaestin

increases expression

manganese chloride results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hexosaminidase D

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXD mRNA

NCBI chr10:106,479,781...106,498,799
Ensembl chr10:106,480,194...106,498,799

G

hes-related family bHLH transcription factor with YRPW motif 1

increases expression

manganese chloride results in increased expression of HEY1 mRNA

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

homeostatic iron regulator

multiple interactions
decreases response to substance

HFE gene mutant form inhibits the reaction [manganese chloride results in decreased activity of SOD1 protein]
HFE gene mutant form results in decreased susceptibility to manganese chloride

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions
decreases hydroxylation
increases stability
decreases degradation
decreases expression

manganese chloride results in increased expression of HIF1A mRNA; manganese chloride results in increased expression of HIF1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased degradation of HIF1A protein; [manganese chloride results in decreased activity of P4HTM protein] which results in decreased hydroxylation of HIF1A protein; Ascorbic Acid inhibits the reaction [manganese chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [manganese chloride results in increased stability of HIF1A protein]; HIF1A mutant form inhibits the reaction [manganese chloride results in increased secretion of VEGFA protein]; Iron inhibits the reaction [manganese chloride results in increased expression of HIF1A protein]; manganese chloride inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Ketoglutaric Acids co-treated with Ascorbic Acid co-treated with ferrous chloride] promotes the reaction [VHL protein binds to HIF1A protein]]; manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of and results in increased stability of HIF1A protein]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of and results in increased activity of HIF1A protein]; VHL protein affects the reaction [manganese chloride results in increased expression of HIF1A protein]
manganese chloride results in decreased degradation of HIF1A protein
manganese chloride results in decreased expression of HIF1A mRNA
[[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A protein

PMID:17175027 PMID:17467022 PMID:19074761 PMID:19263519 PMID:20152896 More...

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 1 subunit alpha inhibitor

decreases expression

manganese chloride results in decreased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

hypoxia inducible lipid droplet-associated

increases expression

manganese chloride results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

homeodomain interacting protein kinase 3

decreases expression

manganese chloride results in decreased expression of HIPK3 mRNA

NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759

G

histone cluster 1, H2an

decreases expression

manganese chloride results in decreased expression of HIST1H2AN mRNA

NCBI chr17:41,534,653...41,535,259
Ensembl chr17:41,534,691...41,539,869

G

histone cluster 1, H2bc

decreases expression

manganese chloride results in decreased expression of HIST1H2BC mRNA

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

histone cluster 1 H2B family member Q

decreases expression

manganese chloride results in decreased expression of HIST1H2BQ mRNA

NCBI chr17:41,432,100...41,441,487
Ensembl chr17:41,429,164...41,442,153

G

histone cluster 2 H2A family member A2

decreases expression

manganese chloride results in decreased expression of HIST2H2AA2 mRNA

NCBI chr 2:183,801,308...183,801,891

G

histone cluster 3, H2ba

decreases expression

manganese chloride results in decreased expression of HIST3H2BA mRNA

NCBI chr10:43,725,836...43,726,465
Ensembl chr10:43,724,930...43,727,107

G

homeobox containing 1

decreases expression

manganese chloride results in decreased expression of HMBOX1 mRNA

NCBI chr15:39,067,805...39,200,633
Ensembl chr15:39,067,804...39,200,323

G

hemicentin 2

increases expression

manganese chloride results in increased expression of HMCN2 mRNA

NCBI chr 3:14,588,353...14,738,320
Ensembl chr 3:14,588,662...14,738,025

G

high mobility group box 1

increases expression
multiple interactions

manganese chloride results in increased expression of HMGB1 mRNA
corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]]; manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]; manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]; manganese chloride results in increased expression of and affects the localization of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

manganese chloride results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

affects response to substance
multiple interactions
increases expression

HMOX1 protein affects the susceptibility to manganese chloride
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]; manganese chloride promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]
HMOX1 protein inhibits the reaction [manganese chloride results in increased abundance of Hydrogen Peroxide]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]
manganese chloride results in increased expression of HMOX1 mRNA; manganese chloride results in increased expression of HMOX1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 mRNA

PMID:21107535 PMID:21384399 PMID:21963524 PMID:22281203 PMID:25288107 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

homeo box B9

decreases expression

manganese chloride results in decreased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

