zinc acetate - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	zinc acetate	go back to main search page
Accession:	CHEBI:62984	browse the term
Definition:	An acetate salt in which the cationic component is zinc(2+).
Synonyms:	related_synonym:	Acetic acid, zinc salt (2:1); Acetic acid, zinc(II) salt; Dicarbomethoxyzinc; Formula=C4H6O4Zn; InChI=1S/2C2H4O2.Zn/c21-2(3)4;/h21H3,(H,3,4);/q;;+2/p-2; InChIKey=DJWUNCQRNNEAKC-UHFFFAOYSA-L; SMILES=[Zn++].CC([O-])=O.CC([O-])=O; Zinc acetate anhydrous; Zinc di(acetate); Zinc(II) acetate; Zn(II)Ac2; Zn(OAc)2; acetic acid, zinc salt; zinc diacetate
	xref:	CAS:557-34-6
	xref_mesh:	MESH:D019345
	xref:	PMID:20634118; PMID:21109379; PMID:21381680; Reaxys:3563830

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Genes (165)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
Zinc Acetate results in decreased expression of AGL mRNA

NCBI chr 2:207,389,949...207,445,959
Ensembl chr 2:207,389,949...207,445,724

G

aminolevulinate dehydratase

multiple interactions
increases activity

EXP

[Zinc Acetate results in increased activity of ALAD protein] which results in increased chemical synthesis of Porphobilinogen; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]

NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]

NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,558,347...40,586,714

G

aldehyde dehydrogenase 6 family, member A1

multiple interactions
increases expression

ISO

Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]
Zinc Acetate results in increased expression of ALDH6A1 mRNA

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

Rho GTPase activating protein 17

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA
Zinc Acetate results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:187,238,675...187,328,093
Ensembl chr 1:187,238,380...187,327,936

G

activating transcription factor 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750

G

ATM serine/threonine kinase

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATPase copper transporting beta

increases response to substance
multiple interactions

ISO

ATP7B gene mutant form results in increased susceptibility to Zinc Acetate
[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of ABCB11 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

ATR serine/threonine kinase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA
Zinc Acetate results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

BTB domain and CNC homolog 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA
Zinc Acetate results in increased expression of BACH1 mRNA

NCBI chr11:40,425,721...40,461,118
Ensembl chr11:40,425,664...40,461,277

G

BAG cochaperone 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280

G

Bcl-2 binding component 3

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

baculoviral IAP repeat-containing 5

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of BIRC5 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BCL2 interacting protein 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA
Zinc Acetate results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962

G

BCL2 interacting protein 3 like

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA
Zinc Acetate results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282

G

basigin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of BSG protein]

NCBI chr 7:10,643,788...10,651,005
Ensembl chr 7:10,643,789...10,651,005

G

calnexin

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:35,124,941...35,157,857

G

caspase 3

multiple interactions
decreases expression

EXP
ISO

[Taurine co-treated with Zinc Acetate] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA
Zinc Acetate results in decreased expression of CASP3 mRNA

PMID:16357179 PMID:26335259

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

core-binding factor subunit beta

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:49,955,133...50,002,661
Ensembl chr19:49,959,096...50,002,657

G

cyclin B1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCNB1 protein]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin J

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
Zinc Acetate results in decreased expression of CCNJ mRNA

NCBI chr 1:249,608,991...249,626,798
Ensembl chr 1:249,608,969...249,626,794

G

cell division cycle 16

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA
Zinc Acetate results in decreased expression of CDC16 mRNA

NCBI chr16:82,475,234...82,498,797
Ensembl chr16:82,474,523...82,498,765

G

cell division cycle 25C

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA
Zinc Acetate results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cell division cycle 27

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,900,676...89,949,770
Ensembl chr10:89,900,684...89,949,770

G

cell division cycle 5-like

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:23,062,397...23,100,901
Ensembl chr 9:23,062,205...23,100,899

G

cell division cycle associated 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA
Zinc Acetate results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:46,071,360...46,116,639

G

cyclin-dependent kinase 19

increases expression

ISO

Zinc Acetate results in increased expression of CDK19 mRNA

NCBI chr20:45,324,911...45,465,121
Ensembl chr20:45,324,862...45,465,121

G

cyclin dependent kinase 2

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA
Zinc Acetate results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cystathionine gamma-lyase

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

cullin 3

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA
Zinc Acetate results in decreased expression of CUL3 mRNA

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:89,040,987...89,118,427

G

C-X-C motif chemokine ligand 1

increases secretion

ISO

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 3

increases secretion

ISO

Zinc Acetate results in increased secretion of CXCL1 protein

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome b5 reductase 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of CYB5R1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA

NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465

G

death-associated protein kinase 3

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of DAPK3 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]

