|
G |
Acbd3 |
acyl-CoA binding domain containing 3 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of ACBD3-AS1 mRNA] which results in increased expression of ACBD3 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
|
|
G |
Aco2 |
aconitase 2 |
multiple interactions |
EXP |
[[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical |
CTD |
PMID:16162655 |
|
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
|
|
G |
Ankar |
ankyrin and armadillo repeat containing |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of OSGEPL1-AS1 mRNA] which results in increased expression of ANKAR mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:48,141,534...48,215,400
Ensembl chr 9:48,141,391...48,215,616
|
|
G |
Arap1 |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of ARAP1-AS1 mRNA] which results in increased expression of ARAP1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184
|
|
G |
Cat |
catalase |
decreases response to substance multiple interactions |
ISO |
CAT protein results in decreased susceptibility to Hydroxyl Radical CAT protein inhibits the reaction [chromium hexavalent ion results in increased chemical synthesis of Hydroxyl Radical] |
CTD |
PMID:10421593 PMID:11678602 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Catip |
ciliogenesis associated TTC17 interacting protein |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of CATIP-AS1 mRNA] which results in increased expression of CATIP mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:75,945,960...75,953,618
Ensembl chr 9:75,945,961...75,953,607
|
|
G |
Cblif |
cobalamin binding intrinsic factor |
affects metabolic processing |
ISO |
CBLIF protein affects the metabolism of Hydroxyl Radical |
CTD |
PMID:11750760 |
|
NCBI chr 1:208,605,983...208,620,231
Ensembl chr 1:208,605,983...208,620,344
|
|
G |
Ccdc183 |
coiled-coil domain containing 183 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of CCDC183-AS1 mRNA] which results in increased expression of CCDC183 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 3:8,428,784...8,438,948
Ensembl chr 3:8,428,787...8,437,194
|
|
G |
Cimap1c |
ciliary microtubule associated protein 1C |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of DNM1P35 mRNA] which results in increased expression of CIMAP1C mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 8:57,248,746...57,281,084
Ensembl chr 8:57,248,746...57,281,004
|
|
G |
Col4a2 |
collagen type IV alpha 2 chain |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of COL4A2-AS1 mRNA] which results in decreased expression of COL4A2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
|
|
G |
Coro1a |
coronin 1A |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of CORO1A-AS1 mRNA] which results in decreased expression of CORO1A mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
|
|
G |
Dcxr |
dicarbonyl and L-xylulose reductase |
multiple interactions increases chemical synthesis |
ISO |
[DCXR protein results in increased metabolism of 9,10-phenanthrenequinone] which results in increased chemical synthesis of Hydroxyl Radical DCXR protein results in increased chemical synthesis of Hydroxyl Radical |
CTD |
PMID:28595002 |
|
NCBI chr10:106,006,404...106,008,293
|
|
G |
Ddit4 |
DNA-damage-inducible transcript 4 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of DDIT4-AS1 mRNA] which results in decreased expression of DDIT4 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
|
|
G |
Ddx59 |
DEAD-box helicase 59 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of DDX59-AS1 mRNA] which results in increased expression of DDX59 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr13:47,876,258...47,901,214
Ensembl chr13:47,876,261...47,901,214
|
|
G |
Dlgap1 |
DLG associated protein 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of DLGAP1-AS2 mRNA] which results in increased expression of DLGAP1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
|
|
G |
Dnmt3l |
DNA methyltransferase 3 like |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of DNMT3L-AS1 mRNA] which results in increased expression of DNMT3L mRNA |
CTD |
PMID:33656867 |
|
NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516
|
|
G |
Dock3 |
dedicator of cyto-kinesis 3 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of LINC02019 mRNA] which results in increased expression of DOCK3 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 8:107,552,462...107,903,527
Ensembl chr 8:107,552,463...107,903,514
|
|
G |
Dynlt2b |
dynein light chain Tctex-type 2B |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of TM4SF19-AS1 mRNA] which results in increased expression of DYNLT2B mRNA |
CTD |
PMID:33656867 |
|
NCBI chr11:68,359,138...68,367,573
Ensembl chr11:68,358,263...68,367,499
|
|
G |
E2f8 |
E2F transcription factor 8 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of CSRP3-AS1 mRNA] which results in increased expression of E2F8 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
|
|
G |
Fam83f |
family with sequence similarity 83, member F |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of TNRC6B-DT mRNA] which results in increased expression of FAM83F mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
|
|
G |
Fbxw7 |
F-box and WD repeat domain containing 7 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of FBXW7-AS1 mRNA] which results in increased expression of FBXW7 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941
|
|
G |
Fhad1 |
forkhead associated phosphopeptide binding domain 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of FHAD1-AS1 mRNA] which results in increased expression of FHAD1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 5:154,191,593...154,310,442
Ensembl chr 5:154,191,745...154,310,354
|
|
G |
Flnb |
filamin B |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of FLNB-AS1 mRNA] which results in decreased expression of FLNB mRNA |
CTD |
PMID:33656867 |
|
NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
|
|
G |
Flnc |
filamin C |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of FLNC-AS1 mRNA] which results in increased expression of FLNC mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844
|
|
G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
increases abundance multiple interactions |
ISO |
FMR1 5' UTR mutant form results in increased abundance of Hydroxyl Radical Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Hydroxyl Radical] |
CTD |
PMID:27385396 |
|
