reactive nitrogen species - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	reactive nitrogen species	go back to main search page
Accession:	CHEBI:62764	browse the term
Definition:	A family of nitrogen molecular entities which are highly reactive and derived from nitric oxide (.NO) and superoxide (O2.(-)) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively.
Synonyms:	related_synonym:	RNI; RNS
	xref_mesh:	MESH:D026361
	xref:	PMID:12076975; PMID:17667957; PMID:9741578; Wikipedia:Reactive_nitrogen_species

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Rat (634) Mouse (631) Human (641) Chinchilla (0) Bonobo (0) Dog (2) Squirrel (0) Pig (27) Green Monkey (0) Naked Mole-rat (0) All
Genes (634)

reactive nitrogen species

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions
increases abundance

vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

nitric oxide synthase 1

multiple interactions

NOS1 protein affects the reaction [1,2,4-trimethylcyclohexane results in increased abundance of Reactive Nitrogen Species]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

multiple interactions

[NOS2 protein results in increased chemical synthesis of Reactive Nitrogen Species] which affects the susceptibility to 2-chloroethyl ethyl sulfide

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

proopiomelanocortin

increases abundance

POMC protein results in increased abundance of Reactive Nitrogen Species

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

surfactant protein A1

affects abundance

SFTPA1 protein affects the abundance of Reactive Nitrogen Species

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

G

solute carrier family 9 member A1

multiple interactions

[manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A1

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

solute carrier family 9 member A3

multiple interactions

[manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A3

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

synuclein alpha

multiple interactions

SNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]; SNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Nitrogen Species]]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

TNF superfamily member 10

multiple interactions
increases abundance

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]; Plant Extracts inhibits the reaction [TNFSF10 protein results in increased abundance of Reactive Nitrogen Species]

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

ammonium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 1 beta

increases expression

ammonium nitrate results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

cadmium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

[cadmium nitrate results in increased abundance of Cadmium] which results in increased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[cadmium nitrate results in increased abundance of Cadmium] which results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caveolin 1

decreases expression

cadmium nitrate results in decreased expression of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

glucose-6-phosphate dehydrogenase

decreases activity

cadmium nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

integrin subunit beta 4

decreases expression

cadmium nitrate results in decreased expression of ITGB4 protein

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

chromium trinitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-HS-glycoprotein

decreases expression

chromium nitrate results in decreased expression of AHSG protein

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

aldehyde dehydrogenase 1 family, member L2

increases expression

chromium nitrate results in increased expression of ALDH1L2 protein

NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776

G

amyloid P component, serum

increases expression

chromium nitrate results in increased expression of APCS protein

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apolipoprotein A1

decreases expression

chromium nitrate results in decreased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

ATP synthase F1 subunit beta

increases expression

chromium nitrate results in increased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

branched chain keto acid dehydrogenase E1 subunit beta

decreases expression

chromium nitrate results in decreased expression of BCKDHB protein

NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812

G

chaperonin containing TCP1 subunit 5

decreases expression

chromium nitrate results in decreased expression of CCT5 protein

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

carboxylesterase 1D

increases expression

chromium nitrate results in increased expression of CES1D protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

dihydrolipoamide branched chain transacylase E2

increases expression

chromium nitrate results in increased expression of DBT protein

NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609

G

dimethylarginine dimethylaminohydrolase 1

decreases expression

chromium nitrate results in decreased expression of DDAH1 protein

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

enoyl-CoA hydratase 1

increases expression

chromium nitrate results in increased expression of ECH1 protein

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

fructose-bisphosphatase 1

increases expression

chromium nitrate results in increased expression of FBP1 protein

NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071

G

fibrinogen beta chain

increases expression

chromium nitrate results in increased expression of FGB protein

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibrinogen gamma chain

increases expression

chromium nitrate results in increased expression of FGG protein

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

fukutin related protein

increases expression

chromium nitrate results in increased expression of FKRP protein

NCBI chr 1:77,479,641...77,486,954
Ensembl chr 1:77,476,084...77,486,992

G

GC, vitamin D binding protein

decreases expression

chromium nitrate results in decreased expression of GC protein

NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567

G

glutamate-cysteine ligase, catalytic subunit

increases expression

chromium nitrate results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

chromium nitrate results in increased expression of HAAO protein

NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877

G

2-hydroxyacyl-CoA lyase 1

increases expression

chromium nitrate results in increased expression of HACL1 protein

NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027

G

3-hydroxyisobutyrate dehydrogenase

increases expression

chromium nitrate results in increased expression of HIBADH protein

NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617

G

heme oxygenase 1

increases expression

chromium nitrate results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family D (Hsp60) member 1

increases expression

chromium nitrate results in increased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

ketohexokinase

decreases expression

chromium nitrate results in decreased expression of KHK protein

NCBI chr 6:25,445,298...25,455,834
Ensembl chr 6:25,445,300...25,455,717

G

kininogen 1

increases expression

chromium nitrate results in increased expression of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

keratin 10

increases expression

chromium nitrate results in increased expression of KRT10 protein

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 16

increases expression

chromium nitrate results in increased expression of KRT16 protein

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin 17

increases expression

chromium nitrate results in increased expression of KRT17 protein

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

G

keratin 18

decreases expression

chromium nitrate results in decreased expression of KRT18 protein

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

keratin 25

increases expression

chromium nitrate results in increased expression of KRT25 protein

NCBI chr10:84,267,399...84,275,025
Ensembl chr10:84,267,399...84,274,965

G

keratin 27

increases expression

chromium nitrate results in increased expression of KRT27 protein

NCBI chr10:84,298,684...84,303,967
Ensembl chr10:84,298,508...84,303,967

G

malate dehydrogenase 1

increases expression

chromium nitrate results in increased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

G

metallothionein 2A

increases expression

chromium nitrate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

Parkinsonism associated deglycase

increases expression

chromium nitrate results in increased expression of PARK7 protein

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

propionyl-CoA carboxylase subunit alpha

increases expression

chromium nitrate results in increased expression of PCCA protein

NCBI chr15:99,627,955...99,969,555
Ensembl chr15:99,627,982...99,968,266

G

pyruvate dehydrogenase E1 subunit beta

decreases expression

chromium nitrate results in decreased expression of PDHB protein

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

prohibitin 1

decreases expression

chromium nitrate results in decreased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

regucalcin

decreases expression

chromium nitrate results in decreased expression of RGN protein

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

G

ribosomal protein lateral stalk subunit P0

decreases expression

chromium nitrate results in decreased expression of RPLP0 protein

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

serpin family C member 1

decreases expression

chromium nitrate results in decreased expression of SERPINC1 protein

NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293

G

succinate-CoA ligase GDP-forming subunit beta

decreases expression

chromium nitrate results in decreased expression of SUCLG2 protein

NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170

G

triokinase and FMN cyclase

increases expression

chromium nitrate results in increased expression of TKFC protein

NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737

G

ubiquinol-cytochrome c reductase core protein 1

decreases expression

chromium nitrate results in decreased expression of UQCRC1 protein

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

G

valosin-containing protein

decreases expression

chromium nitrate results in decreased expression of VCP protein

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

copper(II) nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]; resveratrol inhibits the reaction [[copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to bathophenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

interleukin 2

decreases secretion

copper(II) nitrate results in decreased secretion of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

gallium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 7

decreases expression

gallium nitrate results in decreased expression of ABCB7 mRNA

NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858

G

aconitase 1

increases expression

gallium nitrate results in increased expression of ACO1 mRNA

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

albumin

multiple interactions

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

beta-2 microglobulin

decreases expression

gallium nitrate results in decreased expression of B2M mRNA

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2 associated X, apoptosis regulator

increases expression

gallium nitrate results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

calreticulin

decreases expression

gallium nitrate results in decreased expression of CALR mRNA

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 3

increases activity
multiple interactions

gallium nitrate results in increased activity of CASP3 protein
Bortezomib promotes the reaction [gallium nitrate results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression

gallium nitrate results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

DnaJ heat shock protein family (Hsp40) member A1

increases expression

gallium nitrate results in increased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

early growth response 1

increases expression

gallium nitrate results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

ferritin light chain 1

increases expression

gallium nitrate results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glutathione peroxidase 4

decreases expression

gallium nitrate results in decreased expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

hypoxia inducible factor 1 subunit alpha

decreases expression

gallium nitrate results in decreased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

increases expression
multiple interactions

gallium nitrate results in increased expression of HMOX1 mRNA; gallium nitrate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [gallium nitrate results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

decreases expression

gallium nitrate results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

decreases expression

gallium nitrate results in decreased expression of HSPA9 mRNA

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

decreases expression

gallium nitrate results in decreased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

decreases expression

gallium nitrate results in decreased expression of HSPD1 mRNA

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

metallothionein 2A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of MT2A mRNA]
gallium nitrate results in increased expression of MT2A mRNA; gallium nitrate results in increased expression of MT2A protein

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

increases expression

gallium nitrate results in increased expression of MT3 mRNA

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

metal-regulatory transcription factor 1

increases expression

gallium nitrate results in increased expression of MTF1 mRNA

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

gallium nitrate results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases activity

SB 203580 inhibits the reaction [gallium nitrate results in increased activity of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

popeye domain cAMP effector 2

decreases expression

gallium nitrate results in decreased expression of POPDC2 mRNA

NCBI chr11:62,351,843...62,398,688
Ensembl chr11:62,374,759...62,390,756

G

peroxiredoxin 4

decreases expression

gallium nitrate results in decreased expression of PRDX4 mRNA

NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066

G

parathyroid hormone

multiple interactions

gallium nitrate inhibits the reaction [Tamoxifen results in decreased expression of PTH protein]

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

solute carrier family 39 member 6

decreases expression

gallium nitrate results in decreased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 40 member 1

decreases expression

gallium nitrate results in decreased expression of SLC40A1 mRNA

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

superoxide dismutase 1

decreases expression

gallium nitrate results in decreased expression of SOD1 mRNA

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases expression

gallium nitrate results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transferrin

multiple interactions

gallium nitrate promotes the reaction [TF protein results in increased uptake of Iron]

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

decreases expression

gallium nitrate results in decreased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

lead nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of ACO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in decreased expression of ACO1 protein]

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

actin, alpha 1, skeletal muscle

increases expression

lead nitrate results in increased expression of ACTA1 protein

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

aryl hydrocarbon receptor

multiple interactions
increases expression

AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of AHR mRNA; lead nitrate results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

A-kinase anchoring protein 3

decreases expression

lead nitrate results in decreased expression of AKAP3 mRNA

NCBI chr 4:159,688,049...159,714,067
Ensembl chr 4:159,699,289...159,713,903

G

aminolevulinate dehydratase

multiple interactions
decreases activity

lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]
lead nitrate results in decreased activity of ALAD protein

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

apoptotic peptidase activating factor 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of APAF1 protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein]

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

Rho GDP dissociation inhibitor beta

increases expression

lead nitrate results in increased expression of ARHGDIB protein

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

arrestin domain containing 5

decreases expression

lead nitrate results in decreased expression of ARRDC5 mRNA

NCBI chr 9:1,126,644...1,132,736
Ensembl chr 9:1,126,644...1,132,816

G

antizyme inhibitor 2

decreases expression

lead nitrate results in decreased expression of AZIN2 mRNA

NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of BAX protein]
[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of BAX mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of BAX mRNA]

PMID:23451106 PMID:30738203

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

lead nitrate results in decreased expression of BCL2 protein
[lead nitrate results in increased abundance of Lead] which results in decreased expression of BCL2 mRNA
mangiferin inhibits the reaction [lead nitrate results in decreased expression of BCL2 protein]

PMID:23451106 PMID:30738203

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

similar to human chromosome 1 open reading frame 56

decreases expression

lead nitrate results in decreased expression of C2H1ORF56 mRNA

NCBI chr 2:182,814,794...182,818,387
Ensembl chr 2:182,814,793...182,818,512

G

caspase 3

increases expression
multiple interactions
increases activity

lead nitrate results in increased expression of CASP3 protein
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP3 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP3 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased activity of CASP3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP3 protein]

