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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:esketamine
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Accession:CHEBI:60799 term browser browse the term
Definition:The S- (more active) enantiomer of ketamine.
Synonyms:exact_synonym: (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone
 related_synonym: (-)-ketamine;   (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone;   (S)-ketamine;   Formula=C13H16ClNO;   InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3/t13-/m0/s1;   InChIKey=YQEZLKZALYSWHR-ZDUSSCGKSA-N;   SMILES=CN[C@@]1(CCCCC1=O)c1ccccc1Cl
 xref: CAS:33643-46-8;   DrugBank:DB01221;   Drug_Central:4468;   KEGG:D07283
 xref_mesh: MESH:C000629870
 xref: Reaxys:4295313
 cyclic_relationship: is_enantiomer_of CHEBI:580604


show annotations for term's descendants           Sort by:
esketamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl4 angiopoietin-like 4 increases expression ISO Esketamine results in increased expression of ANGPTL4 mRNA CTD PMID:38219984 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Ankrd1 ankyrin repeat domain 1 decreases expression ISO Esketamine results in decreased expression of ANKRD1 mRNA CTD PMID:38219984 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919 		JBrowse link
G Ankrd2 ankyrin repeat domain 2 decreases expression ISO Esketamine results in decreased expression of ANKRD2 mRNA CTD PMID:38219984 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566 		JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 increases expression ISO Esketamine results in increased expression of ARNT2 mRNA CTD PMID:38219984 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153 		JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression ISO Esketamine results in decreased expression of ARRDC4 mRNA CTD PMID:38219984 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290 		JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions		 ISO Esketamine results in increased expression of ATF4 mRNA; Esketamine results in increased expression of ATF4 protein
N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of ATF4 protein]		 CTD PMID:38219984 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Esketamine results in increased expression of ATF6 mRNA CTD PMID:38219984 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G B3galt9 beta-1,3-galactosyltransferase 9 decreases expression ISO Esketamine results in decreased expression of B3GALT9 mRNA CTD PMID:38219984 NCBI chr 3:18,121,620...18,124,149
Ensembl chr 3:18,101,407...18,123,894
Ensembl chr 3:18,101,407...18,123,894 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
multiple interactions
increases expression		 ISO Esketamine affects the expression of BAX mRNA
EIF2AK3 protein affects the reaction [Esketamine affects the expression of BAX mRNA]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BAX mRNA]
Esketamine results in increased expression of BAX protein		 CTD PMID:38219984 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
affects expression		 ISO Esketamine results in decreased expression of BCL2 protein
EIF2AK3 protein affects the reaction [Esketamine affects the expression of BCL2 mRNA]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BCL2 mRNA]		 CTD PMID:38219984 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage ISO Esketamine results in increased cleavage of CASP3 protein CTD PMID:38219984 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Csta cystatin A increases expression ISO Esketamine results in increased expression of CSTA mRNA CTD PMID:38219984 NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Esketamine results in increased expression of DDIT3 mRNA; Esketamine results in increased expression of DDIT3 protein
EIF2AK3 protein affects the reaction [Esketamine results in increased expression of DDIT3 mRNA]; N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of DDIT3 protein]		 CTD PMID:38219984 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dynlt2b dynein light chain Tctex-type 2B decreases expression ISO Esketamine results in decreased expression of DYNLT2B mRNA CTD PMID:38219984 NCBI chr11:68,359,138...68,367,573
Ensembl chr11:68,358,263...68,367,499 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
increases expression		 ISO EIF2AK3 protein affects the reaction [Esketamine affects the expression of BAX mRNA]; EIF2AK3 protein affects the reaction [Esketamine affects the expression of BCL2 mRNA]; EIF2AK3 protein affects the reaction [Esketamine results in increased expression of DDIT3 mRNA]
Esketamine results in increased phosphorylation of EIF2AK3 protein
Esketamine results in increased expression of EIF2AK3 mRNA		 CTD PMID:38219984 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Fam227b family with sequence similarity 227, member B decreases expression ISO Esketamine results in decreased expression of FAM227B mRNA CTD PMID:38219984 NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:113,233,205...113,392,320 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Esketamine results in decreased expression of GATA3 mRNA CTD PMID:38219984 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Esketamine results in increased expression of GDF15 mRNA CTD PMID:38219984 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpr17 G protein-coupled receptor 17 increases expression ISO Esketamine results in increased expression of GPR17 mRNA CTD PMID:38219984 NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966 		JBrowse link
G Ifitm10 interferon induced transmembrane protein 10 increases expression ISO Esketamine results in increased expression of IFITM10 mRNA CTD PMID:38219984 NCBI chr 1:197,507,501...197,524,180
Ensembl chr 1:197,507,503...197,525,151 		JBrowse link
G Igsf9b immunoglobulin superfamily, member 9B increases expression ISO Esketamine results in increased expression of IGSF9B mRNA CTD PMID:38219984 NCBI chr 8:25,712,644...25,769,481
Ensembl chr 8:25,712,644...25,758,554 		JBrowse link
