CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor
Accession: CHEBI:62871
browse the term
Definition: An EC 4.3.* (C-N lyase) inhibitor that interferes with the action of phenylalanine ammonia-lyase (EC 4.3.1.24).
Synonyms: related_synonym: EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitors; EC 4.3.1.24 inhibitor; EC 4.3.1.24 inhibitors; L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitor; L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitors; L-phenylalanine ammonia-lyase inhibitor; L-phenylalanine ammonia-lyase inhibitors; PAL inhibitor; PAL inhibitors; Phe ammonia-lyase inhibitor; Phe ammonia-lyase inhibitors; phenylalanine ammonia-lyase inhibitor; phenylalanine ammonia-lyase inhibitors; phenylalanine ammonium-lyase inhibitor; phenylalanine ammonium-lyase inhibitors; phenylalanine deaminase inhibitor; phenylalanine deaminase inhibitors
xref: Wikipedia:Phenylalanine_ammonia-lyase
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Aicda
activation-induced cytidine deaminase
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of AICDA mRNA
CTD
PMID:22302311
NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
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Akr1b1
aldo-keto reductase family 1 member B1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA
CTD
PMID:20566472
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of AKR1B10 mRNA
CTD
PMID:20566472
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA
CTD
PMID:20566472
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression affects expression
ISO
hexyl cinnamic aldehyde results in increased expression of AKR1C3 mRNA hexyl cinnamic aldehyde affects the expression of AKR1C18 mRNA
CTD
PMID:20566472 PMID:22302311
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Atf3
activating transcription factor 3
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Cat
catalase
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of CAT mRNA
CTD
PMID:20566472
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases secretion
ISO
hexyl cinnamic aldehyde results in increased secretion of CCL2 protein
CTD
PMID:22245253
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl4
C-C motif chemokine ligand 4
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of CCL4 protein
CTD
PMID:18353026
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccna2
cyclin A2
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CCNA2 mRNA
CTD
PMID:22302311
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA
CTD
PMID:22302311
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccne2
cyclin E2
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CCNE2 mRNA
CTD
PMID:22302311
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Ccr4
C-C motif chemokine receptor 4
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CCR4 mRNA
CTD
PMID:22302311
NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056
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Ccr7
C-C motif chemokine receptor 7
decreases expression
ISO
hexyl cinnamic aldehyde results in decreased expression of CCR7 protein
CTD
PMID:37326882
NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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Cd160
CD160 molecule
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CD160 mRNA
CTD
PMID:22302311
NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
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Cd207
CD207 molecule
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CD207 mRNA
CTD
PMID:22302311
NCBI chr 4:116,155,229...116,161,587
Ensembl chr 4:116,155,212...116,161,518
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Cd5l
Cd5 molecule-like
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CD5L mRNA
CTD
PMID:22302311
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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Cd80
Cd80 molecule
multiple interactions increases expression
ISO
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein hexyl cinnamic aldehyde results in increased expression of CD80 protein
CTD
PMID:31958493
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cd83
CD83 molecule
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CD83 mRNA
CTD
PMID:22302311
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
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Cd86
CD86 molecule
multiple interactions increases expression
ISO
[hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]
CTD
PMID:31958493 PMID:37326882
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdc20
cell division cycle 20
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CDC20 mRNA
CTD
PMID:22302311
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdc25c
cell division cycle 25C
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CDC25C mRNA
CTD
PMID:22302311
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdk1
cyclin-dependent kinase 1
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CDK1 mRNA
CTD
PMID:22302311
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cphx1
cytoplasmic polyadenylated homeobox 1
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CPHX1 mRNA
CTD
PMID:22302311
NCBI chr16:1,533,883...1,537,248
Ensembl chr16:1,528,440...1,537,082
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of CTLA4 mRNA
CTD
PMID:22302311
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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Cxcl14
C-X-C motif chemokine ligand 14
decreases expression
ISO
hexyl cinnamic aldehyde results in decreased expression of CXCL14 protein
CTD
PMID:31734321
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
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Cxcl2
C-X-C motif chemokine ligand 2
increases expression decreases expression
ISO
hexyl cinnamic aldehyde results in increased expression of CXCL2 mRNA; hexyl cinnamic aldehyde results in increased expression of CXCL2 protein hexyl cinnamic aldehyde results in decreased expression of CXCL2 protein
CTD
PMID:23178550 PMID:28826779
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl3
C-X-C motif chemokine ligand 3
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of CXCL1 mRNA
CTD
PMID:28826779
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Dio2
iodothyronine deiodinase 2
decreases activity
ISO
hexyl cinnamic aldehyde results in decreased activity of DIO2 protein
CTD
PMID:30561685
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
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Dio3
iodothyronine deiodinase 3
decreases activity
ISO
hexyl cinnamic aldehyde results in decreased activity of DIO3 protein
CTD
PMID:30561685
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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E2f1
E2F transcription factor 1
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of E2F1 mRNA
CTD
PMID:22302311
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Fabp7
fatty acid binding protein 7
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of FABP7 mRNA
CTD
PMID:22302311
NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