PMID:23451106 PMID:24505050 PMID:30738203

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
decreases expression

lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of CASP7 mRNA

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of CASP9 protein]
[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein; [lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased activity of CASP9 protein]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of CASP9 mRNA]

PMID:23451106 PMID:30738203

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
multiple interactions

lead nitrate results in decreased activity of CAT protein
[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased activity of CAT protein]
Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of CAT protein]; puerarin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]
mangiferin inhibits the reaction [lead nitrate results in decreased activity of CAT protein]

PMID:23315276 PMID:23451106 PMID:24987671 PMID:30738203

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin G1

multiple interactions

lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

CD86 molecule

increases expression

lead nitrate results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

chromodomain Y-like

decreases expression

lead nitrate results in decreased expression of CDYL mRNA

NCBI chr17:28,982,009...29,204,345
Ensembl chr17:28,982,037...29,204,313

G

component of inhibitor of nuclear factor kappa B kinase complex

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of CHUK protein
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome c oxidase subunit 8C

decreases expression

lead nitrate results in decreased expression of COX8C mRNA

NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889

G

cysteine-rich secretory protein 2

decreases expression

lead nitrate results in decreased expression of CRISP2 mRNA

NCBI chr 9:20,107,649...20,131,967
Ensembl chr 9:20,107,701...20,131,959

G

crystallin, alpha A

affects metabolic processing

lead nitrate affects the metabolism of CRYAA protein

NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349

G

crystallin, alpha B

affects metabolic processing

lead nitrate affects the metabolism of CRYAB protein

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cystatin 8

decreases expression

lead nitrate results in decreased expression of CST8 mRNA

NCBI chr 3:136,244,586...136,255,412
Ensembl chr 3:136,244,636...136,251,273

G

catenin alpha 1

multiple interactions

lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein; [lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of and affects the localization of CTNNB1 protein]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of CTNNB1 mRNA]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of CTNNB1 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cut-like homeobox 2

multiple interactions

lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]

NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

lead nitrate inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; lead nitrate promotes the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [lead nitrate results in increased expression of CYP1A1 mRNA]
lead nitrate results in increased expression of CYP1A1 mRNA; lead nitrate results in increased expression of CYP1A1 protein

PMID:8902619 PMID:11162773 PMID:11408366 PMID:17889500 PMID:23391631 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
multiple interactions

lead nitrate results in decreased activity of CYP1A2 protein
lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 mRNA]; lead nitrate inhibits the reaction [2-methoxy-4-aminoazobenzene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; lead nitrate results in decreased expression of and results in decreased activity of CYP1A2 protein

PMID:8902619 PMID:11162773

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, subfamily 2, polypeptide 11

increases expression

lead nitrate results in increased expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily j, polypeptide 3

increases expression

lead nitrate results in increased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

lead nitrate results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases expression

lead nitrate results in increased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 51

increases expression
multiple interactions

lead nitrate results in increased expression of CYP51 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]

PMID:15475176 PMID:22293356

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of CYP7A1 mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression

lead nitrate results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA; [lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of DKK1 protein]

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dentin matrix acidic phosphoprotein 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DMP1 mRNA]

NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323

G

deoxyribonuclease 1

multiple interactions

lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]

NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869

G

DNA methyltransferase 3 alpha

multiple interactions
decreases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]
lead nitrate results in decreased expression of DNMT3A mRNA; lead nitrate results in decreased expression of DNMT3A protein

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

dentin sialophosphoprotein

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of DSPP mRNA]

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

G

E2F transcription factor 1

multiple interactions

E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

EGF-like-domain, multiple 8

increases expression

lead nitrate results in increased expression of EGFL8 protein

NCBI chr20:4,132,930...4,136,024
Ensembl chr20:4,133,629...4,136,018

G

epidermal growth factor receptor

multiple interactions
increases phosphorylation

EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR mutant form affects the reaction [lead nitrate results in increased secretion of Dinoprostone]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2 alpha kinase 1

increases response to substance
multiple interactions

EIF2AK1 gene mutant form results in increased susceptibility to lead nitrate
[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Bilirubin; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased abundance of Malondialdehyde; [lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
increases phosphorylation

puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of EIF4EBP1 protein]

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions

lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

ERCC excision repair 3, TFIIH core complex helicase subunit

multiple interactions

lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]

NCBI chr18:23,883,613...23,914,326
Ensembl chr18:23,883,580...23,914,329

G

ezrin

multiple interactions

lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

fatty acid binding protein 9

decreases expression

lead nitrate results in decreased expression of FABP9 mRNA

NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873

G

farnesyl diphosphate farnesyl transferase 1

increases expression

lead nitrate results in increased expression of FDFT1 mRNA

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

increases expression

lead nitrate results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

four and a half LIM domains 1

decreases expression

lead nitrate results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

lead nitrate results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box A2

multiple interactions

lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

ferritin light chain 1

increases expression

lead nitrate results in increased expression of FTL protein

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glucose-6-phosphate dehydrogenase

decreases activity

lead nitrate results in decreased activity of G6PD protein

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

growth arrest and DNA-damage-inducible, alpha

increases expression

lead nitrate results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

golgi associated RAB2 interactor 1B

decreases expression

lead nitrate results in decreased expression of GARIN1B mRNA

NCBI chr 4:57,915,184...57,938,593
Ensembl chr 4:57,920,790...57,938,591

G

glial fibrillary acidic protein

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of GFAP protein]
lead nitrate results in increased expression of GFAP mRNA; lead nitrate results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gametogenetin binding protein 1

decreases expression

lead nitrate results in decreased expression of GGNBP1 mRNA

NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183

G

growth hormone 1

multiple interactions
decreases secretion

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]
lead nitrate results in decreased secretion of GH1 protein

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone releasing hormone

multiple interactions

lead nitrate inhibits the reaction [GHRH protein results in increased expression of GH1 protein]

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

gap junction protein, alpha 5

multiple interactions
increases expression

lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]
lead nitrate results in increased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gap junction protein, beta 2

multiple interactions

lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glutamate ionotropic receptor NMDA type subunit 2A

multiple interactions

lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

lead nitrate results in increased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

germ cell associated 1

decreases expression

lead nitrate results in decreased expression of GSG1 mRNA

NCBI chr 4:168,090,773...168,107,039
Ensembl chr 4:168,090,776...168,107,039

G

glycogen synthase kinase 3 beta

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions
decreases activity

mangiferin inhibits the reaction [lead nitrate results in decreased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

decreases expression
multiple interactions

lead nitrate results in decreased expression of GSTA1 mRNA
AHR promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; Resveratrol inhibits the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase theta 1

multiple interactions

lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

hepcidin antimicrobial peptide

multiple interactions

[lead nitrate co-treated with EIF2AK1 gene mutant form] results in increased expression of HAMP mRNA

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

high-mobility group box 4

decreases expression

lead nitrate results in decreased expression of HMGB4 mRNA

NCBI chr 5:140,616,040...140,616,722
Ensembl chr 5:140,615,197...140,616,770

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions

lead nitrate results in increased expression of HMGCR mRNA
[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]

PMID:15475176 PMID:16705668 PMID:22293356

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases expression

lead nitrate results in increased expression of HMOX1 mRNA

PMID:23391631 PMID:34189835

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression

lead nitrate results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heat shock protein 90 alpha family class B member 1

multiple interactions

lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 2

multiple interactions
decreases expression
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA2 mRNA]
lead nitrate results in decreased expression of HSPA2 mRNA

PMID:21628963 PMID:24987671

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 5

increases expression

lead nitrate results in increased expression of HSPA5 protein
lead nitrate results in increased expression of HSPA5 mRNA

PMID:14971657 PMID:20435106

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

multiple interactions
increases expression

Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in increased expression of HSPA9 protein]
lead nitrate results in increased expression of HSPA9 mRNA; lead nitrate results in increased expression of HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

insulin-like growth factor 2

multiple interactions

lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 6

multiple interactions

lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 1 alpha

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in decreased expression of CYP7A1 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of CYP51 mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of HMGCR mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]; [IL1A gene mutant form co-treated with IL1B gene mutant form] results in decreased susceptibility to lead nitrate
lead nitrate results in increased expression of IL1B mRNA
lead nitrate results in increased expression of IL1B mRNA; lead nitrate results in increased expression of IL1B protein

PMID:15475176 PMID:16049268 PMID:22293356

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases secretion

lead nitrate results in decreased secretion of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6 receptor

multiple interactions

lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

G

insulin 1

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

IQ motif containing F1

decreases expression

lead nitrate results in decreased expression of IQCF1 mRNA

NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249

G

IQ motif containing F5

decreases expression

lead nitrate results in decreased expression of IQCF5 mRNA

NCBI chr 8:107,151,477...107,152,862
Ensembl chr 8:107,151,462...107,152,869

G

integrin subunit alpha 6

multiple interactions

lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

G

integrin subunit alpha M

multiple interactions

lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

keratin 14

increases expression

lead nitrate results in increased expression of KRT14 protein

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

lysosomal-associated membrane protein 1

increases expression

lead nitrate results in increased expression of LAMP1 protein

NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883

G

lysosomal-associated membrane protein 2

increases expression

lead nitrate results in increased expression of LAMP2 protein

NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase C

decreases expression

lead nitrate results in decreased expression of LDHC mRNA

NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378

G

leucine rich repeat containing 46

decreases expression

lead nitrate results in decreased expression of LRRC46 mRNA

NCBI chr10:82,021,314...82,033,575
Ensembl chr10:82,021,330...82,033,724

G

lymphotoxin alpha

multiple interactions

lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

Ly6/Plaur domain containing 4

decreases expression

lead nitrate results in decreased expression of LYPD4 mRNA

NCBI chr 1:80,460,487...80,466,105
Ensembl chr 1:80,460,487...80,466,011

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK1 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]
mangiferin inhibits the reaction [lead nitrate results in increased phosphorylation of MAPK3 protein]

PMID:20850495 PMID:22502979 PMID:23451106

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

membrane associated ring-CH-type finger 11

decreases expression

lead nitrate results in decreased expression of MARCHF11 mRNA

NCBI chr 2:76,898,330...76,999,690
Ensembl chr 2:76,898,386...76,999,691

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

MET proto-oncogene, receptor tyrosine kinase

multiple interactions

lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microsomal glutathione S-transferase 1

multiple interactions

lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

microRNA 139

increases expression

lead nitrate results in increased expression of MIR139 mRNA

NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902

G

microRNA 142

increases expression

lead nitrate results in increased expression of MIR142 mRNA

NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967

G

maestro heat-like repeat family member 2B

decreases expression

lead nitrate results in decreased expression of MROH2B mRNA

NCBI chr 2:54,003,870...54,063,992
Ensembl chr 2:54,003,862...54,063,984

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX1 mRNA]

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase II

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX2 mRNA]

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases expression

puerarin inhibits the reaction [lead nitrate results in decreased expression of COX3 mRNA]

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

metallothionein 1

increases expression
affects localization
decreases response to substance
multiple interactions

lead nitrate results in increased expression of MT1 mRNA
lead nitrate affects the localization of MT1 protein
MT1 results in decreased susceptibility to lead nitrate
lead nitrate affects the reaction [CASP7 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT1 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT1 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

PMID:11891201 PMID:19542206

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions
decreases response to substance

lead nitrate affects the reaction [CASP7 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CCNG1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CTNNA1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [CUX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [DNASE1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ERCC3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [EZR affects the expression of MT2 mRNA]; lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJA5 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GJB2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GRIN2A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [HSP90AB1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGF2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IGFBP6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [IL6RA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGA6 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ITGAM affects the expression of MT2 mRNA]; lead nitrate affects the reaction [LTA affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MCL1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MET affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MGST1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RAD23 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SERPINA1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]
MT2 results in decreased susceptibility to lead nitrate

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

increases phosphorylation
multiple interactions

lead nitrate results in increased phosphorylation of MTOR protein
puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

lead nitrate affects the reaction [MYC affects the expression of MT1 mRNA]; lead nitrate affects the reaction [MYC affects the expression of MT2 mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin heavy chain 6

decreases expression

lead nitrate results in decreased expression of MYH6 protein

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

increases expression
multiple interactions

lead nitrate results in increased expression of MYH7 mRNA; lead nitrate results in increased expression of MYH7 protein
resveratrol inhibits the reaction [lead nitrate results in increased expression of MYH7 mRNA]