G

homeo box D4

increases expression

manganese chloride results in increased expression of HOXD4 mRNA

NCBI chr 3:59,614,464...59,634,042
Ensembl chr 3:59,614,464...59,631,528

G

hemopexin

decreases expression

manganese chloride results in decreased expression of HPX mRNA

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

histamine receptor H 1

decreases methylation

manganese chloride results in decreased methylation of HRH1 gene

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

harakiri, BCL2 interacting protein

increases expression
decreases methylation

manganese chloride results in increased expression of HRK mRNA
manganese chloride results in decreased methylation of HRK gene

NCBI chr12:38,387,484...38,409,652

G

hydroxysteroid 11-beta dehydrogenase 1

increases expression

manganese chloride results in increased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock protein 90 beta family member 1

multiple interactions
increases expression

SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSP90B1 protein]
manganese chloride results in increased expression of HSP90B1 mRNA; manganese chloride results in increased expression of HSP90B1 protein

PMID:23934647 PMID:23948121

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 4 like

increases expression

manganese chloride results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 mRNA]; SNCA protein promotes the reaction [manganese chloride results in increased expression of HSPA5 protein]
manganese chloride results in increased expression of HSPA5 mRNA; manganese chloride results in increased expression of HSPA5 protein

PMID:23934647 PMID:23948121 PMID:25732873 PMID:32574669

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 8

decreases expression

manganese chloride results in decreased expression of HSPB8 mRNA

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

HtrA serine peptidase 1

increases expression

manganese chloride results in increased expression of HTRA1 mRNA

NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379

G

huntingtin

affects response to substance

HTT affects the susceptibility to manganese chloride

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

G

intercellular adhesion molecule 1

multiple interactions
decreases expression

manganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
manganese chloride results in decreased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

increases expression

manganese chloride results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 2

increases expression
decreases expression

manganese chloride results in increased expression of ID2 mRNA
manganese chloride results in decreased expression of ID2 mRNA

PMID:17175027 PMID:28801915

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of IDH3G mRNA

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

G

interferon gamma

increases expression
multiple interactions

manganese chloride results in increased expression of IFNG protein
manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 mRNA]]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased expression of IFNG protein co-treated with and results in increased expression of NOS2 protein]]

PMID:16168523 PMID:20798247

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

intraflagellar transport 70A1

increases expression

manganese chloride results in increased expression of IFT70A1 mRNA

NCBI chr 3:60,901,896...60,905,350
Ensembl chr 3:60,901,896...60,905,350

G

insulin-like growth factor 1

increases expression

manganese chloride results in increased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

increases expression
decreases expression

manganese chloride results in increased expression of IGF1R protein
manganese chloride results in decreased expression of IGF1R mRNA

PMID:19276553 PMID:21402727

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

decreases methylation

manganese chloride results in decreased methylation of IGF2 gene

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor 2 receptor

decreases expression

manganese chloride results in decreased expression of IGF2R mRNA

NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501

G

insulin-like growth factor binding protein 5

increases expression

manganese chloride results in increased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

immunoglobulin heavy chain 6 like 1

increases expression

manganese chloride results in increased expression of IGH-6L1 mRNA

NCBI chr 5:148,516,031...148,517,519

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

IKBKB gene mutant form results in increased susceptibility to [manganese chloride results in increased abundance of Manganese]
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]

PMID:32692843 PMID:34310962

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 12A

increases expression
multiple interactions

manganese chloride results in increased expression of IL12A mRNA
manganese chloride results in increased expression of [IL12A protein binds to IL12B protein]
manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]]

PMID:17175027 PMID:28539244

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions
increases expression

manganese chloride promotes the reaction [SNCA protein results in increased expression of [IL12A protein binds to IL12B protein]]
manganese chloride results in increased expression of [IL12A protein binds to IL12B protein]
manganese chloride results in increased expression of IL12B mRNA

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 18

multiple interactions
increases expression

acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL18 mRNA]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

increases expression

manganese chloride results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions
decreases expression

manganese chloride results in increased expression of IL1B protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of IL1B protein]
[Lipopolysaccharides co-treated with manganese chloride] results in increased expression of IL1B protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL1B protein; acetovanillone analog inhibits the reaction [manganese chloride results in increased expression of IL1B mRNA]
manganese chloride results in decreased expression of IL1B mRNA
[manganese chloride co-treated with SNCA protein] results in increased expression of IL1B mRNA; [manganese chloride co-treated with SNCA protein] results in increased expression of IL1B protein

