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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-methyl-L-dopa
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Accession:CHEBI:61058 term browser browse the term
Definition:A derivative of L-tyrosine having a methyl group at the α-position and an additional hydroxy group at the 3-position on the phenyl ring.
Synonyms:related_synonym: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;   (S)-(-)-alpha-Methyldopa;   3-Hydroxy-alpha-methyl-L-tyrosine;   AMD;   Alpha medopa;   Alphamethyldopa;   L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine;   L-(alpha-Md);   L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid;   L-alpha-Methyl-3,4-dihydroxyphenylalanine;   L-alpha-Methyldopa;   Methyl-L-dopa;   Methyldopa anhydrous;   alpha-Methyl dopa;   alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine;   alpha-Methyldihydroxyphenylalanine;   alpha-Methyldopa;   l-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   methyldopa;   methyldopum;   metildopa
 xref: CAS:555-30-6;   DrugBank:DB00968;   HMDB:HMDB0011754
 xref_mesh: MESH:D008750
 xref: Reaxys:2807721;   drugcentral:1762;   kegg.compound:C07194;   kegg.drug:D08205;   lincs.smallmolecule:LSM-5596;   pubmed:10576686;   pubmed:11901210;   pubmed:29438107;   pubmed:8301021;   wikipedia.en:Methyldopa
 chemrof_formula: C10H13NO4
 chemrof_inchikey: CJCSPKMFHVPWAR-JTQLQIEISA-N
 chemrof_smiles: C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O
 chemrof_inchi: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1


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alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity 		ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein 		CTD PMID:7053299 PMID:11160877 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Prl prolactin increases expression
increases secretion 		ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein 		CTD PMID:1867878 PMID:7265421 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        hapten 3059
          alpha-methyl-L-dopa 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbon oxoacid 17678
                                    carboxylic acid 17675
                                      amino acid 7910
                                        alpha-amino acid 6187
                                          L-alpha-amino acid 5685
                                            non-proteinogenic L-alpha-amino acid 2927
                                              alpha-methyl-L-dopa 6
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