The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer.
[CALM2 protein affects the susceptibility to Afatinib] which affects the expression of BAX protein; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]
[CALM2 protein affects the susceptibility to Afatinib] which affects the expression of BAX protein; [CALM2 protein affects the susceptibility to Afatinib] which affects the localization of DIABLO protein; [CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein; AKT1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; MCL1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]
[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein; AKT1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BAX protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; BBC3 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]; MCL1 protein affects the reaction [[CALM2 protein affects the susceptibility to Afatinib] which results in increased cleavage of CASP3 protein]
afatinib inhibits the reaction [EGF protein results in increased expression of EHMT2 protein]; afatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]
afatinib results in decreased activity of EGFR protein; afatinib results in decreased activity of EGFR protein mutant form afatinib results in decreased phosphorylation of EGFR protein
afatinib results in decreased expression of POU5F1 protein afatinib inhibits the reaction [EGF protein results in increased expression of POU5F1 protein]
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