PMID:15601679 PMID:18836210 PMID:27427241 PMID:28539244 PMID:33314588 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

increases expression

manganese chloride results in increased expression of IL1R1 mRNA

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 1 receptor type 2

increases expression

manganese chloride results in increased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 1 receptor-like 1

decreases expression
increases expression

manganese chloride results in decreased expression of IL1RL1 mRNA
manganese chloride results in increased expression of IL1RL1 mRNA

PMID:26745496 PMID:28801915

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 1 receptor antagonist

increases expression

manganese chloride results in increased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 23 subunit alpha

increases expression

manganese chloride results in increased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 36 receptor antagonist

increases expression

manganese chloride results in increased expression of IL36RN mRNA

NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016

G

interleukin 4

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression
decreases expression
increases secretion

6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of IL6 protein; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Lipopolysaccharides promotes the reaction [manganese chloride results in increased expression of IL6 protein]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; zinc protoporphyrin inhibits the reaction [manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]]
manganese chloride results in increased expression of IL6 mRNA
manganese chloride results in increased expression of IL6 mRNA; manganese chloride results in increased expression of IL6 protein
manganese chloride results in decreased expression of IL6 mRNA
manganese chloride results in increased secretion of IL6 protein
manganese chloride promotes the reaction [SNCA protein results in increased expression of IL6 mRNA]

PMID:15601679 PMID:17065364 PMID:19815061 PMID:21963524 PMID:25219578 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 7

increases expression

manganese chloride results in increased expression of IL7 mRNA

NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075

G

insulin 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] inhibits the reaction [Glucose results in increased secretion of INS protein]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

insulin induced gene 1

decreases expression
increases methylation

manganese chloride results in decreased expression of INSIG1 mRNA
manganese chloride results in increased methylation of INSIG1 gene

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin receptor

decreases expression
increases phosphorylation
increases expression

manganese chloride results in decreased expression of INSR mRNA
manganese chloride results in increased phosphorylation of INSR protein
manganese chloride results in increased expression of INSR mRNA

PMID:2475105 PMID:19276553 PMID:28801915

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

integrator complex subunit 2

decreases expression

manganese chloride results in decreased expression of INTS2 mRNA

NCBI chr10:71,031,647...71,079,138
Ensembl chr10:71,031,647...71,079,076

G

IQ motif containing G

increases expression

manganese chloride results in increased expression of IQCG mRNA

NCBI chr11:67,730,117...67,771,170
Ensembl chr11:67,730,247...67,771,168

G

IQ motif containing GTPase activating protein 1

increases expression

manganese chloride results in increased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

iron responsive element binding protein 2

decreases activity
increases activity

manganese chloride results in decreased activity of IREB2 protein
manganese chloride results in increased activity of IREB2 protein

PMID:15893546 PMID:16568477

NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611

G

interferon regulatory factor 2

decreases expression

manganese chloride results in decreased expression of IRF2 mRNA

NCBI chr16:45,439,215...45,550,054
Ensembl chr16:45,439,225...45,550,024

G

isthmin 1

increases expression

manganese chloride results in increased expression of ISM1 mRNA

NCBI chr 3:127,023,296...127,102,228
Ensembl chr 3:127,021,865...127,101,894

G

integrin subunit alpha 10

increases expression

manganese chloride results in increased expression of ITGA10 mRNA

NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172

G

integrin subunit alpha 2b

multiple interactions

manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein]

NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168

G

integrin subunit alpha 3

increases expression

manganese chloride results in increased expression of ITGA3 mRNA

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha 8

increases expression
increases methylation

manganese chloride results in increased expression of ITGA8 mRNA
manganese chloride results in increased methylation of ITGA8 gene

NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510

G

integrin subunit alpha M

increases expression

manganese chloride results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha V

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [AG 1879 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; [CGP 77675 results in decreased activity of SRC protein] promotes the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; arginyl-glycyl-aspartic acid inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]; manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]; Wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
manganese chloride inhibits the reaction [TLN1 protein mutant form results in decreased activity of [ITGB3 protein binds to ITGA2B protein]]; manganese chloride results in increased activity of [ITGB3 protein binds to ITGA2B protein]