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
|
|
G |
Foxc2 |
forkhead box C2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of FOXC2-AS1 mRNA] which results in decreased expression of FOXC2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr19:49,186,034...49,188,736
Ensembl chr19:49,185,662...49,188,737
|
|
G |
Foxl2 |
forkhead box L2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of LINC01391 mRNA] which results in increased expression of FOXL2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
|
|
G |
Gcc2 |
GRIP and coiled-coil domain containing 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of GCC2-AS1 mRNA] which results in increased expression of GCC2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr20:26,247,394...26,293,613
Ensembl chr20:26,247,404...26,293,613
|
|
G |
Gk |
glycerol kinase |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of GK-AS1 mRNA] which results in increased expression of GK mRNA; [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of GK-IT1 mRNA] which results in increased expression of GK mRNA |
CTD |
PMID:33656867 |
|
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
|
|
G |
Gsn |
gelsolin |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of GSN-AS1 mRNA] which results in decreased expression of GSN mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
|
|
G |
Hoxb9 |
homeo box B9 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of HOXB-AS4 mRNA] which results in increased expression of HOXB9 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818
|
|
G |
Hoxc13 |
homeobox C13 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of HOXC13-AS mRNA] which results in increased expression of HOXC13 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 7:134,058,640...134,065,479
Ensembl chr 7:134,058,640...134,064,800
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
HRAS protein promotes the reaction [[sodium bichromate results in increased abundance of chromium hexavalent ion] which results in increased abundance of Hydroxyl Radical]; Oxygen deficiency inhibits the reaction [HRAS protein promotes the reaction [[sodium bichromate results in increased abundance of chromium hexavalent ion] which results in increased abundance of Hydroxyl Radical]] |
CTD |
PMID:14971653 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Iapp |
islet amyloid polypeptide |
multiple interactions |
EXP |
IAPP protein promotes the reaction [[Copper co-treated with Ascorbic Acid] results in increased abundance of Hydroxyl Radical] |
CTD |
PMID:23793354 |
|
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
|
|
G |
Icoslg |
inducible T-cell co-stimulator ligand |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of DNMT3L-AS1 mRNA] which results in increased expression of ICOSLG mRNA |
CTD |
PMID:33656867 |
|
NCBI chr20:10,600,420...10,610,718
Ensembl chr20:10,600,420...10,610,703
|
|
G |
Insig1 |
insulin induced gene 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of INSIG1-DT mRNA] which results in decreased expression of INSIG1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
|
|
G |
Itga3 |
integrin subunit alpha 3 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PICART1 mRNA] which results in decreased expression of ITGA3 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
|
|
G |
Kiaa1614 |
KIAA1614 homolog |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of KIAA1614-AS1 mRNA] which results in increased expression of KIAA1614 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr13:67,388,916...67,427,392
Ensembl chr13:67,389,044...67,421,272
|
|
G |
Krt7 |
keratin 7 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of KRT7-AS mRNA] which results in decreased expression of KRT7 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 7:132,528,881...132,545,052
Ensembl chr 7:132,528,895...132,545,052
|
|
G |
Lbx2 |
ladybird homeobox 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of LBX2-AS1 mRNA] which results in increased expression of LBX2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132
|
|
G |
Lif |
LIF, interleukin 6 family cytokine |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of LIF-AS1 mRNA] which results in increased expression of LIF mRNA |
CTD |
PMID:33656867 |
|
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
|
|
G |
Mmel1 |
membrane metallo-endopeptidase-like 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of MMEL1-AS1 mRNA] which results in decreased expression of MMEL1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 5:165,431,278...165,461,716
Ensembl chr 5:165,431,343...165,461,716
|
|
G |
Msr1 |
macrophage scavenger receptor 1 |
decreases degradation |
ISO |
Hydroxyl Radical results in decreased degradation of MSR1 mRNA |
CTD |
PMID:9614211 |
|
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
|
|
G |
Mt3 |
metallothionein 3 |
multiple interactions |
ISO |
[[MT3 protein binds to Zinc] which co-treated with Ascorbic Acid] inhibits the reaction [Copper results in increased chemical synthesis of Hydroxyl Radical] |
CTD |
PMID:17389590 |
|
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
|
|
G |
Ngfr |
nerve growth factor receptor |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of NGFR-AS1 mRNA] which results in increased expression of NGFR mRNA |
CTD |
PMID:33656867 |
|
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
|
|
G |
Nucb1 |
nucleobindin 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of NUCB1-AS1 mRNA] which results in decreased expression of NUCB1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220
|
|
G |
Odc1 |
ornithine decarboxylase 1 |
multiple interactions |
EXP |
[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein] |
CTD |
PMID:14623030 |
|
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
|
|
G |
Osgepl1 |
O-sialoglycoprotein endopeptidase-like 1 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of OSGEPL1-AS1 mRNA] which results in decreased expression of OSGEPL1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:48,214,995...48,229,440
Ensembl chr 9:48,215,402...48,229,388
|
|
G |
Piwil2 |
piwi-like RNA-mediated gene silencing 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of PIWIL2-DT mRNA] which results in increased expression of PIWIL2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702
|
|
G |
Pla2g4e |
phospholipase A2, group IVE |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PLA2G4E-AS1 mRNA] which results in increased expression of PLA2G4E mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 3:107,132,540...107,198,609
