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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tacrolimus hydrate
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Accession:CHEBI:61057 term browser browse the term
Definition:A hydrate that is the monohydrate form of tacrolimus.
Synonyms:exact_synonym: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone--water (1/1)
 related_synonym: (-)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate;   Formula=C44H71NO13;   InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1;   InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N;   Prograf;   Protopic;   SMILES=O.CO[C@@H]1C[C@@H](CC[C@H]1O)\\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)C\\C(C)=C\\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC;   tacrolimus;   tacrolimus monohydrate;   tsukubaenolide hydrate
 xref: CAS:109581-93-3;   DrugBank:DB00864;   KEGG:D00107
 xref_mesh: MESH:D016559
 xref: Reaxys:6265275


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tacrolimus hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Tacrolimus results in increased expression of A2M mRNA CTD PMID:21865292 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO
EXP		 [Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein
Tacrolimus results in increased expression of ABCA1 mRNA		 CTD PMID:17016853 PMID:21865292 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Tacrolimus results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects export
affects response to substance
increases export
increases response to substance
multiple interactions
decreases activity		 ISO ABCB1 protein affects the export of Tacrolimus
ABCB1 protein affects the susceptibility to Tacrolimus
ABCB1 protein results in increased export of Tacrolimus
ABCB1 gene SNP results in increased susceptibility to Tacrolimus
[Tacrolimus binds to ABCB1 protein] inhibits the reaction [azidoprazosin binds to ABCB1 protein]; [Tacrolimus results in decreased activity of ABCB1 protein] which results in decreased export of Dexamethasone; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]		 CTD PMID:1381629 PMID:11920757 PMID:12352921 PMID:15919446 PMID:15964336 More... NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Tacrolimus results in decreased expression of ACAA1B mRNA CTD PMID:25270620 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO Tacrolimus results in decreased expression of ACADL mRNA CTD PMID:25270620 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression EXP Tacrolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:15207740 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Tacrolimus results in increased expression of ACTA2 protein CTD PMID:29362864 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Acvr1b activin A receptor type 1B multiple interactions ISO [Tacrolimus inhibits the reaction [FKBP1A protein binds to ACVR1B protein]] which results in decreased ubiquitination of ACVR1B protein; Tacrolimus inhibits the reaction [FKBP1A protein binds to and results in decreased activity of ACVR1B protein]; Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]] CTD PMID:16720724 NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Tacrolimus results in increased expression of ADAMTS1 mRNA CTD PMID:21865292 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 increases expression ISO Tacrolimus results in increased expression of ADAMTS2 mRNA CTD PMID:29362864 NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821 		JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions ISO Tacrolimus inhibits the reaction [Calcium inhibits the reaction [Miconazole results in increased activity of ADCY9 protein]] CTD PMID:30607468 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Adra1d adrenoceptor alpha 1D increases expression EXP Tacrolimus results in increased expression of ADRA1D mRNA CTD PMID:21865292 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression ISO Tacrolimus results in increased expression of AIF1 mRNA CTD PMID:29362864 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Tacrolimus results in decreased expression of ALDH1A1 mRNA CTD PMID:25270620 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression ISO Tacrolimus results in decreased expression of ALDH2 mRNA CTD PMID:25270620 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression ISO Tacrolimus results in decreased expression of ALDH9A1 mRNA CTD PMID:25270620 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568 		JBrowse link
G Alg3 ALG3, alpha-1,3- mannosyltransferase decreases expression ISO Tacrolimus results in decreased expression of ALG3 mRNA CTD PMID:25270620 NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912 		JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Tacrolimus results in increased expression of ANGPTL6 mRNA CTD PMID:21865292 NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Tacrolimus results in increased expression of ANKRD1 mRNA CTD PMID:29362864 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Ankrd34a ankyrin repeat domain 34A decreases expression ISO Tacrolimus results in decreased expression of ANKRD34A mRNA CTD PMID:25270620 NCBI chr 2:184,129,830...184,135,075
Ensembl chr 2:184,129,238...184,135,116 		JBrowse link
G Anpep alanyl aminopeptidase, membrane increases secretion EXP Tacrolimus results in increased secretion of ANPEP protein CTD PMID:7514309 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Anxa1 annexin A1 increases expression EXP Tacrolimus results in increased expression of ANXA1 CTD PMID:20484890 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases expression ISO Tacrolimus results in increased expression of AOC1 mRNA CTD PMID:29362864 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Areg amphiregulin increases expression EXP Tacrolimus results in increased expression of AREG mRNA CTD PMID:21865292 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arfrp1 ADP-ribosylation factor related protein 1 increases expression ISO Tacrolimus results in increased expression of ARFRP1 mRNA CTD PMID:25270620 NCBI chr 3:168,466,351...168,473,960
Ensembl chr 3:168,466,496...168,473,914 		JBrowse link
G Arhgap45 Rho GTPase activating protein 45 increases expression ISO Tacrolimus results in increased expression of ARHGAP45 mRNA CTD PMID:21621594 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268 		JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 increases expression ISO Tacrolimus results in increased expression of ARHGEF11 mRNA CTD PMID:29380240 NCBI chr 2:173,074,383...173,195,962
Ensembl chr 2:173,074,368...173,196,010 		JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 increases expression ISO Tacrolimus results in increased expression of ARPC5 mRNA CTD PMID:29380240 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410 		JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator increases expression ISO Tacrolimus results in increased expression of ARV1 mRNA CTD PMID:25270620 NCBI chr19:52,692,337...52,704,156
Ensembl chr19:52,692,337...52,704,156 		JBrowse link
G Asxl3 ASXL transcriptional regulator 3 decreases expression ISO Tacrolimus results in decreased expression of ASXL3 mRNA CTD PMID:29362864 NCBI chr18:13,593,529...13,766,324
Ensembl chr18:13,593,985...13,762,427 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Tacrolimus results in increased expression of ATF3 mRNA CTD PMID:23958496 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Tacrolimus results in increased expression of ATF4 mRNA CTD PMID:23958496 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Tacrolimus results in increased expression of ATF6 mRNA CTD PMID:23958496 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression ISO Tacrolimus results in decreased expression of ATP1B1 mRNA CTD PMID:25270620 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO Tacrolimus results in decreased expression of ATP1B3 mRNA CTD PMID:25270620 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO Tacrolimus results in increased expression of ATP2A2 mRNA CTD PMID:25270620 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G B2m beta-2 microglobulin increases expression ISO Tacrolimus results in increased expression of B2M mRNA CTD PMID:29362864 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP
ISO		 Tacrolimus inhibits the reaction [Ammonium Chloride results in decreased phosphorylation of BAD protein]
Tacrolimus inhibits the reaction [Rotenone results in decreased phosphorylation of BAD protein]		 CTD PMID:15036616 PMID:15280438 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Batf3 basic leucine zipper ATF-like transcription factor 3 increases expression ISO Tacrolimus results in increased expression of BATF3 mRNA CTD PMID:29362864 NCBI chr13:102,689,657...102,701,241
Ensembl chr13:102,689,657...102,701,139 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BAX protein
Tacrolimus results in increased expression of BAX protein		 CTD PMID:10205001 PMID:15571979 PMID:27606422 PMID:35033536 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO
EXP		 Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein]
Tacrolimus results in increased expression of BCL2 protein
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BCL2 protein
Tacrolimus results in decreased expression of BCL2 protein		 CTD PMID:10205001 PMID:15571979 PMID:27606422 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Tacrolimus inhibits the reaction [Superantigens results in increased expression of BCL2L1 protein] CTD PMID:10532544 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Tacrolimus results in increased expression of BCL3 mRNA CTD PMID:23958496 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Tacrolimus inhibits the reaction [decamethrin results in increased expression of BDNF exon]; Tacrolimus promotes the reaction [U 0126 inhibits the reaction [decamethrin results in increased expression of BDNF exon]]; U 0126 promotes the reaction [Tacrolimus inhibits the reaction [decamethrin results in increased expression of BDNF exon]] CTD PMID:22079160 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Tacrolimus results in increased expression of BIRC3 mRNA CTD PMID:21865292 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Tacrolimus results in decreased expression of BIRC5 mRNA CTD PMID:16574167 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions
decreases expression		 EXP Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]; valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Tacrolimus results in increased expression of BTG2 mRNA CTD PMID:21865292 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Btnl9 butyrophilin-like 9 decreases expression ISO Tacrolimus results in decreased expression of BTNL9 mRNA CTD PMID:29362864 NCBI chr10:33,466,059...33,489,229