NCBI chr 7:9,174,903...9,183,272
Ensembl chr 7:9,174,904...9,183,272

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

death effector domain containing 2

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of DEDD2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]

NCBI chr 1:89,916,906...89,934,663
Ensembl chr 1:89,919,524...89,936,804

G

DNA fragmentation factor subunit beta

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA
Zinc Acetate results in decreased expression of DFFB mRNA

NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225

G

7-dehydrocholesterol reductase

decreases expression

ISO

Zinc Acetate results in decreased expression of DHCR7 mRNA

NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382

G

DnaJ heat shock protein family (Hsp40) member B1

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of DNAJB1 mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:41,427,453...41,431,416

G

DnaJ heat shock protein family (Hsp40) member B4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA
Zinc Acetate results in increased expression of DNAJB4 mRNA

NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:243,790,297...243,819,042

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA
Zinc Acetate results in increased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:6,128,070...6,232,005

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:102,432,663...102,475,643

G

dopamine receptor D1

multiple interactions

EXP

Zinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166

G

dopamine receptor D2

multiple interactions

EXP

Zinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

dual specificity phosphatase 1

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 mRNA; [Taurine co-treated with Zinc Acetate] results in increased expression of DUSP1 protein

NCBI chr10:17,184,853...17,187,646
Ensembl chr10:17,184,823...17,187,644

G

E2F transcription factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of E2F1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA
Zinc Acetate results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681

G

elongator acetyltransferase complex subunit 1

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA
Zinc Acetate results in decreased expression of ELP1 mRNA

NCBI chr 5:76,248,545...76,300,985
Ensembl chr 5:76,248,550...76,300,985

G

enolase 1

increases expression

ISO

Zinc Acetate results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 3:77,946,261...77,986,003
Ensembl chr 5:77,946,261...77,986,003

G

Fas associated via death domain

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA
Zinc Acetate results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas apoptotic inhibitory molecule

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA
Zinc Acetate results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:108,423,221...108,440,151

G

family with sequence similarity 162, member A

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA
Zinc Acetate results in increased expression of FAM162A mRNA

NCBI chr11:78,186,260...78,215,186
Ensembl chr11:78,185,852...78,216,560

G

fatty acid synthase

decreases expression

ISO

Zinc Acetate results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

forkhead box O3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA
Zinc Acetate results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of GCLM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutaminase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA
Zinc Acetate results in decreased expression of GLS mRNA

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:56,836,584...56,908,861

G

G protein-coupled receptor 146

increases expression

ISO

Zinc Acetate results in increased expression of GPR146 mRNA

NCBI chr12:20,365,790...20,381,122
Ensembl chr12:20,364,269...20,381,345

G

glutamic--pyruvic transaminase 2

increases expression

ISO

Zinc Acetate results in increased expression of GPT2 mRNA

NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917

G

glutathione peroxidase 1

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions
increases expression
decreases activity

ISO
EXP

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA
Zinc Acetate results in increased expression of GSR mRNA
Zinc Acetate results in decreased activity of GSR protein

PMID:16357179 PMID:17382203

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

general transcription factor IIIC subunit 2

increases expression

ISO

Zinc Acetate results in increased expression of GTF3C2 mRNA

NCBI chr 6:30,913,263...30,941,305
Ensembl chr 6:30,923,106...30,940,465

G

HMG-box transcription factor 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of HBP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:54,256,864...54,283,366

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
Zinc Acetate results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

hypoxia inducible lipid droplet-associated

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA
Zinc Acetate results in increased expression of HILPDA mRNA

NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:58,836,463...58,839,423

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]

NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:193,937,261...193,975,164

G

helicase-like transcription factor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
Zinc Acetate results in decreased expression of HLTF mRNA

NCBI chr 2:104,478,725...104,538,531
Ensembl chr 2:104,478,772...104,538,818

G

heme oxygenase 1

multiple interactions
increases expression

ISO
EXP

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
[Taurine co-treated with Zinc Acetate] results in increased expression of HMOX1 protein

PMID:16357179 PMID:26335259

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

harakiri, BCL2 interacting protein

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of HRK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
Zinc Acetate results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA
Zinc Acetate results in increased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835

G

heat shock protein family A (Hsp70) member 4 like

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA
Zinc Acetate results in increased expression of HSPA4L mRNA

NCBI chr 2:125,668,346...125,726,404
Ensembl chr 2:125,668,236...125,720,986

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

heat shock protein family H (Hsp110) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:10,427,297...10,446,891

G

intercellular adhesion molecule 1

multiple interactions
increases expression

ISO

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; [Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

inhibitor of DNA binding 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA
Zinc Acetate results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:47,457,554...47,472,961

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA
Zinc Acetate results in increased expression of IKBKE mRNA

NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396

G

interleukin 10

increases secretion

ISO

Zinc Acetate results in increased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases secretion