Ensembl chr 3:107,132,541...107,198,233
|
|
G |
Plcl2 |
phospholipase C-like 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PLCL2-AS1 mRNA] which results in increased expression of PLCL2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009
|
|
G |
Polh |
DNA polymerase eta |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of POLH-AS1 mRNA] which results in increased expression of POLH mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
|
|
G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
[[Iron co-treated with POR protein] results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; [[Iron co-treated with POR protein] results in increased metabolism of Paraquat] which results in increased abundance of Hydroxyl Radical; [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical [POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical; Dimethyl Sulfoxide inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical] |
CTD |
PMID:21215309 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
|
|
G |
Prickle2 |
prickle planar cell polarity protein 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PRICKLE2-AS1 mRNA] which results in increased expression of PRICKLE2 mRNA; [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of PRICKLE2-AS3 mRNA] which results in increased expression of PRICKLE2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 4:124,869,655...125,214,862
Ensembl chr 4:124,869,552...125,214,824
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein |
CTD |
PMID:11681624 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Sh3rf3 |
SH3 domain containing ring finger 3 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of SH3RF3-AS1 mRNA] which results in decreased expression of SH3RF3 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257
|
|
G |
Smad5 |
SMAD family member 5 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634
|
|
G |
Syp |
synaptophysin |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of SYP-AS1 mRNA] which results in increased expression of SYP mRNA |
CTD |
PMID:33656867 |
|
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
|
|
G |
Tab3 |
TGF-beta activated kinase 1 (MAP3K7) binding protein 3 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of TAB3-AS1 mRNA] which results in increased expression of TAB3 mRNA; [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of TAB3-AS2 mRNA] which results in increased expression of TAB3 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr X:49,972,414...50,044,658
Ensembl chr X:49,972,330...50,042,056
|
|
G |
Thy1 |
Thy-1 cell surface antigen |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of THY1-AS1 mRNA] which results in decreased expression of THY1 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
|
|
G |
Tlx2 |
T-cell leukemia homeobox 2 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of LBX2-AS1 mRNA] which results in increased expression of TLX2 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 4:115,573,736...115,576,097
Ensembl chr 4:115,573,799...115,575,642
|
|
G |
Tm4sf19 |
transmembrane 4 L six family member 19 |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in decreased expression of TM4SF19-AS1 mRNA] which results in decreased expression of TM4SF19 mRNA |
CTD |
PMID:33656867 |
|
NCBI chr11:68,372,945...68,386,192
Ensembl chr11:68,371,647...68,384,591
|
|
G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of TNFRSF10A-AS1 mRNA] which results in increased expression of TNFRSF10A mRNA |
CTD |
PMID:33656867 |
|
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
|
|
G |
Ttc23l |
tetratricopeptide repeat domain 23-like |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of TTC23L-AS1 mRNA] which results in increased expression of TTC23L mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 2:59,476,666...59,538,313
Ensembl chr 2:59,476,669...59,538,282
|
|
G |
Upk1a |
uroplakin 1A |
multiple interactions |
ISO |
[[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of UPK1A-AS1 mRNA] which results in increased expression of UPK1A mRNA |
CTD |
PMID:33656867 |
|
NCBI chr 1:85,859,672...85,870,147
Ensembl chr 1:85,859,671...85,870,354
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions increases abundance |
ISO |
[[Oxygen deficiency results in increased abundance of Hypoxanthine] affects the reaction [XDH protein affects the metabolism of Hypoxanthine]] which affects the abundance of Hydroxyl Radical XDH protein results in increased abundance of Hydroxyl Radical |
CTD |
PMID:7929072 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides] |
CTD |
PMID:17272743 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Aco1 |
aconitase 1 |
decreases activity multiple interactions |
ISO |
Superoxides results in decreased activity of ACO1 protein [SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein |
CTD |
PMID:28542246 |
|
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
|
|
G |
Aco2 |
aconitase 2 |
multiple interactions decreases activity |
EXP |
[[[Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron] which co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Hydroxyl Radical; [Superoxides results in decreased activity of ACO2 protein] which results in increased abundance of Iron |
CTD |
PMID:16162655 |
|
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
|
|
G |
Ada |
adenosine deaminase |
multiple interactions |
ISO |
ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] |
CTD |
PMID:10947063 |
|
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
|
|
G |
Agt |
angiotensinogen |
multiple interactions increases abundance |
ISO EXP |
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ABCC1 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides]; Propranolol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]] SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] AGT protein modified form results in increased abundance of Superoxides; AGT protein results in increased abundance of Superoxides 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; acetovanillone inhibits the reaction [AGT protein results in increased abundance of Superoxides]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]] |
CTD |
PMID:12606818 PMID:16531806 PMID:16864745 PMID:17272743 PMID:17391658 PMID:18250367 PMID:18768397 PMID:20881940 PMID:22753205 PMID:24363997 More...