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

neural cell adhesion molecule 1

multiple interactions
decreases expression

Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 mRNA]; Ashwagandha inhibits the reaction [lead nitrate results in decreased expression of NCAM1 protein]
lead nitrate results in decreased expression of NCAM1 mRNA; lead nitrate results in decreased expression of NCAM1 protein

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

NFKB inhibitor alpha

decreases expression
multiple interactions

lead nitrate results in decreased expression of NFKBIA protein
mangiferin inhibits the reaction [lead nitrate results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

lead nitrate affects the reaction [NFKBIB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NFKBIB affects the expression of MT2 mRNA]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

natriuretic peptide B

increases expression

lead nitrate results in increased expression of NPPB mRNA

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

increases expression

lead nitrate results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

lead nitrate results in decreased expression of NR0B2 mRNA

PMID:15475176 PMID:16049268

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 3

decreases expression

lead nitrate results in decreased expression of NR1H3 mRNA

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 5, group A, member 2

increases expression

lead nitrate results in increased expression of NR5A2 mRNA

NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326

G

NUMB, endocytic adaptor protein

multiple interactions

lead nitrate affects the reaction [NUMB affects the expression of MT1 mRNA]; lead nitrate affects the reaction [NUMB affects the expression of MT2 mRNA]

NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354

G

outer dense fiber of sperm tails 1

decreases expression

lead nitrate results in decreased expression of ODF1 mRNA

NCBI chr 7:69,377,427...69,389,662
Ensembl chr 7:69,380,116...69,389,664

G

3-oxoacid CoA transferase 2A

decreases expression

lead nitrate results in decreased expression of OXCT2A mRNA

NCBI chr 5:135,600,812...135,602,570
Ensembl chr 5:135,591,507...135,602,569

G

progestin and adipoQ receptor family member 5

decreases expression

lead nitrate results in decreased expression of PAQR5 mRNA

NCBI chr 8:62,431,867...62,513,688
Ensembl chr 8:62,431,867...62,513,688

G

protein inhibitor of activated STAT, 2

multiple interactions

lead nitrate affects the reaction [PIAS2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [PIAS2 affects the expression of MT2 mRNA]

NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033

G

phospholipase A2 group 4A

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; [lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone; EGFR mutant form affects the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; EGFR mutant form affects the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; EGFR promotes the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PLA2G4A mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PLA2G4A mRNA]

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

DNA polymerase delta 1, catalytic subunit

multiple interactions

lead nitrate affects the reaction [POLD1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POLD1 affects the expression of MT2 mRNA]

NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465

G

POU class 3 homeobox 3

multiple interactions

lead nitrate affects the reaction [POU3F3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [POU3F3 affects the expression of MT2 mRNA]

NCBI chr 9:44,945,872...44,948,998
Ensembl chr 9:44,945,872...44,948,992

G

protamine 1

decreases expression

lead nitrate results in decreased expression of PRM1 mRNA

NCBI chr10:4,871,817...4,872,312

G

protamine 3

decreases expression

lead nitrate results in decreased expression of PRM3 mRNA

NCBI chr10:4,877,471...4,877,985
Ensembl chr10:4,877,471...4,877,985

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]; [lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone; Decitabine promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; E2F1 protein inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; lead nitrate inhibits the reaction [E2F1 protein results in decreased expression of PTGS2 mRNA]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [[lead nitrate results in increased expression of PTGS2 mRNA] which results in increased secretion of Dinoprostone]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of PTGS2 protein]
lead nitrate results in increased expression of PTGS2 mRNA; lead nitrate results in increased expression of PTGS2 protein

PMID:20850495 PMID:21435385 PMID:24639330

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

multiple interactions
increases expression

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in increased expression of RB1 protein]; lead nitrate promotes the reaction [RB1 protein results in increased expression of PTGS2 mRNA]; RB1 protein promotes the reaction [lead nitrate results in increased expression of PTGS2 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 mRNA]; RTKI cpd inhibits the reaction [lead nitrate results in increased expression of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 2

multiple interactions

lead nitrate affects the reaction [RBL2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RBL2 affects the expression of MT2 mRNA]

NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases expression

mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]
RELA promotes the reaction [lead nitrate results in decreased expression of GSTA1 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]
lead nitrate results in increased expression of RELA mRNA; lead nitrate results in increased expression of RELA protein

PMID:23451106 PMID:31682781

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RIB43A domain with coiled-coils 2

decreases expression

lead nitrate results in decreased expression of RIBC2 mRNA

NCBI chr 7:116,242,863...116,257,868
Ensembl chr 7:116,242,863...116,257,863

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

puerarin inhibits the reaction [lead nitrate results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 1

multiple interactions

lead nitrate affects the reaction [RUNX1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [RUNX1 affects the expression of MT2 mRNA]

NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542

G

RUNX family transcription factor 2

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of RUNX2 protein]
lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of RUNX2 mRNA]

PMID:30731080 PMID:35738543

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sperm mitochondria-associated cysteine-rich protein

decreases expression

lead nitrate results in decreased expression of SMCP mRNA

NCBI chr 2:178,160,948...178,165,951
Ensembl chr 2:178,160,127...178,166,001

G

synuclein alpha

affects localization
multiple interactions
increases expression

lead nitrate affects the localization of SNCA protein
MT1 protein promotes the reaction [lead nitrate results in increased expression of SNCA mRNA]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

suppressor of cytokine signaling 1

multiple interactions

lead nitrate affects the reaction [SOCS1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SOCS1 affects the expression of MT2 mRNA]

NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383

G

superoxide dismutase 1

multiple interactions
decreases activity

Ashwagandha inhibits the reaction [lead nitrate results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

Sp3 transcription factor

multiple interactions
decreases expression

lead nitrate affects the reaction [SP3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SP3 affects the expression of MT2 mRNA]
lead nitrate results in decreased expression of SP3 mRNA

NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342

G

spermatogenesis associated 18

decreases expression

lead nitrate results in decreased expression of SPATA18 mRNA

NCBI chr14:34,531,931...34,558,671
Ensembl chr14:34,531,061...34,558,687

G

spermatogenesis associated 20

decreases expression

lead nitrate results in decreased expression of SPATA20 mRNA

NCBI chr10:79,427,525...79,435,472
Ensembl chr10:79,427,528...79,434,368

G

spermatogenesis associated 21

decreases expression

lead nitrate results in decreased expression of SPATA21 mRNA

NCBI chr 5:153,393,309...153,419,430
Ensembl chr 5:153,393,365...153,418,561

G

spermatogenesis associated 6

decreases expression

lead nitrate results in decreased expression of SPATA6 mRNA

NCBI chr 5:126,593,122...126,676,557
Ensembl chr 5:126,593,122...126,676,557

G

Spetex-2B protein

decreases expression

lead nitrate results in decreased expression of SPETEX2B mRNA

G

Spetex-2D protein

decreases expression

lead nitrate results in decreased expression of SPETEX2D mRNA

G

Spetex-2F protein

decreases expression

lead nitrate results in decreased expression of SPETEX2F mRNA

NCBI chr15:17,716,315...17,720,203
Ensembl chr15:17,716,358...17,733,744

G

sequestosome 1

multiple interactions
increases expression

lead nitrate affects the reaction [SQSTM1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SQSTM1 affects the expression of MT2 mRNA]
puerarin inhibits the reaction [lead nitrate results in increased expression of SQSTM1 protein]

PMID:11891201 PMID:27762461

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 2

increases expression

lead nitrate results in increased expression of SREBF2 mRNA

PMID:15475176 PMID:16705668

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

small ubiquitin-like modifier 1

multiple interactions

lead nitrate affects the reaction [SUMO1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [SUMO1 affects the expression of MT2 mRNA]

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

G

T-box transcription factor 2

multiple interactions

lead nitrate affects the reaction [TBX2 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TBX2 affects the expression of MT2 mRNA]

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

tektin 2

decreases expression

lead nitrate results in decreased expression of TEKT2 mRNA

NCBI chr 5:138,619,665...138,623,301
Ensembl chr 5:138,619,667...138,623,204

G

tektin 4

decreases expression

lead nitrate results in decreased expression of TEKT4 mRNA

NCBI chr10:14,487,760...14,492,936
Ensembl chr10:14,487,760...14,492,936

G

tropomodulin 1

decreases expression

lead nitrate results in decreased expression of TMOD1 mRNA

NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956

G

tumor necrosis factor

multiple interactions
increases expression

[IL1A gene mutant form co-treated with IL1B gene mutant form] inhibits the reaction [lead nitrate results in increased expression of TNF mRNA]
Lead nitrate increases expression of Tnf mRNA in liver

CTD
RGD

PMID:15475176 PMID:16049268 PMID:22293356 PMID:9049203 PMID:7943184

RGD:14995487, RGD:14995476

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

lead nitrate affects the reaction [TNFRSF1A affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1A affects the expression of MT2 mRNA]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

multiple interactions

lead nitrate affects the reaction [TNFRSF1B affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TNFRSF1B affects the expression of MT2 mRNA]

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

transition protein 1

decreases expression

lead nitrate results in decreased expression of TNP1 mRNA

NCBI chr 9:74,594,463...74,595,072
Ensembl chr 9:74,594,466...74,595,274

G

transition protein 2

decreases expression

lead nitrate results in decreased expression of TNP2 mRNA

NCBI chr10:4,879,812...4,880,540
Ensembl chr10:4,879,812...4,880,538

G

tumor protein p53

multiple interactions
increases expression

[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA; AHR promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; RELA promotes the reaction [lead nitrate results in increased expression of TP53 mRNA]; titanium dioxide inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in increased expression of TP53 mRNA]

PMID:30738203 PMID:31682781

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tubulin polymerization-promoting protein family member 2

decreases expression

lead nitrate results in decreased expression of TPPP2 mRNA

NCBI chr15:24,614,284...24,627,123
Ensembl chr15:24,614,006...24,618,967

G

tripartite motif-containing 27

multiple interactions

lead nitrate affects the reaction [TRIM27 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TRIM27 affects the expression of MT2 mRNA]

NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643

G

transient receptor potential cation channel, subfamily M, member 2

multiple interactions

lead nitrate inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]

NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181

G

TSC22 domain family, member 3

multiple interactions

[lead nitrate results in increased abundance of Lead] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

tumor susceptibility 101

multiple interactions

lead nitrate affects the reaction [TSG101 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TSG101 affects the expression of MT2 mRNA]

NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554

G

testis-specific serine kinase 2

decreases expression

lead nitrate results in decreased expression of TSSK2 mRNA

NCBI chr11:83,086,578...83,087,933

G

testis-specific serine kinase 3

decreases expression

lead nitrate results in decreased expression of TSSK3 mRNA

NCBI chr 5:141,827,606...141,829,255
Ensembl chr 5:141,827,606...141,829,255

G

transcription termination factor 1

multiple interactions

lead nitrate affects the reaction [TTF1 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [TTF1 affects the expression of MT2 mRNA]

NCBI chr 3:12,384,626...12,409,257
Ensembl chr 3:12,384,655...12,409,257

G

tubulin, alpha 8

decreases expression

lead nitrate results in decreased expression of TUBA8 mRNA

NCBI chr 4:154,440,045...154,456,918
Ensembl chr 4:154,440,074...154,456,917

G

TUB like protein 2

decreases expression

lead nitrate results in decreased expression of TULP2 mRNA

NCBI chr 1:95,962,496...95,999,775
Ensembl chr 1:95,962,496...96,000,628

G

Wnt family member 1

multiple interactions

lead nitrate inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid co-treated with ascorbate-2-phosphate] results in increased expression of WNT1 mRNA]

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

G

Wnt family member 3A

multiple interactions

[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA; [lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A mRNA]; icaritin inhibits the reaction [[lead nitrate results in increased abundance of Lead] which results in decreased expression of WNT3A protein]

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

G

Wnt family member 4

multiple interactions

lead nitrate affects the reaction [WNT4 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [WNT4 affects the expression of MT2 mRNA]

NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859

G

zinc finger homeobox 3

multiple interactions

lead nitrate affects the reaction [ZFHX3 affects the expression of MT1 mRNA]; lead nitrate affects the reaction [ZFHX3 affects the expression of MT2 mRNA]

NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771

G

zinc and ring finger 4

decreases expression

lead nitrate results in decreased expression of ZNRF4 mRNA

NCBI chr 9:1,353,308...1,354,496
Ensembl chr 9:1,353,306...1,354,584

nitric oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Nitric Oxide]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Iron]

PMID:16679408 PMID:17272743

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions

ABCC2 affects the reaction [Ursodeoxycholic Acid results in increased secretion of Nitric Oxide]
ABCC2 gene SNP affects the susceptibility to [Air Pollutants results in increased abundance of Nitric Oxide]

PMID:20683964 PMID:29681089

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

acyl-CoA binding domain containing 3

multiple interactions

Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]

NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380

G

angiotensin I converting enzyme

multiple interactions
increases expression

Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACE mRNA]

PMID:10948087 PMID:16326922

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

aconitase 1

decreases expression
multiple interactions

Nitric Oxide results in decreased expression of ACO1 mRNA
STAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]; STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

actin, alpha 1, skeletal muscle

multiple interactions
increases expression

Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of ACTA1 mRNA]

PMID:10397678 PMID:16326922

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin, beta

decreases expression

Nitric Oxide deficiency results in decreased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

adrenomedullin

increases expression

Nitric Oxide deficiency results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenomedullin 2

increases expression

Nitric Oxide deficiency results in increased expression of ADM2 mRNA

NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331

G

adrenoceptor beta 2

decreases abundance

ADRB2 protein results in decreased abundance of Nitric Oxide

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

angiotensinogen

decreases secretion
increases chemical synthesis
increases activity
increases abundance
increases secretion
decreases abundance
multiple interactions

AGT protein modified form results in decreased secretion of Nitric Oxide
AGT protein modified form results in increased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in increased activity of AGT protein modified form
AGT protein results in increased abundance of Nitric Oxide
AGT protein alternative form results in increased secretion of Nitric Oxide
AGT protein results in decreased abundance of Nitric Oxide
AGT protein alternative form promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; theaflavin-3,3'-digallate inhibits the reaction [AGT protein results in decreased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Nitric Oxide]
candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; Hydrogen Sulfide promotes the reaction [AGT protein modified form results in increased chemical synthesis of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; troglitazone inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]

PMID:12198334 PMID:14597853 PMID:14620932 PMID:17272743 PMID:17666345 More...

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

angiotensin II receptor, type 1a

affects abundance

AGTR1A protein affects the abundance of Nitric Oxide

NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946

G

angiotensin II receptor, type 1b

affects abundance

AGTR1B protein affects the abundance of Nitric Oxide

NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232

G

angiotensin II receptor, type 2

affects response to substance

AGTR2 protein affects the susceptibility to Nitric Oxide

NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057

G

apoptosis inducing factor, mitochondria associated 1

affects localization

Nitric Oxide affects the localization of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

Nitric Oxide deficiency results in increased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

aryl-hydrocarbon receptor-interacting protein

decreases expression

Nitric Oxide deficiency results in decreased expression of AIP mRNA

NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122

G

AKT serine/threonine kinase 1

multiple interactions

AKT1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Nitric Oxide]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 2 family member

multiple interactions

[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

arachidonate 5-lipoxygenase

multiple interactions

Nitric Oxide promotes the reaction [Reactive Oxygen Species results in decreased activity of ALOX5 protein]

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

angiopoietin-like 2

decreases chemical synthesis

ANGPTL2 gene mutant form results in decreased chemical synthesis of Nitric Oxide

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

annexin A5

increases expression

Nitric Oxide results in increased expression of ANXA5 protein

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

apolipoprotein E

decreases chemical synthesis

APOE gene mutant form results in decreased chemical synthesis of Nitric Oxide

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions

[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 2

decreases expression

Nitric Oxide deficiency results in decreased expression of AQP2 protein

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

argininosuccinate synthase 1

increases response to substance

ASS1 protein results in increased susceptibility to Nitric Oxide

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions

Nitric Oxide deficiency inhibits the reaction [Clofibrate results in increased expression of ATP1A1 protein]

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATP synthase F1 subunit beta

increases expression

Nitric Oxide deficiency results in increased expression of ATP5F1B mRNA

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

arginine vasopressin

affects metabolic processing
increases expression
multiple interactions

AVP protein affects the metabolism of Nitric Oxide
Nitric Oxide results in increased expression of AVP mRNA
IL1B protein affects the reaction [AVP protein affects the metabolism of Nitric Oxide]

PMID:10460269 PMID:21171372

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

Axl receptor tyrosine kinase

decreases expression

Nitric Oxide deficiency results in decreased expression of AXL mRNA

NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265

G

beta-2 microglobulin

increases expression

Nitric Oxide results in increased expression of B2M protein

NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766

G

BCL2 associated X, apoptosis regulator

affects localization
multiple interactions
decreases expression

Nitric Oxide affects the localization of BAX protein
Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of BAX protein]
[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which affects the localization of BAX protein]
Nitric Oxide results in decreased expression of BAX protein
[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of BAX protein

PMID:10828028 PMID:14634119 PMID:22878015 PMID:25726415

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

Nitric Oxide results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCAR1 scaffold protein, Cas family member

multiple interactions
decreases phosphorylation

Nitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein]
Nitric Oxide results in decreased phosphorylation of BCAR1 protein

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

decreases expression
affects expression
multiple interactions

Nitric Oxide results in decreased expression of BCL2 protein
Nitric Oxide affects the expression of BCL2 mRNA
[3,5-dimethoxy-4'-hydroxystilbene results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 mRNA; [linsidomine results in increased abundance of Nitric Oxide] which results in increased expression of BCL2 protein; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased expression of BCL2 protein; Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein; pimagedine inhibits the reaction [Nitric Oxide results in increased nitrosation of and results in decreased degradation of BCL2 protein]

PMID:7706495 PMID:10828028 PMID:15126337 PMID:16980304 PMID:17135264

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression
increases expression
multiple interactions

Nitric Oxide results in decreased expression of BCL2L1 protein
Nitric Oxide results in increased expression of BCL2L1 mRNA
GATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; GATA5 protein promotes the reaction [Nitric Oxide results in increased expression of BCL2L1 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]; Nitric Oxide results in increased expression of and affects the localization of BCL2L1 protein

PMID:15126337 PMID:25726415

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

bradykinin receptor B2

multiple interactions

[kallidin, des-Arg(10)- binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide; [KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

brain-derived neurotrophic factor

increases chemical synthesis
multiple interactions

BDNF protein results in increased chemical synthesis of Nitric Oxide
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased chemical synthesis of Nitric Oxide]

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

BH3 interacting domain death agonist

increases cleavage

Nitric Oxide results in increased cleavage of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

increases expression

Nitric Oxide results in increased expression of BIRC2 protein

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

increases expression
decreases expression

Nitric Oxide results in increased expression of BIRC3 protein
Nitric Oxide results in decreased expression of BIRC3 mRNA

PMID:14634119 PMID:15126337

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

Nitric Oxide results in decreased expression of BIRC5 mRNA
Nitric Oxide results in decreased expression of BIRC5 protein

PMID:15126337 PMID:16166326

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 1

decreases expression

Nitric Oxide deficiency results in decreased expression of BMP1 mRNA

NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776

G

BCL2 interacting protein 3

increases expression
decreases expression

Nitric Oxide results in increased expression of BNIP3 protein
Nitric Oxide results in decreased expression of BNIP3 mRNA

PMID:11592958 PMID:16002567

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

CACNA1A protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

multiple interactions

CACNA1B protein affects the reaction [Potassium Chloride results in increased abundance of Nitric Oxide]

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcitonin receptor like receptor

increases expression

Nitric Oxide deficiency results in increased expression of CALCRL mRNA; Nitric Oxide deficiency results in increased expression of CALCRL protein

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calmodulin 1

multiple interactions

[Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

caspase 1

multiple interactions

[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

multiple interactions

[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

multiple interactions
increases activity
increases metabolic processing
decreases activity
decreases cleavage

[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Nitric Oxide inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
Nitric Oxide results in increased activity of CASP3 protein
Nitric Oxide results in increased metabolism of CASP3 protein
[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; Cyclic GMP affects the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]; Nitric Oxide affects the activity of and affects the cleavage of CASP3 protein; Nitric Oxide results in decreased cleavage of and results in decreased activity of CASP3 protein
[Nitric Oxide Donors results in increased abundance of Nitric Oxide] inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]; [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein; SB 203580 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP3 protein]
Nitric Oxide results in decreased cleavage of CASP3 protein

PMID:9388267 PMID:9706149 PMID:9755104 PMID:10222263 PMID:10358093 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

decreases cleavage

Nitric Oxide results in decreased cleavage of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases activity

Nitric Oxide results in decreased cleavage of and results in decreased activity of CASP8 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP8 protein
Nitric Oxide results in increased activity of CASP8 protein

PMID:10358093 PMID:15126337 PMID:22878015

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

decreases activity
multiple interactions
increases activity

Nitric Oxide results in decreased activity of CASP9 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased activity of CASP9 protein
Nitric Oxide results in increased activity of CASP9 protein

PMID:14634119 PMID:15126337 PMID:22878015

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of CAT mRNA]; Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]

PMID:20305041 PMID:21983654

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

multiple interactions
increases expression

[resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide; Nitric Oxide results in decreased ubiquitination of and results in decreased degradation of CAV1 protein; Nitric Oxide results in increased metabolism of and results in increased stability of CAV1 protein
Nitric Oxide results in increased expression of CAV1 protein

PMID:18296501 PMID:19706615

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 5

decreases secretion
multiple interactions

Nitric Oxide results in decreased secretion of CCL5 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; [CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]

PMID:13678430 PMID:19016906

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

multiple interactions

[[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

C-C motif chemokine receptor 5

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; [CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

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CD14 molecule

multiple interactions

CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [ganglioside, GD1a results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [Gangliosides results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; CD14 protein affects the reaction [trisialoganglioside GT1 results in increased secretion of Nitric Oxide]

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

Cd28 molecule

multiple interactions
increases abundance

1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

CD86 molecule

decreases expression

Nitric Oxide results in decreased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

cadherin 1

decreases expression

Nitric Oxide results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

caudal type homeo box 2

increases chemical synthesis

CDX2 gene mutant form results in increased chemical synthesis of Nitric Oxide

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

CF transmembrane conductance regulator

multiple interactions

Nitric Oxide inhibits the reaction [CFTR protein promotes the reaction [Cyclic AMP results in increased transport of Chlorine]]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cholinergic receptor, muscarinic 1

multiple interactions

[(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to CHRM1 protein] which results in increased abundance of Nitric Oxide; [muscarinic toxin 7 binds to and results in decreased activity of CHRM1 protein] inhibits the reaction [Amphetamine results in increased abundance of Nitric Oxide]

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cannabinoid receptor 1

multiple interactions

[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; [anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; rimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]; SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]
[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]

PMID:10027878 PMID:11727767 PMID:11891798

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

collagen type I alpha 2 chain

multiple interactions
increases expression

Amlodipine inhibits the reaction [Nitric Oxide deficiency results in increased expression of COL1A2 mRNA]

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type V alpha 3 chain

decreases expression

Nitric Oxide deficiency results in decreased expression of COL5A3 mRNA

NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853

G

cytochrome c oxidase subunit 4i1

increases expression

Nitric Oxide deficiency results in increased expression of COX4I1 mRNA

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

carboxypeptidase D

affects chemical synthesis
multiple interactions

CPD affects the chemical synthesis of Nitric Oxide
[PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide; [Testosterone results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

carbamoyl-phosphate synthase 1

affects abundance

CPS1 gene SNP affects the abundance of Nitric Oxide metabolite

NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033

G

corticotropin releasing hormone

multiple interactions
increases expression

CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]
Nitric Oxide results in increased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone receptor 1

increases expression

Nitric Oxide results in increased expression of CRHR1 mRNA

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

CRK proto-oncogene, adaptor protein

multiple interactions

Nitric Oxide inhibits the reaction [BCAR1 protein binds to CRK protein]

