CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (3-phenoxyphenyl)methanol
Accession: CHEBI:62527
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Definition: A member of the class of benzyl alcohols that is benzyl alcohol bearing a phenoxy substituent at C-3. It is a metbaolite of the insecticide permethrin.
Synonyms: related_synonym: 1-hydroxymethyl-3-phenoxybenzene; 3-(Hydroxymethyl)diphenyl ether; 3-PBOH; 3-Phenoxybenzenemethanol; 3-Phenoxybenzyl alcohol; 3-Phenoxybenzylalcohol; Formula=C13H12O2; InChI=1S/C13H12O2/c14-10-11-5-4-8-13(9-11)15-12-6-2-1-3-7-12/h1-9,14H,10H2; InChIKey=KGANAERDZBAECK-UHFFFAOYSA-N; SMILES=OCc1cccc(Oc2ccccc2)c1; m-Phenoxybenzyl alcohol
xref: CAS:13826-35-2
xref_mesh: MESH:C064809
xref: MetaCyc:CPD-13113; PMID:16395479; PMID:21456540; Patent:EP0202838; Patent:EP0394042; Reaxys:475312
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Ar
androgen receptor
multiple interactions
ISO
3-phenoxybenzylalcohol inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases abundance
ISO
CYP2C19 protein results in increased abundance of 3-phenoxybenzylalcohol
CTD
PMID:24548679
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases abundance
ISO
CYP3A4 protein results in increased abundance of 3-phenoxybenzylalcohol
CTD
PMID:24548679
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Esr1
estrogen receptor 1
multiple interactions decreases expression
ISO
3-phenoxybenzylalcohol binds to and results in increased activity of ESR1 protein 3-phenoxybenzylalcohol results in decreased expression of ESR1 mRNA
CTD
PMID:16395479 PMID:20397420 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
3-phenoxybenzylalcohol binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
EXP ISO
3-phenoxybenzylalcohol binds to and results in increased activity of NR1I2 protein
CTD
PMID:31538121 PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
EXP
3-phenoxybenzylalcohol binds to and results in increased activity of PPARA protein
CTD
PMID:31538121
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
3-phenoxybenzylalcohol binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Tff1
trefoil factor 1
increases expression
ISO
3-phenoxybenzylalcohol results in increased expression of TFF1 mRNA
CTD
PMID:20397420
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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