|
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
EXP |
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides] |
CTD |
PMID:23824088 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
multiple interactions |
ISO |
[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Superoxides |
CTD |
PMID:19442656 PMID:21910479 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
|
|
G |
Akr7a2 |
aldo-keto reductase family 7, member A2 |
multiple interactions |
ISO |
[[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of 4-hydroxyequilenin-o-quinone] which results in increased chemical synthesis of Superoxides; [[AKR7A2 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7,8-dione] which results in increased chemical synthesis of Superoxides |
CTD |
PMID:21910479 |
|
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
|
|
G |
Alb |
albumin |
increases chemical synthesis multiple interactions |
ISO |
ALB protein modified form results in increased chemical synthesis of Superoxides Etomidate promotes the reaction [ALB protein modified form results in increased chemical synthesis of Superoxides] |
CTD |
PMID:25421967 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
|
|
G |
Aldh5a1 |
aldehyde dehydrogenase 5 family, member A1 |
multiple interactions |
ISO |
[ALDH5A1 gene mutant form results in increased susceptibility to 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo(h)(1,6)naphthyridin-2(1H)-one] which results in increased abundance of Superoxides; [ALDH5A1 gene mutant form results in increased susceptibility to NCS 382] which results in increased abundance of Superoxides |
CTD |
PMID:29031482 |
|
NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
|
|
G |
Apoe |
apolipoprotein E |
increases chemical synthesis increases abundance multiple interactions |
ISO |
APOE gene mutant form results in increased chemical synthesis of Superoxides APOE gene mutant form results in increased abundance of Superoxides imisopasem manganese inhibits the reaction [APOE gene mutant form results in increased chemical synthesis of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [APOE gene mutant form results in increased abundance of Superoxides] |
CTD |
PMID:11397713 PMID:12871831 |
|
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
|
|
G |
App |
amyloid beta precursor protein |
multiple interactions increases chemical synthesis |
ISO |
3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; GW 501516 inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; Resveratrol inhibits the reaction [APP protein results in increased abundance of Superoxides] |
CTD |
PMID:16212921 PMID:22886847 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Superoxides promotes the reaction [methylselenic acid results in decreased expression of AR protein] |
CTD |
PMID:16928829 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
|
|
G |
Arf6 |
ARF GTPase 6 |
multiple interactions |
ISO |
1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] |
CTD |
PMID:10931844 |
|
NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
|
|
G |
Arrb2 |
arrestin, beta 2 |
affects abundance |
ISO |
ARRB2 protein affects the abundance of Superoxides |
CTD |
PMID:16210646 |
|
NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
|
|
G |
Atox1 |
antioxidant 1 copper chaperone |
multiple interactions |
ISO |
ATOX1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] |
CTD |
PMID:22753205 |
|
NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
|
|
G |
Atp7a |
ATPase copper transporting alpha |
increases abundance multiple interactions |
ISO |
ATP7A mutant form results in increased abundance of Superoxides [ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]] |
CTD |
PMID:18768397 PMID:23884884 |
|
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
|
|
G |
C5 |
complement C5 |
multiple interactions increases abundance |
ISO |
8-(4-sulfophenyl)theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline inhibits the reaction [C5 protein modified form results in increased abundance of Superoxides]; Theophylline promotes the reaction [C5 protein modified form results in increased abundance of Superoxides] |
CTD |
PMID:10947063 |
|
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
|
|
G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] |
CTD |
PMID:19268487 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
|
|
G |
Cbs |
cystathionine beta synthase |
affects abundance multiple interactions |
ISO |
CBS protein affects the abundance of Superoxides SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] |
CTD |
PMID:23024785 |
|
NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
|
|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
ISO |
Superoxides affects the reaction [Fructose results in increased secretion of CCL2 protein] Superoxides results in increased expression of CCL2 mRNA 1,3-dimethylthiourea inhibits the reaction [Superoxides results in increased expression of CCL2 mRNA] |
CTD |
PMID:8856246 PMID:19158351 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cd38 |
CD38 molecule |
affects localization multiple interactions |
ISO |
Superoxides affects the localization of CD38 protein tempol inhibits the reaction [Superoxides affects the localization of CD38 protein] |
CTD |
PMID:23940720 |
|
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
|
|
G |
Crp |
C-reactive protein |
multiple interactions |
EXP |
CRP protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] |
CTD |
PMID:9767445 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
|
|
G |
Cyba |
cytochrome b-245 alpha chain |
multiple interactions increases abundance |
ISO EXP |
CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides] CYBA protein results in increased abundance of Superoxides |
CTD |