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Fech
ferrochelatase
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of FECH mRNA
CTD
PMID:20566472
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Ftl1
ferritin light chain 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of FTL mRNA
CTD
PMID:20566472
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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Fxyd4
FXYD domain-containing ion transport regulator 4
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of FXYD4 mRNA
CTD
PMID:22302311
NCBI chr 4:151,109,779...151,113,659
Ensembl chr 4:151,109,779...151,113,637
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G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of G6PD mRNA
CTD
PMID:20566472
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of GCLC mRNA
CTD
PMID:20566472
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of GCLM mRNA
CTD
PMID:20566472
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gpx3
glutathione peroxidase 3
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of GPX3 mRNA
CTD
PMID:20566472
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Gsr
glutathione-disulfide reductase
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of GSR mRNA
CTD
PMID:20566472
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gzmb
granzyme B
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of GZMB mRNA
CTD
PMID:22302311
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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Hmox1
heme oxygenase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of HMOX1 mRNA
CTD
PMID:20566472 PMID:26244607
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
increases secretion
ISO
hexyl cinnamic aldehyde results in increased secretion of IFNG protein
CTD
PMID:22245253
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il12b
interleukin 12B
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of IL12B mRNA
CTD
PMID:22302311
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il17a
interleukin 17A
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of IL17A mRNA; hexyl cinnamic aldehyde results in increased expression of IL17A protein
CTD
PMID:28826779
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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Il1a
interleukin 1 alpha
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of IL1A protein
CTD
PMID:23178550
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il2
interleukin 2
increases secretion increases expression
ISO
hexyl cinnamic aldehyde results in increased secretion of IL2 protein hexyl cinnamic aldehyde results in increased expression of IL2 protein
CTD
PMID:22245253 PMID:22381623
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il21
interleukin 21
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of IL21 mRNA
CTD
PMID:22302311
NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996
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Il2ra
interleukin 2 receptor subunit alpha
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of IL2RA mRNA
CTD
PMID:22302311
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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Il4
interleukin 4
affects expression multiple interactions
ISO
hexyl cinnamic aldehyde affects the expression of IL4 mRNA [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD
PMID:22302311 PMID:31958493
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il4r
interleukin 4 receptor
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of IL4RA protein
CTD
PMID:22381623
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
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Il6
interleukin 6
increases secretion
ISO
hexyl cinnamic aldehyde results in increased secretion of IL6 protein
CTD
PMID:22245253
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgav
integrin subunit alpha V
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of ITGAV mRNA
CTD
PMID:22302311
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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Maff
MAF bZIP transcription factor F
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of MAFF mRNA
CTD
PMID:20566472
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Mafg
MAF bZIP transcription factor G
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of MAFG mRNA
CTD
PMID:20566472
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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Mafk
MAF bZIP transcription factor K
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of MAFK mRNA
CTD
PMID:20566472
NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048 Ensembl chr12:14,833,984...14,837,048
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Me1
malic enzyme 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of ME1 mRNA
CTD
PMID:20566472
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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Mgst1
microsomal glutathione S-transferase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of MGST1 mRNA
CTD
PMID:20566472
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Mir146a
microRNA 146a
increases expression multiple interactions
ISO
hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]
CTD
PMID:37326882
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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Mir27a
microRNA 27a
decreases expression
ISO
hexyl cinnamic aldehyde results in decreased expression of MIR27A mRNA
CTD
PMID:37326882
NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
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Mki67
marker of proliferation Ki-67
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of MKI67 mRNA
CTD
PMID:22302311
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mmp10
matrix metallopeptidase 10
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of MMP10 mRNA
CTD
PMID:22302311
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of NQO1 mRNA
CTD
PMID:20566472
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nts
neurotensin
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of NTS mRNA
CTD
PMID:22302311
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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Pgd
phosphogluconate dehydrogenase
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of PGD mRNA
CTD
PMID:20566472
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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Prkcb
protein kinase C, beta
multiple interactions
ISO
PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of CD86 protein]; PRKCB protein affects the reaction [hexyl cinnamic aldehyde results in increased expression of MIR146A mRNA]
CTD
PMID:37326882
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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Ptgr1
prostaglandin reductase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of PTGR1 mRNA
CTD
PMID:20566472
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Sod1
superoxide dismutase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of SOD1 mRNA
CTD