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

colony stimulating factor 1

multiple interactions
decreases activity

[CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]; [Lipopolysaccharides co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; CSF1 protein promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; CSF1 protein promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]; Enzyme Inhibitors inhibits the reaction [CSF1 protein promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]]; Enzyme Inhibitors inhibits the reaction [Nitric Oxide results in decreased activity of CSF1 protein]
[Benzene promotes the reaction [[CSF1 protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]] which results in increased chemical synthesis of Nitric Oxide

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

multiple interactions

[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; Benzene promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; quinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

multiple interactions

[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide; CSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]
[CSF1 protein co-treated with CSF2 protein] promotes the reaction [Lipopolysaccharides results in increased chemical synthesis of Nitric Oxide]
[Benzene co-treated with Enzyme Inhibitors] promotes the reaction [[Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; [CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; hydroquinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; hydroxyhydroquinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; quinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

PMID:7884313 PMID:8193360 PMID:8600936

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cardiotrophin 1

increases chemical synthesis

CTF1 protein results in increased chemical synthesis of Nitric Oxide

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

G

cystathionine gamma-lyase

decreases expression

Nitric Oxide deficiency results in decreased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cathepsin D

increases secretion

Nitric Oxide results in increased secretion of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

C-X-C motif chemokine ligand 10

decreases secretion

Nitric Oxide results in decreased secretion of CXCL10 protein

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

Nitric Oxide deficiency results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 4

decreases expression

Nitric Oxide deficiency results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome c, somatic

decreases secretion
affects localization

Nitric Oxide results in decreased secretion of CYCS protein
Nitric Oxide affects the localization of CYCS protein

PMID:10222263 PMID:10356289 PMID:10358093 PMID:16024610

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Nitric Oxide

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DAB adaptor protein 1

decreases expression

Nitric Oxide deficiency results in decreased expression of DAB1 mRNA

NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552

G

DDAH family member 2, ADMA-independent

multiple interactions

DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

dopa decarboxylase

increases activity

Nitric Oxide deficiency results in increased activity of DDC protein

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA fragmentation factor subunit beta

increases activity

Nitric Oxide results in increased activity of DFFB protein

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

diablo, IAP-binding mitochondrial protein

affects localization

Nitric Oxide affects the localization of DIABLO protein

NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387

G

dual specificity phosphatase 1

increases expression

Nitric Oxide results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

enoyl-CoA hydratase 1

increases expression

Nitric Oxide deficiency results in increased expression of ECH1 mRNA

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

endothelin 1

increases chemical synthesis
increases expression
increases secretion
decreases activity
increases abundance
multiple interactions
decreases expression

EDN1 protein results in increased chemical synthesis of Nitric Oxide
Nitric Oxide results in increased expression of EDN1 mRNA
Nitric Oxide results in increased secretion of EDN1 protein
Nitric Oxide deficiency results in increased expression of EDN1 mRNA
Nitric Oxide deficiency results in decreased activity of EDN1 protein
EDN1 protein results in increased abundance of Nitric Oxide
[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide; [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide; BQ 788 inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]; Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of EDN1 mRNA]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]; S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide]
Nitric Oxide results in increased expression of EDN1 protein
Nitric Oxide results in decreased expression of EDN1 protein

PMID:11187978 PMID:15640287 PMID:15838368 PMID:16326922 PMID:16380457 More...

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

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endothelin receptor type B

multiple interactions

[EDN1 protein results in increased activity of EDNRB protein] which results in increased abundance of Nitric Oxide

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

eukaryotic translation elongation factor 1 alpha 1

increases expression

Nitric Oxide deficiency results in increased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

eukaryotic translation elongation factor 1 beta 2

increases expression

Nitric Oxide deficiency results in increased expression of EEF1B2 mRNA

NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737

G

euchromatic histone lysine methyltransferase 2

decreases expression

Nitric Oxide results in decreased expression of EHMT2 protein

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 1A

decreases expression

Nitric Oxide deficiency results in decreased expression of EIF1A mRNA

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

eukaryotic translation initiation factor 2 alpha kinase 1

multiple interactions

Nitric Oxide inhibits the reaction [Mercury results in decreased activity of EIF2AK1 protein]

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 2B subunit delta

decreases expression

Nitric Oxide deficiency results in decreased expression of EIF2B4 mRNA

NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829

G

eukaryotic translation initiation factor 3, subunit G

increases expression

Nitric Oxide deficiency results in increased expression of EIF3G mRNA

NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808

G

endothelial PAS domain protein 1

multiple interactions

EPAS1 protein affects the reaction [Cobalt results in increased abundance of Nitric Oxide]; EPAS1 protein affects the reaction [Nickel results in increased abundance of Nitric Oxide]

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erythropoietin

decreases response to substance

EPO protein results in decreased susceptibility to Nitric Oxide

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

estrogen receptor 1

multiple interactions

[resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

enhancer of zeste 1 polycomb repressive complex 2 subunit

decreases expression

Nitric Oxide deficiency results in decreased expression of EZH1 mRNA

NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921

G

ezrin

increases phosphorylation

Nitric Oxide deficiency results in increased phosphorylation of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor II, thrombin

multiple interactions
increases abundance

arsenite inhibits the reaction [F2 protein results in increased abundance of Nitric Oxide]; F2 protein promotes the reaction [Heparin results in increased abundance of Nitric Oxide]

PMID:8408661 PMID:22244921

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

Fas cell surface death receptor

increases expression

Nitric Oxide results in increased expression of FAS mRNA; Nitric Oxide results in increased expression of FAS protein

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

[linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter]; Nitric Oxide inhibits the reaction [Etoposide results in increased activity of FASLG promoter]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 1

increases abundance
multiple interactions

FGF1 protein results in increased abundance of Nitric Oxide
PD 166866 inhibits the reaction [FGF1 protein results in increased abundance of Nitric Oxide]

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases activity

Nitric Oxide results in increased activity of FOSB protein

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

ferritin light chain 1

increases expression

Nitric Oxide deficiency results in increased expression of FTL1 mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions
increases expression

[7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat affects the localization of GAPDH protein]
Nitric Oxide deficiency results in increased expression of GAPDH mRNA

PMID:15878706 PMID:20478973

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

GATA binding protein 5

multiple interactions
increases expression
increases response to substance

GATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; GATA5 protein promotes the reaction [Nitric Oxide results in increased expression of BCL2L1 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 mRNA]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of GATA5 protein]
Nitric Oxide results in increased expression of GATA5 mRNA; Nitric Oxide results in increased expression of GATA5 protein
GATA5 protein results in increased susceptibility to Nitric Oxide

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

Nitric Oxide deficiency results in decreased expression of GCLC mRNA; Nitric Oxide deficiency results in decreased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

GCLM gene SNP affects the abundance of and affects the activity of and affects the susceptibility to Nitric Oxide

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GDP dissociation inhibitor 2

decreases expression

Nitric Oxide deficiency results in decreased expression of GDI2 mRNA

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

glial fibrillary acidic protein

decreases expression

Nitric Oxide deficiency results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

gap junction protein, alpha 1

decreases expression

Nitric Oxide deficiency results in decreased expression of GJA1 mRNA; Nitric Oxide deficiency results in decreased expression of GJA1 protein; Nitric Oxide results in decreased expression of GJA1 protein

PMID:10397678 PMID:11856964 PMID:20004189

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

galactosidase, beta 1

decreases activity

Nitric Oxide results in decreased activity of GLB1 protein

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

glycolipid transfer protein

increases expression

Nitric Oxide deficiency results in increased expression of GLTP mRNA

NCBI chr12:41,907,168...41,927,321
Ensembl chr12:41,907,144...41,927,319

G

glypican 1

increases nitrosation
multiple interactions

Nitric Oxide results in increased nitrosation of GPC1 protein
[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form; Zinc promotes the reaction [[Ascorbic Acid co-treated with Nitric Oxide] results in increased degradation of GPC1 protein modified form]

PMID:15677459 PMID:16923158

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

glucose-6-phosphate isomerase

increases expression

Nitric Oxide deficiency results in increased expression of GPI1 mRNA

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione peroxidase 1

affects metabolic processing
multiple interactions

GPX1 protein affects the metabolism of Nitric Oxide
GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

increases expression

Nitric Oxide deficiency results in increased expression of GPX2 mRNA

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression
multiple interactions

Nitric Oxide deficiency results in increased expression of GPX3 mRNA
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of GPX3 mRNA]

PMID:15878706 PMID:21983654

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

growth factor receptor bound protein 2

decreases expression

Nitric Oxide deficiency results in decreased expression of GRB2 mRNA

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

G

gelsolin

increases expression

Nitric Oxide deficiency results in increased expression of GSN mRNA

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione-disulfide reductase

increases expression
multiple interactions
affects activity

Nitric Oxide deficiency results in increased expression of GSR protein
tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of GSR protein]
Nitric Oxide deficiency affects the activity of GSR protein

PMID:15925750 PMID:19631198

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase mu 1

increases expression

Nitric Oxide deficiency results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression

Nitric Oxide deficiency results in increased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions
increases response to substance

1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]
GUCY1A1 gene mutant form results in increased susceptibility to Nitric Oxide

PMID:11744065 PMID:25373139

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole affects the folding of [Nitric Oxide binds to [GUCY1A1 protein binds to GUCY1B1 protein]]

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

G

hydroxyacyl-CoA dehydrogenase

increases expression

Nitric Oxide deficiency results in increased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hepatitis A virus cellular receptor 1

increases expression

Nitric Oxide deficiency results in increased expression of HAVCR1 protein

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

HBS1-like translational GTPase

decreases expression

Nitric Oxide deficiency results in decreased expression of HBS1L mRNA

NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074

G

hypocretin neuropeptide precursor

increases abundance

HCRT results in increased abundance of Nitric Oxide

NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Nitric Oxide results in decreased stability of and results in decreased expression of HIF1A protein; U 0126 inhibits the reaction [Nitric Oxide results in decreased degradation of and results in increased activity of HIF1A protein]

PMID:16310922 PMID:18424783

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

decreases response to substance
increases expression
affects activity
multiple interactions
affects response to substance

HMOX1 protein results in decreased susceptibility to Nitric Oxide
Nitric Oxide results in increased expression of HMOX1 protein
Nitric Oxide affects the activity of HMOX1 protein
Nitric Oxide results in increased expression of HMOX1 mRNA; Nitric Oxide results in increased expression of HMOX1 protein
HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Nitric Oxide results in increased stability of and results in increased expression of HMOX1 mRNA
HMOX1 protein affects the susceptibility to Nitric Oxide

PMID:9699677 PMID:15220209 PMID:17020887 PMID:17401437 PMID:18178725 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Nitric Oxide results in increased mutagenesis of HPRT1 gene

PMID:22303861 PMID:28454271

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 protein
[Nitroprusside results in increased abundance of Nitric Oxide] which results in decreased expression of HSPA5 protein

PMID:18675883 PMID:19320461

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

multiple interactions

[sodium arsenite results in increased expression of HSPA8 protein] which results in decreased chemical synthesis of Nitric Oxide

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

hyaluronidase 2

decreases expression

Nitric Oxide deficiency results in decreased expression of HYAL2 mRNA

NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850

G

intercellular adhesion molecule 1

multiple interactions

Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

indoleamine 2,3-dioxygenase 1

multiple interactions

Nitric Oxide binds to and affects the folding of and results in increased degradation of and results in decreased activity of IDO1 protein

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon beta 1

multiple interactions

[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; Dexamethasone inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

increases secretion
increases chemical synthesis
multiple interactions
increases abundance