PMID:10720412 PMID:14871555 PMID:20523355 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
|
|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
ISO |
CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein affects the reaction [Folic Acid deficiency results in increased chemical synthesis of Superoxides]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein promotes the reaction [[Doxorubicin co-treated with NADP] results in increased abundance of Superoxides] IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] |
CTD |
PMID:16354686 PMID:17275678 PMID:20116427 PMID:21647593 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases abundance |
ISO |
CYP1A1 protein results in increased abundance of Superoxides |
CTD |
PMID:20634294 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Dcxr |
dicarbonyl and L-xylulose reductase |
multiple interactions increases chemical synthesis |
ISO |
[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides; Diacetyl inhibits the reaction [[DCXR protein results in increased metabolism of Vitamin K 3] which results in increased chemical synthesis of Superoxides] DCXR protein results in increased chemical synthesis of Superoxides |
CTD |
PMID:28595002 |
|
NCBI chr10:106,006,404...106,008,293
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases abundance increases expression multiple interactions |
ISO |
DDIT3 protein results in increased abundance of Superoxides Superoxides results in increased expression of DDIT3 mRNA; Superoxides results in increased expression of DDIT3 protein [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein; [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein |
CTD |
PMID:16400006 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
|
|
G |
Edn1 |
endothelin 1 |
multiple interactions increases abundance |
EXP ISO |
[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides; Catechin inhibits the reaction [EDN1 protein results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides]; Polyphenols inhibits the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides] NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides] |
CTD |
PMID:20977430 PMID:23940720 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
|
|
G |
Ednra |
endothelin receptor type A |
affects abundance |
EXP |
EDNRA protein affects the abundance of Superoxides |
CTD |
PMID:12600921 |
|
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
|
|
G |
Ep300 |
E1A binding protein p300 |
decreases abundance |
ISO |
EP300 protein results in decreased abundance of Superoxides |
CTD |
PMID:25440059 |
|
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
|
|
G |
Epo |
erythropoietin |
multiple interactions |
ISO |
EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides] |
CTD |
PMID:25490417 |
|
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
|
|
G |
Ercc6 |
ERCC excision repair 6, chromatin remodeling factor |
multiple interactions decreases abundance increases abundance |
ISO |
3-aminobenzamide inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides]; NU 1025 inhibits the reaction [ERCC6 gene mutant form results in increased abundance of Superoxides] ERCC6 protein results in decreased abundance of Superoxides |
CTD |
PMID:25440059 |
|
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
|
|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
[4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol binds to and results in increased activity of ESR1 protein] which results in decreased abundance of Superoxides; [ESR1 protein results in increased susceptibility to Estradiol] which results in increased abundance of Superoxides; ESR1 protein affects the reaction [Estradiol results in decreased chemical synthesis of Superoxides] |
CTD |
PMID:18354059 PMID:23000059 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
multiple interactions increases abundance |
ISO |
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [FMR1 5' UTR mutant form results in increased abundance of Superoxides] |
CTD |
PMID:27385396 |
|
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Superoxides affects the reaction [Glucose results in increased expression of FN1 mRNA] |
CTD |
PMID:16572112 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA] |
CTD |
PMID:9067545 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO EXP |
SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] |
CTD |
PMID:11050244 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
|
|
G |
Gas5 |
growth arrest specific 5 |
increases expression |
ISO |
Superoxides results in increased expression of GAS5 mRNA; Superoxides results in increased expression of GAS5 protein |
CTD |
PMID:16400006 |
|
NCBI chr13:73,303,611...73,306,932
|
|
G |
Gch1 |
GTP cyclohydrolase 1 |
affects abundance |
ISO |
GCH1 protein affects the abundance of Superoxides |
CTD |
PMID:21963838 |
|
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
|
|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions decreases abundance increases abundance |
ISO EXP |
[[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides] HMOX1 protein results in decreased abundance of Superoxides [tetrathiomolybdate analog results in increased abundance of Superoxides] which results in increased reduction of HMOX1 protein [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [cobaltous chloride results in increased expression of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [tin mesoporphyrin results in decreased activity of HMOX1 protein] which results in increased abundance of Superoxides; Deferoxamine inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides]; zinc protoporphyrin inhibits the reaction [HMOX1 protein results in increased abundance of Superoxides] |
CTD |
PMID:15821039 PMID:16959961 PMID:18073186 PMID:18178725 PMID:18334666 PMID:19323979 More...