Ensembl chr10:33,470,536...33,489,025 		JBrowse link
G C1qa complement C1q A chain increases expression ISO Tacrolimus results in increased expression of C1QA mRNA CTD PMID:29362864 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain increases expression ISO Tacrolimus results in increased expression of C1QB mRNA CTD PMID:29362864 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain increases expression ISO Tacrolimus results in increased expression of C1QC mRNA CTD PMID:29362864 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C2 complement C2 increases expression EXP Tacrolimus results in increased expression of C2 mRNA CTD PMID:21865292 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 increases expression EXP
ISO		 Tacrolimus results in increased expression of C3 mRNA CTD PMID:21865292 PMID:29362864 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4b complement C4B increases expression EXP Tacrolimus results in increased expression of C4B mRNA CTD PMID:21865292 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Calb1 calbindin 1 decreases expression EXP Tacrolimus results in decreased expression of CALB1 mRNA; Tacrolimus results in decreased expression of CALB1 protein CTD PMID:14978156 PMID:21865292 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Calcr calcitonin receptor multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Calr calreticulin increases expression ISO Tacrolimus results in increased expression of CALR mRNA CTD PMID:25270620 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Tacrolimus results in increased expression of CAMK1D mRNA CTD PMID:23958496 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556 		JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Tacrolimus results in increased expression of CAPG mRNA CTD PMID:21865292 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
Tacrolimus results in increased activity of CASP3 protein
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
MK0626 inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; NGF protein inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Tacrolimus results in increased cleavage of CASP3 protein		 CTD PMID:10205001 PMID:12642403 PMID:12871656 PMID:12892836 PMID:15207740 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein]
Tacrolimus results in increased expression of CASP8 protein		 CTD PMID:15548389 PMID:27606422 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP9 protein]
Tacrolimus results in increased expression of CASP9 protein		 CTD PMID:15548389 PMID:27606422 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases expression
decreases response to substance		 EXP
ISO		 Tacrolimus results in increased expression of CAT protein
CAT protein results in decreased susceptibility to Tacrolimus		 CTD PMID:14675044 PMID:18766458 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbll1 Cbl proto-oncogene like 1 increases expression ISO Tacrolimus results in increased expression of CBLL1 mRNA CTD PMID:21621594 NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444 		JBrowse link
G Ccdc88b coiled-coil domain containing 88B increases expression ISO Tacrolimus results in increased expression of CCDC88B mRNA CTD PMID:29362864 NCBI chr 1:204,036,913...204,052,878
Ensembl chr 1:204,036,918...204,052,970 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Tacrolimus results in decreased expression of CCL11 mRNA CTD PMID:15948978 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Tacrolimus results in increased expression of CCL17 mRNA CTD PMID:29362864 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 EXP
ISO		 pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; 7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; sulforaphane inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
Tacrolimus inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]		 CTD PMID:12472797 PMID:23958496 PMID:29362864 PMID:36416909 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Tacrolimus results in increased expression of CCL20 mRNA CTD PMID:23958496 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Tacrolimus inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:36416909 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
multiple interactions
increases expression		 ISO Tacrolimus results in decreased expression of CCL5 mRNA
7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; sulforaphane inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]		 CTD PMID:15948978 PMID:23958496 PMID:25270620 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Tacrolimus results in increased expression of CCL7 mRNA CTD PMID:23958496 PMID:29362864 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression EXP
ISO		 Tacrolimus results in increased expression of CCL6 mRNA CTD PMID:21865292 PMID:29362864 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Tacrolimus inhibits the reaction [Paraquat results in increased expression of CCN2 mRNA]; Tacrolimus inhibits the reaction [Paraquat results in increased secretion of CCN2 protein] CTD PMID:33000210 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO Tacrolimus results in increased expression of CCNA2 mRNA CTD PMID:29362864 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb2 cyclin B2 decreases expression
increases expression		 ISO Tacrolimus results in decreased expression of CCNB2 mRNA
Tacrolimus results in increased expression of CCNB2 mRNA		 CTD PMID:16574167 PMID:29362864 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Tacrolimus results in increased expression of CCR2 mRNA CTD PMID:29362864 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO Tacrolimus results in decreased expression of CCR3 mRNA CTD PMID:15948978 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 increases expression ISO Tacrolimus results in increased expression of CCRL2 mRNA CTD PMID:23958496 NCBI chr 8:111,034,279...111,036,914
Ensembl chr 8:111,034,279...111,036,664 		JBrowse link
G Cd2 Cd2 molecule multiple interactions ISO Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein] CTD PMID:1705513 NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026 		JBrowse link
G Cd44 CD44 molecule increases expression EXP Tacrolimus results in increased expression of CD44 mRNA CTD PMID:21865292 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd68 Cd68 molecule increases expression EXP Tacrolimus results in increased expression of CD68 mRNA CTD PMID:21865292 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd74 CD74 molecule increases expression ISO Tacrolimus results in increased expression of CD74 mRNA CTD PMID:23958496 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd80 Cd80 molecule decreases expression ISO Tacrolimus results in decreased expression of CD80 protein CTD PMID:15241357 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd83 CD83 molecule increases expression ISO Tacrolimus results in increased expression of CD83 mRNA CTD PMID:29362864 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule decreases expression ISO Tacrolimus results in decreased expression of CD86 protein CTD PMID:15241357 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO Tacrolimus results in increased expression of CDCA3 mRNA CTD PMID:29362864 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799 		JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Tacrolimus results in increased expression of CDCA5 mRNA CTD PMID:29362864 NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023 		JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO Tacrolimus results in increased expression of CDCA8 mRNA CTD PMID:29362864 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Tacrolimus results in decreased expression of CDH1 protein CTD PMID:22416070 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh11 cadherin 11 increases expression ISO Tacrolimus results in increased expression of CDH11 mRNA CTD PMID:29362864 NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272 		JBrowse link
G Cdh16 cadherin 16 decreases expression ISO Tacrolimus results in decreased expression of CDH16 mRNA CTD PMID:22416070 NCBI chr19:360,824...371,008
Ensembl chr19:360,824...371,007 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Tacrolimus results in increased expression of CDKN1B mRNA CTD PMID:21865292 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO Tacrolimus results in increased expression of CEBPA mRNA CTD PMID:29362864 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cenpw centromere protein W increases expression ISO Tacrolimus results in increased expression of CENPW mRNA CTD PMID:29362864 NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464 		JBrowse link
G Cfi complement factor I increases expression EXP Tacrolimus results in increased expression of CFI mRNA CTD PMID:21865292 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression ISO Tacrolimus results in increased expression of CKAP2 mRNA CTD PMID:29362864 NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913 		JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Tacrolimus results in increased expression of CKAP4 mRNA CTD PMID:21865292 NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO Tacrolimus results in decreased expression of CLDN1 mRNA CTD PMID:22416070 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724 		JBrowse link
G Cldn4 claudin 4 increases expression EXP Tacrolimus results in increased expression of CLDN4 mRNA CTD PMID:21865292 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436 		JBrowse link
G Cldn7 claudin 7 increases expression EXP Tacrolimus results in increased expression of CLDN7 mRNA CTD PMID:21865292 NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171 		JBrowse link
G Clec7a C-type lectin domain containing 7A increases expression ISO Tacrolimus results in increased expression of CLEC7A mRNA CTD PMID:29362864 NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897 		JBrowse link
G Clk3 CDC-like kinase 3 increases expression ISO Tacrolimus results in increased expression of CLK3 mRNA CTD PMID:25270620 NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181 		JBrowse link