Nitric Oxide results in increased secretion of IFNG protein
IFNG protein results in increased chemical synthesis of Nitric Oxide
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 mRNA] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides co-treated with quinone] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lead acetate results in increased abundance of Lead] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased secretion of Nitric Oxide; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Aminosalicylic Acids inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; aristolochic acid I inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF2 protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Benzene promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; Capsaicin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Capsaicin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; catalpol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; chromous chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; ciglitazone inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltiprotoporphyrin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Dexamethasone inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Diquat promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Dronabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased abundance of Nitric Oxide]; Estriol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Genistein inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Glyburide inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; GPX1 protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; IFNG promotes the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; IFNG protein inhibits the reaction [Cyclophosphamide results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with Benzene] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with hydroquinone] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide]; IFNG protein promotes the reaction [Lipopolysaccharides results in increased secretion of Nitric Oxide]; IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; JAK2 protein promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Lipopolysaccharides promotes the reaction [[IFNG protein co-treated with hydroxyhydroquinone] results in increased abundance of Nitric Oxide]; Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; MK 473 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]; NOS2 protein promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NS 1652 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; NS-3728 inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; pimagedine inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; pimagedine inhibits the reaction [Lipopolysaccharides promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Progesterone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Tamoxifen inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide]; TBE 31 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; U 0126 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL5 protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; Benzene promotes the reaction [[[Lipopolysaccharides co-treated with IFNG protein] co-treated with CSF1 protein] results in increased chemical synthesis of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Clofibrate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; CSF1 protein promotes the reaction [IFNG protein results in increased chemical synthesis of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; morin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]; pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
IFNG protein results in increased abundance of Nitric Oxide; IFNG results in increased abundance of Nitric Oxide
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; [IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide; [IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein co-treated with Manganese] results in decreased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide; [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [pyrazolanthrone co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [SB 203580 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [U 0126 co-treated with Manganese] inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Chenodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Deoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; IFNG promotes the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]; Indomethacin inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Manganese inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Nitric Oxide affects the susceptibility to [IFNG protein co-treated with Lipopolysaccharides]; Ozone promotes the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Polyphenols inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; S-methylisothiopseudouronium inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; U 0126 inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]

PMID:7519435 PMID:7689037 PMID:7884313 PMID:8193360 PMID:8341679 More...

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

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interleukin 10

decreases secretion

Nitric Oxide results in decreased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12B

decreases expression

Nitric Oxide results in decreased expression of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

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interleukin 12 receptor subunit beta 2

increases expression

Nitric Oxide results in increased expression of IL12RB2 mRNA

NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289

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interleukin 1 alpha

multiple interactions
increases abundance

[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]; Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]; Y 27632 inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]

PMID:15705589 PMID:16968468

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

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interleukin 1 beta

multiple interactions
increases chemical synthesis
increases abundance

15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; [IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with Fatty Acids, Nonesterified] results in increased chemical synthesis of Nitric Oxide; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; bisphenol A inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Clofibrate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; cordycepin inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Cytochalasin B inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Cytochalasin B inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; Estradiol inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Gemfibrozil inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Glucosamine analog affects the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Glucosamine inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; IL1B protein promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Methotrexate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]; nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Nitric Oxide]; pimagedine inhibits the reaction [Asbestos, Crocidolite promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; pimagedine inhibits the reaction [Asbestos, Serpentine promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]]; sauchinone inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; sodium arsenite inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Triglycerides affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Troglitazone inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Troglitazone inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]
[TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; [TNF protein co-treated with IFNG protein co-treated with IL1B protein] results in increased abundance of Nitric Oxide; IL1B protein promotes the reaction [Cobalt results in increased abundance of Nitric Oxide]; IL1B protein promotes the reaction [Nickel results in increased abundance of Nitric Oxide]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] affects the localization of Zinc]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]; Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]
IL1B protein results in increased abundance of Nitric Oxide; IL1B results in increased abundance of Nitric Oxide
[Enzyme Inhibitors results in decreased abundance of Nitric Oxide] inhibits the reaction [IL1B protein results in decreased secretion of INS1 protein]; [IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; [IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [TNF co-treated with IL1B co-treated with IFNG] results in increased abundance of Nitric Oxide; Active Hexose Correlated Compound inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Active Hexose Correlated Compound inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Adenosine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Glucosamine inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; IL1B protein affects the reaction [AVP protein affects the metabolism of Nitric Oxide]; Luteolin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [IL1B protein results in increased abundance of Nitric Oxide]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; SOD2 protein inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; Vitamin E inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased chemical synthesis of Nitric Oxide]

PMID:7519435 PMID:8903404 PMID:8982730 PMID:9312173 PMID:9576743 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 4

multiple interactions

IL4 protein inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]
IL4 protein inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]

PMID:12115740 PMID:12612912

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions
decreases secretion

[IL5 protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide
Nitric Oxide results in decreased secretion of IL5 protein

PMID:13678430 PMID:18206661

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

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interleukin 6

multiple interactions

Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of IL6 protein] which results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of IL6 protein]

PMID:20708382 PMID:21983654

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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insulin 1

multiple interactions

[Enzyme Inhibitors results in decreased abundance of Nitric Oxide] inhibits the reaction [IL1B protein results in decreased secretion of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

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insulin 2

increases secretion
decreases secretion
multiple interactions
increases chemical synthesis

INS protein results in increased secretion of Nitric Oxide
INS protein results in decreased secretion of Nitric Oxide
[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide; [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; Kynurenic Acid inhibits the reaction [[INS protein co-treated with Glucose] results in decreased chemical synthesis of Nitric Oxide]; Orotic Acid inhibits the reaction [INS protein results in increased abundance of Nitric Oxide]; Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]; Sodium Salicylate inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]

PMID:20960276 PMID:23504962 PMID:25601987 PMID:26364587 PMID:28951307

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

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integrin subunit alpha 6

multiple interactions
decreases abundance

AG 1879 inhibits the reaction [ITGA6 protein results in decreased abundance of Nitric Oxide]

NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428

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integrin subunit beta 2

multiple interactions
increases abundance

Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]; Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein]
ITGB2 protein results in increased abundance of Nitric Oxide
[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide; [ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxide; CSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]

PMID:8600936 PMID:16963453

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

increases expression

Nitric Oxide results in increased expression of ITGB3 protein

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

Janus kinase 1

decreases expression

Nitric Oxide deficiency results in decreased expression of JAK1 mRNA

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

multiple interactions
decreases expression

JAK2 protein promotes the reaction [IFNG protein results in increased abundance of Nitric Oxide]
Nitric Oxide deficiency results in decreased expression of JAK2 mRNA

PMID:12847270 PMID:15878706

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

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Jun proto-oncogene, AP-1 transcription factor subunit

increases activity

Nitric Oxide results in increased activity of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

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JunB proto-oncogene, AP-1 transcription factor subunit

increases activity

Nitric Oxide results in increased activity of JUNB protein

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lysine demethylase 1A

increases expression

Nitric Oxide results in increased expression of KDM1A mRNA

NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319

G

lysine demethylase 3A

increases expression

Nitric Oxide results in increased expression of KDM3A mRNA; Nitric Oxide results in increased expression of KDM3A protein

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

lysine demethylase 3B

increases expression

Nitric Oxide results in increased expression of KDM3B mRNA

NCBI chr18:26,380,859...26,436,701
Ensembl chr18:26,380,964...26,436,628

G

lysine demethylase 4A

increases expression

Nitric Oxide results in increased expression of KDM4A mRNA

NCBI chr 5:131,672,754...131,719,534
Ensembl chr 5:131,672,754...131,719,501

G

lysine demethylase 4B

increases expression

Nitric Oxide results in increased expression of KDM4B mRNA

NCBI chr 9:1,158,737...1,237,233
Ensembl chr 9:1,158,752...1,236,543

G

lysine demethylase 4C

increases expression

Nitric Oxide results in increased expression of KDM4C mRNA

NCBI chr 5:88,100,710...88,306,821
Ensembl chr 5:88,100,733...88,306,818

G

lysine demethylase 4D

increases expression

Nitric Oxide results in increased expression of KDM4D mRNA

NCBI chr 8:11,279,756...11,304,920
Ensembl chr 8:11,268,859...11,305,290

G

lysine demethylase 7A

increases expression

Nitric Oxide results in increased expression of KDM7A mRNA

NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998

G

kallikrein 1

multiple interactions
increases abundance

icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]; KLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

kininogen 1

increases secretion
multiple interactions
increases abundance
affects abundance

KNG1 protein results in increased secretion of Nitric Oxide
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
KNG1 protein results in increased abundance of Nitric Oxide
[KNG1 protein modified form binds to and results in increased activity of BDKRB2 protein] which results in increased chemical synthesis of Nitric Oxide; Lipopolysaccharides promotes the reaction [KNG1 protein modified form results in increased chemical synthesis of Nitric Oxide]

PMID:10535458 PMID:16514058 PMID:16733097 PMID:29775649

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

leptin

multiple interactions

LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

LIF, interleukin 6 family cytokine

multiple interactions

LIF protein affects the reaction [Progesterone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]]; LIF protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased abundance of Nitric Oxide]

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

lactotransferrin

increases chemical synthesis
decreases activity

LTF protein results in increased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in decreased activity of LTF protein

NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
decreases expression

Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK1 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
Nitric Oxide results in decreased phosphorylation of MAPK1 protein
Nitric Oxide results in decreased expression of MAPK1 protein

PMID:14713289 PMID:15640287 PMID:16389725 PMID:16575906 PMID:16603213

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
decreases expression

Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK3 protein]; Nitric Oxide inhibits the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
Nitric Oxide results in decreased phosphorylation of MAPK3 protein
Nitric Oxide results in decreased expression of MAPK3 protein

PMID:14713289 PMID:15640287 PMID:16389725 PMID:16575906 PMID:16603213

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myelin basic protein

increases abundance
multiple interactions

MBP protein results in increased abundance of Nitric Oxide
Testosterone inhibits the reaction [MBP protein results in increased abundance of Nitric Oxide]

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

myocyte enhancer factor 2a

decreases expression

Nitric Oxide deficiency results in decreased expression of MEF2A mRNA

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

G

microsomal glutathione S-transferase 1

multiple interactions

[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; [S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

matrix metallopeptidase 2

decreases expression
multiple interactions

Nitric Oxide results in decreased expression of MMP2 protein
Nitric Oxide results in increased expression of and results in increased activity of MMP2 protein

PMID:16575906 PMID:18796497

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

increases expression

Nitric Oxide results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

increases expression
multiple interactions
increases oxidation

Nitric Oxide results in increased expression of MPO protein
4-amino-TEMPO inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [ethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]
[Paraquat co-treated with Nitric Oxide] results in increased activity of MPO protein

PMID:10706834 PMID:15820443 PMID:34085520

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial ribosomal protein S7

decreases expression

Nitric Oxide deficiency results in decreased expression of MRPS7 mRNA

NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129

G

moesin

increases phosphorylation

Nitric Oxide deficiency results in increased phosphorylation of MSN protein

NCBI chr X:60,996,043...61,064,011
Ensembl chr X:60,995,951...61,065,628

G

mitochondrially encoded cytochrome c oxidase I

affects activity
affects expression

Nitric Oxide affects the activity of COX1 protein
Nitric Oxide affects the expression of COX1 mRNA

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

metallothionein 1

multiple interactions

Nitric Oxide binds to and results in decreased activity of MT1A protein
Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT1 mRNA]

PMID:10548558 PMID:14617770

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions

Nitric Oxide affects the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of MT2 mRNA]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

decreases response to substance

MT3 protein results in decreased susceptibility to Nitric Oxide

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

multiple interactions

[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

myosin heavy chain 6

decreases expression

Nitric Oxide deficiency results in decreased expression of MYH6 mRNA

NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720

G

myosin heavy chain 7

increases expression
multiple interactions

Nitric Oxide deficiency results in increased expression of MYH7 mRNA
Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of MYH7 mRNA]

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

necdin, MAGE family member

decreases expression

Nitric Oxide deficiency results in decreased expression of NDN mRNA

NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767

G

N-myc downstream regulated 1

increases expression

Nitric Oxide results in increased expression of NDRG1 mRNA; Nitric Oxide results in increased expression of NDRG1 protein

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase subunit A13

increases expression

Nitric Oxide deficiency results in increased expression of NDUFA13 mRNA

NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726

G

nuclear factor kappa B subunit 1

multiple interactions

NFKB1 protein promotes the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

NFKBIA protein affects the reaction [manganese chloride promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]; NFKBIA protein affects the reaction [Manganese promotes the reaction [TNF protein co-treated with and results in increased chemical synthesis of IFNG protein co-treated with and results in increased chemical synthesis of Nitric Oxide]]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions

Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK1 protein]; Nitric Oxide affects the reaction [NGF protein results in increased activity of MAPK3 protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 1

multiple interactions
increases chemical synthesis
decreases expression

7-nitroindazole inhibits the reaction [[N-isopropylbenzylamine results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide]; [N-isopropylbenzylamine results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide; PLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency results in decreased expression of NOS1 protein
[Calcium binds to CALM1 protein] promotes the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]; [Cisplatin results in increased expression of NOS1 mRNA] which results in increased abundance of Nitric Oxide; [EDN1 protein results in increased activity of NOS1 protein] which results in increased abundance of Nitric Oxide; [Formaldehyde results in increased expression of NOS1 protein] which results in increased abundance of Nitric Oxide; [NOS1 protein results in increased reduction of Trinitrotoluene] which results in decreased chemical synthesis of Nitric Oxide

PMID:15223068 PMID:15249212 PMID:16380457 PMID:17098364 PMID:18195371 More...