ISO

Zinc Acetate results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interleukin 7

increases secretion

ISO

Zinc Acetate results in increased secretion of IL7 protein

NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389

G

interferon regulatory factor 2 binding protein 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA
Zinc Acetate results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368

G

JunD proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA
Zinc Acetate results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148

G

lysine demethylase 3A

increases expression

ISO

Zinc Acetate results in increased expression of KDM3A mRNA

NCBI chr 4:105,189,208...105,233,526
Ensembl chr 4:105,189,208...105,233,370

G

mitogen-activated protein kinase 8

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK8 protein modified form

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in decreased expression of MAPK9 protein modified form

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microtubule-associated protein tau

multiple interactions

ISO

[Zinc Acetate results in decreased abundance of Copper] which results in decreased phosphorylation of MAPT protein

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

MDM2 proto-oncogene

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MOB kinase activator 1A

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:117,389,278...117,406,255
Ensembl chr 4:117,389,186...117,406,250

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
Zinc Acetate results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:79,695,809...79,696,200

G

metallothionein 1A

increases expression

ISO

Zinc Acetate results in increased expression of MT1 protein

NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200

G

metallothionein 2

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of MT2 mRNA; Zinc Acetate results in increased expression of MT2 protein
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]

PMID:8876661 PMID:15306638 PMID:16357179

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]

NCBI chr20:3,163,749...3,164,121

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of CXCL8 protein]; MYD88 mutant form inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]
Zinc Acetate results in decreased expression of MYD88 mRNA

PMID:16357179 PMID:24080332

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

NAD kinase

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA
Zinc Acetate results in increased expression of NADK mRNA

NCBI chr 5:171,427,973...171,458,586
Ensembl chr 5:171,428,000...171,458,579

G

neurofibromin 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of NF1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NFKB inhibitor alpha

increases degradation
increases phosphorylation
multiple interactions

ISO

Zinc Acetate results in increased degradation of NFKBIA protein
Zinc Acetate results in increased phosphorylation of NFKBIA protein
[Zinc Acetate results in increased phosphorylation of NFKBIA protein] inhibits the reaction [Zinc Acetate results in increased expression of ICAM1 protein]

PMID:21974847 PMID:24080332

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nischarin

decreases expression

ISO

Zinc Acetate results in decreased expression of NISCH mRNA

NCBI chr16:6,370,809...6,407,104
Ensembl chr16:6,370,809...6,407,387

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475

G

nuclear receptor subfamily 1, group D, member 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:9,954,906...9,981,330

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911

G

programmed cell death 11

decreases expression

ISO

Zinc Acetate results in decreased expression of PDCD11 mRNA

NCBI chr 1:255,922,198...255,963,336
Ensembl chr 1:255,922,225...255,963,336

G

programmed cell death 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA
Zinc Acetate results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189

G

programmed cell death 5

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA
Zinc Acetate results in decreased expression of PDCD5 mRNA

NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA
Zinc Acetate results in increased expression of PFKFB3 mRNA

NCBI chr17:71,893,320...71,974,526
Ensembl chr17:71,893,416...71,975,052

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA
Zinc Acetate results in increased expression of PFKFB4 mRNA

NCBI chr 8:118,522,371...118,565,478
Ensembl chr 8:118,522,365...118,565,468

G

phosphofructokinase, muscle

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PFKM protein]

NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:131,100,753...131,138,248

G

phosphoglycerate kinase 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:75,336,687...75,352,959

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]

NCBI chr 4:15,107,341...15,222,683
Ensembl chr 4:15,107,373...15,222,692

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]

NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315

G

phosphoinositide-3-kinase interacting protein 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA
Zinc Acetate results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261
Ensembl chr14:82,428,248...82,440,260

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of PMAIP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
Zinc Acetate results in increased expression of PRKACB mRNA

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315

G

protein kinase C, delta

decreases expression

ISO

Zinc Acetate results in decreased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

protein kinase D2

decreases expression

ISO

Zinc Acetate results in decreased expression of PRKD2 mRNA

NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675

G

protein kinase, DNA-activated, catalytic subunit

increases expression

ISO

Zinc Acetate results in increased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108

G

peptidyl-tRNA hydrolase 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA
Zinc Acetate results in decreased expression of PTRH2 mRNA

NCBI chr10:72,002,450...72,012,606
Ensembl chr10:71,985,245...72,045,352

G

PTTG1 regulator of sister chromatid separation, securin

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTTG1 protein]

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RB transcriptional corepressor 1

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA
Zinc Acetate results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
Zinc Acetate results in decreased expression of RCBTB2 mRNA

NCBI chr15:54,729,367...54,774,004
Ensembl chr15:54,729,332...54,793,313

G

RELB proto-oncogene, NF-kB subunit

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA
Zinc Acetate results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420