PMID:15213856 PMID:20971947

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

integrin subunit beta 5

increases expression

manganese chloride results in increased expression of ITGB5 mRNA

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

integrin subunit beta 6

decreases methylation
increases methylation
increases expression

manganese chloride results in decreased methylation of ITGB6 gene
manganese chloride results in increased methylation of ITGB6 gene
manganese chloride results in increased expression of ITGB6 mRNA

PMID:27913844 PMID:28801915

NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671

G

inter-alpha trypsin inhibitor, heavy chain 1

multiple interactions

manganese chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]

NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363

G

inter-alpha-trypsin inhibitor heavy chain 2

multiple interactions

manganese chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]

NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases phosphorylation

manganese chloride results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [manganese chloride results in increased phosphorylation of JUN protein]

PMID:9751194 PMID:15342272

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel modifier subfamily G member 1

increases expression

manganese chloride results in increased expression of KCNG1 mRNA

NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635

G

potassium voltage-gated channel subfamily H member 4

decreases expression

manganese chloride results in decreased expression of KCNH4 mRNA

NCBI chr10:85,668,332...85,688,166
Ensembl chr10:85,668,337...85,688,158

G

potassium voltage-gated channel subfamily H member 6

increases expression

manganese chloride results in increased expression of KCNH6 mRNA

NCBI chr10:90,949,240...90,970,746
Ensembl chr10:90,949,846...90,970,701

G

potassium voltage-gated channel interacting protein 3

increases expression

manganese chloride results in increased expression of KCNIP3 mRNA

NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556

G

potassium inwardly-rectifying channel, subfamily J, member 11

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ11 protein

NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082

G

potassium inwardly-rectifying channel, subfamily J, member 3

increases expression

manganese chloride results in increased expression of KCNJ3 mRNA

NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124

G

potassium inwardly-rectifying channel, subfamily J, member 8

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of KCNJ8 protein

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

G

potassium two pore domain channel subfamily K member 12

decreases expression

manganese chloride results in decreased expression of KCNK12 mRNA

NCBI chr 6:6,740,147...6,790,664
Ensembl chr 6:6,739,991...6,790,661

G

potassium voltage-gated channel subfamily Q member 1

increases expression

manganese chloride results in increased expression of KCNQ1 mRNA

NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669

G

potassium voltage-gated channel subfamily Q member 2

increases expression

manganese chloride results in increased expression of KCNQ2 mRNA

NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071

G

Kelch-like ECH-associated protein 1

affects expression
multiple interactions

manganese chloride affects the expression of KEAP1 protein
Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

keratocan

increases expression

manganese chloride results in increased expression of KERA mRNA

NCBI chr 7:32,397,382...32,404,837
Ensembl chr 7:32,397,382...32,404,837

G

KIAA1671 homolog

increases expression

manganese chloride results in increased expression of KIAA1671 mRNA

NCBI chr12:43,409,479...43,552,152
Ensembl chr12:43,411,069...43,552,157

G

kinesin family member 3B

increases expression

manganese chloride results in increased expression of KIF3B mRNA

NCBI chr 3:141,758,466...141,798,012
Ensembl chr 3:141,758,466...141,797,963

G

kinesin family member 5C

increases expression

manganese chloride results in increased expression of KIF5C mRNA

NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413

G

KISS1 receptor

increases expression

manganese chloride results in increased expression of KISS1R mRNA

NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793

G

KLF transcription factor 2

increases expression

manganese chloride results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 4

increases expression

manganese chloride results in increased expression of KLF4 mRNA

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 5

decreases expression
increases expression
decreases methylation

manganese chloride results in decreased expression of KLF5 mRNA
manganese chloride results in increased expression of KLF5 mRNA
manganese chloride results in decreased methylation of KLF5 gene

