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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbimazole
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Accession:CHEBI:617099 term browser browse the term
Definition:A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Synonyms:exact_synonym: ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
 related_synonym: Athyromazole;   Carbethoxymethimazole;   Carbinazole;   Ethyl 3-methyl-2-thioimidazoline-1-carboxylate;   Formula=C7H10N2O2S;   InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3;   InChIKey=CFOYWRHIYXMDOT-UHFFFAOYSA-N;   SMILES=CCOC(=O)n1ccn(C)c1=S;   Thyrostat;   carbimazol;   carbimazolum
 alt_id: CHEBI:3397
 xref: CAS:22232-54-8;   DrugBank:DB00389;   Drug_Central:497;   KEGG:C07615;   KEGG:D07616;   LINCS:LSM-5930
 xref_mesh: MESH:D002231
 xref: PMID:1502708;   PMID:18954039;   PMID:23343442;   PMID:23391946;   PMID:23776913;   PMID:23900475;   PMID:24049063;   PMID:24255992;   PMID:24265129;   PMID:25013255;   Patent:US2671088;   Patent:US2815349;   Reaxys:144339;   VSDB:1876;   Wikipedia:Carbimazole


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carbimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression		 EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of AR mRNA] CTD PMID:38342389 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP Carbimazole results in increased expression of CASP3 mRNA
Thioctic Acid inhibits the reaction [Carbimazole results in increased expression of CASP3 mRNA]		 CTD PMID:38342389 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of CAT protein] CTD PMID:38342389 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ckm creatine kinase, M-type increases expression ISO Carbimazole results in increased expression of CKM protein CTD PMID:2565460 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity		 EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of GSR protein] CTD PMID:38342389 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression		 EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of NFE2L2 mRNA] CTD PMID:38342389 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression
multiple interactions		 EXP Carbimazole results in decreased expression of SRD5A1 mRNA
Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of SRD5A1 mRNA]		 CTD PMID:38342389 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pro-agent 11549
          prodrug 11293
            carbimazole 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  heteroarene 17151
                                    monocyclic heteroarene 14980
                                      azole 14503
                                        diazole 10770
                                          imidazoles 10220
                                            1,3-dihydroimidazole-2-thiones 3620
                                              carbimazole 7
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