G

retinoid X receptor alpha

multiple interactions

ISO

[ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] promotes the reaction [RXRA protein binds to NR0B2 promoter]; [ATP7B gene mutant form results in increased susceptibility to Zinc Acetate] which results in increased expression of RXRA mRNA

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
Zinc Acetate results in increased expression of SAMTOR mRNA

NCBI chr 4:42,847,720...42,911,546
Ensembl chr 4:42,836,172...42,917,567

G

selenoprotein W

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
Zinc Acetate results in increased expression of SELENOW mRNA

NCBI chr 1:85,727,631...85,732,703
Ensembl chr 1:85,727,632...85,732,703

G

sestrin 2

multiple interactions
increases expression

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
Zinc Acetate results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

solute carrier family 16 member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 16 member 3

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of SLC16A3 protein]

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,714,466...106,720,903

G

solute carrier family 16, member 6

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of SLC16A6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965

G

solute carrier family 1 member 4

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of SLC1A4 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]

NCBI chr14:98,718,646...98,761,672
Ensembl chr14:98,730,450...98,761,790

G

solute carrier family 2 member 1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of SLC2A1 protein]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 30 member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 31 member 1

increases expression

ISO

Zinc Acetate results in increased expression of SLC31A1 mRNA

NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809

G

solute carrier family 38, member 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619

G

solute carrier family 39 member 10

affects expression
multiple interactions

ISO

Zinc Acetate affects the expression of SLC39A10 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:62,370,598...62,454,747

G

solute carrier family 39 member 14

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA
Zinc Acetate results in increased expression of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:51,786,623...51,833,229

G

solute carrier family 39, member 9

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA
Zinc Acetate results in increased expression of SLC39A9 mRNA

NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:106,022,850...106,071,176

G

solute carrier family 3 member 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
Zinc Acetate results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 43 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
Zinc Acetate results in increased expression of SLC43A1 mRNA

NCBI chr 3:90,327,250...90,353,438
Ensembl chr 3:90,327,149...90,353,438

G

solute carrier family 7 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
Zinc Acetate results in increased expression of SLC7A1 mRNA

NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030

G

solute carrier family 7 member 11

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA
Zinc Acetate results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA
Zinc Acetate results in decreased expression of SMARCA4 mRNA

NCBI chr 8:28,438,370...28,535,071
Ensembl chr 8:28,443,810...28,535,070

G

SNF2 related chromatin remodeling ATPase 5

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA
Zinc Acetate results in decreased expression of SMARCA5 mRNA

NCBI chr19:44,172,465...44,208,967
Ensembl chr19:44,175,733...44,208,957

G

superoxide dismutase 1

multiple interactions

ISO

[Zinc Acetate results in increased abundance of Zinc] inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased activity of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

Sp1 transcription factor

increases expression

ISO

Zinc Acetate results in increased expression of SP1 mRNA

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:135,420,050...135,450,513

G

T-cell activation RhoGTPase activating protein

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA
Zinc Acetate results in increased expression of TAGAP mRNA

NCBI chr 1:49,575,750...49,584,747
Ensembl chr 1:49,575,750...49,583,838

G

transferrin receptor

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]

NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318

G

TNF alpha induced protein 8

decreases expression
multiple interactions

ISO

Zinc Acetate results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:45,370,334...45,486,036
Ensembl chr18:45,370,406...45,486,036

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
Zinc Acetate results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,808,023...4,813,857

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF superfamily member 8

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]

NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:82,266,436...82,292,858

G

TNFAIP3 interacting protein 2

decreases expression

ISO

Zinc Acetate results in decreased expression of TNIP2 mRNA

NCBI chr14:80,452,936...80,470,141
Ensembl chr14:80,452,845...80,470,992

G

tumor protein p53

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tribbles pseudokinase 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA
Zinc Acetate results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

thioredoxin reductase 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA
Zinc Acetate results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions

EXP

[Taurine co-treated with Zinc Acetate] results in increased expression of UGT2B1 mRNA

NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331

G

vascular endothelial growth factor A

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA
Zinc Acetate results in increased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

von Hippel-Lindau tumor suppressor

increases expression
multiple interactions

ISO

Zinc Acetate results in increased expression of VHL mRNA
motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]

NCBI chr 4:148,328,099...148,334,992
Ensembl chr 4:148,328,079...148,334,991

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20862
role	20820
application	20621
pharmaceutical	20416
drug	20416
astringent	11456
zinc acetate	165
Path 2
Term	Annotations
CHEBI ontology	20862
subatomic particle	20860
composite particle	20860
hadron	20860
baryon	20860
nucleon	20860
atomic nucleus	20860
atom	20860
group	20803
polyatomic entity	20803
heteroatomic molecular entity	20740
salt	16667
organic salt	3433
acetate salt	214
zinc acetate	165

paths to the root