G Clu clusterin increases expression EXP Tacrolimus results in increased expression of CLU mRNA CTD PMID:21865292 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Coch cochlin increases expression ISO Tacrolimus results in increased expression of COCH mRNA CTD PMID:25270620 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Tacrolimus results in increased expression of COL1A1 mRNA CTD PMID:29362864 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Tacrolimus results in increased expression of COL1A2 mRNA CTD PMID:29362864 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Tacrolimus results in increased expression of COL3A1 mRNA CTD PMID:29362864 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cops8 COP9 signalosome subunit 8 increases expression ISO Tacrolimus results in increased expression of COPS8 mRNA CTD PMID:25270620 NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258 		JBrowse link
G Cp ceruloplasmin increases expression EXP Tacrolimus results in increased expression of CP mRNA CTD PMID:21865292 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 decreases expression ISO Tacrolimus results in decreased expression of CREB3L3 mRNA CTD PMID:25270620 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression ISO Tacrolimus results in increased expression of CRELD2 mRNA CTD PMID:25270620 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO Tacrolimus results in increased expression of CSF1 mRNA CTD PMID:23958496 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
multiple interactions
increases expression		 ISO Tacrolimus results in decreased expression of CSF2 protein
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CSF2 protein]]; Tacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CSF2 protein]
Tacrolimus results in increased expression of CSF2 mRNA		 CTD PMID:1376361 PMID:11407316 PMID:23958496 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Tacrolimus results in increased expression of CSF2RB2 mRNA CTD PMID:29362864 NCBI chr 7:109,876,919...109,901,589
Ensembl chr 7:109,886,425...109,904,157 		JBrowse link
G Ctsl cathepsin L multiple interactions
increases expression		 ISO
EXP		 Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSL protein]
Tacrolimus results in increased expression of CTSL mRNA		 CTD PMID:18172886 PMID:21865292 PMID:25270620 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP
ISO		 Tacrolimus results in increased expression of CXCL10 mRNA CTD PMID:21865292 PMID:23958496 PMID:25270620 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Tacrolimus results in increased expression of CXCL11 mRNA CTD PMID:23958496 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression		 ISO Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA] CTD PMID:12352326 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP Tacrolimus results in increased expression of CYP27B1 mRNA CTD PMID:21865292 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus] CTD PMID:15010519 PMID:15285851 PMID:17377957 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
decreases methylation
affects metabolic processing		 ISO CYP3A4 protein results in increased metabolism of Tacrolimus
Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus]
CYP3A4 protein results in decreased methylation of Tacrolimus
CYP3A4 protein affects the metabolism of Tacrolimus		 CTD PMID:15010519 PMID:15855244 PMID:15919446 PMID:15951320 PMID:15964336 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects response to substance
affects metabolic processing
decreases methylation		 ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]; CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]
CYP3A5 gene affects the susceptibility to Tacrolimus; CYP3A5 polymorphism affects the susceptibility to Tacrolimus
CYP3A5 gene polymorphism affects the metabolism of Tacrolimus; CYP3A5 gene SNP affects the metabolism of Tacrolimus; CYP3A5 protein affects the metabolism of Tacrolimus; CYP3A5 protein polymorphism affects the metabolism of Tacrolimus
CYP3A5 protein results in decreased methylation of Tacrolimus		 CTD PMID:15502717 PMID:15723604 PMID:15729180 PMID:15808586 PMID:15919447 More... NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dcn decorin increases expression ISO Tacrolimus results in increased expression of DCN mRNA CTD PMID:29362864 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein]
Tacrolimus results in increased expression of DDIT3 mRNA		 CTD PMID:23958496 PMID:25270620 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like decreases expression EXP Tacrolimus results in decreased expression of DDIT4L mRNA CTD PMID:21865292 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Tacrolimus results in decreased expression of DHCR24 mRNA CTD PMID:25270620 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dnajc30 DnaJ heat shock protein family (Hsp40) member C30 decreases expression ISO Tacrolimus results in decreased expression of DNAJC30 mRNA CTD PMID:25270620 NCBI chr12:21,628,319...21,629,398
Ensembl chr12:21,626,450...21,629,408 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein]
Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]		 CTD PMID:19492085 PMID:26318285 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Doc2a double C2 domain alpha decreases expression ISO Tacrolimus results in decreased expression of DOC2A mRNA CTD PMID:25270620 NCBI chr 1:181,457,415...181,462,528
Ensembl chr 1:181,458,390...181,462,030 		JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Tacrolimus results in increased expression of DOCK10 mRNA CTD PMID:29362864 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases activity
multiple interactions		 EXP Tacrolimus results in increased activity of DPP4 protein
MK0626 inhibits the reaction [Tacrolimus results in increased activity of DPP4 protein]		 CTD PMID:24959755 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901 		JBrowse link
G Drd2 dopamine receptor D2 affects activity
multiple interactions		 EXP Tacrolimus affects the activity of DRD2 protein
Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]		 CTD PMID:15332494 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression ISO Tacrolimus results in decreased expression of ECH1 mRNA CTD PMID:25270620 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Tacrolimus results in increased expression of EDEM1 mRNA CTD PMID:25270620 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edn1 endothelin 1 increases expression EXP Tacrolimus results in increased expression of EDN1 mRNA; Tacrolimus results in increased expression of EDN1 protein CTD PMID:9517403 PMID:9931093 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A increases activity
increases expression		 EXP Tacrolimus results in increased activity of EDNRA protein
Tacrolimus results in increased expression of EDNRA mRNA		 CTD PMID:8587392 PMID:15964565 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 increases expression ISO Tacrolimus results in increased expression of EFEMP2 mRNA CTD PMID:29362864 NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Tacrolimus results in increased expression of EGR1 mRNA CTD PMID:21865292 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 increases expression EXP Tacrolimus results in increased expression of EGR2 mRNA CTD PMID:21865292 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Tacrolimus inhibits the reaction [Sirolimus results in decreased phosphorylation of and results in increased activity of EIF4EBP1 protein] CTD PMID:8599949 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elac2 elaC ribonuclease Z 2 decreases expression ISO Tacrolimus results in decreased expression of ELAC2 mRNA CTD PMID:25270620 NCBI chr10:49,632,308...49,655,614
Ensembl chr10:49,632,378...49,655,614 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of ERN1 protein CTD PMID:23958496 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Tacrolimus results in increased expression of ERO1A mRNA CTD PMID:23958496 NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478 		JBrowse link
G Exosc4 exosome component 4 decreases expression ISO Tacrolimus results in decreased expression of EXOSC4 mRNA CTD PMID:25270620 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO Tacrolimus results in decreased expression of F2R mRNA CTD PMID:25270620 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870 		JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression ISO Tacrolimus results in decreased expression of FABP2 mRNA CTD PMID:25270620 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP9 protein] CTD PMID:15548389 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand decreases secretion ISO Tacrolimus results in decreased secretion of FASLG protein CTD PMID:11692113 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbln1 fibulin 1 increases expression EXP Tacrolimus results in increased expression of FBLN1 mRNA CTD PMID:21865292 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Tacrolimus results in increased expression of FGA mRNA CTD PMID:21865292 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Tacrolimus results in increased expression of FGB mRNA CTD PMID:21865292 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgd2 FYVE, RhoGEF and PH domain containing 2 increases expression ISO Tacrolimus results in increased expression of FGD2 mRNA CTD PMID:29362864 NCBI chr20:7,424,795...7,441,603
Ensembl chr20:7,424,790...7,441,603 		JBrowse link
G Fgf21 fibroblast growth factor 21 decreases expression ISO Tacrolimus results in decreased expression of FGF21 mRNA CTD PMID:25270620 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fgl2 fibrinogen-like 2 increases expression EXP
ISO		 Tacrolimus results in increased expression of FGL2 mRNA CTD PMID:21865292 PMID:29362864 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Tacrolimus results in increased expression of FHL2 mRNA CTD PMID:29362864 NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions
increases expression		 ISO
EXP		 [Tacrolimus binds to FKBP1A protein] inhibits the reaction [Sirolimus binds to FKBP1A protein]; [Tacrolimus inhibits the reaction [FKBP1A protein binds to ACVR1B protein]] which results in decreased ubiquitination of ACVR1B protein; Tacrolimus inhibits the reaction [FKBP1A protein binds to and results in decreased activity of ACVR1B protein]; Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]
Tacrolimus results in increased expression of FKBP1A protein		 CTD PMID:10361256 PMID:11041285 PMID:16720724 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Tacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein] CTD PMID:15697228 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 increases expression ISO Tacrolimus results in increased expression of FLT3 mRNA CTD PMID:29362864 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO Tacrolimus results in increased expression of FMO2 mRNA CTD PMID:21621594 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression		 ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of FN1 mRNA]
