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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
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Accession:CHEBI:62434 term browser browse the term
Definition:An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Synonyms:related_synonym: AATK inhibitor;   AATYK inhibitor;   AATYK2 inhibitor;   AATYK3 inhibitor;   ACH inhibitor;   ALK inhibitor;   ALK inhibitors;   ARK inhibitor;   ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor;   ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors;   AXL inhibitor;   BRT inhibitor;   Bek inhibitor;   Bfgfr inhibitor;   Bsk inhibitor;   C-FMS inhibitor;   CAK inhibitor;   CCK4 inhibitor;   CD115 inhibitor;   CD135 inhibitor;   CDw135 inhibitor;   CFD1 inhibitor;   CKIT inhibitor;   CSF1R inhibitor;   Cek1 inhibitor;   Cek10 inhibitor;   Cek11 inhibitor;   Cek2 inhibitor;   Cek3 inhibitor;   Cek5 inhibitor;   Cek6 inhibitor;   Cek7 inhibitor;   DAlk inhibitor;   DDR1 inhibitor;   DDR2 inhibitor;   DKFZp434C1418 inhibitor;   DRT inhibitor;   DTK inhibitor;   Dek inhibitor;   Drosophila Eph kinase inhibitor;   EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors;   EC 2.7.10.1 inhibitor;   EC 2.7.10.1 inhibitors;   ECK inhibitor;   EDDR1 inhibitor;   EGFR inhibitor;   EPH inhibitor;   EPHA1 inhibitor;   EPHA2 inhibitor;   EPHA6 inhibitor;   EPHA7 inhibitor;   EPHA8 inhibitor;   EPHB1 inhibitor;   EPHB2 inhibitor;   EPHB3 inhibitor;   EPHB4 inhibitor;   EPHT inhibitor;   EPHT2 inhibitor;   EPHT3 inhibitor;   EPHX inhibitor;   ERBB inhibitor;   ERBB1 inhibitor;   ERBB2 inhibitor;   ERBB3 inhibitor;   ERBB4 inhibitor;   ERK inhibitor;   Ebk inhibitor;   Eek inhibitor;   Ehk2 inhibitor;   Ehk3 inhibitor;   Elk inhibitor;   EphB5 inhibitor;   Eyk inhibitor;   FGFR1 inhibitor;   FGFR2 inhibitor;   FGFR3 inhibitor;   FGFR4 inhibitor;   FLG inhibitor;   FLK1 inhibitor;   FLK2 inhibitor;   FLT1 inhibitor;   FLT2 inhibitor;   FLT3 inhibitor;   FLT4 inhibitor;   FMS inhibitor;   Fv2 inhibitor;   HBGFR inhibitor;   HEK11 inhibitor;   HEK2 inhibitor;   HEK3 inhibitor;   HEK5 inhibitor;   HEK6 inhibitor;   HEP inhibitor;   HER2 inhibitor;   HER3 inhibitor;   HER4 inhibitor;   HGFR inhibitor;   HSCR1 inhibitor;   HTK inhibitor;   IGF1R inhibitor;   INSR inhibitor;   INSRR inhibitor;   IR inhibitor;   IRR inhibitor;   JTK12 inhibitor;   JTK13 inhibitor;   JTK14 inhibitor;   JWS inhibitor;   K-SAM inhibitor;   KDR inhibitor;   KGFR inhibitor;   KIA0641 inhibitor;   KIAA1079 inhibitor;   KIAA1459 inhibitor;   KIT inhibitor;   KLG inhibitor;   Kil inhibitor;   Kin15 inhibitor;   Kin16 inhibitor;   LTK inhibitor;   MCF3 inhibitor;   MEN2A/B inhibitor;   MER inhibitor;   MERTK inhibitor;   MEhk1 inhibitor;   MST1R inhibitor;   MTC1 inhibitor;   MUSK inhibitor;   Mdk1 inhibitor;   Mdk2 inhibitor;   Mdk5 inhibitor;   Mep inhibitor;   Mlk1 inhibitor;   Mlk2 inhibitor;   Mrk inhibitor;   Myk1 inhibitor;   N-SAM inhibitor;   NEP inhibitor;   NET inhibitor;   NGL inhibitor;   NOK inhibitor;   NTRK1 inhibitor;   NTRK2 inhibitor;   NTRK3 inhibitor;   NTRK4 inhibitor;   NTRKR1 inhibitor;   NTRKR2 inhibitor;   NTRKR3 inhibitor;   NYK inhibitor;   Neu inhibitor;   Nsk2 inhibitor;   Nuk inhibitor;   PCL inhibitor;   PDGFR inhibitor;   PDGFRA inhibitor;   PDGFRB inhibitor;   PHB6 inhibitor;   PTK inhibitor;   PTK3 inhibitor;   PTK7 inhibitor;   RET inhibitor;   RON inhibitor;   ROR1 inhibitor;   ROR2 inhibitor;   ROS1 inhibitor;   RSE inhibitor;   RTK inhibitor;   RYK inhibitor;   SEA inhibitor;   SKY inhibitor;   STK inhibitor;   STK1 inhibitor;   Sek2 inhibitor;   Sek3 inhibitor;   Sek4 inhibitor;   Sfr inhibitor;   TEK inhibitor;   TIE inhibitor;   TIE1 inhibitor;   TIE2 inhibitor;   TIF inhibitor;   TKT inhibitor;   TRK inhibitor;   TRKA inhibitor;   TRKB inhibitor;   TRKC inhibitor;   TRKE inhibitor;   TYK1 inhibitor;   TYRO10 inhibitor;   TYRO3 inhibitor;   TYRO7 inhibitor;   Tyro11 inhibitor;   Tyro5 inhibitor;   Tyro6 inhibitor;   UFO inhibitor;   VEGFR1 inhibitor;   VEGFR2 inhibitor;   VEGFR3 inhibitor;   Vik inhibitor;   YK1 inhibitor;   Yrk inhibitor;   anaplastic lymphoma kinase inhibitor;   anaplastic lymphoma kinase inhibitors;   ephrin-B3 receptor tyrosine kinase inhibitor;   insulin receptor protein-tyrosine kinase inhibitor;   neurite outgrowth regulating kinase inhibitor;   nork inhibitor;   novel oncogene with kinase-domain inhibitor;   receptor protein-tyrosine kinase inhibitor;   receptor protein-tyrosine kinase inhibitors
 xref: Wikipedia:Anaplastic_lymphoma_kinase


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    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19874
        role 19844
          biological role 19842
            inhibitor 18918
              enzyme inhibitor 18744
                EC 2.* (transferase) inhibitor 14969
                  EC 2.7.* (P-containing group transferase) inhibitor 14384
                    EC 2.7.10.* (protein-tyrosine kinase) inhibitor 9967
                      EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor 9649
                        1-(3-\{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}phenyl)-3-(2-phenoxyphenyl)urea 0
                        1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                        2,5-dihydroxycinnamic acid methyl ester 1
                        3,21-dioxoolean-18-en-28-oic acid 0
                        AEE788 0