PMID:17467022 PMID:28801915

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

KLF transcription factor 9

decreases expression

manganese chloride results in decreased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch domain containing 8A

increases expression

manganese chloride results in increased expression of KLHDC8A mRNA

NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277

G

kininogen 1

decreases expression

manganese chloride results in decreased expression of KNG1 mRNA

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

keratin 7

increases expression

manganese chloride results in increased expression of KRT7 mRNA

NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052

G

keratin 76

increases expression

manganese chloride results in increased expression of KRT76 mRNA

NCBI chr 7:133,016,990...133,025,475
Ensembl chr 7:133,016,992...133,025,496

G

keratin 79

decreases expression

manganese chloride results in decreased expression of KRT79 mRNA

NCBI chr 7:133,056,710...133,067,750
Ensembl chr 7:133,056,709...133,067,705

G

keratin 81

increases expression

manganese chloride results in increased expression of KRT81 mRNA

NCBI chr 7:132,577,112...132,582,238
Ensembl chr 7:132,576,492...132,582,170

G

keratin 87

increases expression

manganese chloride results in increased expression of KRT83 mRNA

NCBI chr 7:132,547,388...132,555,005
Ensembl chr 7:132,548,141...132,554,978

G

keratin associated protein 1-5

increases expression

manganese chloride results in increased expression of KRTAP1-3 mRNA

NCBI chr10:84,543,288...84,543,711
Ensembl chr10:84,543,062...84,543,682

G

laccase domain containing 1

increases expression

manganese chloride results in increased expression of LACC1 mRNA

NCBI chr15:52,390,267...52,407,630
Ensembl chr15:52,395,183...52,407,545

G

lysosomal-associated membrane protein 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 mRNA]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP1 protein]

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lysosomal-associated membrane protein 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lecithin cholesterol acyltransferase

increases expression

manganese chloride results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein; Tetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein]

NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794

G

low density lipoprotein receptor class A domain containing 4

increases expression

manganese chloride results in increased expression of LDLRAD4 mRNA

NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238

G

galectin 3

increases expression

manganese chloride results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

leucine-rich repeat LGI family, member 4

increases expression

manganese chloride results in increased expression of LGI4 mRNA

NCBI chr 1:86,294,539...86,305,909
Ensembl chr 1:86,295,074...86,304,874

G

leucine-rich repeat-containing G protein-coupled receptor 4

decreases expression

manganese chloride results in decreased expression of LGR4 mRNA

NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899

G

luteinizing hormone subunit beta

multiple interactions
decreases expression

Quercetin inhibits the reaction [manganese chloride results in decreased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

LHFPL tetraspan subfamily member 2

increases expression

manganese chloride results in increased expression of LHFPL2 mRNA

NCBI chr 2:25,281,771...25,428,128
Ensembl chr 2:25,281,901...25,427,950

G

LIM homeobox 1

decreases expression

manganese chloride results in decreased expression of LHX1 mRNA

NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617

G

LIF, interleukin 6 family cytokine

increases expression

manganese chloride results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lectin, mannose-binding 2

increases expression

manganese chloride results in increased expression of LMAN2 mRNA

NCBI chr17:9,269,236...9,286,923
Ensembl chr17:9,269,022...9,287,265

G

leiomodin 2

decreases expression

manganese chloride results in decreased expression of LMOD2 mRNA

NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120

G

lysyl oxidase

decreases expression

manganese chloride results in decreased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

lipoprotein(a) like 2, pseudogene

decreases expression

manganese chloride results in decreased expression of LPAL2 mRNA

NCBI chr 4:165,207,378...165,264,321
Ensembl chr 4:165,207,328...165,264,340

G

lysophosphatidic acid receptor 1

decreases expression

manganese chloride results in decreased expression of LPAR1 mRNA

NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895

G

lysophosphatidylcholine acyltransferase 4

decreases expression

manganese chloride results in decreased expression of LPCAT4 mRNA

NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875

G

lipin 1

decreases expression

manganese chloride results in decreased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