Tacrolimus results in increased expression of FN1 mRNA		 CTD PMID:15939815 PMID:29362864 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fndc3a fibronectin type III domain containing 3a increases expression ISO Tacrolimus results in increased expression of FNDC3A mRNA CTD PMID:25270620 NCBI chr15:47,689,909...47,867,354
Ensembl chr15:47,689,919...47,866,784 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of FOS mRNA CTD PMID:23958496 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of FOSL1 mRNA CTD PMID:23958496 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Tacrolimus results in decreased expression of GBP1 mRNA CTD PMID:21621594 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131 		JBrowse link
G Gc GC, vitamin D binding protein decreases expression
increases expression		 EXP
ISO		 Tacrolimus results in decreased expression of GC mRNA
Tacrolimus results in increased expression of GC mRNA		 CTD PMID:21865292 PMID:29362864 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gcg glucagon multiple interactions
decreases secretion		 EXP MK0626 inhibits the reaction [Tacrolimus results in decreased secretion of GCG protein modified form] CTD PMID:24959755 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gins2 GINS complex subunit 2 increases expression ISO Tacrolimus results in increased expression of GINS2 mRNA CTD PMID:29362864 NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339 		JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO Tacrolimus results in increased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925 		JBrowse link
G Gldc glycine decarboxylase decreases expression ISO Tacrolimus results in decreased expression of GLDC mRNA CTD PMID:25270620 NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor decreases expression
multiple interactions		 EXP Tacrolimus results in decreased expression of GLP1R protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of GLP1R protein]		 CTD PMID:24959755 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO Tacrolimus results in decreased expression of GPIHBP1 mRNA CTD PMID:29362864 NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702 		JBrowse link
G Gpn2 GPN-loop GTPase 2 increases expression ISO Tacrolimus results in increased expression of GPN2 mRNA CTD PMID:25270620 NCBI chr 5:145,809,455...145,817,252
Ensembl chr 5:145,809,651...145,817,252 		JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Tacrolimus results in increased expression of GPNMB mRNA CTD PMID:21865292 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367 		JBrowse link
G Grn granulin precursor increases expression ISO Tacrolimus results in increased expression of GRN mRNA CTD PMID:25270620 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases phosphorylation		 ISO [GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]
Tacrolimus results in increased phosphorylation of GSK3A protein		 CTD PMID:22416070 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 ISO [GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]
Tacrolimus results in increased phosphorylation of GSK3B protein		 CTD PMID:22416070 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression EXP Tacrolimus results in decreased expression of GTPBP4 mRNA CTD PMID:21865292 NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009 		JBrowse link
G Guca2a guanylate cyclase activator 2A increases expression EXP Tacrolimus results in increased expression of GUCA2A mRNA CTD PMID:21865292 NCBI chr 5:133,237,177...133,239,019
Ensembl chr 5:133,237,177...133,239,018 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Tacrolimus results in decreased expression of HADHB mRNA CTD PMID:25270620 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Tacrolimus results in increased expression of HAVCR1 mRNA CTD PMID:21865292 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Tacrolimus results in increased expression of HERPUD1 mRNA CTD PMID:23958496 PMID:25270620 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hexa hexosaminidase subunit alpha increases expression ISO Tacrolimus results in increased expression of HEXA mRNA CTD PMID:25270620 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate increases expression ISO Tacrolimus results in increased expression of HGS mRNA CTD PMID:29380240 NCBI chr10:105,739,617...105,757,838
Ensembl chr10:105,739,296...105,757,835 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO Tacrolimus results in increased expression of HK2 mRNA CTD PMID:29362864 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hk3 hexokinase 3 increases expression ISO Tacrolimus results in increased expression of HK3 mRNA CTD PMID:29362864 NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Tacrolimus results in decreased expression of HMGCS2 mRNA CTD PMID:25270620 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Tacrolimus results in increased expression of HMOX1 mRNA; Tacrolimus results in increased expression of HMOX1 protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of HMOX1 protein]		 CTD PMID:23958496 PMID:24959755 PMID:26260164 PMID:29362864 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1b HNF1 homeobox B decreases expression ISO Tacrolimus results in decreased expression of HNF1B mRNA CTD PMID:22416070 NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888 		JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression ISO Tacrolimus results in decreased expression of HSDL2 mRNA CTD PMID:25270620 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Tacrolimus results in increased expression of HSPA5 mRNA CTD PMID:25270620 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression		 EXP Tacrolimus inhibits the reaction [Acrylamide results in decreased expression of HSPA8 protein]
Tacrolimus results in increased expression of HSPA8 protein		 CTD PMID:15081597 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A decreases expression ISO Tacrolimus results in decreased expression of HTR1A protein CTD PMID:27606422 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B decreases expression ISO Tacrolimus results in decreased expression of HTR1B protein CTD PMID:27606422 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression		 EXP
ISO		 Tacrolimus results in decreased expression of ICAM1; Tacrolimus results in decreased expression of ICAM1 protein
Tacrolimus results in increased expression of ICAM1 mRNA		 CTD PMID:9794552 PMID:10385251 PMID:23958496 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO Tacrolimus results in increased expression of ID1 mRNA CTD PMID:25270620 PMID:29362864 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Tacrolimus results in increased expression of ID2 mRNA CTD PMID:25270620 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Tacrolimus results in increased expression of ID3 mRNA CTD PMID:29362864 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Id4 inhibitor of DNA binding 4 increases expression ISO Tacrolimus results in increased expression of ID4 mRNA CTD PMID:25270620 NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Tacrolimus results in decreased expression of IDI1 mRNA CTD PMID:25270620 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Ifi27l2a interferon, alpha-inducible protein 27 like 2A increases expression ISO Tacrolimus results in increased expression of IFI27L2A mRNA CTD PMID:29362864 NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
decreases expression		 ISO
EXP		 [Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IFNG protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IFNG protein]; Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IFNG mRNA]
Tacrolimus results in decreased secretion of IFNG protein
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TRP53 protein]
Tacrolimus results in decreased expression of IFNG mRNA; Tacrolimus results in decreased expression of IFNG protein
[Tacrolimus co-treated with TAK 779] results in decreased expression of IFNG protein		 CTD PMID:1371491 PMID:8986461 PMID:10205001 PMID:11407316 PMID:11692113 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance EXP IGF1 protein results in increased susceptibility to Tacrolimus CTD PMID:12826230 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression
increases expression		 EXP Tacrolimus results in decreased expression of IGFBP1 mRNA
Tacrolimus results in increased expression of IGFBP1 mRNA		 CTD PMID:21865292 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Tacrolimus results in increased expression of IGFBP5 mRNA CTD PMID:21865292 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Tacrolimus inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il15ra interleukin 15 receptor subunit alpha increases expression ISO Tacrolimus results in increased expression of IL15RA mRNA CTD PMID:23958496 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278 		JBrowse link
G Il17ra interleukin 17 receptor A increases expression ISO Tacrolimus results in increased expression of IL17RA mRNA CTD PMID:23958496 NCBI chr 4:153,667,534...153,690,174
Ensembl chr 4:153,667,534...153,690,174 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO Tacrolimus results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO Tacrolimus results in increased expression of IL1RN mRNA CTD PMID:23958496 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression		 ISO
EXP		 [Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Tacrolimus inhibits the reaction [Zinc Sulfate inhibits the reaction [Mitogens results in increased expression of IL2 mRNA]]
Tacrolimus results in decreased expression of IL2 protein
Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2 protein]; Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]
Tacrolimus results in decreased expression of IL2 mRNA
Tacrolimus results in decreased expression of IL2 mRNA; Tacrolimus results in decreased expression of IL2 protein		 CTD PMID:1371491 PMID:1614535 PMID:1701765 PMID:1705513 PMID:8986461 More... NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Tacrolimus results in increased expression of IL23A mRNA CTD PMID:25270620 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Tacrolimus results in decreased expression of IL2RA protein CTD PMID:1701765 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il3 interleukin 3 decreases expression
multiple interactions		 ISO Tacrolimus results in decreased expression of IL3 protein
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]; Tacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]		 CTD PMID:1376361 PMID:11407316 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 ISO
EXP		 Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein]
Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol results in increased expression of IL4 protein]