|
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hras |
HRas proto-oncogene, GTPase |
increases abundance multiple interactions |
ISO |
HRAS protein mutant form results in increased abundance of Superoxides [HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein |
CTD |
PMID:11313892 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
|
|
G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions decreases abundance |
ISO |
[tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of HSPB1 protein HSPB1 protein results in decreased abundance of Superoxides |
CTD |
PMID:14975446 PMID:19193722 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
|
|
G |
Ier3 |
immediate early response 3 |
affects chemical synthesis |
ISO |
IER3 protein affects the chemical synthesis of Superoxides |
CTD |
PMID:20713914 |
|
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
|
|
G |
Igf1 |
insulin-like growth factor 1 |
decreases abundance |
ISO |
IGF1 protein results in decreased abundance of Superoxides |
CTD |
PMID:22843358 |
|
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions increases abundance |
ISO |
diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; IL1B protein promotes the reaction [CYBB protein results in increased chemical synthesis of Superoxides] |
CTD |
PMID:16354686 PMID:21211511 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] |
CTD |
PMID:16238794 |
|
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
|
|
G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] |
CTD |
PMID:20457604 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
|
|
G |
Itga3 |
integrin subunit alpha 3 |
multiple interactions |
ISO |
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 protein |
CTD |
PMID:16400006 |
|
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
|
|
G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions |
ISO |
[DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 protein |
CTD |
PMID:16400006 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
EXP ISO |
Superoxides affects the reaction [Glucose results in increased phosphorylation of JUN protein] Superoxides results in increased expression of JUN mRNA SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA] |
CTD |
PMID:9067545 PMID:16572112 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Kat2a |
lysine acetyltransferase 2A |
decreases abundance |
ISO |
KAT2A protein results in decreased abundance of Superoxides |
CTD |
PMID:25440059 |
|
NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166
|
|
G |
Kat2b |
lysine acetyltransferase 2B |
decreases abundance |
ISO |
KAT2B protein results in decreased abundance of Superoxides |
CTD |
PMID:25440059 |
|
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
|
|
G |
Kdr |
kinase insert domain receptor |
increases phosphorylation |
ISO |
Superoxides results in increased phosphorylation of KDR protein |
CTD |
PMID:19571580 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
|
|
G |
Lep |
leptin |
multiple interactions increases abundance |
ISO |
acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides]; BQ 788 inhibits the reaction [LEP protein results in increased abundance of Superoxides]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein results in increased abundance of Superoxides] [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides |
CTD |
PMID:11342529 PMID:16380530 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Lepr |
leptin receptor |
multiple interactions increases abundance |
ISO |
acetovanillone inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides] |
CTD |
PMID:19478208 |
|
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK1 protein] Superoxides results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:16572112 PMID:19268487 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP ISO |
Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein] Superoxides results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:16572112 PMID:19268487 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
Superoxides results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:33290831 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
ISO |
Superoxides results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:33290831 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
[MPO protein results in increased oxidation of hydrazine] which results in increased chemical synthesis of Superoxides |
CTD |
PMID:26867495 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Mt3 |
metallothionein 3 |
decreases response to substance |
ISO |
MT3 protein results in decreased susceptibility to Superoxides |
CTD |
PMID:12383939 |
|
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
|
|
G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
NCF1 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] |
CTD |
PMID:17448908 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
|
|
G |
Ncf2 |
neutrophil cytosolic factor 2 |
multiple interactions |
EXP |
NCF2 protein affects the reaction [Lipopolysaccharides results in increased abundance of Superoxides] |
CTD |
PMID:17448908 |
|
NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[Ozone results in increased expression of NOS2 protein] which results in increased abundance of Superoxides |
CTD |
PMID:11919077 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions affects chemical synthesis decreases abundance increases abundance |
ISO EXP |
7,8-dihydrobiopterin promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; sapropterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides]; sapropterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein] NOS3 protein affects the chemical synthesis of Superoxides NOS3 protein results in decreased abundance of Superoxides [NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides; EPO protein inhibits the reaction [[NOS3 protein co-treated with sapropterin deficiency] results in increased chemical synthesis of Superoxides]; NOS3 protein affects the reaction [AGT protein results in increased abundance of Superoxides] [Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides]; NOS3 protein affects the reaction [[EDN1 protein co-treated with Calcimycin] results in increased abundance of Superoxides] |
CTD |
PMID:10625313 PMID:17272743 PMID:18714161 PMID:19011239 PMID:19696404 PMID:20977430 PMID:21300668 PMID:25490417 More...