lecithin retinol acyltransferase

increases expression

manganese chloride results in increased expression of LRAT mRNA

NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619

G

LDL receptor related protein 2

decreases expression

manganese chloride results in decreased expression of LRP2 mRNA

NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708

G

LDL receptor related protein 8

increases expression

manganese chloride results in increased expression of LRP8 mRNA

NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352

G

leucine rich repeat containing 10B

increases methylation

manganese chloride results in increased methylation of LRRC10B gene

NCBI chr 1:207,096,471...207,097,699
Ensembl chr 1:207,022,919...207,098,045

G

leucine rich repeat containing 15

increases expression

manganese chloride results in increased expression of LRRC15 mRNA

NCBI chr11:70,469,817...70,484,268
Ensembl chr11:70,469,804...70,484,267

G

leucine rich repeat containing 8 VRAC subunit B

increases expression

manganese chloride results in increased expression of LRRC8B mRNA

NCBI chr14:4,350,462...4,416,336
Ensembl chr14:4,354,508...4,416,311

G

leucine-rich repeat kinase 1

increases expression

manganese chloride results in increased expression of LRRK1 mRNA

NCBI chr 1:119,844,360...119,972,885
Ensembl chr 1:119,845,146...119,979,734

G

LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of LSM2 mRNA

NCBI chr20:3,843,467...3,847,217
Ensembl chr20:3,843,466...3,847,266

G

lymphocyte antigen 6 family member G5B

increases expression

manganese chloride results in increased expression of LY6G5B mRNA

NCBI chr20:3,705,464...3,707,830
Ensembl chr20:3,706,124...3,707,133

G

LYN proto-oncogene, Src family tyrosine kinase

decreases methylation

manganese chloride results in decreased methylation of LYN gene

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

Ly6/Plaur domain containing 6B

decreases expression

manganese chloride results in decreased expression of LYPD6B mRNA

NCBI chr 3:34,199,101...34,360,770
Ensembl chr 3:34,199,599...34,360,770

G

LYR motif containing 7

increases expression

manganese chloride results in increased expression of LYRM7 mRNA

NCBI chr10:38,964,299...38,983,628
Ensembl chr10:38,964,311...38,983,601

G

LYR motif containing 9

increases expression

manganese chloride results in increased expression of LYRM9 mRNA

NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772

G

mono-ADP ribosylhydrolase 2

increases expression

manganese chloride results in increased expression of MACROD2 mRNA

NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492

G

mucosal vascular addressin cell adhesion molecule 1

increases expression

manganese chloride results in increased expression of MADCAM1 mRNA

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

G

MAF bZIP transcription factor F

increases expression

manganese chloride results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

MAGE family member B7

increases expression

manganese chloride results in increased expression of MAGEB7 mRNA

NCBI chr X:50,965,892...50,969,116
Ensembl chr X:50,966,208...50,967,245

G

mal, T-cell differentiation protein-like

decreases expression

manganese chloride results in decreased expression of MALL mRNA

NCBI chr 3:114,927,897...114,950,840
Ensembl chr 3:114,927,897...114,950,785

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MAP1LC3B mRNA]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

microtubule-associated protein 2

decreases expression

manganese chloride results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 3

decreases methylation

manganese chloride results in decreased methylation of MAP2K3 gene

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase 4

increases phosphorylation

manganese chloride results in increased phosphorylation of MAP2K4 protein

PMID:9751194 PMID:15342272

NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993

G

mitogen-activated protein kinase kinase kinase 11

increases phosphorylation

manganese chloride results in increased phosphorylation of MAP3K11 protein

NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652

G

mitogen activated protein kinase kinase kinase 7

increases methylation

manganese chloride results in increased methylation of MAP3K7 gene

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen-activated protein kinase kinase kinase kinase 3

decreases expression

manganese chloride results in decreased expression of MAP4K3 mRNA

NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334

G

microtubule-associated protein 7

increases expression

manganese chloride results in increased expression of MAP7 mRNA

NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574

G

MAP7 domain containing 2

increases methylation
decreases expression

manganese chloride results in increased methylation of MAP7D2 gene
manganese chloride results in decreased expression of MAP7D2 mRNA

NCBI chr X:35,372,453...35,488,073
Ensembl chr X:35,372,700...35,488,091

G

mitogen activated protein kinase 1

multiple interactions
increases activity
increases phosphorylation
decreases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK1 protein]
manganese chloride results in increased activity of MAPK1 protein
manganese chloride results in decreased phosphorylation of MAPK1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK1 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK1 protein]

PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 11

increases expression

manganese chloride results in increased expression of MAPK11 mRNA

NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395

G

mitogen activated protein kinase 14

increases phosphorylation
increases expression

manganese chloride results in increased phosphorylation of MAPK14 protein
manganese chloride results in increased expression of MAPK14 mRNA