Tacrolimus results in decreased expression of IL4 protein
Tacrolimus results in decreased expression of IL4 mRNA; Tacrolimus results in decreased expression of IL4 protein		 CTD PMID:1371491 PMID:10685002 PMID:11407316 PMID:12709020 PMID:16368244 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression		 ISO Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL5 protein]
Tacrolimus results in decreased expression of IL5 mRNA; Tacrolimus results in decreased expression of IL5 protein		 CTD PMID:1371491 PMID:7540862 PMID:11407316 PMID:15948978 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [Tacrolimus co-treated with quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with quinapril] results in increased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein
Tacrolimus results in decreased expression of IL6 protein
Tacrolimus results in increased expression of IL6 protein
parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]; sulforaphane inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]		 CTD PMID:16549154 PMID:23958496 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Imp4 IMP U3 small nucleolar ribonucleoprotein 4 decreases expression ISO Tacrolimus results in decreased expression of IMP4 mRNA CTD PMID:25270620 NCBI chr 9:36,654,127...36,659,265
Ensembl chr 9:36,654,401...36,660,075 		JBrowse link
G Ino80e INO80 complex subunit E decreases expression ISO Tacrolimus results in decreased expression of INO80E mRNA CTD PMID:25270620 NCBI chr 1:181,461,406...181,472,059
Ensembl chr 1:181,461,408...181,472,469 		JBrowse link
G Ins1 insulin 1 decreases expression
multiple interactions		 EXP Tacrolimus results in decreased expression of INS1 protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of INS1 protein]		 CTD PMID:24959755 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 decreases expression ISO Tacrolimus results in decreased expression of INS protein CTD PMID:17391142 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of IRAK1 protein CTD PMID:23958496 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Itgal integrin subunit alpha L decreases expression EXP Tacrolimus results in decreased expression of ITGAL CTD PMID:9794552 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of JAK2 protein CTD PMID:23958496 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Tacrolimus results in decreased expression of JUN protein CTD PMID:9674596 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of JUNB mRNA CTD PMID:23958496 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kifap3 kinesin-associated protein 3 decreases expression EXP Tacrolimus results in decreased expression of KIFAP3 mRNA CTD PMID:21865292 NCBI chr13:76,127,702...76,264,654
Ensembl chr13:76,127,696...76,264,650 		JBrowse link
G Kifc1 kinesin family member C1 decreases expression EXP Tacrolimus results in decreased expression of KIFC1 mRNA CTD PMID:21865292 NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression EXP Tacrolimus results in increased expression of KLF5 mRNA CTD PMID:21865292 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Klf6 KLF transcription factor 6 increases expression EXP Tacrolimus results in increased expression of KLF6 mRNA CTD PMID:21865292 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression EXP Tacrolimus results in increased expression of KLK1C10 mRNA CTD PMID:21865292 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 increases expression EXP Tacrolimus results in increased expression of KLK1C9 mRNA CTD PMID:21865292 NCBI chr 1:94,597,359...94,601,245
Ensembl chr 1:94,597,359...94,601,245 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression ISO Tacrolimus results in increased expression of KRAS mRNA CTD PMID:25270620 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt20 keratin 20 increases expression ISO Tacrolimus results in increased expression of KRT20 mRNA CTD PMID:29362864 NCBI chr10:84,384,790...84,394,125
Ensembl chr10:84,384,802...84,394,107 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Tacrolimus results in increased expression of LAMC2 mRNA CTD PMID:21865292 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Tacrolimus results in increased expression of LBP mRNA CTD PMID:21865292 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP
ISO		 Tacrolimus results in increased expression of LCN2 mRNA CTD PMID:21865292 PMID:29362864 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lias lipoic acid synthetase decreases expression ISO Tacrolimus results in decreased expression of LIAS mRNA CTD PMID:21621594 NCBI chr14:42,876,699...42,893,824
Ensembl chr14:42,876,699...42,893,783 		JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Tacrolimus results in increased expression of LIF mRNA CTD PMID:23958496 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482 		JBrowse link
G Limk1 LIM domain kinase 1 increases expression ISO Tacrolimus results in increased expression of LIMK1 mRNA CTD PMID:29380240 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606 		JBrowse link
G Llgl1 LLGL scribble cell polarity complex component 1 increases expression ISO Tacrolimus results in increased expression of LLGL1 mRNA CTD PMID:29380240 NCBI chr10:45,379,423...45,394,096
Ensembl chr10:45,379,515...45,394,094 		JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein] CTD PMID:1371491 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Ltf lactotransferrin increases expression ISO Tacrolimus results in increased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Ly86 lymphocyte antigen 86 increases expression ISO Tacrolimus results in increased expression of LY86 mRNA CTD PMID:29362864 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260 		JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 decreases expression ISO Tacrolimus results in decreased expression of LYVE1 mRNA CTD PMID:25270620 NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309 		JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Tacrolimus results in increased expression of MAFF mRNA CTD PMID:23958496 NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Tacrolimus results in increased expression of MAFK mRNA CTD PMID:23958496 NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048
Ensembl chr12:14,833,984...14,837,048 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO Tacrolimus results in increased expression of MANF mRNA CTD PMID:25270620 NCBI chr 8:107,500,856...107,551,595
Ensembl chr 8:107,548,352...107,551,438 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of MAP3K7 protein CTD PMID:23958496 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases activity
multiple interactions		 EXP Tacrolimus results in decreased activity of MAPK8 protein
Tacrolimus inhibits the reaction [Oxygen deficiency results in increased activity of MAPK8 protein]		 CTD PMID:12892836 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 decreases expression ISO Tacrolimus results in decreased expression of MBNL2 mRNA CTD PMID:25270620 NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937 		JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression ISO Tacrolimus results in decreased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571 		JBrowse link
G Mcrs1 microspherule protein 1 decreases expression ISO Tacrolimus results in decreased expression of MCRS1 mRNA CTD PMID:25270620 NCBI chr 7:130,383,853...130,392,667
Ensembl chr 7:130,383,853...130,392,685 		JBrowse link
G Mettl1 methyltransferase 1, tRNA methylguanosine increases expression ISO Tacrolimus results in increased expression of METTL1 mRNA CTD PMID:25270620 NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202 		JBrowse link
G Mfsd1 major facilitator superfamily domain containing 1 increases expression ISO Tacrolimus results in increased expression of MFSD1 mRNA CTD PMID:25270620 NCBI chr 2:151,846,130...151,866,168
Ensembl chr 2:151,846,146...151,867,045 		JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Tacrolimus results in decreased expression of MGLL mRNA CTD PMID:25270620 NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179 		JBrowse link
G Mir146a microRNA 146a increases expression ISO Tacrolimus results in increased expression of MIR146 mRNA CTD PMID:29362864 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir146b microRNA 146b increases expression ISO Tacrolimus results in increased expression of MIR146B mRNA CTD PMID:29362864 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir193a microRNA 193a decreases expression ISO Tacrolimus results in decreased expression of MIR193A mRNA CTD PMID:29362864 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mir200b microRNA 200b decreases expression ISO Tacrolimus results in decreased expression of MIR200B mRNA CTD PMID:29362864 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mir21 microRNA 21 increases expression ISO Tacrolimus results in increased expression of MIR21A mRNA CTD PMID:29362864 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir214 microRNA 214 increases expression ISO Tacrolimus results in increased expression of MIR214 mRNA CTD PMID:29362864 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G Mir34b microRNA 34b increases expression ISO Tacrolimus results in increased expression of MIR34B mRNA CTD PMID:29362864 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327 		JBrowse link
G Mir551b microRNA 551b decreases expression ISO Tacrolimus results in decreased expression of MIR551B mRNA CTD PMID:29362864 NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300 		JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO Tacrolimus results in increased expression of MOB4 mRNA CTD PMID:25270620 NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression		 EXP Tacrolimus inhibits the reaction [Indomethacin results in increased activity of MPO protein]
Tacrolimus results in decreased expression of MPO protein		 CTD PMID:9655420 PMID:17202747 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Tacrolimus results in decreased expression of MRM3 mRNA CTD PMID:25270620 NCBI chr10:61,095,920...61,125,421
Ensembl chr10:61,095,952...61,102,630 		JBrowse link
G Ms4a6a membrane spanning 4-domains A6A increases expression ISO Tacrolimus results in increased expression of MS4A6C mRNA CTD PMID:29362864 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758 		JBrowse link
G Msln mesothelin increases expression ISO Tacrolimus results in increased expression of MSLN mRNA CTD PMID:29362864 NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP
