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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scutellarin
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Accession:CHEBI:61278 term browser browse the term
Definition:The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.
Synonyms:exact_synonym: 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
 related_synonym: Formula=C21H18O12;   InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1;   InChIKey=DJSISFGPUUYILV-ZFORQUDYSA-N;   SMILES=O[C@H]1[C@@H](O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O)Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccc(O)cc1;   Scutellarein 7-O-beta-D-glucuronide;   Scutellarein-7-glucuronide;   Scutellarein-7beta-D-glucuronide;   Scutellarein-7beta-D-glucuronoside
 xref: CAS:27740-01-8
 xref_mesh: MESH:C484876
 xref: PMID:10724177;   PMID:22092277;   PMID:23147714;   PMID:23177255;   PMID:23192830;   Reaxys:71779;   Wikipedia:Scutellarin
 cyclic_relationship: is_conjugate_acid_of CHEBI:61284



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scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX protein] CTD PMID:34610774 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 protein] CTD PMID:34610774 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Casp1 caspase 1 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] CTD PMID:37081038 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 protein]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]
CTD PMID:18442013 PMID:34610774 PMID:36252740 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 protein] CTD PMID:34610774 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Gsdmd gasdermin D multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] CTD PMID:37081038 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA] CTD PMID:34610774 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IKBKB protein] CTD PMID:34610774 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il18 interleukin 18 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:37081038 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il6 interleukin 6 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 mRNA] CTD PMID:34610774 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] CTD PMID:36252740 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 protein] CTD PMID:34610774 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of MYD88 mRNA] CTD PMID:34610774 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein] CTD PMID:34610774 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 mRNA] CTD PMID:34610774 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFKBIB mRNA] CTD PMID:34610774 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:37081038 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NPPB protein] CTD PMID:34610774 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NQO1 mRNA] CTD PMID:34610774 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PARP1 mRNA] CTD PMID:34610774 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pla2g2a phospholipase A2 group IIA affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein] CTD PMID:34610774 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] CTD PMID:36252740 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TLR4 mRNA] CTD PMID:34610774 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein] CTD PMID:34610774 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP
ISO
scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]
CTD PMID:16297343 PMID:25192544 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antineoplastic agent 17817
              scutellarin 37
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  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  oxacycle 17903
                                    benzopyran 11971
                                      1-benzopyran 11725
                                        flavonoid 7225
                                          anthoxanthin 4584
                                            flavones 4584
                                              hydroxyflavone 4561
                                                trihydroxyflavone 453
                                                  apigenin 306
                                                    scutellarein 71
                                                      scutellarin 37
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