G Il12a interleukin 12A decreases expression ISO Esketamine results in decreased expression of IL12A mRNA CTD PMID:38219984 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Klrg1 killer cell lectin like receptor G1 decreases expression ISO Esketamine results in decreased expression of KLRG1 mRNA CTD PMID:38219984 NCBI chr 4:155,455,465...155,467,301
Ensembl chr 4:155,455,495...155,467,424 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 increases expression ISO Esketamine results in increased expression of LAPTM5 mRNA CTD PMID:38219984 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Mafb MAF bZIP transcription factor B increases expression ISO Esketamine results in increased expression of MAFB mRNA CTD PMID:38219984 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031 		JBrowse link
G Marchf4 membrane associated ring-CH-type finger 4 decreases expression ISO Esketamine results in decreased expression of MARCHF4 mRNA CTD PMID:38219984 NCBI chr 9:74,078,437...74,196,070
Ensembl chr 9:74,078,434...74,198,199 		JBrowse link
G Mdga1 MAM domain containing glycosylphosphatidylinositol anchor 1 increases expression ISO Esketamine results in increased expression of MDGA1 mRNA CTD PMID:38219984 NCBI chr20:7,900,327...7,964,309
Ensembl chr20:7,904,358...7,963,471 		JBrowse link
G Ntng2 netrin G2 increases expression ISO Esketamine results in increased expression of NTNG2 mRNA CTD PMID:38219984 NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890 		JBrowse link
G Pde2a phosphodiesterase 2A increases expression ISO Esketamine results in increased expression of PDE2A mRNA CTD PMID:38219984 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 increases expression ISO Esketamine results in increased expression of PPFIA4 mRNA CTD PMID:38219984 NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261 		JBrowse link
G Prelid3a PRELI domain containing 3A decreases expression ISO Esketamine results in decreased expression of PRELID3A mRNA CTD PMID:38219984 NCBI chr18:60,998,898...61,034,821
Ensembl chr18:61,017,764...61,031,883 		JBrowse link
G Pycr3 pyrroline-5-carboxylate reductase 3 decreases expression ISO Esketamine results in decreased expression of PYCR3 mRNA CTD PMID:38219984 NCBI chr 7:107,603,543...107,608,831
Ensembl chr 7:107,581,930...107,608,799 		JBrowse link
G Reln reelin decreases expression ISO Esketamine results in decreased expression of RELN mRNA CTD PMID:38219984 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rgs5 regulator of G-protein signaling 5 decreases expression ISO Esketamine results in decreased expression of RGS5 mRNA CTD PMID:38219984 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518 		JBrowse link
G Rida reactive intermediate imine deaminase A homolog decreases expression ISO Esketamine results in decreased expression of RIDA mRNA CTD PMID:38219984 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716 		JBrowse link
G Rora RAR-related orphan receptor A increases expression ISO Esketamine results in increased expression of RORA mRNA CTD PMID:38219984 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Sall4 spalt-like transcription factor 4 decreases expression ISO Esketamine results in decreased expression of SALL4 mRNA CTD PMID:38219984 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822 		JBrowse link
G Sema5a semaphorin 5A decreases expression ISO Esketamine results in decreased expression of SEMA5A mRNA CTD PMID:38219984 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084 		JBrowse link
G Slc6a12 solute carrier family 6 member 12 increases expression ISO Esketamine results in increased expression of SLC6A12 mRNA CTD PMID:38219984 NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO Esketamine results in decreased expression of SLCO2A1 mRNA CTD PMID:38219984 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546 		JBrowse link
G Slitrk6 SLIT and NTRK-like family, member 6 increases expression ISO Esketamine results in increased expression of SLITRK6 mRNA CTD PMID:38219984 NCBI chr15:87,563,506...87,570,125
Ensembl chr15:87,563,322...87,570,393 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Esketamine results in increased expression of SPP1 mRNA CTD PMID:38219984 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sycp2 synaptonemal complex protein 2 increases expression ISO Esketamine results in increased expression of SYCP2 mRNA CTD PMID:38219984 NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type decreases expression ISO Esketamine results in decreased expression of TNNC1 mRNA CTD PMID:38219984 NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases expression ISO Esketamine results in increased expression of TRPV3 mRNA CTD PMID:38219984 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Unc13a unc-13 homolog A increases expression ISO Esketamine results in increased expression of UNC13A mRNA CTD PMID:38219984 NCBI chr16:18,333,910...18,381,813
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
G Vwa5a von Willebrand factor A domain containing 5A increases expression ISO Esketamine results in increased expression of VWA5A mRNA CTD PMID:38219984 NCBI chr 8:38,815,176...38,848,674
Ensembl chr 8:38,815,210...38,839,112 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Esketamine results in increased expression of XBP1 mRNA CTD PMID:38219984 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Zfp239 zinc finger protein 239 decreases expression ISO Esketamine results in decreased expression of ZNF239 mRNA CTD PMID:38219984 NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:151,029,405...151,039,529 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          analgesic 14769
            esketamine 49
              esketamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbonyl compound 18908
                                    ketone 17258
                                      cyclic ketone 15908
                                        alicyclic ketone 1268
                                          cyclohexanones 971
                                            ketamine 966
                                              esketamine 49
                                                esketamine hydrochloride 0
paths to the root