ISO		 Tacrolimus results in increased expression of MYC mRNA CTD PMID:21865292 PMID:23958496 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Naaa N-acylethanolamine acid amidase increases expression ISO Tacrolimus results in increased expression of NAAA mRNA CTD PMID:29362864 NCBI chr14:15,777,306...15,796,411
Ensembl chr14:15,777,306...15,796,410 		JBrowse link
G Nckap1l NCK associated protein 1 like increases expression ISO Tacrolimus results in increased expression of NCKAP1L mRNA CTD PMID:29362864 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 increases expression ISO Tacrolimus results in increased expression of NCR3 CTD PMID:20736080 NCBI chr20:3,637,242...3,643,748
Ensembl chr20:3,638,240...3,643,799 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Tacrolimus results in increased expression of NDRG1 mRNA CTD PMID:25270620 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions ISO Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [Thapsigargin affects the localization of and results in increased activity of NFATC3 protein] CTD PMID:10339586 PMID:12709020 NCBI chr19:33,960,643...34,035,150
Ensembl chr19:33,960,852...34,035,150 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions ISO
EXP		 Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein] CTD PMID:16055480 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Tacrolimus results in increased expression of NFE2L2 protein CTD PMID:23958496 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFKB1 protein]
Tacrolimus results in increased expression of NFKB1 mRNA		 CTD PMID:18172213 PMID:18172886 PMID:23958496 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression ISO Tacrolimus results in increased expression of NFKB2 mRNA CTD PMID:23958496 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation
multiple interactions
increases phosphorylation		 ISO Tacrolimus results in decreased degradation of NFKBIA protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased phosphorylation of NFKBIA protein]		 CTD PMID:16181452 PMID:23958496 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NFKBIB protein] CTD PMID:18172213 PMID:18172886 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nfkbie NFKB inhibitor epsilon increases expression ISO Tacrolimus results in increased expression of NFKBIE mRNA CTD PMID:23958496 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP NGF protein inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein] CTD PMID:17385075 PMID:23825664 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nol8 nucleolar protein 8 increases expression ISO Tacrolimus results in increased expression of NOL8 mRNA CTD PMID:25270620 NCBI chr17:14,990,394...15,013,784
Ensembl chr17:14,990,417...15,013,848 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein] CTD PMID:20149694 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Tacrolimus inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]		 CTD PMID:12144947 PMID:17202747 PMID:20149694 PMID:27246103 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
decreases activity
decreases expression		 ISO
EXP		 Tacrolimus results in increased expression of NOS3 mRNA
Tacrolimus results in decreased activity of NOS3 protein
Tacrolimus results in decreased expression of NOS3 mRNA		 CTD PMID:9931093 PMID:12352326 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nox1 NADPH oxidase 1 increases expression EXP Tacrolimus results in increased expression of NOX1 mRNA CTD PMID:17085464 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPA mRNA] CTD PMID:15939815 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPB mRNA] CTD PMID:15939815 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npr1 natriuretic peptide receptor 1 multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of FN1 mRNA]; Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPA mRNA]; Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPB mRNA] CTD PMID:15939815 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity		 ISO Tacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein]; Tacrolimus promotes the reaction [Dexamethasone binds to NR3C1 protein]; Tacrolimus promotes the reaction [NR3C1 protein binds to PPP5C protein]
Tacrolimus results in increased activity of NR3C1 protein		 CTD PMID:15697228 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Ogn osteoglycin increases expression EXP
ISO		 Tacrolimus results in increased expression of OGN mRNA CTD PMID:21865292 PMID:29362864 NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739 		JBrowse link
G Olfml3 olfactomedin-like 3 increases expression ISO Tacrolimus results in increased expression of OLFML3 mRNA CTD PMID:29362864 NCBI chr 2:191,244,221...191,247,050
Ensembl chr 2:191,244,221...191,247,050 		JBrowse link
G Panx1 Pannexin 1 increases expression ISO Tacrolimus results in increased expression of PANX1 mRNA CTD PMID:29362864 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Pbk PDZ binding kinase increases expression ISO Tacrolimus results in increased expression of PBK mRNA CTD PMID:29362864 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 decreases expression ISO Tacrolimus results in decreased expression of PCBP4 mRNA CTD PMID:25270620 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]; Tacrolimus affects the reaction [Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]] CTD PMID:25770929 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pcolce procollagen C-endopeptidase enhancer decreases expression ISO Tacrolimus results in decreased expression of PCOLCE mRNA CTD PMID:25270620 NCBI chr12:19,084,191...19,090,508
Ensembl chr12:19,084,210...19,090,508 		JBrowse link
G Pdcd2 programmed cell death 2 increases expression ISO Tacrolimus results in increased expression of PDCD2 mRNA CTD PMID:25270620 NCBI chr 1:56,484,947...56,490,437
Ensembl chr 1:56,463,931...56,490,437 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression ISO Tacrolimus results in increased expression of PDGFRA mRNA CTD PMID:29362864 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression ISO Tacrolimus results in increased expression of PDIA4 mRNA CTD PMID:25270620 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Tacrolimus results in increased expression of PDIA6 mRNA CTD PMID:25270620 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Tacrolimus results in increased expression of PHLDA1 mRNA CTD PMID:23958496 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Tacrolimus results in increased expression of PID1 mRNA CTD PMID:29362864 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein] CTD PMID:19492085 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression ISO Tacrolimus results in increased expression of PKMYT1 mRNA CTD PMID:29362864 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995 		JBrowse link
G Pkp4 plakophilin 4 decreases expression EXP Tacrolimus results in decreased expression of PKP4 mRNA CTD PMID:21865292 NCBI chr 3:43,632,364...43,835,834
Ensembl chr 3:43,631,880...43,835,474 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO Tacrolimus results in increased expression of PLA2G12A mRNA CTD PMID:25270620 NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740 		JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO Tacrolimus results in decreased expression of PLAT mRNA CTD PMID:25270620 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plbd2 phospholipase B domain containing 2 decreases expression ISO Tacrolimus results in decreased expression of PLBD2 mRNA CTD PMID:25270620 NCBI chr12:36,062,802...36,081,984
Ensembl chr12:36,062,802...36,081,983 		JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR polymorphism affects the susceptibility to Tacrolimus CTD PMID:24113216 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance ISO PPARA polymorphism affects the susceptibility to Tacrolimus CTD PMID:24113216 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Sirolimus co-treated with Tacrolimus] results in increased expression of PPARG protein CTD PMID:17016853 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppl periplakin increases expression EXP Tacrolimus results in increased expression of PPL mRNA CTD PMID:21865292 NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Tacrolimus results in increased expression of PPP1R15A mRNA CTD PMID:23958496 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
decreases activity		 ISO [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953 PMID:19553475 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO Tacrolimus promotes the reaction [NR3C1 protein binds to PPP5C protein] CTD PMID:15697228 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prcp prolylcarboxypeptidase increases expression EXP Tacrolimus results in increased expression of PRCP mRNA CTD PMID:21865292 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Prlr prolactin receptor decreases expression EXP Tacrolimus results in decreased expression of PRLR mRNA CTD PMID:21865292 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression ISO Tacrolimus results in increased expression of PSMB10 mRNA CTD PMID:29362864 NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO Tacrolimus inhibits the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]
Tacrolimus results in increased expression of PTGS2 mRNA		 CTD PMID:12493747 PMID:23958496 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 decreases activity ISO Tacrolimus results in decreased activity of PTPN5 protein CTD PMID:17360923 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 increases expression EXP Tacrolimus results in increased expression of PTPRZ1 mRNA CTD PMID:21865292 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family increases expression ISO Tacrolimus results in increased expression of RAB4A mRNA CTD PMID:29380240 NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703 		JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP Tacrolimus results in increased expression of RAC1 mRNA CTD PMID:17085464 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Ramp1 receptor activity modifying protein 1 increases expression ISO Tacrolimus results in increased expression of RAMP1 mRNA CTD PMID:29362864 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151 		JBrowse link
G Rcc1 regulator of chromosome condensation 1 decreases expression ISO Tacrolimus results in decreased expression of RCC1 mRNA CTD PMID:25270620 NCBI chr 5:144,526,025...144,544,445
Ensembl chr 5:144,526,025...144,544,577 		JBrowse link
G Rcor2 REST corepressor 2 decreases expression ISO Tacrolimus results in decreased expression of RCOR2 mRNA CTD PMID:25270620 NCBI chr 1:204,453,403...204,461,403