PMID:20566472
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of SOD2 mRNA
CTD
PMID:20566472
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of SOD3 mRNA
CTD
PMID:20566472
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Srxn1
sulfiredoxin 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of SRXN1 mRNA
CTD
PMID:20566472
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Thbs1
thrombospondin 1
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of THBS1 mRNA
CTD
PMID:22302311
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
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Thbs4
thrombospondin 4
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of THBS4 mRNA
CTD
PMID:22302311
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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Timd2
T-cell immunoglobulin and mucin domain containing 2
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA
CTD
PMID:22302311
NCBI chr10:31,060,308...31,101,262
Ensembl chr10:31,060,326...31,094,623
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Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
hexyl cinnamic aldehyde results in increased expression of TNF mRNA [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD80 protein; [hexyl cinnamic aldehyde co-treated with IL4 protein co-treated with TNF protein co-treated with Ionomycin] results in increased expression of CD86 protein
CTD
PMID:28826779 PMID:31958493
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpm6
transient receptor potential cation channel, subfamily M, member 6
affects expression
ISO
hexyl cinnamic aldehyde affects the expression of TRPM6 mRNA
CTD
PMID:22302311
NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520
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Txn2
thioredoxin 2
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of TXN2 mRNA
CTD
PMID:20566472
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of TXNRD1 mRNA
CTD
PMID:20566472
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Txnrd2
thioredoxin reductase 2
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of TXNRD2 mRNA
CTD
PMID:20566472
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of UGT1A6 mRNA
CTD
PMID:20566472
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
hexyl cinnamic aldehyde results in increased expression of VEGFA protein
CTD
PMID:25617811
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
coniferaldehyde results in increased expression of ABCC2 mRNA
CTD
PMID:26275128
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
ISO
coniferaldehyde results in increased expression of ABCC3 mRNA
CTD
PMID:26275128
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions increases expression
ISO
NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein] coniferaldehyde results in increased expression of AKR1C1 mRNA; coniferaldehyde results in increased expression of AKR1C1 protein
CTD
PMID:26275128
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
coniferaldehyde results in increased expression of AKR1C2 mRNA; coniferaldehyde results in increased expression of AKR1C2 protein
CTD
PMID:26275128
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression
ISO
coniferaldehyde results in increased expression of AKR1C3 mRNA
CTD
PMID:26275128
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
coniferaldehyde results in increased expression of GCLC mRNA
CTD
PMID:26275128
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
coniferaldehyde results in increased expression of GCLM mRNA
CTD
PMID:26275128
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gsr
glutathione-disulfide reductase
increases expression
ISO
coniferaldehyde results in increased expression of GSR mRNA coniferaldehyde results in increased expression of GSR protein
CTD
PMID:26275128
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein] coniferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 protein
CTD
PMID:26275128
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
multiple interactions
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
CTD
PMID:27378624
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Jak2
Janus kinase 2
multiple interactions
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein] coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of JAK2 protein]
CTD
PMID:27378624
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
CTD
PMID:26275128
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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Mapkapk2
MAPK activated protein kinase 2
multiple interactions
ISO
MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
CTD
PMID:26275128
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
increases expression multiple interactions
ISO
coniferaldehyde results in increased expression of MUC5AC mRNA 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; A 967079 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]; coniferaldehyde results in increased expression of and results in increased secretion of MUC5AC protein; TWS 119 inhibits the reaction [coniferaldehyde results in increased expression of MUC5AC mRNA]
CTD
PMID:31944254
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions increases expression
ISO
coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein; MAPK14 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein] coniferaldehyde results in increased expression of NFE2L2 protein
CTD
PMID:26275128
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein] coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
CTD
PMID:27378624
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
coniferaldehyde results in increased expression of NQO1 protein
CTD
PMID:26275128
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pkn3
protein kinase N3
multiple interactions
ISO
PKN3 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]
CTD
PMID:26275128
NCBI chr 3:13,350,082...13,363,572
Ensembl chr 3:13,335,041...13,363,567
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein] coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein modified form]; coniferaldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein]
CTD
PMID:27378624
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Tnf
tumor necrosis factor
multiple interactions
ISO
coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of NOS2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of JAK2 protein]; coniferaldehyde inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of STAT1 protein]
CTD
PMID:27378624
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trpa1
transient receptor potential cation channel, subfamily A, member 1
increases activity
ISO
coniferaldehyde results in increased activity of TRPA1 protein
CTD
PMID:23541125
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
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Txnrd1
thioredoxin reductase 1
increases expression
ISO
coniferaldehyde results in increased expression of TXNRD1 mRNA
CTD
PMID:26275128
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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