|
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G |
Nox1 |
NADPH oxidase 1 |
multiple interactions increases abundance |
EXP ISO |
[Mevinphos results in increased activity of AGTR1A protein] promotes the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mRNA promotes the reaction [Tobacco Smoke Pollution results in increased chemical synthesis of Superoxides] diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]; NOX1 mutant form inhibits the reaction [EDN1 protein results in increased abundance of Superoxides] |
CTD |
PMID:23824088 PMID:23940720 PMID:24912985 PMID:27816504 |
|
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
|
|
G |
Nox3 |
NADPH oxidase 3 |
multiple interactions |
ISO |
[resveratrol results in decreased expression of and results in decreased activity of NOX3 protein] which results in decreased abundance of Superoxides |
CTD |
PMID:20675566 |
|
NCBI chr 1:44,238,012...44,302,851
Ensembl chr 1:44,236,992...44,302,851
|
|
G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
ISO |
NOX4 promotes the reaction [sodium arsenite results in increased abundance of Superoxides] |
CTD |
PMID:26535918 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
|
|
G |
Park7 |
Parkinsonism associated deglycase |
multiple interactions |
ISO |
PARK7 protein affects the reaction [Paraquat results in increased abundance of Superoxides] |
CTD |
PMID:21300143 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
|
|
G |
Pdha1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
affects abundance |
ISO |
PDHA1 protein affects the abundance of Superoxides |
CTD |
PMID:21846590 |
|
NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
|
|
G |
Pink1 |
PTEN induced kinase 1 |
affects abundance |
ISO |
PINK1 protein affects the abundance of Superoxides |
CTD |
PMID:21421046 |
|
NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
|
|
G |
Polg |
DNA polymerase gamma, catalytic subunit |
increases chemical synthesis multiple interactions |
ISO |
POLG gene mutant form results in increased chemical synthesis of Superoxides Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin inhibits the reaction [POLG protein results in increased chemical synthesis of Superoxides]; polyethylene glycol-superoxide dismutase inhibits the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides]; Rotenone promotes the reaction [POLG gene mutant form results in increased chemical synthesis of Superoxides] |
CTD |
PMID:30038268 |
|
NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
|
|
G |
Pomc |
proopiomelanocortin |
increases abundance |
EXP |
POMC protein results in increased abundance of Superoxides |
CTD |
PMID:16620303 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
|
|
G |
Pon2 |
paraoxonase 2 |
increases expression |
ISO |
Superoxides results in increased expression of PON2 protein |
CTD |
PMID:15544923 |
|
NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
|
|
G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
ISO |
[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; [POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides] [POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides] |
CTD |
PMID:21215309 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
|
|
G |
Prkca |
protein kinase C, alpha |
multiple interactions |
ISO |
[Ethanol results in increased localization of and results in increased activity of PRKCA protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] |
CTD |
PMID:10651808 |
|
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
|
|
G |
Prkcb |
protein kinase C, beta |
multiple interactions |
ISO |
[Ethanol results in increased localization of and results in increased activity of PRKCB protein] promotes the reaction [Tetradecanoylphorbol Acetate results in increased abundance of Superoxides] |
CTD |
PMID:10651808 |
|
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
resveratrol inhibits the reaction [Superoxides results in increased expression of PTGS2 protein] |
CTD |
PMID:10718345 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
ISO |
[resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides |
CTD |
PMID:21544240 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
|
|
G |
Selenoh |
selenoprotein H |
decreases abundance |
ISO |
SELENOH protein results in decreased abundance of Superoxides |
CTD |
PMID:17389926 |
|
NCBI chr 3:69,751,850...69,753,417
Ensembl chr 3:69,752,757...69,753,417
|
|
G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
[[Superoxides co-treated with Hydroxyl Radical] results in increased oxidation of LPA protein] which results in decreased secretion of SERPINE1 protein |
CTD |
PMID:11681624 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]] |
CTD |
PMID:18424637 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Slc25a14 |
solute carrier family 25 member 14 |
multiple interactions |
ISO |
SLC25A14 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased abundance of Superoxides]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides] |
CTD |
PMID:20600837 |
|
NCBI chr X:127,807,630...127,845,823
Ensembl chr X:127,807,449...127,845,823
|
|
G |
Smpd1 |
sphingomyelin phosphodiesterase 1 |
multiple interactions |
ISO |
SMPD1 protein affects the reaction [CBS protein affects the abundance of Superoxides] |
CTD |
PMID:23024785 |
|
NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
|
|
G |
Sod1 |
superoxide dismutase 1 |
increases abundance decreases abundance multiple interactions decreases chemical synthesis |
ISO |
SOD1 protein results in increased abundance of Superoxides SOD1 protein results in decreased abundance of Superoxides [[Chelating Agents binds to Copper] which affects the activity of SOD1 protein] which results in increased abundance of Superoxides; [tetrathiomolybdate results in decreased activity of SOD1 protein] which results in increased abundance of Superoxides; SOD1 protein inhibits the reaction [[spermine nitric oxide complex results in increased abundance of Nitric Oxide] which results in increased abundance of Superoxides]; SOD1 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] SOD1 protein results in decreased chemical synthesis of Superoxides [SOD1 protein results in decreased abundance of Superoxides] which results in increased expression of ACO1 protein; SOD1 protein inhibits the reaction [AGT protein results in increased abundance of Superoxides] |
CTD |
PMID:11756504 PMID:12489993 PMID:15364863 PMID:15829915 PMID:17391658 PMID:18480265 PMID:21443684 PMID:21900685 PMID:24363997 PMID:28542246 PMID:31162603 More...