Ensembl chr 1:204,454,360...204,460,838 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of REL protein] CTD PMID:18172213 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Tacrolimus co-treated with Thapsigargin] affects the localization of and results in increased activity of RELA protein; Tacrolimus affects the localization of and results in increased activity of RELA protein; Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; Tacrolimus results in increased phosphorylation of and affects the localization of RELA protein CTD PMID:10339586 PMID:18172886 PMID:23958496 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Tacrolimus results in increased expression of RELB mRNA CTD PMID:23958496 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Ren renin multiple interactions
decreases activity
increases expression		 EXP nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]
Tacrolimus results in decreased activity of REN protein
Tacrolimus results in increased expression of REN mRNA; Tacrolimus results in increased expression of REN protein		 CTD PMID:7509514 PMID:7532090 PMID:7533848 PMID:12469222 PMID:21865292 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Renbp renin binding protein increases expression ISO Tacrolimus results in increased expression of RENBP mRNA CTD PMID:25270620 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
G Rgn regucalcin decreases expression EXP Tacrolimus results in decreased expression of RGN mRNA CTD PMID:21865292 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Tacrolimus results in increased expression of RGS16 mRNA CTD PMID:29362864 NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Tacrolimus results in increased expression of RHEBL1 mRNA CTD PMID:23958496 NCBI chr 7:130,026,255...130,031,127
Ensembl chr 7:130,026,341...130,030,248 		JBrowse link
G Rhou ras homolog family member U increases expression ISO Tacrolimus results in increased expression of RHOU mRNA CTD PMID:29362864 NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552 		JBrowse link
G Rnase2 ribonuclease A family member 2 increases expression ISO Tacrolimus results in increased expression of RNASE2A mRNA CTD PMID:29362864 NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479 		JBrowse link
G Rnase3 ribonuclease A family member 3 increases expression ISO Tacrolimus results in increased expression of EAR1 mRNA CTD PMID:29362864 NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790 		JBrowse link
G Rpn1 ribophorin I increases expression ISO Tacrolimus results in increased expression of RPN1 mRNA CTD PMID:25270620 NCBI chr 4:120,543,667...120,565,069
Ensembl chr 4:120,543,667...120,565,069 		JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]] CTD PMID:1614535 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rrp9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein decreases expression ISO Tacrolimus results in decreased expression of RRP9 mRNA CTD PMID:25270620 NCBI chr 8:107,116,411...107,126,123
Ensembl chr 8:107,117,471...107,126,123 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Tacrolimus results in decreased expression of RUNX2 mRNA CTD PMID:15780950 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RYR1 protein] CTD PMID:18172213 PMID:18172886 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO Tacrolimus results in increased expression of S100A6 mRNA CTD PMID:29362864 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180 		JBrowse link
G Sct secretin increases expression ISO Tacrolimus results in increased expression of SCT mRNA CTD PMID:29362864 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression ISO Tacrolimus results in increased expression of SDF2L1 mRNA CTD PMID:25270620 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Seh1l SEH1-like nucleoporin increases expression ISO Tacrolimus results in increased expression of SEH1L mRNA CTD PMID:25270620 NCBI chr18:61,346,986...61,369,987 JBrowse link
G Sele selectin E increases expression EXP Tacrolimus results in increased expression of SELE mRNA CTD PMID:21865292 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selenos selenoprotein S increases expression ISO Tacrolimus results in increased expression of SELENOS mRNA CTD PMID:25270620 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Serinc3 serine incorporator 3 decreases expression ISO Tacrolimus results in decreased expression of SERINC3 mRNA CTD PMID:21621594 NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO Tacrolimus results in increased expression of SERP1 mRNA CTD PMID:25270620 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Serpina3n serpin family A member 3N increases expression EXP Tacrolimus results in increased expression of SERPINA3N mRNA CTD PMID:21865292 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpinb9 serpin family B member 9 increases expression ISO Tacrolimus results in increased expression of SERPINB9 mRNA CTD PMID:23958496 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230 		JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions		 EXP Tacrolimus results in increased expression of SERPINE1 mRNA
Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of SERPINE1 protein]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein]		 CTD PMID:9422427 PMID:14620542 PMID:21865292 PMID:23825664 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sgo1 shugoshin 1 increases expression ISO Tacrolimus results in increased expression of SGO1 mRNA CTD PMID:29362864 NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805 		JBrowse link
G Shf Src homology 2 domain containing F decreases expression ISO Tacrolimus results in decreased expression of SHF mRNA CTD PMID:25270620 NCBI chr 3:109,296,517...109,316,315
Ensembl chr 3:109,296,784...109,316,328 		JBrowse link
G Sla src-like adaptor increases expression ISO Tacrolimus results in increased expression of SLA mRNA CTD PMID:29362864 NCBI chr 7:98,534,431...98,584,810
Ensembl chr 7:98,535,368...98,584,648 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 affects response to substance
increases phosphorylation
decreases expression		 ISO
EXP		 SLC12A3 protein affects the susceptibility to Tacrolimus
Tacrolimus results in increased phosphorylation of SLC12A3 protein
Tacrolimus results in decreased expression of SLC12A3 mRNA; Tacrolimus results in decreased expression of SLC12A3 protein		 CTD PMID:21865292 PMID:21963515 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Tacrolimus results in decreased expression of SLC16A1 mRNA CTD PMID:21865292 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression EXP Tacrolimus results in decreased expression of SLC22A13 mRNA CTD PMID:21865292 NCBI chr 8:118,922,367...118,934,020
Ensembl chr 8:118,922,367...118,953,635 		JBrowse link
G Slc25a25 solute carrier family 25 member 25 decreases expression EXP Tacrolimus results in decreased expression of SLC25A25 mRNA CTD PMID:21865292 NCBI chr 3:15,708,702...15,742,195
Ensembl chr 3:15,708,703...15,742,216 		JBrowse link
G Slc34a2 solute carrier family 34 member 2 increases expression EXP Tacrolimus results in increased expression of SLC34A2 mRNA CTD PMID:21865292 NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP Tacrolimus inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD3 protein]; Tacrolimus inhibits the reaction [Paraquat results in increased expression of SMAD3 mRNA] CTD PMID:33000210 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO
EXP		 Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]; Tacrolimus inhibits the reaction [SMAD7 protein binds to SMURF1 protein]
Tacrolimus promotes the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD7 protein]; Tacrolimus promotes the reaction [Paraquat results in increased expression of SMAD7 mRNA]		 CTD PMID:16720724 PMID:33000210 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Smim14 small integral membrane protein 14 increases expression ISO Tacrolimus results in increased expression of SMIM14 mRNA CTD PMID:25270620 NCBI chr14:42,783,361...42,829,762
Ensembl chr14:42,783,332...42,829,760 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 multiple interactions ISO Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]; Tacrolimus inhibits the reaction [SMAD7 protein binds to SMURF1 protein] CTD PMID:16720724 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions		 ISO Tacrolimus results in increased expression of SNAI1 protein
[GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]		 CTD PMID:22416070 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Tacrolimus results in increased expression of SNAI2 mRNA CTD PMID:22416070 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Sod2 superoxide dismutase 2 increases response to substance
multiple interactions
decreases expression		 ISO
EXP		 SOD2 protein results in increased susceptibility to Tacrolimus
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of SOD2 protein]		 CTD PMID:14675044 PMID:24959755 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Tacrolimus results in increased expression of SOX9 mRNA CTD PMID:29362864 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Sp7 Sp7 transcription factor decreases expression EXP Tacrolimus results in decreased expression of SP7 mRNA CTD PMID:15780950 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spaca7 sperm acrosome associated 7 increases expression ISO Tacrolimus results in increased expression of SPACA7 mRNA CTD PMID:29362864 NCBI chr16:76,928,611...76,955,547
Ensembl chr16:76,928,581...76,955,543 		JBrowse link
G Spcs2 signal peptidase complex subunit 2 increases expression ISO Tacrolimus results in increased expression of SPCS2 mRNA CTD PMID:25270620 NCBI chr 1:154,163,724...154,183,152
Ensembl chr 1:154,163,724...154,183,186 		JBrowse link
G Sphk2 sphingosine kinase 2 decreases expression ISO Tacrolimus results in decreased expression of SPHK2 mRNA CTD PMID:25270620 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391 		JBrowse link
G Spic Spi-C transcription factor increases expression ISO Tacrolimus results in increased expression of SPIC mRNA CTD PMID:29362864 NCBI chr 7:23,069,815...23,077,517
Ensembl chr 7:23,069,821...23,077,548 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Tacrolimus results in increased expression of SPP1 mRNA CTD PMID:12472797 PMID:21865292 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqor sulfide quinone oxidoreductase decreases expression ISO Tacrolimus results in decreased expression of SQOR mRNA CTD PMID:25270620 NCBI chr 3:109,841,225...109,886,724
Ensembl chr 3:109,841,250...109,960,778 		JBrowse link
G Ssr3 signal sequence receptor subunit 3 increases expression ISO Tacrolimus results in increased expression of SSR3 mRNA CTD PMID:25270620 NCBI chr 2:149,605,005...149,625,069