PMID:15737199 PMID:17467022

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases activity
increases phosphorylation
decreases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]; manganese chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein; pyrazolanthrone promotes the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [manganese chloride results in increased phosphorylation of MAPK3 protein]
manganese chloride results in increased activity of MAPK3 protein
manganese chloride results in decreased phosphorylation of MAPK3 protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK3 protein]

PMID:15010209 PMID:15342272 PMID:16787641 PMID:19084589 PMID:20152896 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases activity
increases phosphorylation
increases methylation
multiple interactions

manganese chloride results in increased activity of MAPK8 protein
manganese chloride results in increased phosphorylation of MAPK8 protein
manganese chloride results in increased methylation of MAPK8 gene
[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of MAPK8 protein]

PMID:19084589 PMID:20152896 PMID:24324973 PMID:27913844 PMID:30951808 More...

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases activity
increases phosphorylation

manganese chloride results in increased activity of MAPK9 protein
manganese chloride results in increased phosphorylation of MAPK9 protein

PMID:19084589 PMID:20152896

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [manganese chloride results in increased phosphorylation of MAPT protein]; GSK3B protein affects the reaction [manganese chloride results in increased phosphorylation of MAPT protein]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MBL associated serine protease 1

decreases methylation

manganese chloride results in decreased methylation of MASP1 gene

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

matrilin 3

decreases expression

manganese chloride results in decreased expression of MATN3 mRNA

NCBI chr 6:31,748,517...31,768,564
Ensembl chr 6:31,748,474...31,768,101

G

myelin basic protein

increases expression

manganese chloride results in increased expression of MBP mRNA

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

MCF.2 cell line derived transforming sequence-like

increases expression

manganese chloride results in increased expression of MCF2L mRNA

NCBI chr16:76,507,133...76,652,893
Ensembl chr16:76,507,133...76,652,733

G

melanin-concentrating hormone receptor 1

increases expression

manganese chloride results in increased expression of MCHR1 mRNA

NCBI chr 7:112,761,554...112,764,746
Ensembl chr 7:112,761,554...112,764,032

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

manganese chloride results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance complex component 4

decreases expression

manganese chloride results in decreased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

decreases expression

manganese chloride results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

mucolipin TRP cation channel 3

increases expression

manganese chloride results in increased expression of MCOLN3 mRNA

NCBI chr 2:235,008,716...235,042,885
Ensembl chr 2:234,966,010...235,043,047

G

malate dehydrogenase 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MDH1 mRNA

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

MDM2 proto-oncogene

increases expression

manganese chloride results in increased expression of MDM2 mRNA

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

malic enzyme 3

increases expression

manganese chloride results in increased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

mesenteric estrogen-dependent adipogenesis

increases expression

manganese chloride results in increased expression of MEDAG mRNA

NCBI chr12:5,613,191...5,634,583
Ensembl chr12:5,613,208...5,634,767

G

myocyte enhancer factor 2C

decreases expression
increases methylation

manganese chloride results in decreased expression of MEF2C mRNA
manganese chloride results in increased methylation of MEF2C gene

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

matrix extracellular phosphoglycoprotein

increases methylation
increases expression

manganese chloride results in increased methylation of MEPE gene
manganese chloride results in increased expression of MEPE mRNA

NCBI chr14:5,420,634...5,432,186
Ensembl chr14:5,420,635...5,432,183

G

methionyl aminopeptidase 2

multiple interactions
increases activity

manganese chloride inhibits the reaction [Triazoles results in decreased activity of METAP2 protein]
manganese chloride results in increased activity of METAP2 protein

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

microfibril associated protein 2

decreases expression
decreases methylation

manganese chloride results in decreased expression of MFAP2 mRNA
manganese chloride results in decreased methylation of MFAP2 gene

NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259

G

mitofusin 2

decreases expression
multiple interactions

manganese chloride results in decreased expression of MFN2 mRNA; manganese chloride results in decreased expression of MFN2 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [manganese chloride results in decreased expression of MFN2 protein]]; Resveratrol inhibits the reaction [manganese chloride results in decreased expression of MFN2 protein]

