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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-methyl-L-dopa
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Accession:CHEBI:61058 term browser browse the term
Definition:A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.
Synonyms:related_synonym: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;   (S)-(-)-alpha-Methyldopa;   3-Hydroxy-alpha-methyl-L-tyrosine;   AMD;   Alpha medopa;   Alphamethyldopa;   Formula=C10H13NO4;   InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1;   InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N;   L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine;   L-(alpha-Md);   L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid;   L-alpha-Methyl-3,4-dihydroxyphenylalanine;   L-alpha-Methyldopa;   Methyl-L-dopa;   Methyldopa anhydrous;   SMILES=C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O;   alpha-Methyl dopa;   alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine;   alpha-Methyldihydroxyphenylalanine;   alpha-Methyldopa;   l-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   methyldopa;   methyldopum;   metildopa
 xref: CAS:555-30-6;   DrugBank:DB00968;   Drug_Central:1762;   HMDB:HMDB0011754;   KEGG:C07194;   KEGG:D08205;   LINCS:LSM-5596
 xref_mesh: MESH:D008750
 xref: PMID:10576686;   PMID:11901210;   PMID:29438107;   PMID:8301021;   Reaxys:2807721;   Wikipedia:Methyldopa


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alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity		 ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein		 CTD PMID:7053299 PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Prl prolactin increases expression
increases secretion		 ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein		 CTD PMID:1867878 PMID:7265421 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        hapten 3058
          alpha-methyl-L-dopa 6
            3-methoxy-alpha-methyl-L-tyrosine 0
            alpha-methyl-L-dopa ethyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    monocyclic hydrocarbon 6164
                                      annulene 5817
                                        aromatic annulene 5817
                                          benzene 5817
                                            alkylbenzene 3538
                                              methylbenzene 3392
                                                toluene 3264
                                                  benzyl group 2674
                                                    phenylalanine 2674
                                                      phenylalanine derivative 2636
                                                        tyrosine derivative 463
                                                          L-tyrosine derivative 6
                                                            alpha-methyl-L-dopa 6
                                                              3-methoxy-alpha-methyl-L-tyrosine 0
                                                              alpha-methyl-L-dopa ethyl ester 0
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