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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketorolac tromethamine
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Accession:CHEBI:6130 term browser browse the term
Definition:An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
 related_synonym: Acular;   Acuvail;   Dolac;   Formula=C19H24N2O6;   InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2;   InChIKey=BWHLPLXXIDYSNW-UHFFFAOYSA-N;   Lixidol;   SMILES=[NH3+]C(CO)(CO)CO.[O-]C(=O)C1CCn2c1ccc2C(=O)c1ccccc1;   Sprix;   Toradol
 xref: CAS:74103-07-4;   DrugBank:DB00465;   HMDB:HMDB0014608;   KEGG:D00813
 xref_mesh: MESH:D020911
 xref: PMID:19663721;   PMID:23016110;   PMID:23098098;   PMID:23199134;   PMID:23302965;   PMID:23992042;   PMID:8863973;   Reaxys:6463165


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ketorolac tromethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aanat aralkylamine N-acetyltransferase multiple interactions EXP Ketorolac Tromethamine results in decreased localization of and results in decreased activity of AANAT protein CTD PMID:37348669 NCBI chr10:101,827,072...101,831,805
Ensembl chr10:101,827,301...101,831,801 		JBrowse link
G Cat catalase multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of CAT protein] CTD PMID:37348669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ereg epiregulin increases expression ISO Ketorolac Tromethamine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of GPX1 protein CTD PMID:37348669 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP Ketorolac Tromethamine results in increased activity of GSR protein CTD PMID:37348669 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Il24 interleukin 24 increases expression ISO Ketorolac Tromethamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Maoa monoamine oxidase A multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [Ketorolac Tromethamine results in increased activity of MAOA protein] CTD PMID:37348669 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mtnr1a melatonin receptor 1A increases localization EXP Ketorolac Tromethamine results in increased localization of MTNR1A protein CTD PMID:37348669 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Ketorolac Tromethamine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ketorolac Tromethamine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD1 protein CTD PMID:37348669 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Ketorolac Tromethamine results in decreased activity of SOD2 protein CTD PMID:37348669 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          analgesic 14769
            ketorolac tromethamine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  ammonium 8312
                                    ammonium ion derivative 8307
                                      ammonium compound 5196
                                        organoammonium salt 671
                                          ketorolac tromethamine 12
paths to the root