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases abundance
affects abundance
multiple interactions
increases chemical synthesis
decreases expression
affects expression
increases expression

NOS2 protein results in increased abundance of Nitric Oxide
NOS2 promoter polymorphism affects the abundance of Nitric Oxide
1,2-naphthoquinone inhibits the reaction [[lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; [3,5-dimethoxy-4'-hydroxystilbene results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide; [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of CCN2 protein; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 mRNA] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] affects the expression of NOS2 protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [[TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of RETN mRNA; [Acetaminophen results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Benzene promotes the reaction [[CSF1 protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 mRNA]] which results in increased chemical synthesis of Nitric Oxide; [Cisplatin results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [cobaltous chloride results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Deferoxamine results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide; [diferuloylputrescine results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [ferulic acid results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein; [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide; [Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Nicotine results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased expression of TJP1 mRNA; [Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [p-coumaric acid results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [pimobendan results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Plant Extracts results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [prunetin results in decreased expression of NOS2 mRNA] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased chemical synthesis of Nitric Oxide]; [Putrescine metabolite results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Selenium inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]] which results in decreased chemical synthesis of Nitric Oxide; [Sodium Salicylate results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Thiourea analog results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; [TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Zoledronic Acid results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; Arsenic Trioxide inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; bepafant inhibits the reaction [[Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; bisphenol A inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Capsaicin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Capsaicin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Carthamus yellow inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Chalcone analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2] which results in increased abundance of Nitric Oxide]; chromous chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; ciglitazone inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Cilostazol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltiprotoporphyrin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cobaltous chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; cupric chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Cyclosporine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; diphenylmethyl selenocyanate inhibits the reaction [[Cisplatin results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Drugs, Chinese Herbal inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide]]; erythraline inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; flavokawain A inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Fluoxetine analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Ginkgo biloba extract inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; GW 1929 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; hinokiresinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; manganese chloride promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Manganese promotes the reaction [[TNF protein co-treated with IFNG protein] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; matairesinol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[TNF protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NFKB1 protein promotes the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; nickel chloride promotes the reaction [[[TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; nimesulide inhibits the reaction [bepafant inhibits the reaction [[Mycoplasma arthritidis mitogen results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]]; Nitroprusside inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; NOS2 protein promotes the reaction [cobaltous chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein promotes the reaction [nickel chloride promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]]; NOS2 protein results in increased chemical synthesis of and results in increased abundance of Nitric Oxide; Plant Extracts inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; praeruptorin A inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Pyrazines inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Quercetin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; quercetin pentaacetate inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; resiniferatoxin inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; resiniferatoxin inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; Resveratrol inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased abundance of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Resveratrol metabolite inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; SB 203580 inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; STAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; timosaponin BIII inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; zinc chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]
Nitric Oxide deficiency results in decreased expression of NOS2 protein
Nitric Oxide deficiency affects the expression of NOS2 protein
[Endotoxins results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Ethanol results in decreased expression of and results in decreased activity of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Formaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Fructose results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Gentamicins results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Indomethacin results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; [NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased susceptibility to endothelium-dependent hyperpolarization factor; [notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Taurocholic Acid results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; Active Hexose Correlated Compound inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Edaravone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Endotoxins inhibits the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; natakalim inhibits the reaction [[Isoproterenol results in increased expression of NOS2] which results in increased chemical synthesis of Nitric Oxide]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of NOS2 mRNA]; NOS2 protein affects the reaction [Adenosine Triphosphate results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Ozone promotes the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Ozone results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Resveratrol inhibits the reaction [[Taurocholic Acid results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Rotenone inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; wuzi yanzong analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
[[Fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [[Particulate Matter results in increased abundance of Ammonium Compounds] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [[Particulate Matter results in increased abundance of Carbon] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [[Particulate Matter results in increased abundance of Nitrates] which results in decreased methylation of NOS2 promoter] which results in increased abundance of Nitric Oxide; [Acetaldehyde results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Ethanol results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; [Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [Fluvastatin results in increased abundance of Nitric Oxide]; [Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [NOS2 protein results in increased abundance of Nitric Oxide] affects the susceptibility to [IL1B protein co-treated with TNF protein co-treated with IFNG protein]; [NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein; [Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; [Resveratrol results in decreased expression of NOS2 protein] which results in decreased abundance of Nitric Oxide; [Tobacco Smoke Pollution results in increased expression of and results in increased activity of NOS2 protein] which results in increased abundance of Nitric Oxide; [Trichloroethylene results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; [Vehicle Emissions results in increased abundance of Air Pollutants] inhibits the reaction [NOS2 promoter polymorphism affects the abundance of Nitric Oxide]; Bee Venoms inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Bee Venoms inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Cyclosporine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; IL1B protein promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; Leflunomide inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; lornoxicam inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Melitten inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Methotrexate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Nicotine promotes the reaction [NOS2 protein results in increased abundance of Nitric Oxide]; Peptides inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; pyrazolanthrone inhibits the reaction [[Nitroprusside results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]
Nitric Oxide results in increased expression of NOS2 mRNA; Nitric Oxide results in increased expression of NOS2 protein

PMID:7519435 PMID:7705308 PMID:8193360 PMID:8652180 PMID:8975779 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases chemical synthesis
multiple interactions
increases chemical synthesis
affects chemical synthesis
decreases expression
affects expression
increases abundance

NOS3 gene mutant form results in decreased chemical synthesis of Nitric Oxide
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; [[resveratrol results in increased activity of PPARA protein] which results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Estradiol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [Glycochenodeoxycholic Acid results in decreased expression of NOS3 protein] which results in decreased abundance of Nitric Oxide; [Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide; [Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of RCN1 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of TXNDC5 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in decreased expression of HSPA5 protein; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 protein; [Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; [puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [resveratrol results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [resveratrol results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide; [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; [Trichloroethylene results in increased activity of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; Amiodarone promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; desethylamiodarone promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; fulvestrant inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Nifedipine promotes the reaction [Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; NOX5 protein promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]; resveratrol inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; Simvastatin inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]; Simvastatin promotes the reaction [Nifedipine inhibits the reaction [[Hydrogen Peroxide results in decreased expression of NOS3 protein] which results in decreased secretion of Nitric Oxide]]; SOD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]; Stilbenes inhibits the reaction [[Hydrogen Peroxide results in decreased activity of NOS3 protein] which results in decreased chemical synthesis of Nitric Oxide]; Tretinoin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; U 0126 inhibits the reaction [[resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; W 7 inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]
NOS3 protein affects the chemical synthesis of Nitric Oxide
[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; [GULO protein co-treated with NOS3 protein] results in increased abundance of Nitric Oxide; [Resveratrol results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide; dorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]
Nitric Oxide deficiency results in decreased expression of NOS3 mRNA; Nitric Oxide deficiency results in decreased expression of NOS3 protein
Nitric Oxide deficiency affects the expression of NOS3 protein
[Sildenafil Citrate results in increased expression of NOS3 protein] which results in increased secretion of Nitric Oxide; AGT protein alternative form promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of NOS3 mRNA]; Thioacetamide promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]
NOS3 protein results in increased abundance of Nitric Oxide

PMID:10445667 PMID:11740345 PMID:12270858 PMID:12489993 PMID:15207323 More...

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NPC intracellular cholesterol transporter 1

decreases expression

Nitric Oxide deficiency results in decreased expression of NPC1 mRNA

NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049

G

natriuretic peptide A

multiple interactions
increases expression

Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Nitric Oxide deficiency results in increased expression of NPPA mRNA; Nitric Oxide deficiency results in increased expression of NPPA protein

PMID:10397678 PMID:12198334 PMID:14700747 PMID:15177930

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

multiple interactions
increases expression

Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Nitric Oxide deficiency results in increased expression of NPPB mRNA; Nitric Oxide deficiency results in increased expression of NPPB protein

PMID:12198334 PMID:16326922

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

nuclear receptor subfamily 2, group F, member 2

decreases expression

Nitric Oxide deficiency results in decreased expression of NR2F2 mRNA

NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[ginsenoside Re results in increased activity of NR3C1 protein] which results in increased abundance of Nitric Oxide

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Nitric Oxide results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear protein 1, transcriptional regulator

decreases expression

Nitric Oxide deficiency results in decreased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

occludin

decreases expression

Nitric Oxide deficiency results in decreased expression of OCLN protein

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

Nitric Oxide deficiency results in decreased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
PARP1 gene mutant form inhibits the reaction [S100B protein results in increased secretion of Nitric Oxide]
Nitric Oxide results in increased cleavage of PARP1 protein

PMID:10811113 PMID:15126337 PMID:16024610 PMID:27444121

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 6 interacting protein

decreases expression

Nitric Oxide deficiency results in decreased expression of PDCD6IP mRNA

NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773

G

phosphodiesterase 5A

increases expression
affects response to substance

Nitric Oxide results in increased expression of PDE5A mRNA; Nitric Oxide results in increased expression of PDE5A protein
PDE5A protein affects the susceptibility to Nitric Oxide

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

PHD finger protein 8

increases expression

Nitric Oxide results in increased expression of PHF8 mRNA

NCBI chr X:20,524,103...20,623,459
Ensembl chr X:20,524,558...20,623,410

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

PIK3CA protein inhibits the reaction [[Orotic Acid inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide]

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phospholipase A2 group 4A

multiple interactions

Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]

NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266

G

plasminogen activator, tissue type

multiple interactions
increases secretion

PLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]
PLAT protein results in increased secretion of Nitric Oxide

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Nitric Oxide results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

PMS1 homolog 2, mismatch repair system component

increases expression

Nitric Oxide deficiency results in increased expression of PMS2 mRNA

NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066

G

prepronociceptin

decreases activity

Nitric Oxide deficiency results in decreased activity of PNOC protein

NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867

G

proopiomelanocortin

multiple interactions
decreases abundance
increases secretion

CRH protein affects the reaction [Nitric Oxide results in increased secretion of POMC protein alternative form]
POMC protein results in decreased abundance of Nitric Oxide

PMID:10460269 PMID:11193135 PMID:11703388

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peroxisome proliferator activated receptor alpha

affects activity
multiple interactions
increases expression

Nitric Oxide affects the activity of PPARA protein
[[resveratrol results in increased activity of PPARA protein] which results in increased expression of NOS3 protein] which results in increased chemical synthesis of Nitric Oxide
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Clofibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in increased expression of PPARA protein]
Nitric Oxide deficiency results in increased expression of PPARA mRNA; Nitric Oxide deficiency results in increased expression of PPARA protein

PMID:15018640 PMID:16054168 PMID:16411023 PMID:19834340 PMID:21791144

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

[rosiglitazone binds to and affects the activity of PPARG protein] which results in increased abundance of Nitric Oxide
[1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane binds to and results in increased activity of PPARG protein] inhibits the reaction [Manganese results in increased chemical synthesis of Nitric Oxide]
Nitric Oxide deficiency results in increased expression of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; ciglitazone inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; GW 1929 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; PPARG protein affects the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]