|
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases metabolic processing affects metabolic processing decreases abundance multiple interactions increases expression affects abundance affects chemical synthesis |
ISO EXP |
SOD2 protein results in increased metabolism of Superoxides SOD2 protein polymorphism affects the metabolism of Superoxides SOD2 protein results in decreased abundance of Superoxides [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in decreased abundance of Superoxides] which results in decreased expression of SOD2 protein; SOD2 protein affects the reaction [Troglitazone results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [sodium arsenite results in increased abundance of Superoxides]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of FOS mRNA]; SOD2 protein inhibits the reaction [Superoxides results in increased expression of JUN mRNA] Superoxides results in increased expression of SOD2 protein [Rotenone results in increased abundance of Superoxides] which results in increased expression of SOD2 protein; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; SOD2 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] [SOD2 protein results in increased metabolism of Superoxides] which results in increased chemical synthesis of Hydrogen Peroxide; Tamoxifen inhibits the reaction [SOD2 protein affects the abundance of Superoxides] SOD2 protein affects the chemical synthesis of Superoxides |
CTD |
PMID:1850207 PMID:9067545 PMID:11050244 PMID:16179351 PMID:17150972 PMID:17901229 PMID:18594523 PMID:19193722 PMID:19265433 PMID:20304815 PMID:20638473 PMID:25561743 PMID:26108578 PMID:28495429 PMID:32243540 More...
|
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sod3 |
superoxide dismutase 3 |
multiple interactions |
ISO |
[ATP7A protein results in increased activity of SOD3 protein] which results in decreased chemical synthesis of Superoxides; [Streptozocin results in decreased activity of SOD3 protein] which results in increased chemical synthesis of Superoxides; SOD3 gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; SOD3 protein inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] |
CTD |
PMID:16864745 PMID:23884884 |
|
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
|
|
G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions increases secretion increases abundance |
EXP ISO |
Superoxides affects the reaction [Glucose results in increased expression of TGFB1 mRNA] Superoxides results in increased secretion of TGFB1 protein [[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; CAT protein inhibits the reaction [Superoxides results in increased secretion of TGFB1 protein] TGFB1 protein results in increased abundance of Superoxides |
CTD |
PMID:12606818 PMID:16572112 PMID:19268487 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions affects abundance decreases abundance increases abundance |
ISO |
[HRAS protein mutant form results in increased abundance of Superoxides] which results in decreased susceptibility to TNF protein; [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; [TNF protein results in increased expression of SOD2 protein] which results in decreased susceptibility to Superoxides; acetovanillone inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Acetylcysteine inhibits the reaction [TNF protein results in increased abundance of Superoxides]; cobaltiprotoporphyrin inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides] TNF protein affects the abundance of Superoxides TNF gene mutant form results in decreased abundance of Superoxides TNF protein inhibits the reaction [Dichloroacetic Acid results in increased abundance of Superoxides] |
CTD |
PMID:1850207 PMID:11121130 PMID:11313892 PMID:15450858 PMID:19478208 PMID:19608869 PMID:21211511 More...
|
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G |
Txn1 |
thioredoxin 1 |
multiple interactions |
EXP |
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] |
CTD |
PMID:20457604 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
|
|
G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
EXP |
[TXN1 protein co-treated with INS1 protein] inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; [TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dinitrochlorobenzene promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; formic acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Oxygen deficiency inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Pentetic Acid promotes the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Sodium Selenite inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides] |
CTD |
PMID:20457604 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
|
|
G |
Ucp1 |
uncoupling protein 1 |
multiple interactions |
EXP |
UCP1 protein inhibits the reaction [[Glucose results in increased chemical synthesis of Superoxides] which results in decreased activity of GAPDH protein] |
CTD |
PMID:11050244 |
|
NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
|
|
G |
Ucp2 |
uncoupling protein 2 |
multiple interactions decreases abundance |
EXP ISO |
[[benzo(a)pyrene-1,6-quinone results in increased abundance of Superoxides] co-treated with [benzo(a)pyrene-1,6-quinone results in decreased abundance of Hydrogen Peroxide]] results in increased expression of UCP2 mRNA UCP2 protein results in decreased abundance of Superoxides |
CTD |
PMID:10860543 PMID:25440059 |
|
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
|
|
G |
Vav2 |
vav guanine nucleotide exchange factor 2 |
multiple interactions increases abundance |
ISO |
2-acetylphenothiazine inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides] |
CTD |
PMID:23940720 |
|
NCBI chr 3:10,584,688...10,754,128
Ensembl chr 3:10,584,688...10,754,052
|
|
G |
Vdr |
vitamin D receptor |
decreases abundance |
ISO |
VDR protein results in decreased abundance of Superoxides |
CTD |
PMID:25201890 |
|
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
|
|
G |
Xdh |
xanthine dehydrogenase |
multiple interactions increases chemical synthesis |
ISO |
[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein; CAT protein inhibits the reaction [[[Xanthine co-treated with XDH protein] results in increased abundance of Superoxides] which results in increased secretion of TGFB1 protein]; taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides] |
CTD |
PMID:19268487 PMID:19555678 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
|
|