Ensembl chr 2:149,605,005...149,625,132 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 decreases expression ISO Tacrolimus results in decreased expression of STARD4 mRNA CTD PMID:25270620 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of STAT3 protein CTD PMID:23958496 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tada3 transcriptional adaptor 3 decreases expression ISO Tacrolimus results in decreased expression of TADA3 mRNA CTD PMID:25270620 NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590 		JBrowse link
G Tamalin trafficking regulator and scaffold protein tamalin increases expression ISO Tacrolimus results in increased expression of TAMALIN mRNA CTD PMID:25270620 NCBI chr 7:132,338,900...132,359,519
Ensembl chr 7:132,338,900...132,346,666 		JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Tacrolimus results in increased expression of TATDN1 mRNA CTD PMID:25270620 NCBI chr 7:90,449,979...90,481,000
Ensembl chr 7:90,441,079...90,481,133 		JBrowse link
G Tekt1 tektin 1 increases expression EXP Tacrolimus results in increased expression of TEKT1 mRNA CTD PMID:21865292 NCBI chr10:56,952,164...56,980,572
Ensembl chr10:56,952,167...56,980,572 		JBrowse link
G Tfeb transcription factor EB multiple interactions ISO [Cyclosporine co-treated with Tacrolimus] inhibits the reaction [4-(4-fluorophenyl)sulfonyl-5-methylthio-2-phenyloxazole affects the localization of TFEB protein] CTD PMID:29650965 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tfrc transferrin receptor decreases expression ISO Tacrolimus results in decreased expression of TFRC protein CTD PMID:1701765 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Tacrolimus results in increased expression of TGFB1 mRNA; Tacrolimus results in increased expression of TGFB1 protein
[Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]; Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of TGFB1 protein]; Tacrolimus inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of TGFB1 protein]; Tacrolimus inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
Tacrolimus results in decreased expression of TGFB1 mRNA		 CTD PMID:9422427 PMID:11091246 PMID:12352326 PMID:12472797 PMID:14620542 More... NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO Tacrolimus results in increased expression of TGFBI mRNA CTD PMID:29362864 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Tacrolimus results in increased expression of TGFBR1 mRNA; Tacrolimus results in increased expression of TGFBR1 protein CTD PMID:16980036 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Tacrolimus results in increased expression of TGFBR2 mRNA; Tacrolimus results in increased expression of TGFBR2 protein CTD PMID:16980036 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Tacrolimus results in increased expression of TGM1 mRNA CTD PMID:21865292 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression
decreases expression		 EXP pirfenidone promotes the reaction [Tacrolimus results in decreased expression of TIMP1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of TIMP1 mRNA] CTD PMID:11091246 PMID:12472797 PMID:15854665 PMID:21865292 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Tacrolimus results in increased expression of TLR2 mRNA CTD PMID:29362864 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tmem202 transmembrane protein 202 decreases expression ISO Tacrolimus results in decreased expression of TMEM202 mRNA CTD PMID:25270620 NCBI chr 8:59,910,824...59,919,342
Ensembl chr 8:59,910,824...59,916,609 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
increases expression		 ISO
EXP		 Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; Tacrolimus inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of TNF protein]; Tacrolimus inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Tacrolimus inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Tacrolimus results in decreased secretion of TNF protein
Tacrolimus results in decreased expression of TNF mRNA; Tacrolimus results in decreased expression of TNF protein
[Tacrolimus co-treated with Thapsigargin] results in increased expression of TNF protein
Tacrolimus inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]
Tacrolimus results in increased expression of TNF mRNA		 CTD PMID:1371491 PMID:10339586 PMID:10385251 PMID:10685002 PMID:11121130 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip8l2 TNF alpha induced protein 8 like 2 increases expression ISO Tacrolimus results in increased expression of TNFAIP8L2 mRNA CTD PMID:29362864 NCBI chr 2:182,710,433...182,726,724
Ensembl chr 2:182,709,378...182,726,760 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Tacrolimus results in decreased expression of TNFRSF11B mRNA CTD PMID:21865292 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:15207740 PMID:21869564 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO Tacrolimus results in increased expression of TNNT2 protein CTD PMID:12975596 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO		 Tacrolimus inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TRP53 protein]		 CTD PMID:10205001 PMID:12642403 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Tacrolimus results in increased expression of TRIB3 mRNA CTD PMID:23958496 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Tacrolimus results in decreased expression of TRIM2 mRNA CTD PMID:25270620 NCBI chr 2:169,500,628...169,652,855
Ensembl chr 2:169,500,634...169,652,927 		JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO Tacrolimus results in increased expression of TRIP13 mRNA CTD PMID:29362864 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074 		JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 decreases expression EXP Tacrolimus results in decreased expression of TRPM6 mRNA CTD PMID:14978156 NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO
EXP		 Tacrolimus results in increased phosphorylation of and affects the activity of TRPV1 protein
Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]		 CTD PMID:19553475 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 decreases expression EXP Tacrolimus results in decreased expression of TRPV5 mRNA; Tacrolimus results in decreased expression of TRPV5 protein CTD PMID:14978156 NCBI chr 4:70,536,432...70,562,743
Ensembl chr 4:70,536,440...70,562,745 		JBrowse link
G Txn1 thioredoxin 1 decreases expression EXP Tacrolimus results in decreased expression of TXN mRNA CTD PMID:17085464 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Ubd ubiquitin D increases expression ISO Tacrolimus results in increased expression of UBD mRNA CTD PMID:29362864 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Utf1 undifferentiated embryonic cell transcription factor 1 decreases expression ISO Tacrolimus results in decreased expression of UTF1 mRNA CTD PMID:25270620 NCBI chr 1:194,740,339...194,741,465
Ensembl chr 1:194,740,339...194,741,465 		JBrowse link
G Vasn vasorin decreases expression EXP Tacrolimus results in decreased expression of VASN mRNA CTD PMID:17028423 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases expression ISO Tacrolimus results in decreased expression of VASP mRNA CTD PMID:29380240 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Tacrolimus results in increased expression of VCAM1 mRNA CTD PMID:23958496 PMID:29362864 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vcan versican increases expression EXP Tacrolimus results in increased expression of VCAN mRNA CTD PMID:21865292 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Tacrolimus results in increased expression of VEGFA protein CTD PMID:17703430 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin increases expression ISO Tacrolimus results in increased expression of VIM protein CTD PMID:22416070 PMID:29362864 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wdfy4 WDFY family member 4 increases expression ISO Tacrolimus results in increased expression of WDFY4 mRNA CTD PMID:29362864 NCBI chr16:8,221,853...8,450,494
Ensembl chr16:8,221,719...8,450,491 		JBrowse link
G Wdr31 WD repeat domain 31 decreases expression ISO Tacrolimus results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 5:75,897,074...75,917,461
Ensembl chr 5:75,898,353...75,917,417 		JBrowse link
G Wdr54 WD repeat domain 54 decreases expression ISO Tacrolimus results in decreased expression of WDR54 mRNA CTD PMID:25270620 NCBI chr 4:115,654,968...115,677,979
Ensembl chr 4:115,654,968...115,661,562 		JBrowse link
G Wdr73 WD repeat domain 73 decreases expression ISO Tacrolimus results in decreased expression of WDR73 mRNA CTD PMID:25270620 NCBI chr 1:134,860,329...134,868,475
Ensembl chr 1:134,860,180...134,868,479 		JBrowse link
G Wfdc17 WAP four-disulfide core domain 17 increases expression ISO Tacrolimus results in increased expression of WFDC17 mRNA CTD PMID:29362864 NCBI chr10:68,561,954...68,562,801
Ensembl chr10:68,561,954...68,562,801 		JBrowse link
G Wfdc18 WAP four-disulfide core domain 18 increases expression ISO Tacrolimus results in increased expression of WFDC18 mRNA CTD PMID:29362864 NCBI chr10:68,588,818...68,590,972
Ensembl chr10:68,588,818...68,589,671 		JBrowse link
G Wnk3 WNK lysine deficient protein kinase 3 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of WNK3 protein CTD PMID:21963515 NCBI chr  X:20,156,260...20,299,252
Ensembl chr  X:20,157,041...20,296,821 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of WNK4 protein CTD PMID:21963515 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression		 ISO Tacrolimus results in increased expression of and affects the localization of XBP1 protein modified form
Tacrolimus results in increased expression of XBP1 mRNA		 CTD PMID:23958496 PMID:25270620 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Xcl1 X-C motif chemokine ligand 1 increases expression ISO Tacrolimus results in increased expression of XCL1 mRNA CTD PMID:29362864 NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329 		JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 increases expression ISO Tacrolimus results in increased expression of ZFYVE16 mRNA CTD PMID:25270620 NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        immunomodulator 15057
          immunosuppressive agent 13937
            tacrolimus hydrate 431
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          carbamoyl group 17576
                                            carboxamide 17576
                                              lactam 8394
                                                macrolide lactam 826
                                                  tacrolimus (anhydrous) 434
                                                    tacrolimus hydrate 431
paths to the root