PMID:12847270 PMID:16527820 PMID:17063326 PMID:18041089

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

Nitric Oxide results in increased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase, Mg2+/Mn2+ dependent, 1G

decreases expression

Nitric Oxide deficiency results in decreased expression of PPM1G mRNA

NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

Nitric Oxide deficiency results in decreased expression of PPP3CA mRNA

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

protein phosphatase 5, catalytic subunit

decreases expression

Nitric Oxide deficiency results in decreased expression of PPP5C mRNA

NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456

G

PR/SET domain 2

increases expression

Nitric Oxide results in increased expression of PRDM2 mRNA

NCBI chr 5:155,421,066...155,531,884
Ensembl chr 5:155,422,134...155,531,825

G

DNA primase subunit 2

decreases expression

Nitric Oxide deficiency results in decreased expression of PRIM2 mRNA

NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

PRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, alpha

multiple interactions

Nitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, delta

multiple interactions

Nitric Oxide deficiency inhibits the reaction [Brimonidine Tartrate affects the localization of PRKCD protein]

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prolactin

multiple interactions

2-mercaptomethyl-3-guanidinoethylthiopropionic acid inhibits the reaction [[PRL co-treated with furylacryloylalanylarginine co-treated with Testosterone] results in increased abundance of Nitric Oxide]; [PRL co-treated with furylacryloylalanylarginine co-treated with Testosterone] results in increased abundance of Nitric Oxide; [PRL co-treated with furylacryloylalanylarginine] results in increased abundance of Nitric Oxide; [PRL results in increased expression of CPD mRNA] which results in increased chemical synthesis of Nitric Oxide

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 1

multiple interactions

Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of PTGS1 mRNA]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide
Nitric Oxide deficiency results in decreased expression of PTGS2 mRNA

PMID:18976649 PMID:21983654

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases expression

Nitric Oxide deficiency results in decreased expression of PTK2 mRNA

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

Nitric Oxide deficiency results in increased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

[Lipopolysaccharides results in increased activity of RAF1 protein] which results in decreased secretion of Nitric Oxide

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

receptor activity modifying protein 1

increases expression

Nitric Oxide deficiency results in increased expression of RAMP1 mRNA; Nitric Oxide deficiency results in increased expression of RAMP1 protein

NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151

G

receptor activity modifying protein 2

multiple interactions
increases expression

Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP2 protein]
Nitric Oxide deficiency results in increased expression of RAMP2 mRNA; Nitric Oxide deficiency results in increased expression of RAMP2 protein

NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829

G

receptor activity modifying protein 3

multiple interactions
increases expression

Hydralazine inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein]; Hydrochlorothiazide inhibits the reaction [Nitric Oxide deficiency results in increased expression of RAMP3 protein]
Nitric Oxide deficiency results in increased expression of RAMP3 mRNA; Nitric Oxide deficiency results in increased expression of RAMP3 protein

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902

G

RAP1A, member of RAS oncogene family

multiple interactions

Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RAP2A, member of RAS oncogene family

multiple interactions

Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein]

NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138

G

ras related dexamethasone induced 1

multiple interactions

Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]

NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186

G

RB binding protein 6, ubiquitin ligase

decreases expression

Nitric Oxide deficiency results in decreased expression of RBBP6 mRNA

NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678

G

reticulocalbin 1

multiple interactions

[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which affects the expression of RCN1 protein

NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295

G

radixin

increases phosphorylation

Nitric Oxide deficiency results in increased phosphorylation of RDX protein

NCBI chr 8:52,379,494...52,437,673
Ensembl chr 8:52,379,494...52,437,678

G

RELA proto-oncogene, NF-kB subunit

affects localization

Nitric Oxide deficiency affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

multiple interactions
increases expression

[Nitric Oxide deficiency co-treated with Sodium Chloride, Dietary] results in increased expression of REN protein; Nebivolol inhibits the reaction [Nitric Oxide deficiency results in increased expression of REN protein]

PMID:7541960 PMID:10679504 PMID:12806161 PMID:15123544

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

resistin

multiple interactions
increases expression

[[TNF protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide] which results in decreased expression of RETN mRNA
Nitric Oxide deficiency results in increased expression of RETN mRNA

PMID:17063326 PMID:18369347

NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620

G

ras homolog family member A

multiple interactions

Nitric Oxide deficiency affects the localization of and results in increased activity of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ribosomal protein L10A

increases expression

Nitric Oxide deficiency results in increased expression of RPL10A mRNA

NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357

G

ribosomal protein L12

increases expression

Nitric Oxide deficiency results in increased expression of RPL12 mRNA

NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642

G

ribosomal protein L3

decreases expression

Nitric Oxide deficiency results in decreased expression of RPL3 mRNA

NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468

G

ribosomal protein L8

increases expression

Nitric Oxide deficiency results in increased expression of RPL8 mRNA

NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482

G

ribosomal protein lateral stalk subunit P0

increases expression

Nitric Oxide deficiency results in increased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

ribosomal protein lateral stalk subunit P1

increases expression

Nitric Oxide deficiency results in increased expression of RPLP1 mRNA

NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339

G

ribosomal protein S12

increases expression

Nitric Oxide deficiency results in increased expression of RPS12 mRNA

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S14

increases expression

Nitric Oxide deficiency results in increased expression of RPS14 mRNA

NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166

G

ribosomal protein S15

increases expression

Nitric Oxide deficiency results in increased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450

G

ribosomal protein S20

increases expression

Nitric Oxide deficiency results in increased expression of RPS20 mRNA

NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475

G

ribosomal protein S26

increases expression

Nitric Oxide deficiency results in increased expression of RPS26 mRNA

NCBI chr 7:1,057,332...1,058,882
Ensembl chr X:107,822,178...107,822,525

G

ribosomal protein S6

increases expression

Nitric Oxide deficiency results in increased expression of RPS6 mRNA

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions

[resveratrol results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S7

increases expression

Nitric Oxide deficiency results in increased expression of RPS7 mRNA

NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145

G

ribosomal protein S8

increases expression

Nitric Oxide deficiency results in increased expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

RT1 class II, locus Db1

increases abundance

HLA-DRB1 protein results in increased abundance of Nitric Oxide

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

S100 calcium binding protein B

multiple interactions
increases secretion

[S100B protein results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide; PARP1 gene mutant form inhibits the reaction [S100B protein results in increased secretion of Nitric Oxide]

PMID:16376947 PMID:27444121

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

SAP30 binding protein

decreases expression

Nitric Oxide deficiency results in decreased expression of SAP30BP mRNA

NCBI chr10:101,165,777...101,198,503
Ensembl chr10:101,165,856...101,198,502

G

secretoglobin family 1A member 1

decreases expression

Nitric Oxide results in decreased expression of SCGB1A1 protein

NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610

G

syndecan 2

increases expression

Nitric Oxide deficiency results in increased expression of SDC2 mRNA

NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081

G

selectin E

multiple interactions

Nitric Oxide deficiency inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of SELE protein]]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

SET domain bifurcated histone lysine methyltransferase 2

increases expression

Nitric Oxide results in increased expression of SETDB2 mRNA

NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470

G

surfactant protein A1

multiple interactions
decreases expression

bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPA1 mRNA]

NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685

G

surfactant protein B

multiple interactions
decreases expression

bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPB mRNA]

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein C

multiple interactions
decreases expression

bosentan inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [Nitric Oxide results in decreased expression of SFTPC mRNA]

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

sirtuin 1

multiple interactions

SIRT1 protein affects the reaction [INS protein results in increased secretion of Nitric Oxide]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 11 member 2

multiple interactions
affects expression

Nitric Oxide promotes the reaction [[RASD1 protein binds to ACBD3 protein binds to SLC11A2 protein] which results in increased uptake of Iron]
Nitric Oxide affects the expression of SLC11A2 protein alternative form

PMID:16232120 PMID:16908409

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 40 member 1

decreases expression

Nitric Oxide deficiency results in decreased expression of SLC40A1 protein

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 4 member 2

multiple interactions

Nitric Oxide inhibits the reaction [SLC4A2 protein promotes the reaction [Cyclic AMP results in increased transport of Bicarbonates]]

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

G

solute carrier family 5 member 2

decreases activity

Nitric Oxide deficiency results in decreased activity of SLC5A2 protein

NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306

G

solute carrier family 7 member 7

decreases abundance

SLC7A7 protein results in decreased abundance of Nitric Oxide

NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648

G

SMAD family member 3

multiple interactions

[SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 4

multiple interactions

[SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

synuclein alpha

multiple interactions

[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

syntrophin, alpha 1

decreases expression

Nitric Oxide deficiency results in decreased expression of SNTA1 mRNA

NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709

G

superoxide dismutase 1

increases abundance
multiple interactions
decreases response to substance

SOD1 protein results in increased abundance of Nitric Oxide
Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of SOD1 mRNA]
SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]; SOD1 protein inhibits the reaction [Nitric Oxide results in increased abundance of Peroxynitrous Acid]
Nitric Oxide deficiency results in decreased susceptibility to SOD1 protein mutant form

PMID:12489993 PMID:19845829 PMID:21443684 PMID:21983654

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
decreases abundance
affects abundance
multiple interactions

Nitric Oxide deficiency results in increased expression of SOD2 protein
SOD2 protein results in decreased abundance of Nitric Oxide
SOD2 protein affects the abundance of Nitric Oxide
[NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 mRNA; [NOS3 protein polymorphism results in decreased chemical synthesis of Nitric Oxide] which results in increased expression of SOD2 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein]; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA; Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]; Nitric Oxide deficiency inhibits the reaction [Formaldehyde results in increased expression of SOD2 mRNA]; SOD2 protein inhibits the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide]; tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of SOD2 protein]

PMID:9576743 PMID:14996425 PMID:15925750 PMID:19320461 PMID:20110409 More...

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

decreases expression

Nitric Oxide deficiency results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

[resveratrol promotes the reaction [ESR1 protein binds to CAV1 protein binds to SRC protein]] which results in increased abundance of Nitric Oxide

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

signal transducer and activator of transcription 1

multiple interactions

STAT1 protein promotes the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 5A

decreases expression
multiple interactions

Nitric Oxide results in decreased expression of STAT5A protein
STAT5A protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 5B

multiple interactions
decreases expression

STAT5B protein affects the reaction [Nitric Oxide results in decreased expression of ACO1 mRNA]
Nitric Oxide results in decreased expression of STAT5B protein

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

SUV39H2 histone lysine methyltransferase

increases expression

Nitric Oxide results in increased expression of SUV39H2 mRNA

NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332

G

synapsin I

increases expression

Nitric Oxide deficiency results in increased expression of SYN1 mRNA

NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396

G

transaldolase 1

multiple interactions
decreases abundance

Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Nitric Oxide]

NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974

G

tubulin folding cofactor A

increases expression

Nitric Oxide deficiency results in increased expression of TBCA mRNA

NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907

G

transferrin receptor

multiple interactions
decreases expression

[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC
Nitric Oxide deficiency results in decreased expression of TFRC protein

PMID:24184442 PMID:24964743

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta 1

multiple interactions
increases expression

candesartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of TGFB1 mRNA]; Nitric Oxide inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]

PMID:15820443 PMID:16778335

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thrombomodulin

multiple interactions
decreases expression

candesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]; Hydralazine inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein]

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

TIMP metallopeptidase inhibitor 2

decreases expression

Nitric Oxide results in decreased expression of TIMP2 mRNA; Nitric Oxide results in decreased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TERF1 interacting nuclear factor 2

increases expression

Nitric Oxide deficiency results in increased expression of TINF2 mRNA

NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984

G

tight junction protein 1

decreases expression
multiple interactions

Nitric Oxide deficiency results in decreased expression of TJP1 protein
[NOS2 protein results in increased chemical synthesis of Nitric Oxide] which results in decreased expression of TJP1 mRNA

PMID:15763998 PMID:25870319

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

thymidine kinase 1

increases mutagenesis

Nitric Oxide results in increased mutagenesis of TK1 gene

PMID:22303861 PMID:28454271

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920