                        AMG-925 0
                        ASP-3026 0
                        AZD3463 0
                        BAY-826 0
                        BMS-754807 8
                        CHIR-265 0
                        CP-724714 0
                        DDR1-IN-1 1
                        DDR1-IN-2 1
                        DMH4 0
                        Ki11502 0
                        N-\{4-[(3-bromophenyl)amino]quinazolin-6-yl\}but-2-ynamide 0
                        PD-153035 0
                        PD-153035 hydrochloride 0
                        PD-166866 + 21
                        PD158780 0
                        PD173074 18
                        PDGF receptor tyrosine kinase inhibitor III 0
                        PQIP 0
                        RepSox 0
                        SB 431542 6499
                        SU11652 0
                        TTT-3002 0
                        ZM 323881 hydrochloride 0
                        alectinib 3
                        alectinib hydrochloride 0
                        brivanib + 0
                        brivanib alaninate 0
                        c-Met tyrosine kinase inhibitor + 19
                        ceritinib 17
                        crenolanib 0
                        crizotinib + 55
                        ebselen 58
                        entrectinib 0
                        fruquintinib 0
                        gilteritinib 0
                        lenvatinib 24
                        lenvatinib mesylate 0
                        linifanib 0
                        lorlatinib 3
                        orantinib 4
                        pexidartinib 13
                        quizartinib 34
                        rac-crizotinib 0
                        repotrectinib 0
                        sapitinib 0
                        semaxanib 3
                        sunitinib + 5826
                        tandutinib 0
                        telatinib 0
                        tesevatinib 0
                        varlitinib 0
                        vatalanib + 2
                        vatalanib succinate 0
                        xestospongin C 12
    Path 2
    Term Annotations click to browse term
      CHEBI ontology 19874
        role 19844
          biological role 19842
            inhibitor 18918
              enzyme inhibitor 18744
                EC 2.* (transferase) inhibitor 14969
                  EC 2.7.* (P-containing group transferase) inhibitor 14384
                    protein kinase inhibitor 13993
                      tyrosine kinase inhibitor 11869
                        EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor 9649
                          1-(3-\{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}phenyl)-3-(2-phenoxyphenyl)urea 0
                          1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                          2,5-dihydroxycinnamic acid methyl ester 1
                          3,21-dioxoolean-18-en-28-oic acid 0
                          AEE788 0
                          AMG-925 0
                          ASP-3026 0
                          AZD3463 0
                          BAY-826 0
                          BMS-754807 8
                          CHIR-265 0
                          CP-724714 0
                          DDR1-IN-1 1
                          DDR1-IN-2 1
                          DMH4 0
                          Ki11502 0
                          N-\{4-[(3-bromophenyl)amino]quinazolin-6-yl\}but-2-ynamide 0
                          PD-153035 0
                          PD-153035 hydrochloride 0
                          PD-166866 + 21
                          PD158780 0
                          PD173074 18
                          PDGF receptor tyrosine kinase inhibitor III 0
                          PQIP 0
                          RepSox 0
                          SB 431542 6499
                          SU11652 0
                          TTT-3002 0
                          ZM 323881 hydrochloride 0
                          alectinib 3
                          alectinib hydrochloride 0
                          brivanib + 0
                          brivanib alaninate 0
                          c-Met tyrosine kinase inhibitor + 19
                          ceritinib 17
                          crenolanib 0
                          crizotinib + 55
                          ebselen 58
                          entrectinib 0
                          fruquintinib 0
                          gilteritinib 0
                          lenvatinib 24
                          lenvatinib mesylate 0
                          linifanib 0
                          lorlatinib 3
                          orantinib 4
                          pexidartinib 13
                          quizartinib 34
                          rac-crizotinib 0
                          repotrectinib 0
                          sapitinib 0
                          semaxanib 3
                          sunitinib + 5826
                          tandutinib 0
                          telatinib 0
                          tesevatinib 0
                          varlitinib 0
                          vatalanib + 2
                          vatalanib succinate 0
                          xestospongin C 12
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