PMID:28539244 PMID:34738708

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

G

major facilitator superfamily domain containing 6

increases expression

manganese chloride results in increased expression of MFSD6 mRNA

NCBI chr 9:48,773,171...48,858,471
Ensembl chr 9:48,773,414...48,858,465

G

MAX dimerization protein MGA

increases expression

manganese chloride results in increased expression of MGA mRNA

NCBI chr 3:106,851,216...106,942,908
Ensembl chr 3:106,851,140...106,941,043

G

alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

increases expression

manganese chloride results in increased expression of MGAT1 mRNA

NCBI chr10:33,563,642...33,582,718
Ensembl chr10:33,561,388...33,591,503

G

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

increases expression

manganese chloride results in increased expression of MGAT5B mRNA

NCBI chr10:102,120,757...102,190,235
Ensembl chr10:102,120,445...102,190,233

G

O-6-methylguanine-DNA methyltransferase

increases methylation
increases expression

manganese chloride results in increased methylation of MGMT gene
manganese chloride results in increased expression of MGMT mRNA

PMID:27913844 PMID:28801915

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

matrix Gla protein

increases expression

manganese chloride results in increased expression of MGP mRNA

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microsomal glutathione S-transferase 1

decreases expression

manganese chloride results in decreased expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

microsomal glutathione S-transferase 3

increases expression

manganese chloride results in increased expression of MGST3 mRNA

NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411

G

MIA SH3 domain containing

increases expression

manganese chloride results in increased expression of MIA mRNA

PMID:17175027 PMID:28801915

NCBI chr 1:82,473,677...82,476,378
Ensembl chr 1:82,473,678...82,475,370

G

microtubule associated monooxygenase, calponin and LIM domain containing 1

decreases expression

manganese chloride results in decreased expression of MICAL1 mRNA

NCBI chr20:44,974,137...44,986,089
Ensembl chr20:44,974,138...44,986,089

G

microRNA 107

decreases expression

manganese chloride results in decreased expression of MIR107 mRNA

NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853

G

microRNA 125b-1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR125B1 mRNA

NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052

G

microRNA 134

increases expression

manganese chloride results in increased expression of MIR134 mRNA

NCBI chr 6:128,748,908...128,748,980

G

microRNA 139

decreases expression

manganese chloride results in decreased expression of MIR139 mRNA

NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902

G

microRNA 143

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR143 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR143 mRNA

NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110

G

microRNA 146b

decreases expression

manganese chloride results in decreased expression of MIR146B mRNA

NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525

G

microRNA 150

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR150 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of MIR150 mRNA

NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108

G

microRNA 221

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR221 mRNA

NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573

G

microRNA 298

decreases expression

manganese chloride results in decreased expression of MIR298 mRNA

NCBI chr 3:163,052,291...163,052,372
Ensembl chr 3:163,052,291...163,052,372

G

microRNA 29a

decreases expression

manganese chloride results in decreased expression of MIR29A mRNA

NCBI chr 4:59,650,608...59,650,695

G

microRNA 31

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR31 mRNA

NCBI chr 5:103,599,038...103,599,143

G

microRNA 320a

increases expression

manganese chloride results in increased expression of MIR320A mRNA

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

microRNA 328

decreases expression

manganese chloride results in decreased expression of MIR328 mRNA

NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849

G

microRNA 409

decreases expression

manganese chloride results in decreased expression of MIR409 mRNA

NCBI chr 6:128,757,780...128,757,856
Ensembl chr 6:128,757,779...128,757,858

G

microRNA 433

decreases expression

manganese chloride results in decreased expression of MIR433 mRNA

NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217

G

microRNA 582

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR582 mRNA

NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651

G

microRNA 98

decreases expression

manganese chloride results in decreased expression of MIR98 mRNA

NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342

G

microRNA 99a

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of MIR99A mRNA

NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523

G

microRNA let-7b

increases expression

manganese chloride results in increased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

G

metabolism of cobalamin associated B

decreases expression

manganese chloride results in decreased expression of MMAB mRNA

NCBI chr12:42,159,109...42,172,518
Ensembl chr12:42,159,089...42,172,490

G

matrix metallopeptidase 13

increases expression

manganese chloride results in increased expression of MMP13 mRNA

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

decreases expression
increases methylation

manganese chloride results in decreased expression of MMP14 mRNA
manganese chloride results in increased methylation of MMP14 gene

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 24

increases expression

manganese chloride results in increased expression of MMP24 mRNA

NCBI chr 3:144,279,096...144,323,572
Ensembl chr 3:144,279,096...144,323,572

G

matrix metallopeptidase 3

increases expression

manganese chloride results