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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:metabotropic glutamate receptor agonist
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Accession:CHEBI:61966 term browser browse the term
Definition:An agonist that selectively binds to and activates a metabotropic glutamate receptor.
Synonyms:related_synonym: mGluRs agonist;   metabotropic glutamate receptor agonists


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LY 379268 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein] CTD PMID:17293559 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
multiple interactions		 EXP LY 379268 results in increased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased expression of BCL2L1 protein]		 CTD PMID:17293559 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]] CTD PMID:17293559 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 increases phosphorylation EXP LY 379268 results in increased phosphorylation of MAP3K5 protein CTD PMID:17293559 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; LY 341495 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein] CTD PMID:17293559 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP LY 379268 results in increased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; LY 341495 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]		 CTD PMID:17293559 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP LY 379268 inhibits the reaction [bisphenol A results in decreased expression of NR3C1 mRNA] CTD PMID:25812946 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
xanthurenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO xanthurenic acid binds to and results in increased activity of AHR protein CTD PMID:20106948 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of xanthurenic acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      biological role 19835
        pharmacological role 19069
          agonist 18596
            metabotropic glutamate receptor agonist 9
              (2S)-2-amino-4-phosphonobutanoic acid 0
              3-sulfino-L-alanine + 0
              AMN082 dihydrochloride 0
              D-homocysteic acid + 0
              DL-homocysteic acid 0
              LY 379268 7
              LY404039 0
              N,N'-bis(diphenylmethyl)ethane-1,2-diamine 0
              xanthurenic acid + 2
paths to the root